071007-遗传学
071021-生物信息学

表观遗传学
肿瘤遗传学
癌症进化的生物信息学分析

2005-05--2006-07 耶鲁大学 博士后
2003-11--2005-04 密西根大学 博士后
1998-09--2003-07 中国科学院生物物理研究所 博士

-- 研究生

-- 博士

   

2009-03--今 中科院北京基因组所 研究员
2006-08--2009-06 芝加哥大学 研究助理教授

   

（1） 全基因组 DNA 去甲基化和甲基化重编程在哺乳动物早期胚胎发育过程中的机制及作用，主持，国家级，2013-01--2015-12
（2） E3泛素转移酶连接蛋白SPOP在肾癌发生发展进程中的作用机制，主持，国家级，2012-01--2015-12
（3） 中科院**择优支持，主持，部委级，2012-01--2014-12
（4） 973 子课题 表观遗传在肺癌发生发展中的作用机制，主持，国家级，2011-01--2015-12

已指导学生

孙昕  硕士研究生  071022-基因组学  

张立  硕士研究生  071022-基因组学  

蒋岚  博士研究生  071022-基因组学  

李林  硕士研究生  071022-基因组学  

现指导学生

李国强  博士研究生  071022-基因组学  

马鑫  硕士研究生  071021-生物信息学  

李从儒  硕士研究生  071021-生物信息学  

王璐  博士研究生  071022-基因组学  

王京京  博士研究生  071022-基因组学  

王欣欣  硕士研究生  0710J3-生物信息学  

陈雪鹏  硕士研究生  0710J3-生物信息学  

祝为  博士研究生  0710J3-生物信息学  

   

