基本信息
黄力 男 博导 微生物研究所
电子邮件:huangl@sun.im.ac.cn
通信地址:北京朝阳区北辰西路1号中国科学院微生物研究所
邮政编码:100101

招生信息

   
招生专业
071010-生物化学与分子生物学
071005-微生物学
招生方向
极端环境微生物遗传机制

教育背景

1985-09--1988-07 加拿大Guelph大学微生物学系 博士
1983-09--1985-06 加拿大Guelph大学微生物学系 硕士
1978-04--1982-02 中国西北大学生物系 学士
学历
-- 研究生
学位
-- 博士

工作经历

   
工作简历
1998-05--今 中国科学院微生物研究所 教授
1996-09--1998-04 中国科学院微生物研究所 副教授
1993-07--1996-06 美国Pomona学院 助理教授
1988-09--1993-06 美国Johns Hopkins大学生物化学系 博士后

出版信息

   
发表论文
[1] Li Huang, Jizhong Zhou. A successful start for mLife. mLife[J]. 2023, 2(1): 1-1, https://www.doi.org/10.1002/mlf2.12061.
[2] Huang, Li. Structural insights into a spindle-shaped archaeal virus with a sevenfold symmetrical tail. Proc Natl Acad Sci U S A[J]. 2022, [3] Huang, Li. Sulfolobus islandicus Employs Orc1-2-Mediated DNA Damage Response in Defense against Infection by SSV2. J Virol[J]. 2022, [4] Niannian Ding, Yuanyuan Chen, Yindi Chu, Cheng Zhong, Huang, Li, Zhenfeng Zhang. Lysine Methylation Modulates the Interaction of Archaeal Chromatin Protein Cren7 With DNA. FRONTIERS IN MICROBIOLOGY[J]. 2022, 13: [5] Zheng, Xiaowei, Dai, Xin, Zhu, Yaxin, Yang, Jian, Jiang, Hongchen, Dong, Hailiang, Huang, Li. (Meta)Genomic Analysis Reveals Diverse Energy Conservation Strategies Employed by Globally Distributed Gemmatimonadota. MSYSTEMS[J]. 2022, 7(4): http://dx.doi.org/10.1128/msystems.00228-22.
[6] Zhang, Xinxu, Huang, Yuhan, Liu, Yang, Xu, Wei, Pan, Jie, Zheng, Xiaowei, Du, Huan, Zhang, Cuijing, Lu, Zhongyi, Zou, Dayu, Liu, Zongbao, Cai, Mingwei, Xiong, Jinbo, Zhu, Yaxin, Dong, Zhiyang, Jiang, Hongchen, Dong, Hailiang, Jiang, Juquan, Luo, Zhuhua, Huang, Li, Li, Meng. An Ancient Respiratory System in the Widespread Sedimentary Archaea Thermoprofundales. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2022, 39(10): http://dx.doi.org/10.1093/molbev/msac213.
[7] Wang Liu, Xiaowei Zheng, Xin Dai, Zhenfeng Zhang, Wenyan Zhang, Tian Xiao, Huang, Li. Isolation and Characterization of the First Temperate Virus Infecting Psychrobacillus from Marine Sediments. VIRUSES[J]. 2022, 14(108): https://doaj.org/article/85cd441bad434f4fb685f04f02d9d04b.
[8] Huang, Li, Wang, Haina, ICTV Report Consortium. ICTV Virus Taxonomy Profile: Ovaliviridae. JOURNAL OF GENERAL VIROLOGY[J]. 2021, 102(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000635958900018.
[9] Zheng, Xiaowei, Liu, Wang, Dai, Xin, Zhu, Yaxin, Wang, Jinfeng, Zhu, Yongqiang, Zheng, Huajun, Huang, Ying, Dong, Zhiyang, Du, Wenbin, Zhao, Fangqing, Huang, Li. Extraordinary diversity of viruses in deep-sea sediments as revealed by metagenomics without prior virion separation. ENVIRONMENTAL MICROBIOLOGY[J]. 2021, 23(2): 728-743, http://dx.doi.org/10.1111/1462-2920.15154.
[10] Zhang, Junxia, Huang, Li. Construction of a Fusellovirus with a Minimal Set of Genes. ACS SYNTHETIC BIOLOGY[J]. 2021, 10(10): 2617-2627, http://dx.doi.org/10.1021/acssynbio.1c00232.
[11] Li, Jie, Zheng, Xiaowei, Li, Lingyan, Zhang, Shengjie, Ren, Mifang, Huang, Li, Dong, Xiuzhu. The Archaeal Transcription Termination Factor aCPSF1 is a Robust Phylogenetic Marker for Archaeal Taxonomy. MICROBIOLOGY SPECTRUM[J]. 2021, 9(3): http://dx.doi.org/10.1128/spectrum.01539-21.
