​

1.神经退行性疾病的细胞分子机制，治疗靶点及药物筛选。

2.缺氧损伤和缺氧耐受。

3.成体神经干细胞在生理和病理条件下增生与分化的调节。

   

071006-神经生物学
071010-生物化学与分子生物学
070321-化学生物学

神经退性疾病的细胞分子机制研究, 治疗靶点和药物筛选
成体神经干细胞在病理条件下的增殖与分化
缺氧损伤和缺氧耐受

2002-09--2005-12   美国范德堡大学 （Vanderbilt University）   Ph.D
1999-09--2002-08   美国犹他大学（University of Utah）   神经科学研究生
1997-10--1999-08   新加坡国立大学（National University of Singapore）   硕士
1994-09--1997-07   中国科学院上海脑研究所   神经生物学硕士学位
1987-09--1992-07   衡阳医学院   临床医疗学士学位

-- 研究生

-- 博士

2006.1-2008.1，中国科学院上海生命科学院神经科学研究所，副研究员

2008.1-2013.1，中国科学院上海生命科学院神经科学研究所，研究员，神经退行性疾病小组组长。

2013.1-                中国科学院上海高等研究院神经科学研究所，研究员，神经退行性疾病课题组组长。  

2015.10-              中国科学院大学岗位教授

2015-10~现在, 中国科学院大学, 岗位教授
2013-01~现在, 中科院上海高等研究院, 研究员
2008-01~2012-12,中科院上海生命科学院神经所, 研究员
2006-01~2007-12,中科院上海生命科学院神经所, 副研究员
1992-08~1994-08,湖南省汝城县人民医院, 住院医师

神经科学中的动物模型
神经科学

1 Huang FD. (2014), Patent number: 201420128803.0

2 Huang et al. (2015), Patent number: 201210234165.6

3 Huang et al. (2015), Patent application number: PCT/CN2015/078070

4 Huang et al. (2016), Patent application number: PCT/CN2016/080907

（ 1 ） Rbo/efr3a/efr3b基因或其蛋白在诊断和治疗阿尔兹海默病中的作用, 发明, 2012, 第 1 作者, 专利号: 201210234165.6
（ 2 ） 一种自动检测昆虫移行能力的装置, 实用新型, 2014, 第 1 作者, 专利号: 201420128803.0
（ 3 ） PI4KIIIa蛋白及相关膜蛋白复合体, 发明, 2015, 第 1 作者, 专利号: PCT/CN2015/078058
（ 4 ） 一种筛选治疗阿尔茨海默病的药物和靶点的方法, 发明, 2015, 第 1 作者, 专利号: PCT/CN2015/078070
（ 5 ） 一种筛选治疗阿尔茨海默病的药物和靶点的方法 （专利申请人是被转让企业）, 发明, 2016, 第 1 作者, 专利号: PCT/CN2016/080907
（ 6 ） 抑制肝纤维化的小分子化合物及应用, 发明, 2017, 第 1 作者, 专利号: 201710245431.8
（ 7 ） 抑制肝纤维化的试剂及应用 等, 发明, 2017, 第 1 作者, 专利号: 201710245671.8

   

