表观遗传与细胞命运决定

   

071007-遗传学
071008-发育生物学
071009-细胞生物学

表观遗传学，表观基因组学，发育生物学，染色质
发育生物学
人类与动物分子遗传学

2004-09--2011-07   中国科学院大学/中国科学院遗传与发育生物学研究所   博士
2000-09--2004-06   北京大学   学士

分子遗传学
高级分子遗传学

   

（1） 国家自然科学奖, 二等奖, 国家级, 2019
（2） Harvard Chinese Life Science YongJin Distinguished Research Award, , 其他, 2016
（3） 北京市科学技术奖, 二等奖, 省级, 2015

[1] 刘玉胜, 陆发隆. poly(A)尾巴非A修饰在促进mRNA翻译中的应用. CN: CN115216483A, 2022-10-21.

[2] 陆发隆, 刘玉胜. 一种待测样品中具有poly（A）尾巴的RNA的测序文库的构建方法. CN: CN110499356A, 2019-11-26.

   

（1） Sequencing of Transcriptome-Wide Poly(A) Tails by PAIso-seq, Methods in Molecular Biology, 2024, 通讯作者
（2） KLF4 facilitates chromatin accessibility remodeling in porcine early embryos, SCIENCE CHINA Life Sciences, 2024, 通讯作者
（3） Reprogramming mechanism dissection and trophoblast replacement application in monkey somatic cell nuclear transfer, NATURE COMMUNICATIONS, 2024, 通讯作者
（4） Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy, NATURE GENETICS, 2024, 通讯作者
（5） Mutation in Polycomb repressive complex 2 gene OsFIE2 promotes asexual embryo formation in rice, NATURE PLANTS, 2023, 第11作者
（6） Comprehensive analysis of mRNA poly(A)tails by PAIso-seq2, Comprehensive analysis of mRNA poly(A) tails by PAIso-seq2, SCIENCE CHINA-LIFE SCIENCES, 2023, 通讯作者
（7） Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2023, 通讯作者
（8） Visualization of in vivo cell-cell contact in the present and in the past, Visualization of in vivo cell-cell contact in the present and in the past, SCIENCE CHINA-LIFE SCIENCES, 2023, 通讯作者
（9） The piRNA size matters, NATIONAL SCIENCE REVIEW, 2023, 通讯作者
（10） Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat, Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat, BIOACTIVE MATERIALS, 2023, 通讯作者
（11） Resurrection of endogenous retroviruses during aging reinforces senescence, CELL, 2023, 第 26 作者
（12） m6A-modified RNA possess distinct poly(A) tails, JOURNAL OF GENETICS AND GENOMICS, 2022, 通讯作者
（13） Cnot8 eliminates naive regulation networks and is essential for naive-to-formative pluripotency transition., Nucleic Acids Research, 2022, 通讯作者
（14） Single-cell RNA sequencing reveals Nestin(+) active neural stem cells outside the central canal after spinal cord injury, SCIENCE CHINA-LIFE SCIENCES, 2022, 通讯作者
（15） Single-cell chromatin accessibility identifies enhancer networks driving gene expression during spinal cord development in mouse, DEVELOPMENTAL CELL, 2022, 通讯作者
（16） Transcriptome-wide measurement of poly(A) tail length and composition at subnanogram total RNA sensitivity by PAIso-seq, NATURE PROTOCOLS, 2022, 通讯作者
（17） H3K27me3 shapes DNA methylome by inhibiting UHRF1-mediated H3 ubiquitination, H3K27me3 shapes DNA methylome by inhibiting UHRF1-mediated H3 ubiquitination, SCIENCE CHINA-LIFE SCIENCES, 2022, 通讯作者
（18） Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 通讯作者
（19） Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis, BRIEFINGS IN BIOINFORMATICS, 2022, 第 6 作者
（20） BAP60 plays an opposite role to the MRT-NURF complex in regulating lipid droplet size., Journal of Genetics and Genomics, 2022, 第 5 作者
（21） Mapping Genome-wide Binding Sites of Prox1 in Mouse Cochlea Using the CUT&RUN Approach, Mapping Genome-wide Binding Sites of Prox1 in Mouse Cochlea Using the CUT&RUN Approach, NEUROSCIENCE BULLETIN, 2021, 通讯作者
（22） Hypothalamic Rax(+) tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice, NATURE COMMUNICATIONS, 2021, 第 9 作者
（23） Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation, CELL STEM CELL, 2020, 第 7 作者
（24） Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer, CELL STEM CELL, 2020, 通讯作者
（25） Rett mutations attenuate phase separation of MeCP2, CELL DISCOVERY, 2020, 通讯作者
（26） Dynamic RNA 3′ Uridylation and Guanylation during Mitosis, ISCIENCE, 2020, 通讯作者
（27） Poly(A) inclusive RNA isoform sequencing (PAIso−seq) reveals wide-spread non-adenosine residues within RNA poly(A) tails, NATURE COMMUNICATIONS, 2019, 通讯作者
