070302-分析化学

单细胞蛋白质组分析新方法
外泌体富集新材料与新方法
蛋白质组样品处理仪器创制

2003-09--2010-01   中国科学院大连化学物理研究所   博士
1999-09--2003-07   江西师范大学   学士

   

2021-07~现在, 中国科学院大连化学物理研究所, 研究员
2020-07~2021-06,中国科学院大连化学物理研究所, 项目研究员
2011-10~2020-06,中国科学院大连化学物理研究所, 副研究员
2010-01~2011-09,中国科学院大连化学物理研究所, 助理研究员

2023-04-30-2025-12-31,Journal of Analysis and testing, 青年编委
2020-11-01-今,《分析实验室》, 青年编委
2017-12-01-今,辽宁省细胞生物学学会肿瘤外科治疗与转化医学专业委员会, 理事

   

（ 1 ） 一种生物样品溶液中外泌体富集方法, 发明专利, 2021, 第 3 作者, 专利号: CN113000038A

（ 2 ） 一种烟气体液代谢糖苷衍生物集成化样品处理系统及应用, 发明专利, 2021, 第 2 作者, 专利号: CN112903831A

（ 3 ） 一种利用滤膜实现外泌体富集的装置和外泌体富集方法, 发明专利, 2021, 第 4 作者, 专利号: CN112903403A

（ 4 ） 一种阵列高通量蛋白质样品预处理装置, 发明专利, 2020, 第 3 作者, 专利号: CN111220429A

（ 5 ） 一种蛋白质吸附材料及其制备及应用, 发明专利, 2020, 第 3 作者, 专利号: CN111220680A

（ 6 ） 一种外泌体的富集方法, 发明专利, 2019, 第 5 作者, 专利号: CN110411816A

（ 7 ） 一种离体体液中蛋白质的预处理方法, 发明专利, 2018, 第 2 作者, 专利号: CN108088727A

（ 8 ） 一种高通量体液蛋白质样品预处理装置及其应用, 发明专利, 2018, 第 2 作者, 专利号: CN108088933A

（ 9 ） 一种硫巯化翻译后修饰肽段的定性与定量方法, 专利授权, 2018, 第 3 作者, 专利号: CN108089004A

（ 10 ） 一种高通量蛋白质样品预处理设备, 发明专利, 2018, 第 3 作者, 专利号: CN107588997A

（ 11 ） 一种用于蛋白质样品预处理装置中的高温变性和还原器, 专利授权, 2017, 第 3 作者, 专利号: CN107478472A

（ 12 ） 一种硫巯化多肽的富集方法, 专利授权, 2017, 第 2 作者, 专利号: CN106854231A

（ 13 ） 蛋白质固相烷基化试剂的制备及固相烷基化试剂和应用, 发明专利, 2017, 第 2 作者, 专利号: CN106632877A

（ 14 ） 一种固定化酶反应器及其制备方法和应用, 发明专利, 2016, 第 3 作者, 专利号: CN105274000A

（ 15 ） 一种蛋白质定量方法, 发明专利, 2014, 第 5 作者, 专利号: CN104237363A

（ 16 ） 基于亲水作用机理富集糖肽的酰胺型整体柱及制备和应用, 发明专利, 2014, 第 3 作者, 专利号: CN103877955A

（ 17 ） 低残留无机-有机杂化整体基质固定化酶反应器及其制备, 发明专利, 2014, 第 2 作者, 专利号: CN103881999A

（ 18 ） 一种 18 O在线标记的蛋白质定量分析平台及其操作方法, 发明专利, 2014, 第 4 作者, 专利号: CN103884807A

（ 19 ） 一种集成化的蛋白质C-端富集方法, 发明专利, 2014, 第 3 作者, 专利号: CN103884574A

（ 20 ） 一种高通量蛋白质样品预处理装置, 发明专利, 2014, 第 2 作者, 专利号: CN103852527A

（ 21 ） 一种微液相分离系统与质谱联用的多通道电喷雾离子源, 发明专利, 2012, 第 4 作者, 专利号: CN101206207B

（ 22 ） 用于生物大分子分离纯化的柱切换循环体积排阻色谱系统, 发明专利, 2010, 第 2 作者, 专利号: CN101619090A

（ 23 ） 集蛋白质收集和酶解于一体的样品预处理装置及其制备, 发明专利, 2009, 第 2 作者, 专利号: CN101470052A

   