[12] Dai, Xin, Wang, Yuanliang, Luo, Liqiang, Pfiffner, Susan M, Li, Guangyu, Dong, Zhiyang, Xu, Zhiqin, Dong, Hailiang, Huang, Li. Detection of the deep biosphere in metamorphic rocks from the Chinese continental scientific drilling. GEOBIOLOGY[J]. 2021, 19(3): 278-291, http://dx.doi.org/10.1111/gbi.12430.
[13] Zhenfeng Zhang, Zhengyan Zhan, Bing Wang, Yuanyuan Chen, Xiuqiang Chen, Cuihong Wan, Yu Fu, Li Huang. Archaeal Chromatin Proteins Cren7 and Sul7d Compact DNA by Bending and Bridging. MBIO[J]. 2020, 11(3): https://doaj.org/article/12631e7841c045db8fc733fa68b1886b.
[14] Wang, Jian, Ruan, ChuJin, Song, Lei, Li, Ang, Zhu, YaXin, Zheng, XiaoWei, Wang, Li, Lu, ZuJun, Huang, Ying, Du, Wenbin, Zhou, Yuguang, Huang, Li, Dai, Xin. Gimesia benthica sp. nov., a planctomycete isolated from a deep-sea water sample of the Northwest Indian Ocean. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2020, 70(7): 4384-4389, https://www.webofscience.com/wos/woscc/full-record/WOS:000560646100043.
[15] Zhang, Junxia, Zheng, Xiaowei, Wang, Haina, Jiang, Hongchen, Dong, Hailiang, Huang, Li. Novel Sulfolobus Fuselloviruses with Extensive Genomic Variations. JOURNAL OF VIROLOGY[J]. 2020, 94(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000510867500011.
[16] Hu, Beiyu, Xu, Bingxue, Yun, Juanli, Wang, Jian, Xie, Bingliang, Li, Caiming, Yu, Yanghuan, Lan, Ying, Zhu, Yaxin, Dai, Xin, Huang, Ying, Huang, Li, Pan, Jianzhang, Du, Wenbin. High-throughput single-cell cultivation reveals the underexplored rare biosphere in deep-sea sediments along the Southwest Indian Ridge. LAB ON A CHIP[J]. 2020, 20(2): 363-372, https://www.webofscience.com/wos/woscc/full-record/WOS:000508846700012.
[17] Ruan, ChuJin, Wang, Jian, Zheng, XiaoWei, Song, Lei, Zhu, YaXin, Huang, Ying, Lu, ZuJun, Du, WenBin, Huang, Li, Dai, Xin. Halovulum marinum sp. nov., isolated from deep-sea water of the Indian Ocean, and emended description of the genus Halovulum. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2020, 70(8): 4523-4530, http://dx.doi.org/10.1099/ijsem.0.004307.
[18] Zhang, Ningning, Guo, Li, Huang, Li. The Sac10b homolog from Sulfolobus islandicus is an RNA chaperone. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(16): 9273-9284, http://dx.doi.org/10.1093/nar/gkaa656.
[19] Cao, Jingjing, Wang, Tongkun, Wang, Qian, Zheng, Xiaowei, Huang, Li. Functional Insights Into Protein Acetylation in the Hyperthermophilic Archaeon Sulfolobus islandicus. MOLECULAR & CELLULAR PROTEOMICS[J]. 2019, 18(8): 1572-1587, https://www.webofscience.com/wos/woscc/full-record/WOS:000482263500007.
[20] Huang Li. Interfacial Nanoinjection-Based Nanoliter Single-Cell Analysis.. Small. 2019, [21] Wang, Baozhan, Qin, Wei, Ren, Yi, Zhou, Xue, Jung, ManYoung, Han, Ping, EloeFadrosh, Emiley A, Li, Meng, Zheng, Yue, Lu, Lu, Yan, Xin, Ji, Junbin, Liu, Yang, Liu, Linmeng, Heiner, Cheryl, Hall, Richard, MartensHabbena, Willm, Herbold, Craig W, Rhee, Sungkeun, Bartlett, Douglas H, Huang, Li, Ingalls, Anitra E, Wagner, Michael, Stahl, David A, Jia, Zhongjun. Expansion of Thaumarchaeota habitat range is correlated with horizontal transfer of ATPase operons. ISME JOURNAL[J]. 2019, 13(12): 3067-3079, http://dx.doi.org/10.1038/s41396-019-0493-x.