[1] Zhang, Qichao., Zhang, Baozhu, Lim, Nastasia K.H., Zhang, Xiao, Meng, Shiquan, Nyengaard, Jens R., Huang, Fu-De, Wang, Wen-An. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIalpha in Drosophila. BBRC[J]. 2022, 589: 71-77, https://www.ncbi.nlm.nih.gov/pubmed/34894559.
[2] Xie, Yiyu, Huang, Jason J., Zhang, Hao, Hong, Feng, Huang, Fu-De, Wang, Wen-An. Phenylarsine oxide inhibits the accumulation of lipid droplets in macrophages. ABBS[J]. 2022, https://www.ncbi.nlm.nih.gov/pubmed/36239353.
[3] Zheng, Linan, Hong, Feng, Huang, Fude, Wang, Wenan. Inhibition of PI4KIII alpha as a Novel Potential Approach for Gaucher Disease Treatment. NEUROSCIENCE BULLETIN. 2021, 37(8): 1234-1239, http://dx.doi.org/10.1007/s12264-021-00704-w.
[4] Du, Qingqing, Lim, Nastasia K H, Xia, Yiling, Xu, Wangchao, Zhang, Qichao, Zhang, Liyao, Huang, Fude, Wang, Wenan. Pgant4 and Tango1 Mediate Anoxia and Reoxygenation Injury. NEUROSCIENCE BULLETIN. 2020, 36(12): 1552-1557, http://lib.cqvip.com/Qikan/Article/Detail?id=7103720246.
[5] Mu, Shujing, Lim, Nastasia K H, Huang, Fude. Inhibition of phosphatidylinositol kinase-III alpha induces or facilitates lysosome exocytosis from microglia.. NEUROREPORT[J]. 2020, 31(10): 697-701, https://www.webofscience.com/wos/woscc/full-record/WOS:000545918200001.
[6] He, Yang, Wei, Mengdi, Wu, Yan, Qin, Huaping, Li, Weinan, Ma, Xiaolin, Cheng, Jingjing, Ren, Jinshuai, Shen, Ye, Chen, Zhong, Sun, Binggui, Huang, FuDe, Shen, Yi, Zhou, YuDong. Amyloid beta oligomers suppress excitatory transmitter release via presynaptic depletion of phosphatidylinositol-4,5-bisphosphate. NATURE COMMUNICATIONS[J]. 2019, 10: http://dx.doi.org/10.1038/s41467-019-09114-z.
[7] Sun, Minghao, Zhao, Yinghui, Han, Men, Zhang, Baozhu, Zhang, Xiao, Zhang, Qichao, Lim, Nastasia KH, Wang, WenAn, Huang, FuDe. TTC7 and Hyccin Regulate Neuronal A beta(42) Accumulation and its Associated Neural Deficits in A beta(42)-Expressing Drosophila. JOURNAL OF ALZHEIMERS DISEASE[J]. 2018, 65(3): 1001-1010, https://www.webofscience.com/wos/woscc/full-record/WOS:000444339800023.
[8] Lim, Nastasia KH, Moestrup, Visse, Zhang, Xiao, Wang, WenAn, Moller, Arne, Huang, FuDe. An Improved Method for Collection of Cerebrospinal Fluid from Anesthetized Mice. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS[J]. 2018, https://www.webofscience.com/wos/woscc/full-record/WOS:000443329500126.
[9] Xia, Yiling, Xu, Wangchao, Meng, Shiquan, Lim, Nastasia K H, Wang, Wenan, Huang, FuDe. An Efficient and Reliable Assay for Investigating the Effects of Hypoxia/Anoxia on Drosophila. NEUROSCIENCE BULLETIN[J]. 2018, 34(2): 397-402, http://lib.cqvip.com/Qikan/Article/Detail?id=674956891.
[10] Wenze Cao, Li Song, Jingjing Cheng, Na Yi, Luyi Cai, Fude Huang, Margaret Ho. An Automated Rapid Iterative Negative Geotaxis Assay for Analyzing Adult Climbing Behavior in a Drosophila Model of Neurodegeneration. Journal of Visualized Experiments : JoVE. 2017, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752225/.