（1） Widespread protein N-phosphorylation in organism revealed by SiO2@DpaZn beads based mild-acidic enrichment method, TALANTA, 2023, 第 5 作者
（2） 单细胞蛋白质组学分析技术研究进展, Progress in technologies for single-cell proteome analysis, 分析试验室, 2022, 第 2 作者
（3） A Temporal PROTAC Cocktail-Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells, ADVANCED SCIENCE, 2022, 第 16 作者
（4） Solid-phase alkylation: a low-loss and anti-interference sample preparation strategy for low-input proteome profiling, SCIENCE BULLETIN, 2022, 通讯作者
（5） Fully integrated protein absolute quantification platform for analysis of multiple tumor markers in human plasma, TALANTA, 2021, 通讯作者
（6） Integrated proteomic sample preparation with combination of on-line high-abundance protein depletion, denaturation, reduction, desalting and digestion to achieve high throughput plasma proteome quantification, ANALYTICA CHIMICA ACTA, 2021, 通讯作者
（7） Fully automated sample treatment method for high throughput proteome analysis, Fully automated sample treatment method for high throughput proteome analysis, SCIENCE CHINA-CHEMISTRY, 2021, 通讯作者
（8） Comprehensive Analysis of Protein N-Terminome by Guanidination of Terminal Amines, ANALYTICAL CHEMISTRY, 2020, 第 6 作者
（9） A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases, THERANOSTICS, 2020, 其他（合作组作者）
（10） Site-Specific Quantification of Persulfidome by Combining an Isotope-Coded Affinity Tag with Strong Cation-Exchange-Based Fractionation, ANALYTICAL CHEMISTRY, 2019, 通讯作者
（11） Advances in exosome isolation methods and their applications in proteomic analysis of biological samples, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2019, 通讯作者
（12） Recent advances in multidimensional separation for proteome analysis, ANALYTICAL CHEMISTRY, 2019, 第 1 作者
（13） Integrated platform with combination of on-line protein digestion, isotope dimethyl labeling and multidimensional peptide separation for high-throughput proteome quantification, ANALYTICA CHIMICA ACTA, 2018, 第 2 作者
（14） Enzymatic Reactor with Trypsin Immobilized on Graphene Oxide Modified Polymer Microspheres To Achieve Automated Proteome Quantification, ANALYTICAL CHEMISTRY, 2017, 第 1 作者
（15） Preparation of Hydrophilic Monolithic Capillary Column by in Situ Photo-polymerization of N-vinyl-2-pyrrolidinone and Acrylamide for Highly Selective and Sensitive Enrichment of N-linked Glycopeptides, TALANTA, 2016, 第 2 作者
（16） Depletion of internal peptides by site-selective blocking, phosphate labeling, and TiO2 adsorption for in-depth analysis of C-terminome, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2016, 第 4 作者
（17） Integrated SDS removal and protein digestion by hollow fiber membrane based device for SDS-assisted proteome analysis, TALANTA, 2015, 第 2 作者
（18） Particulate capillary precolumns with double-end polymer monolithic frits for on-line peptide trapping and preconcentration, CHINESE CHEMICAL LETTERS, 2015, 第 2 作者
（19） Integrated platform with a combination of online digestion and O-18 labeling for proteome quantification via an immobilized trypsin microreactor, ANALYST, 2015, 第 2 作者
（20） Preparation of high efficiency and low carry-over immobilized enzymatic reactor with methacrylic acid–silica hybrid monolith as matrix for on-line protein digestion, JOURNAL OF CHROMATOGRAPHY A, 2014, 第 1 作者
（21） SIMULTANEOUS PROTEIN DIGESTION AND 18O LABELING BY A GRAPHENE OXIDE BASED IMMOBILIZED ENZYMATIC REACTOR FOR HIGH THROUGHPUT QUANTITATIVE PROTEOME ANALYSIS, the 13th world congress of the human proteome, 2014, 第 1 作者
（22） 1-Dodecyl-3-methylimidazolium chloride-assisted sample preparation method for efficient integral membrane proteome analysis., ANALYTICAL CHEMISTRY, 2014, 第 4 作者
（23） An integrated sample pretreatment platform for quantitative N-glycoproteome analysis with combination of on-line glycopeptide enrichment, deglycosylation and dimethyl labeling, ANALYTICA CHIMICA ACTA, 2014, 第 6 作者
（24） 集成化蛋白质组定量分析平台的构建及应用, Establishment and application of integrated platform for proteome quantification, 色谱, 2014, 第 3 作者
