生物质谱和有机质谱及其相关的应用研究，主要包括：
1、生物大分子与小分子的相互作用研究
2、药物筛选的方法学研究
3、生物大分子分析的新方法研究
4、环境有机污染物研究

   

070304-物理化学（含：化学物理）
0703J1-纳米科学与技术

生物质谱和有机质谱

   

1994年 哈尔滨工业大学  工学学士学位
2001年 中科院长春应用化学研究所  理学博士学位

理学博士

2004-2005    美国加利福尼亚大学尔湾分校 访问学者
2001-2004  加拿大科学院国家测量标准研究所 博士后

 

2006--今       中科院长春应用化学研究所 研究员
2004--2005  美国加利福尼亚大学尔湾分校 访问学者
2001--2004  加拿大科学院国家测量标准研究所 博士后

有机质谱原理、 物理化学前沿（专题）

（1） 吉林省科技进步一等奖，2001
（2） 中国科学院院长优秀奖，2001

1. Yu Z, Cui M, Yan CY, Song FR, Liu ZQ, Liu SY, Zhang HX. Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl) -β-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Journal of Mass Spectrometry. 45： 444–450（2010）
2. Wan CH, Cui M, Song FR, Liu ZQ, Liu SY. Evaluate Effects of Bivalent Cations on the Formation of Purine-rich Triple Helix DNA by ESI-FT-MS. Journal of the American Society for Mass Spectrometry. 20(7):1281-1286 (2009)
3. Wan CH, Cui M, Song FR, Liu ZQ, Liu SY. A Study of the Non-Covalent Interaction between Flavonoids and DNA Triplexes by Electrospray Ionization Mass Spectrometry. International Journal of Mass Spectrometry. 283(1): 48-55 ( 2009)
4. Wang ZF, Yu XM, Cui M, Liu ZQ, Song FR, Liu SY. Investigation of Calmodulin-Peptide Interactions Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry. Journal of the American Society for Mass Spectrometry 20(4):576-83（2009）
5. Wang ZF, Cui M, Song FR, Lu L, Liu ZQ, Liu SY. Evaluation of Flavonoids Binding to DNA Duplexes by Electrospray Ionization Mass Spectrometry Journal of the American Society for Mass Spectrometry, 19, 914-922 (2008)
6. Wang Z, Guo X, Liu Z, Cui M, Song F, Liu S.Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry. Journal of Mass Spectrometry 43(3):327-35 (2008).
7. Yan C, Liu S, Zhou Y, Song F, Cui M, Liu Z.A study of isomeric diglycosyl flavonoids by SORI CID of Fourier transform ion cyclotron mass spectrometry in negative ion mode. Journal of the American Society for mass Spectrometry. 18(12):2127-36 (2007).
8. Zhang X, Song FR, Cui M, Liu ZQ and Liu SY. “Investigation of the hydrolysis of ginsenosides by high performance liquid chromatography-electrospray ionization mass spectrometry”. Planta Medica. 73(11):1225-9 (2007).
9. Qiu XY, Cui M, Li HL, Liu ZQ and Liu SY. “A study of disulfide-linked peptides using matrix-assisted laser desorption/ionization mass spectrometry”. Rapid Communications in Mass Spectrometry. 21(21):3520-5 (2007).
10. Yu Z, Cui M, Yan CY, Song FR, Liu ZQ, Liu SY, Zhang G, Zhang HX. Gas-phase chiral discrimination of ephedrine and pseudoephedrine associated with cyclodextrins. Journal of Mass Spectrometry 42(8):1106-10 (2007)
11. Friedrich ML, Cui M, Hernandez JB, Weist BM, Andersen HM, Zhang X, Huang L and Walsh CM. “Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes”. Journal of Biological Chemistry 282(7):4573-84 (2007).
12. Yu Z, Cui M, Yan CY, Song FR, Liu ZQ and Liu SY. “Investigation of heptakis(2,6-di-O-methyl) -beta-cyclodextrin inclusion complexes with flavonoid glycosides by electrospray ionization mass spectrometry”. Rapid Communications in Mass Spectrometry. 21(5):683-90 (2007).
13. Friedrich ML, Cui M, Zhang XW, Polakiewicz RD, Comb MJ, Huang L, Walsh CM. Determination of the sites of DRAK2 autophosphorylation using mass spectrometry reveals differential modes of kinase activation following stimulation of primary lymphocytes. Journal of Immunology. 176: S199-S199 (2006).
14. Tagerker C, Flick K, Cui M, Guerrero C, Dou YM, Auer B, Baldi P, Huang L , Kaiser P. A tandem-affinity tag for two-step purification under fully denaturing conditions : application in ubiquitin profiling and protein complex identification combined with in vivo cross-linking.  Molecular & Cellular Proteomics. 5: 737-748 (2006).
16. Cui M, McCooeye MA, Fraser C. and Mester Z. Quantitation of Lysergic Acid Diethylamide (LSD) in urine by Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Ion Trap Mass Spectrometry. Analytical Chemistry. 76: 7143-7148 (2004).
17. Liu SY, Cui M, Liu ZQ, Song FR and Mo WJ. Structural analysis of saponins from medicinal herbs using electrospray ionization tandem mass spectrometry. Journal of the American Society for mass Spectrometry. 15: 133-141 (2004).
18. Song FR, Cui M, Liu ZQ, Yu B and Liu SY. Multiple-stage tandem mass spectrometry for differentiation of isomeric saponins. Rapid Communications in Mass Spectrometry 18 : 2241-2248 (2004).
19. Cui M, Ding LY and Mester Z. Separation of cisplatin and its hydrolysis products using electrospray ionization high-field asymmetric waveform ion mobility spectrometry coupled with ion trap mass spectrometry. Analytical Chemistry. 75: 5847-5853 (2003).
20. Cui M and Mester Z. Electrospray ionization mass spectrometry coupled to liquid chromatography for detection of cisplatin and its hydrated complexes. Rapid Communication in Mass Spectrometry. 17: 1517-1527 (2003).
21. Cui M, Song FR, Liu ZQ and Liu SY. Metal ions in the structural analysis of ginsenosides in electrospray ionization multi-stage mass spectrometry. Rapid Communication in Mass Spectrometry. 15: 586-595 (2001).
24. Cui M, Song FR, Zhou Y, Liu ZQ and Liu SY. Rapid identification of saponins in plant extracts by electrospray ionization multi-stage tandem mass spectrometry and liquid chromatography/tandem mass spectrometry. Rapid Communication in Mass Spectrometry. 14: 1280-1286 (2000).
25. Sun WX, Song FR, Cui M and Liu SY. Simultaneous determination of lipo-alkaloids extracted from Aconitum carmiechaeli using electrospray ionization mass spectrometry and multiple tandem mass spectrometry. Planta Medica 65 (5): 432-436 (1999).
26. Cui M, Sun WX., Song FR, Liu ZQ and Liu SY. Multi-stage mass spectrometric studies of triterpenoid saponins in crude extracts from Acanthopanax senticosus Harms. Rapid Communication in Mass Spectrometry.13: 873-879 (1999).

现指导学生

张宁波  硕士研究生  070304-物理化学  

杜永刚  博士研究生  070304-物理化学