[11] 黄福德. SH2B1 is involved in the accumulation of Aβ42 in Alzheimer’s disease model. Journal of Alzheimer's Disease. 2017, [12] 黄福德. Down regulation of RBO-PI4KIIIα facilitates Aβ42 secretion and ameliorates neural deficits in Drosophila. J. Neurosci.. 2017, [13] Hu, Haixia, Ye, Bin, Zhang, Le, Wang, Quan, Liu, Zhiwei, Ji, Suying, Liu, Qiuju, Lv, Jingrong, Ma, Yan, Xu, Ying, Wu, Hao, Huang, Fude, Xiang, Mingliang. Efr3a Insufficiency Attenuates the Degeneration of Spiral Ganglion Neurons after Hair Cell Loss. FRONTIERS IN MOLECULAR NEUROSCIENCE[J]. 2017, 10: https://www.webofscience.com/wos/woscc/full-record/WOS:000397570500001.
[14] Qian, Qi, Liu, Qiuji, Zhou, Dongming, Pan, Hongyu, Liu, Zhiwei, He, Fangping, Ji, Suying, Wang, Dongpi, Bao, Wangxiao, Liu, Xinyi, Liu, Zhaoling, Zhang, Heng, Zhang, Xiaoqin, Zhang, Ling, Wang, Mingkai, Xu, Ying, Huang, Fude, Luo, Benyan, Sun, Binggui. Brain-specific ablation of Efr3a promotes adult hippocampal neurogenesis via the brain-derived neurotrophic factor pathway. FASEB JOURNAL[J]. 2017, 31(5): 2104-2113, https://www.webofscience.com/wos/woscc/full-record/WOS:000399195500029.
[15] 仝艳艳, 李光明, 邓怡林, 石翠翠, 黄福德, 范建高. 氧化苯砷体外对大鼠原代肝星状细胞活化的阻抑作用研究. 实用肝脏病杂志[J]. 2016, 19(4): 413-417, http://lib.cqvip.com/Qikan/Article/Detail?id=669540701.
[16] Shen, YiJun, Wang, WenAn, Huang, FuDe, Chen, Jie, Liu, HaiYan, Xia, YiLing, Han, Meng, Zhang, Le. The use of MMSE and MoCA in patients with acute ischemic stroke in clinical. INTERNATIONAL JOURNAL OF NEUROSCIENCE[J]. 2016, 126(5): 442-447, https://www.webofscience.com/wos/woscc/full-record/WOS:000376392400010.
[17] 韩萌, 马萍丽, 叶春艳, 张保柱, 章海燕, 孙晓江, 黄福德. 阿尔茨海默病果蝇模型中Aβ毒性的长度依赖性. 中国老年学杂志[J]. 2015, 1315-, http://lib.cqvip.com/Qikan/Article/Detail?id=90768890504849534853485557.
[18] Liu Haiyan, Han Meng, Li Qingyi, Zhang Xiao, Wang Wenan, Huang Fude. Automated rapid iterative negative geotaxis assay and its use in a genetic screen for modifi ers of Aβ_(42)-induced locomotor decline in Drosophila. Neuroscience Bulletin[J]. 2015, 31(5): 541-549, [19] 黄福德. Automated rapid iterative negative geotaxis assay and its use in a genetic screening for modifiers of Aβ42-induced locomotor decline in Drosophila. Neuroscience Bulletin. 2015, [20] Han, M, Huang, J K, Liu, H Y, Wang, W A, Sun, X J, Huang, F D. Neither insufficiency nor overexpression of sac1 affects the accumulation of A beta(42) in Drosophila expressing A beta(42). EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES[J]. 2015, 19(9): 1700-1705, https://www.webofscience.com/wos/woscc/full-record/WOS:000355744400024.