（25） Improved accuracy for label-free absolute quantification of proteome by combining the absolute protein expression profiling algorithm and summed tandem mass spectrometric total ion current, ANALYST, 2014, 第 5 作者
（26） Integrated sample pretreatment approach for high throughput quantitative proteome analysis, the 5th asia oceania mass spectrometry conference & the 33rd chinese mass spectrometry society annual conference, 2014, 第 1 作者
（27） Biphasic microreactor for efficient membrane protein pretreatment with a combination of formic acid assisted solubilization, on-column pH adjustment, reduction, alkylation, and tryptic digestion., ANALYTICAL CHEMISTRY, 2013, 第 3 作者
（28） An integrated platform for quantitative glycoproteome analysis, 22nd international symposium on glycoconjugates, 2013, 第 4 作者
（29） An activity-maintaining sequential protein extraction method for bioactive assay and proteome analysis of velvet antlers, TALANTA, 2013, 第 2 作者
（30） Preparation of amide functionalized hydrophilic monolith by in situ photo-polymerization for highly selective enrichment of glycopeptides, 22nd international symposium on glycoconjugates, 2013, 第 2 作者
（31） A Novel Method Combining MS and MS/MS Spectral for Quantitative, ASIA OCEANIA HUMAN PROTEOME ORGANIZATION 6TH CONGRESS, 2012, 第 3 作者
（32） Prefractionation and separation by C8 stationary phase: Effective strategies for integral membrane proteins analysis, TALANTA, 2012, 第 5 作者
（33） A Hydrophilic Methacrylic Acid Modified Silica Hybrid Monolith Based Immobilized Enzymatic Reactor for on Line Protein Digestion with Low Peptide/Protein Nonspecific Adsorption, ASIA OCEANIA HUMAN PROTEOME ORGANIZATION 6TH CONGRESS, 2012, 第 1 作者
（34） Mechanism Study of Lonic Liquids for Solubilizing Membrane Proteins, ASIA OCEANIA HUMAN PROTEOME ORGANIZATION 6TH CONGRESS, 2012, 第 2 作者
（35） Integrated Platform for Proteome Profiling with Combination of Microreversed Phase Based Protein and Peptide Separation via Online Solvent Exchange and Protein Digestion, ANALYTICAL CHEMISTRY, 2012, 第 1 作者
（36） Development of Hydrophilic Immobilized Enzymatic Reactors and Applications in High Throughput Proteome Digestion, ASIA OCEANIA HUMAN PROTEOME ORGANIZATION 6TH CONGRESS, 2012, 第 4 作者
（37） A hydrophilic immobilized trypsin reactor with N-vinyl-2-pyrrolidinone modified polymer microparticles as matrix for highly efficient protein digestion with low nonspecific adsorption, Journal of Chromatography A, 2012, 第 1 作者
（38） Recent advances on multidimensional liquid chromatography–mass spectrometry for proteomics: From qualitative to quantitative analysis—A review, ANALYTICA CHIMICA ACTA, 2012, 第 2 作者
（39） A hydrophilic immobilized trypsin reactor with N-vinyl-2-pyrrolidinone modified polymer microparticles as matrix for highly efficient protein digestion with low peptide residue, JOURNAL OF CHROMATOGRAPHY A, 2012, 第 2 作者
（40） Preparation of methacrylic acid modified silica hybrid monolith based immobilized enzymatic reactor with \, 27TH INTERNATIONAL SYMPOSIUM ON MICROSCALE BIOSEPARATIONS AND ANALYSES, 2012, 第 1 作者
（41） Boronic Acid Functionalized Core-shell Polymer Nanoparticles for Selective Enrichment of Glycopeptides, ASIA OCEANIA HUMAN PROTEOME ORGANIZATION 6TH CONGRESS, 2012, 第 4 作者
（42） Nano-flow multidimensional liquid chromatography platform integrated with combination of protein and peptide separation for proteome analysis, JOURNAL OF SEPARATION SCIENCE, 2012, 第 3 作者
（43） Integrated Sample Pretreatment System for N-Linked Glycosylation Site Profiling with Combination of Hydrophilic Interaction Chromatography and PNGase F Immobilized Enzymatic Reactor via a Strong Cation Exchange Precolumn, ANALYTICAL CHEMISTRY, 2011, 第 3 作者
（44） Monolithic Materials for Sample Preparation and Separation in Proteome Study, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 3 作者
（45） An integrated protein pretreatment device as the interface of two-dimensional high performance liquid chromatography system for high throughput huiman serum proteome analysis, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 1 作者