（28） In vivo nuclear capture and molecular profiling identifies Gmeb1 as a transcriptional regulator essential for dopamine neuron function, NATURE COMMUNICATIONS, 2019, 第 4 作者
（29） DNA methylation repels targeting of Arabidopsis REF6, NATURE COMMUNICATIONS, 2019, 第 8 作者
（30） The start of a human life program, JOURNAL OF GENETICS AND GENOMICS, 2018, 通讯作者
（31） Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent, CELL REPORTS, 2018, 第 6 作者
（32） Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development, CELL STEM CELL, 2018, 第 4 作者
（33） Maternal H3K27me3 controls DNA methylation-independent imprinting, NATURE, 2017, 第 3 作者
（34） Genomic imprinting of Xist by maternal H3K27me3, GENES & DEVELOPMENT, 2017, 第 3 作者
（35） Loss of HDAC-Mediated Repression and Gain of NF-kappa B Activation Underlie Cytokine Induction in ARID1A-and PIK3CA-Mutation-Driven Ovarian Cancer, CELL REPORTS, 2016, 第 2 作者
（36） REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis, NATURE GENETICS, 2016, 第 2 作者
（37） Establishing chromatin regulatory landscape during mouse preimplantation development, CELL, 2016, 第 1 作者
（38） Drosophila Homolog of FMRP Maintains Genome Integrity by Interacting with Piwi, JOURNAL OF GENETICS AND GENOMICS, 2016, 第 2 作者
（39） Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells, CELL STEM CELL, 2015, 第 5 作者
（40） C-terminal domains of histone demethylase JMJ14 interact with a pair of NAC transcription factors to mediate specific chromatin association, CELL DISCOVERY, 2015, 第 10 作者
（41） Cell totipotency: molecular features, induction, and maintenance, NATIONAL SCIENCE REVIEW, 2015, 第 1 作者
（42） Tet3 and DNA Replication Mediate Demethylation of Both the Maternal and Paternal Genomes in Mouse Zygotes, CELL STEM CELL, 2014, 第 5 作者
（43） Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation, CELL, 2014, 第 3 作者
（44） Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 第 5 作者
（45） Role of Tet proteins in enhancer activity and telomere elongation, GENES & DEVELOPMENT, 2014, 第 1 作者
（46） Ubiquitin-Specific Proteases UBP12 and UBP13 Act in Circadian Clock and Photoperiodic Flowering Regulation in Arabidopsis, PLANT PHYSIOLOGY, 2013, 第 2 作者
（47） The enzymatic activity of Arabidopsis protein arginine methyltransferase 10 is essential for flowering time regulation, The enzymatic activity of Arabidopsis protein arginine methyltransferase 10 is essential for flowering time regulation, PROTEIN & CELL, 2012, 第 2 作者
（48） Crystal Structure of the Plant Epigenetic Protein Arginine Methyltransferase 10, JOURNAL OF MOLECULAR BIOLOGY, 2011, 第 3 作者
（49） Arabidopsis REF6 is a Histone H3 Lysine 27 Demethylase, NATURE GENETICS, 2011, 第 1 作者
（50） Histone Methylation in Higher Plants, ANNUAL REVIEW OF PLANT BIOLOGY, 2010, 第 2 作者
（51） Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 第 5 作者
（52） JMJ14 is an H3K4 demethylase regulating flowering time in Arabidopsis, CELL RESEARCH, 2010, 第 1 作者
（53） Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome, EMBO JOURNAL, 2010, 第 4 作者
（54） Comparative Analysis of JmjC Domain-containing Proteins Reveals the Potential Histone Demethylases in Arabidopsis and Rice, JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2008, 第 1 作者
（55） Regulation of flowering time by the protein arginine methyltransferase AtPRMT10, EMBO REPORTS, 2007, 第 2 作者
（56） Mutations in the type II protein arginine methyltransferase AtPRMT5 result in pleiotropic developmental defects in Arabidopsis, Plant Physiology, 2007, 第 3 作者

已指导学生

聂虎  博士研究生  071008-发育生物学  

刘媛  硕士研究生  071009-细胞生物学  

张吉祥  博士研究生  071007-遗传学  

李雅梅  博士研究生  071007-遗传学  

王逵  博士研究生  071007-遗传学  

朱运济  硕士研究生  0710J3-生物信息学  

刘莹  硕士研究生  071007-遗传学  

谢亚莉  硕士研究生  071007-遗传学  

现指导学生

杜毅  博士研究生  071007-遗传学  

尹曼  博士研究生  071007-遗传学  

李尚泽  硕士研究生  071007-遗传学  

胡迪  博士研究生  071007-遗传学  

刘静雯  博士研究生  071007-遗传学  

牛卓越  硕士研究生  071006-神经生物学  

程浩  博士研究生  071008-发育生物学