[1] Keliang Wu, Dongdong Fan, Han Zhao, Zhenbo Liu, Zhenzhen Hou, Wenrong Tao, Guanling Yu, Shenli Yuan, Xiaoxiao Zhu, Mengyao Kang, Yong Tian, Zi-Jiang Chen, Jiang Liu, Lei Gao. Dynamics of histone acetylation during human early embryogenesis. CELL DISCOVERY[J]. 2023, 9(1): http://dx.doi.org/10.1038/s41421-022-00514-y.
[2] Shenli Yuan, Jianhong Zhan, Jingye Zhang, Zhenbo Liu, Zhenzhen Hou, Chuanxin Zhang, Lizhi Yi, Lei Gao, Han Zhao, Zi-Jiang Chen, Jiang Liu, Keliang Wu. Human zygotic genome activation is initiated from paternal genome. CELL DISCOVERY[J]. 2023, 9(1): 1-17, http://dx.doi.org/10.1038/s41421-022-00494-z.
[3] Gao, Yuan, Yi, Lizhi, Zhan, Jianhong, Wang, Lijuan, Yao, Xuelong, Yan, Junhao, Jian, Sijing, Gao, Lei, Farangez, Mamadboqirova, Gao, Ming, Zou, Yang, Gao, Xuan, Wu, Keliang, Liu, Jiang, Chen, ZiJiang. A clinical study of preimplantation DNA methylation screening in assisted reproductive technology. CELL RESEARCH[J]. 2023, 33(6): http://dx.doi.org/10.1038/s41422-023-00809-z.
[4] Shan Jiang, Zheng Huang, Yun Li, Chengwei Yu, Hao Yu, Yuwen Ke, Lan Jiang, Jiang Liu. Single-cell chromatin accessibility and transcriptome atlas of mouse embryos. CELL REPORTS. 2023, 42(3): http://dx.doi.org/10.1016/j.celrep.2023.112210.
[5] Xuelong Yao, Zongyang Lu, Zhanying Feng, Lei Gao, Xin Zhou, Min Li, Suijuan Zhong, Qian Wu, Zhenbo Liu, Haofeng Zhang, Zeyuan Liu, Lizhi Yi, Tao Zhou, Xudong Zhao, Jun Zhang, Yong Wang, Xingxu Huang, Xiaoqun Wang, Jiang Liu. Comparison of chromatin accessibility landscapes during early development of prefrontal cortex between rhesus macaque and human. Nature Communications[J]. 2022, 13:3883: [6] Shenli Yuan, Tao Huang, Ziyou Bao, Shiyu Wang, Xinyue Wu, Jiang Liu, Hongbin Liu, ZiJiang Chen. The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots. GENOME BIOLOGY[J]. 2022, 23(1): 1-26, http://dx.doi.org/10.1186/s13059-022-02758-z.
[7] Wang, Xinxin, Ma, Xin, Wei, Gaobo, Ma, Weirui, Zhang, Zhen, Chen, Xuepeng, Gao, Lei, Liu, Zhenbo, Yuan, Yue, Yi, Lizhi, Wang, Jun, Tokumoto, Toshinobu, Huang, Junjiu, Chen, Dahua, Zhang, Jian, Liu, Jiang. The Role of DNA Methylation Reprogramming during Sex Determination and Transition in Zebrafish. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2021, 19(1): 48-63, http://dx.doi.org/10.1016/j.gpb.2020.10.004.
[8] Huang, Tao, Yuan, Shenli, Gao, Lei, Li, Mengjing, Yu, Xiaochen, Zhang, Jianhong, Yin, Yingying, Liu, Chao, Zhang, Chuanxin, Lu, Gang, Li, Wei, Liu, Jiang, Chen, ZiJiang, Liu, Hongbin. The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair. ELIFE[J]. 2020, 9(6): [9] Xiaocui Xu, Guoqiang Li, Congru Li, Jing Zhang, Qiang Wang, David KSimmons, Xuepeng Chen, Naveen Wijesena, Wei Zhu, Zhanyang Wang, Zhenhua Wang, Bao Ju, Weimin Ci, Xuemei Lu, Daqi Yu, Qianfei Wang, Neelakanteswar Aluru, Paola Oliveri, Yong EZhang, Mark QMartindale, Jiang Liu. Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis. 国家科学评论:英文版[J]. 2019, 6(5): 993–1003-1003, http://lib.cqvip.com/Qikan/Article/Detail?id=7101064951.
[10] Wei Zhu, Xiaocui Xu, Xinxin Wang, Jiang Liu. Reprogramming histone modification patterns to coordinate gene expression in early zebrafish embryos. BMC GENOMICS[J]. 2019, 20: https://doaj.org/article/939903ef11a24142a4a62a0558ea8648.
[11] Chen, Xuepeng, Ke, Yuwen, Wu, Keliang, Zhao, Han, Sun, Yaoyu, Gao, Lei, Liu, Zhenbo, Zhang, Jingye, Tao, Wenrong, Hou, Zhenzhen, Liu, Hui, Liu, Jiang, Chen, ZiJiang. Key role for CTCF in establishing chromatin structure in human embryos. NATURE[J]. 2019, 576(7786): 306-+, http://dx.doi.org/10.1038/s41586-019-1812-0.
[12] Gao, Lei, Wu, Keliang, Liu, Zhenbo, Yao, Xuelong, Yuan, Shenli, Tao, Wenrong, Yi, Lizhi, Yu, Guanling, Hou, Zhenzhen, Fan, Dongdong, Tian, Yong, Liu, Jianqiao, Chen, ZiJiang, Liu, Jiang. Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution. CELL[J]. 2018, 173(1): 248-+, http://dx.doi.org/10.1016/j.cell.2018.02.028.
[13] Li, Congru, Fan, Yong, Li, Guoqiang, Xu, Xiaocui, Duan, Jialei, Li, Rong, Kang, Xiangjin, Ma, Xin, Chen, Xuepeng, Ke, Yuwen, Yan, Jie, Lian, Ying, Liu, Ping, Zhao, Yue, Zhao, Hongcui, Chen, Yaoyong, Yu, Yang, Liu, Jiang. DNA methylation reprogramming of functional elements during mammalian embryonic development. CELL DISCOVERY[J]. 2018, 4(1): https://doaj.org/article/a097f28b21f649d780434035d804afd0.