（46） An efficient method for membrane protein prefractionation based on the difference of the solvent solubility, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 3 作者
（47） Integration of click maltose hydrophilic interaction chromatography, SCX preolumn and PNGase F immobilized enzymatic reactor for N-linked glycosylation sites profiling, 26TH INTERNATIONAL SYMPOSIUM ON MICROSCALE BIOSEPARATIONS, 2011, 第 2 作者
（48） Integrated Multidimensional Liquid Chromatography Mass Spectrometry for High Throughput Proteome Anaysis, PITTCON-THE MAGNET FOR SCIENTIFIC INNOVATION, 2011, 第 2 作者
（49） Preparation of poymer nanospheres entrapped monolithic precolumn and its application for proteome analysis, 7TH CNUPO ANNUAL CONGRESS AND 3RD INTERNATIONAL FORUM OF PROTEOMICS PROTEOMICS AND TRANSLATIONAL MEDICINE, 2011, 第 2 作者
（50） A Hydrophilic Immobilized Trypsin Reactor In Capillary For Highly Efficient Protein Digestion, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 2 作者
（51） Analysis of integral membrane proteome by micro HPLC coupled with MALDI-TOF-MS, 7TH CNUPO ANNUAL CONGRESS AND 3RD INTERNATIONAL FORUM OF PROTEOMICS PROTEOMICS AND TRANSLATIONAL MEDICINE, 2011, 第 4 作者
（52） Integrated Multidimensional Liquid Chromatography Mass Spectrometry for High Throughput Proteome Anaysis, PITTSBURGH CONFERENCE ON ANALYTICAL CHEMISTRY AND APPLIED SPECTROSCOPY, 2011, 第 2 作者
（53） Integrated platform of capillary isoelectric focusing, trypsin immobilized enzyme microreactor and nanoreversed-phase liquid chromatography with mass spectrometry for online protein profiling, ELECTROPHORESIS, 2011, 第 4 作者
（54） Integrated sample pretreatment system for N-linked glycosylation site profiling with combination of click maltose hydrophilic interaction chromatography and PNGase F immobilized enzymatic reactor enzymatic reactor via strong cation exchange precolumn, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 2 作者
（55） Integration of Protein Digestion Microreactors in a Comprehensive Two-Dimensional Liquid Chromatorgraphy System, 36TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 2 作者
（56） An integrated platform for quantitative proteome analysis with combination of protein labeling, separation and peptide separation via online digestion, HUMAN PROTEOME ORGANISATION, 2011, 第 2 作者
（57） Highly efficient two dimensional nano-liquid chromatography tandem mass spectrometry platform combining strong cation excha, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 2 作者
（58） A sequential protein extraction strategy for analysis of deer antler proteome and biological activity, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 2 作者
（59） On-line combination of monolithic immobilized pH gradient-based capillary isoelectric focusing and capillary zone electrophoresis via a partially etched porous interface for protein analysis, JOURNAL OF CHROMATOGRAPHY B, 2011, 第 5 作者
（60） Analysis of low molecular weight acids by monolithic immobilized pH gradient-based capillary isoelectric focusing coupled with mass spectrometry, JOURNAL OF SEPARATION SCIENCE, 2011, 第 6 作者
（61） Comparative Proteomics Analysis of Lymphatic Metastasis-associated Proteins of Highly and Low Lymphatic Metastatic Potentiality in Mouse Hepatocarcinoma Cell Lines Using Reductive Dimethylation-coupled HPLC-Chip ESI-QTOF, 7TH CNUPO ANNUAL CONGRESS AND 3RD INTERNATIONAL FORUM OF PROTEOMICS PROTEOMICS AND TRANSLATIONAL MEDICINE, 2011, 第 2 作者
（62） An Integrated Debice with Combination of Protein Denaturation, Reduction, Desalting and on-column Digestion for High Throughput Pretreatment of Proteins, 7TH CNUPO ANNUAL CONGRESS AND 3RD INTERNATIONAL FORUM OF PROTEOMICS PROTEOMICS AND TRANSLATIONAL MEDICINE, 2011, 第 1 作者
（63） On-line combination of monolithic immobilized pH gradient-based capillary isoelectric focusing and capillary zone electrophoresis via a partially etched porous interface for protein analysis, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 第 5 作者