[22] Li Huang, Xiang Xiao, Guoping Zhao. Microbes: the hidden giant behind the biogeochemical cycling of elements in the hydrosphere. 中国科学:生命科学英文版. 2019, 62(10): 1271-1274, http://lib.cqvip.com/Qikan/Article/Detail?id=7003117692.
[23] Zhang, Zhenfeng, Zhao, Mohan, Chen, Yuanyuan, Wang, Li, Liu, Qinghua, Dong, Yuhui, Gong, Yong, Huang, Li. Architectural roles of Cren7 in folding crenarchaeal chromatin filament. MOLECULAR MICROBIOLOGY[J]. 2019, 111(3): 556-569, https://www.webofscience.com/wos/woscc/full-record/WOS:000461081000002.
[24] Ruan, ChuJin, Zheng, XiaoWei, Wang, Jian, Song, Lei, Zhu, YaXin, Du, WenBin, Lu, ZuJun, Huang, Ying, Huang, Li, Dai, Xin. Hyphobacterium indicum sp. nov., isolated from deep seawater, and emended description of the genus Hyphobacterium. INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY[J]. 2018, 68(12): 3760-3765, https://www.webofscience.com/wos/woscc/full-record/WOS:000453513900012.
[25] Cao, Jingjing, Wang, Qian, Liu, Tao, Peng, Nan, Huang, Li. Insights into the post-translational modifications of archaeal Sis10b (Alba): lysine-16 is methylated, not acetylated, and this does not regulate transcription or growth. MOLECULAR MICROBIOLOGY[J]. 2018, 109(2): 192-208, https://www.webofscience.com/wos/woscc/full-record/WOS:000439513200004.
[26] Junhua Zhang, Bailong Pan, Zhimeng Li, Xin Sheng Zhao, Li Huang. Kinetic insights into the temperature dependence of DNA strand cleavage and religation by topoisomerase III from the hyperthermophile Sulfolobus solfataricus. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/801302d679f649ae88b2e36adeb5d4dc.
[27] Zhang, Zhenfeng, Zhao, Mohan, Wang, Li, Chen, Yuanyuan, Dong, Yuhui, Gong, Yong, Huang, Li. Roles of Leu28 side chain intercalation in the interaction between Cren7 and DNA. BIOCHEMICAL JOURNAL[J]. 2017, 474(10): 1727-1739, http://www.corc.org.cn/handle/1471x/2177413.
[28] Huang Li. A novel Sulfolobus virus with an exceptional capsid architecture.. J Virol.. 2017, [29] Dai, Xin, Wang, Haina, Zhang, Zhenfeng, Li, Kuan, Zhang, Xiaoling, MoraLopez, Marielos, Jiang, Chengying, Liu, Chang, Wang, Li, Zhu, Yaxin, HernandezAscencio, Walter, Dong, Zhiyang, Huang, Li. Genome Sequencing of Sulfolobus sp A20 from Costa Rica and Comparative Analyses of the Putative Pathways of Carbon, Nitrogen, and Sulfur Metabolism in Various Sulfolobus Strains. FRONTIERS IN MICROBIOLOGY[J]. 2016, 7: https://doaj.org/article/63780680ae094b0c81287816ac05627e.
[30] Zhan, Zhengyan, Zhou, Ju, Huang, Li. Site-Specific Recombination by SSV2 Integrase: Substrate Requirement and Domain Functions. JOURNAL OF VIROLOGY[J]. 2015, 89(21): 10934-10944, https://www.webofscience.com/wos/woscc/full-record/WOS:000363465900018.