[14] Ke, Yuwen, Xu, Yanan, Chen, Xuepeng, Feng, Songjie, Liu, Zhenbo, Sun, Yaoyu, Yao, Xuelong, Li, Fangzhen, Zhu, Wei, Gao, Lei, Chen, Haojie, Du, Zhenhai, Xie, Wei, Xu, Xiaocui, Huang, Xingxu, Liu, Jiang. 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis. CELL[J]. 2017, 170(2): 367-+, http://dx.doi.org/10.1016/j.cell.2017.06.029.
[15] Li, Guoqiang, Yu, Yang, Fan, Yong, Li, Congru, Xu, Xiaocui, Duan, Jialei, Li, Rong, Kang, Xiangjin, Ma, Xin, Chen, Xuepeng, Ke, Yuwen, Yan, Jie, Lian, Ying, Liu, Ping, Zhao, Yue, Zhao, Hongcui, Chen, Yaoyong, Sun, Xiaofang, Liu, Jianqiao, Qiao, Jie, Liu, Jiang. Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology. JOURNAL OF GENETICS AND GENOMICS[J]. 2017, 44(10): 475-481, http://lib.cqvip.com/Qikan/Article/Detail?id=673702386.
[16] Wang, Yunfang, Qin, Jinhua, Wang, Shuyong, Zhang, Wencheng, Duan, Jialei, Zhang, Jing, Wang, Xin, Yan, Fang, Chang, Mingyang, Liu, Xiaofang, Feng, Bo, Liu, Jiang, Pei, Xuetao. Conversion of Human Gastric Epithelial Cells to Multipotent Endodermal Progenitors using Defined Small Molecules. CELL STEM CELL[J]. 2016, 19(4): 449-461, http://dx.doi.org/10.1016/j.stem.2016.06.006.
[17] Chen, Ke, Zhang, Jing, Guo, Zhongqiang, Ma, Qin, Xu, Zhengzheng, Zhou, Yuanyuan, Xu, Ziying, Li, Zhongwu, Liu, Yiqiang, Ye, Xiongjun, Li, Xuesong, Yuan, Bifeng, Ke, Yuwen, He, Chuan, Zhou, Liqun, Liu, Jiang, Ci, Weimin. Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. CELLRESEARCH[J]. 2016, 26(1): 103-118, https://www.webofscience.com/wos/woscc/full-record/WOS:000367615200010.
[18] 蒋华良. Small-molecule targeting of E3 ligase adaptor SPOP in kidney cancer. CANCER CELL[J]. 2016, 30(3): 474-484, http://www.corc.org.cn/handle/1471x/2376307.
[19] Wang JingJing, Liu Jiang. The Programming of DNA Methylation During Vertebrate Embryogenesis and Gametogenesis. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2015, 42(11): 1047-1053, https://www.webofscience.com/wos/woscc/full-record/WOS:000365558600009.
[20] Ci, Weimin, Liu, Jiang. Programming and Inheritance of Parental DNA Methylomes in Vertebrates. PHYSIOLOGYnull. 2015, 30(1): 63-68, https://www.webofscience.com/wos/woscc/full-record/WOS:000347306100009.
[21] Wang, Lu, Zhang, Jun, Duan, Jialei, Gao, Xinxing, Zhu, Wei, Lu, Xingyu, Yang, Lu, Zhang, Jing, Li, Guoqiang, Ci, Weimin, Li, Wei, Zhou, Qi, Aluru, Neel, Tang, Fuchou, He, Chuan, Huang, Xingxu, Liu, Jiang. Programming and Inheritance of Parental DNA Methylomes in Mammals. CELL[J]. 2014, 157(4): 979-991, http://dx.doi.org/10.1016/j.cell.2014.05.029.
[22] Li, Guoqiang, Ci, Weimin, Karmakar, Subhradip, Chen, Ke, Dhar, Ruby, Fan, Zhixiang, Guo, Zhongqiang, Zhang, Jing, Ke, Yuwen, Wang, Lu, Zhuang, Min, Hu, Shengdi, Li, Xuesong, Zhou, Liqun, Li, Xianghong, Calabrese, Matthew F, Watson, Edmond R, Prasad, Sandip M, RinkerSchaeffer, Carrie, Eggener, Scott E, Stricker, Thomas, Tian, Yong, Schulman, Brenda A, Liu, Jiang, White, Kevin P. SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer. CANCER CELL[J]. 2014, 25(4): 455-468, http://dx.doi.org/10.1016/j.ccr.2014.02.007.
[23] Jiang, Lan, Zhang, Jing, Wang, JingJing, Wang, Lu, Zhang, Li, Li, Guoqiang, Yang, Xiaodan, Ma, Xin, Sun, Xin, Cai, Jun, Zhang, Jun, Huang, Xingxu, Yu, Miao, Wang, Xuegeng, Liu, Feng, Wu, ChungI, He, Chuan, Zhang, Bo, Ci, Weimin, Liu, Jiang. Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos. CELL[J]. 2013, 153(4): 773-784, http://dx.doi.org/10.1016/j.cell.2013.04.041.
[24] Liu, Jiang, Ghanim, Murad, Xue, Lei, Brown, Christopher D, Iossifov, Ivan, Angeletti, Cesar, Hua, Sujun, Negre, Nicolas, Ludwig, Michael, Stricker, Thomas, AlAhmadie, Hikmat A, Tretiakova, Maria, Camp, Robert L, PereraAlberto, Montse, Rimm, David L, Xu, Tian, Rzhetsky, Andrey, White, Kevin P. Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer. SCIENCE[J]. 2009, 323(5918): 1218-1222, https://www.webofscience.com/wos/woscc/full-record/WOS:000263687600040.