[21] 黄福德. The toxicity of beta amyloid peptide depends on its length in transgenic Drosophila model of Alzheimer’s disease. China Journal of Gerontology. 2015, [22] Lin Jingya, Wang Wenan, Zhang Xiao, Liu Haiyan, Zhao Xiaoliang, Huang Fude. Intraneuronal accumulation of Aβ_(42) induces age-dependent slowing of neuronal transmission in Drosophila. Neuroscience Bulletin[J]. 2014, 30(2): 185-190, [23] 黄福德. β淀粉样肽在阿尔兹海默病中作用的逐步认识. 生命科学[J]. 2014, 26(1): 9-14, [24] Lin, JingYa, Wang, WenAn, Zhang, Xiao, Liu, HaiYan, Zhao, XiaoLiang, Huang, FuDe. Intraneuronal accumulation of A beta(42) induces age-dependent slowing of neuronal transmission in Drosophila. NEUROSCIENCE BULLETIN[J]. 2014, 30(2): 185-190, http://www.irgrid.ac.cn/handle/1471x/850744.
[25] Huang, JianKang, Ma, PingLi, Ji, SuYing, Zhao, XiaoLiang, Tan, JiangXiu, Sun, XiaoJiang, Huang, FuDe. Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's Disease. NEUROBIOLOGY OF DISEASE[J]. 2013, 51(1): 161-167, http://dx.doi.org/10.1016/j.nbd.2012.11.006.
[26] Bao, GuanShui, Wang, WenAn, Wang, TianZhe, Huang, JianKang, He, Hua, Liu, Zhenguo, Huang, FuDe. Overexpression of Human MRP1 in Neurons causes resistance to Antiepileptic Drugs in Drosophila Seizure Mutants. JOURNAL OF NEUROGENETICS[J]. 2011, 25(4): 201-206, http://www.irgrid.ac.cn/handle/1471x/502283.
[27] XiaoLiang Zhao, WenAn Wang, JiangXiu Tan, JianKang Huang, Xiao Zhang, BaoZhu Zhang, YuHang Wang, HanYu YangCheng, HongLian Zhu, XiaoJiang Sun, FuDe Huang. Expression of β-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila. The Journal of Neuroscience. 2010, 30(4): 1512-1522, [28] Yu, Y, Xu, C, Pan, X, Ren, H, Wang, W, Meng, X, Huang, F, Chen, N. Identification and functional analysis of novel mutations of the CLCNKB gene in Chinese patients with classic Bartter syndrome. CLINICAL GENETICS[J]. 2010, 77(2): 155-162, http://www.irgrid.ac.cn/handle/1471x/502347.
[29] 黄福德. Rolling Blackout is required for synaptic vesicle exocytosis in Drosophila. Journal of neuroscience. 2006, [30] Tai, SK, Huang, FD, Moochhala, S, Khanna, S. Hippocampal theta state in relation to formalin nociception. PAIN[J]. 2006, 121(1-2): 29-42, http://dx.doi.org/10.1016/j.pain.2005.11.016.
[31] Huang, FD, Matthies, HJG, Speese, SD, Smith, MA, Broadie, K. Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. NATURE NEUROSCIENCE[J]. 2004, 7(10): 1070-1078, https://www.webofscience.com/wos/woscc/full-record/WOS:000224156900016.
[32] Huang, FD, Chen, J, Lin, M, Keating, MT, Sanguinetti, MC. Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. CIRCULATION[J]. 2001, 104(9): 1071-1075, https://www.webofscience.com/wos/woscc/full-record/WOS:000170774400028.
[33] 黄福德. Neuronal activity of monkey dorso-lateral premotor cortex during tasks of figure recognition guided motor sequence vs memorized spatial motor sequence. ACTA PHYSIOLOGICA SINICA. 1998, 

   

（ 1 ） 条件性敲除Efr3a基因对 APP/Psn 转基因小鼠神经退行性变的影响及机制研究, 主持, 国家级, 2014-01--2017-12
（ 2 ） Hyccin缺失导致神经髓鞘形成不良的动物模型构建及机制研究, 主持, 国家级, 2016-01--2019-12
（ 3 ） 老年痴呆症相关分子标记和潜在治疗靶点的筛选与鉴定, 主持, 国家级, 2013-01--2017-12
（ 4 ） 阿尔茨海默病新靶点和化合物筛选, 主持, 院级, 2015-06--2020-08
（ 5 ） PI4KIIIa及其抑制剂在焦虑抑郁中的作用与机制 （挂靠中科院药物所，可续）, 主持, 国家级, 2017-01--2018-12

已指导学生

马平丽  02  19179  

张潇  01  19179  

张建夫  02  63228  

蒋理想  02  63228  

现指导学生

孙名皓  02  63228  

张起超  02  19179  

张丽瑶  02  19179  

沐舒静   02  63228