[31] Liu, Bing, Ouyang, Songying, Makarova, Kira S, Xia, Qiu, Zhu, Yanping, Li, Zhimeng, Guo, Li, Koonin, Eugene V, Liu, ZhiJie, Huang, Li. A primase subunit essential for efficient primer synthesis by an archaeal eukaryotic-type primase. NATURE COMMUNICATIONS[J]. 2015, 6: 7300-7300, https://www.webofscience.com/wos/woscc/full-record/WOS:000357171600004.
[32] Lang, Shiwei, Huang, Li. The Sulfolobus solfataricus GINS Complex Stimulates DNA Binding and Processive DNA Unwinding by Minichromosome Maintenance Helicase. JOURNAL OF BACTERIOLOGY[J]. 2015, 197(21): 3409-3420, [33] Wang, Haina, Peng, Nan, Shah, Shiraz A, Huang, Li, She, Qunxin. Archaeal Extrachromosomal Genetic Elements. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWSnull. 2015, 79(1): 117-152, https://www.webofscience.com/wos/woscc/full-record/WOS:000350978300007.
[34] Dai, Xin, Tian, Yan, Li, Jinting, Su, Xiaoyun, Wang, Xuewei, Zhao, Shengguo, Liu, Li, Luo, Yingfeng, Liu, Di, Zheng, Huajun, Wang, Jiaqi, Dong, Zhiyang, Hu, Songnian, Huang, Li. Metatranscriptomic Analyses of Plant Cell Wall Polysaccharide Degradation by Microorganisms in the Cow Rumen. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2015, 81(4): 1375-1386, http://dx.doi.org/10.1128/AEM.03682-14.
[35] Xing, Xuanxuan, Zhang, Likui, Guo, Li, She, Qunxin, Huang, Li. Sulfolobus Replication Factor C Stimulates the Activity of DNA Polymerase B1. JOURNAL OF BACTERIOLOGY[J]. 2014, 196(13): 2367-2375, http://dx.doi.org/10.1128/JB.01552-14.
[36] 王大成. Biochemical and Structural Insights into RNA Binding by Ssh10b, a Member of the Highly Conserved Sac10b Protein Family in Archaea. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2014, 289(3): 1478-1490, http://dx.doi.org/10.1074/jbc.M113.521351.
[37] Ren, Yi, She, Qunxin, Huang, Li. Transcriptomic analysis of the SSV2 infection of Sulfolobus solfataricus with and without the integrative plasmid pSSVi. VIROLOGY[J]. 2013, 441(2): 126-134, http://dx.doi.org/10.1016/j.virol.2013.03.012.
[38] Sun, Fei, Huang, Li. Sulfolobus chromatin proteins modulate strand displacement by DNA polymerase B1. NUCLEIC ACIDS RESEARCH[J]. 2013, 41(17): 8182-8195, https://www.webofscience.com/wos/woscc/full-record/WOS:000325175900023.
[39] Zhan, Zhengyan, Ouyang, Songying, Liang, Wenguang, Zhang, Zhenfeng, Liu, ZhiJie, Huang, Li. Structural and functional characterization of the C-terminal catalytic domain of SSV1 integrase. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY[J]. 2012, 68: 659-670, http://www.irgrid.ac.cn/handle/1471x/756936.
[40] Hu, Jinchuan, Guo, Li, Wu, Kangyun, Liu, Bing, Lang, Shiwei, Huang, Li. Template-dependent polymerization across discontinuous templates by the heterodimeric primase from the hyperthermophilic archaeon Sulfolobus solfataricus. NUCLEIC ACIDS RESEARCH[J]. 2012, 40(8): 3470-3483, https://www.webofscience.com/wos/woscc/full-record/WOS:000303333500022.
[41] Chu, Yindi, Zhang, Zhenfeng, Wang, Qian, Luo, Yuanming, Huang, Li. Identification and Characterization of a Highly Conserved Crenarchaeal Protein Lysine Methyltransferase with Broad Substrate Specificity. JOURNAL OF BACTERIOLOGY[J]. 2012, 194(24): 6917-6926, http://dx.doi.org/10.1128/JB.01535-12.