（64） An integrated protein pretreatment device as the interface of two-dimensional high performance liquid chromatography systography system for hai throuput huiman serum proteome analysis, THE 11TH ASIAN CONFERENCE ON ANALYTICAL SCIENCES, 2011, 第 1 作者
（65） Doubile-chamber SPE-based protein pretreatment device for quantitative proteomics study, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 2 作者
（66） Multidimensional liquid chromatography based integrated platform for high efficient analysis of intact proteins, 全球第九届人类蛋白质组学会议, 2010, 第 1 作者
（67） New Methods and Platforma for Liquid Phase Based Proteome Separation and Identification, 35th international symposium on high performance liquid phase separations and related techniques, 2010, 第 3 作者
（68） 多维集成化蛋白质分离鉴定平台, 2010年微纳尺度分离和分析技术学术会议暨第六届全国微全分析学术会议, 2010, 第 1 作者
（69） Weak anion and cation exchange mixed-bed microcolumn for protein separation, JOURNAL OF SEPARATION SCIENCE, 2010, 第 2 作者
（70） 在线微酶反应器-微柱液相色谱-电喷雾质谱用于蛋白质快速分析, On-line Microenzymatic Reactor-Micro Column HPLC-ESI-MS/MS for Rapid Protein Analysis, 化学通报, 2009, 第 1 作者
（71） Integrated Platform for Proteome Analysis with Combination of Protein and Peptide Separation via Online Digestion, ANALYTICAL CHEMISTRY, 2009, 第 1 作者
（72） Columns switch recycling size exclusion chromatography for high resolution protein separation, JOURNAL OF CHROMATOGRAPHY A, 2009, 第 1 作者
（73） Integrated protein analysis platform based on column switch recycling size exclusion chromatography, microenzymatic reactor and mu RPLC-ESI-MS/MS, JOURNAL OF CHROMATOGRAPHY A, 2009, 第 1 作者
（74） Integrated microscale multidimensional liquid phase separation platforms for proteome analysis, the 24th msb 2009, 2009, 第 2 作者
（75） Multidimensional liquid chromatography based integrated platform for proteome study, post-genome technologies(ifpt6), 2009, 第 1 作者
（76） Column swich recycling size exclusion chromatography for protein separation, 32nd international symposium &exhibit on high performance liquid phase separations and related techniques, 2008, 第 1 作者
（77） Column switch recycling size exclusion chromatography for high efficient protein separation, 7th annual world congress hupo2008, 2008, 第 1 作者
（78） Novel chromatography techniques for high-throughput analysis of proteomes, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2008, 第 1 作者
（79） 新型全二维微柱液相色谱分离平台的构建, Construction of a Novel Comprehensive Two-dimensional Microcolumn Liquid Chromatography Separation Platform, 分析测试学报, 2008, 第 1 作者
（80） Multidimensional separation platform based on column swich recycling size exclusion chromatography for high efficiency analysis of proteins, the 33rd international symposium on high performance liquid phase separations and related techniques, 2008, 第 1 作者
（81） Recent development of monolithic materials as matrices in microcolumn separation systems, JOURNAL OF SEPARATION SCIENCE, 2007, 第 3 作者
（82） 不同代数永生化支气管上皮细胞中蛋白质的分布特征, Distribution of proteins in immortalized human bronchial epithelial cells of different passages, 中国组织工程研究与临床康复, 2007, 第 2 作者
（83） Integration of enzymatic microreactor with uHPLC/MS/MS for rapid protein identification, dalian international symposia and exhibitoon on chromatography, 2007, 第 1 作者
（84） 微柱液相色谱-电喷雾串联质谱检测多磷酸化肽位点, Detection of Multi-Phosphopeptide Sites Using Microcolumn High Performance Liquid Chromatography- Electrospray Ionization Tandem Mass Spectrometry, 色谱, 2007, 第 3 作者
（85） Macroporous polyacrylamide-based monolithic column with immobilize pH gradient for protein analysis, ELECTROPHORESIS, 2006, 第 2 作者
（86） Macroporous polyacrylamide-based monolithic column with immobilized pH gradient for protein analysis, ELECTROPHORESIS, 2006, 第 2 作者
（87） Fast analysis of rocuronium in the human plasma by microcolumn liquid chromatography with electrospray ionization time of flight mass spectrometry, the 4th international symposium of worldwide chinese scholars on analysis chemistry, 2006, 第 1 作者
（88） A simple and robust two-dimentional micro-column liquid chromatography platform, human proteome organisation, 2006, 第 1 作者

（1）  整体柱，样品预处理的原理, Comprehensive Sampling and Sample Preparation: Monoliths, fundamentals for sample preparation, Elsevier, 2012-05, 第 1 作者

   

（ 1 ） 用于膜蛋白质组样品高通量预处理的串级膜接口与平行酶反应器的集成化方法研究, 负责人, 国家任务, 2012-01--2014-12
（ 2 ） 膜蛋白质样品高通量分析方法的建立及应用研究, 负责人, 研究所自选, 2011-01--2013-12
（ 3 ） 肿瘤转移预警的蛋白质组分离鉴定新技术新方法研究, 参与, 国家任务, 2010-01--2013-12
（ 4 ） 蛋白质定量新方法及相关技术研究, 参与, 国家任务, 2013-01--2017-12
（ 5 ） 在线蛋白质预处理系统, 负责人, 国家任务, 2012-07--2017-03
（ 6 ） 基于液质联用的单细胞分泌蛋白质组定量分析新方法, 负责人, 国家任务, 2020-01--2023-12
（ 7 ） 深度覆盖的蛋白质组精准鉴定与定量新技术, 参与, 国家任务, 2017-07--2022-06
（ 8 ） 医学生命组学数据质量控制关键技术研发与应用示范, 参与, 国家任务, 2018-07--2020-12
（ 9 ） 细胞中重要调控蛋白质的发现和原位相互作用的分析新方法, 参与, 国家任务, 2020-01--2024-12
（ 10 ） 面向临床应用的干细胞外泌体膜法规模化制备及质量评价体系研究, 负责人, 研究所自选, 2022-01--2023-12
（ 11 ） 基于肺泡灌洗液外泌体的早期肺癌体外诊断标志物筛选及应用, 负责人, 地方任务, 2023-01--2024-12

（1）Preparation of methacrylic acid modified silica hybrid monolith based immobilized enzymatic reactor with “one-pot” approach for on line protein digestion with low protein carry-over   Yuan Huiming   2012-02-11
（2）An Integrated Protein Pretreatment Device as the Interface of Two-dimensional High Performance Liquid Chromatography System for High Throughput Human Serum Proteome Analysis   Yuan Huiming   2011-10-08
（3）An integrated device with combination of protein denaturation, reduction, desalting and on-column digestion for high throughput pretreatment of proteins    Yuan Huiming   2011-04-15