[42] Guo, Li, Brugger, Kim, Liu, Chao, Shah, Shiraz A, Zheng, Huajun, Zhu, Yongqiang, Wang, Shengyue, Lillestol, Reidun K, Chen, Lanming, Frank, Jeremy, Prangishvili, David, Paulin, Lars, She, Qunxin, Huang, Li, Garrett, Roger A. Genome Analyses of Icelandic Strains of Sulfolobus islandicus, Model Organisms for Genetic and Virus-Host Interaction Studies. JOURNAL OF BACTERIOLOGY[J]. 2011, 193(7): 1672-1680, http://124.16.144.217/handle/311023/1304.
[43] Li, Xiyang, Guo, Li, Deng, Ling, Feng, Deqin, Ren, Yi, Chu, Yindi, She, Qunxin, Huang, Li. Deletion of the topoisomerase III gene in the hyperthermophilic archaeon Sulfolobus islandicus results in slow growth and defects in cell cycle control. JOURNAL OF GENETICS AND GENOMICS[J]. 2011, 38(6): 253-259, http://lib.cqvip.com/Qikan/Article/Detail?id=38444081.
[44] Huang Li. An SF3 DNA helicase encoded by plasmid pSSVi from the hyperthermophilic Archaeon Sulfolobus solfataricus unwinds DNA as a higher-order oligomer and interacts with host primase.. J. Bacteriol.. 2010, [45] Zhang, Zhenfeng, Gong, Yong, Guo, Li, Jiang, Tao, Huang, Li. Structural insights into the interaction of the crenarchaeal chromatin protein Cren7 with DNA. MOLECULAR MICROBIOLOGY[J]. 2010, 76(3): 749-759, http://dx.doi.org/10.1111/j.1365-2958.2010.07136.x.
[46] Zhang, Likui, Lou, Huiqiang, Guo, Li, Zhan, Zhengyan, Duan, Zhenhong, Guo, Xin, Huang, Li. Accurate DNA synthesis by Sulfolobus solfataricus DNA polymerase B1 at high temperature. EXTREMOPHILES[J]. 2010, 14(1): 107-117, http://124.16.144.217/handle/311023/2963.
[47] Liu, Yuchen, Guo, Li, Guo, Rong, Wong, Richard L, Hernandez, Hilda, Hu, Jinchuan, Chu, Yindi, Amster, I Jonathan, Whitman, William B, Huang, Li. The Sac10b Homolog in Methanococcus maripaludis Binds DNA at Specific Sites. JOURNAL OF BACTERIOLOGY[J]. 2009, 191(7): 2315-2329, http://124.16.144.217/handle/311023/1288.
[48] Guo, Li, Feng, Yingang, Zhang, Zhenfeng, Yao, Hongwei, Luo, Yuanming, Wang, Jinfeng, Huang, Li. Biochemical and structural characterization of Cren7, a novel chromatin protein conserved among Crenarchaea. NUCLEIC ACIDS RESEARCH[J]. 2008, 36(4): 1129-1137, http://124.16.144.217/handle/311023/1610.
[49] Chu Yindi, Zhu Yanping, Chen Yuling, Li Wei, Zhang Zhenfeng, Liu Di, Wang Tongkun, Ma Juncai, Deng Haiteng, Liu Zhi-Jie, Ouyang Songying, Huang Li. aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism *. MOLECULAR & CELLULAR PROTEOMICS : MCP. 15(9): 2908-2923, http://dx.doi.org/10.1074/mcp.M115.057778.

科研活动

   
科研项目
(1) 极端环境微生物生命特征及环境适应机理,主持,国家级,2010-01--2012-12
(2) 古菌Sac10b 家族蛋白的RNA 结合性质及生理功能,主持,国家级,2009-01--2011-12
(3) 古菌引物合成与延伸的偶联机制及调控规律,主持,国家级,2008-01--2011-12

指导学生

已指导学生

刘丹旭  博士研究生  071005-微生物学  

郭欣  博士研究生  071005-微生物学  

向晓宇  博士研究生  071005-微生物学  

吴康云  博士研究生  071005-微生物学  

张立奎  博士研究生  071005-微生物学  

陈亮  博士研究生  071005-微生物学  

郭荣  博士研究生  071005-微生物学  

楼慧强  博士研究生  071005-微生物学  

赖小勤  博士研究生  071005-微生物学  

王颖  博士研究生  071005-微生物学  

李希阳  博士研究生  071005-微生物学  

郭莉  博士研究生  071005-微生物学  

现指导学生

胡晋川  博士研究生  071010-生物化学与分子生物学  

詹争艳  博士研究生  071010-生物化学与分子生物学  

任奕  博士研究生  071010-生物化学与分子生物学  

储引娣  博士研究生  071010-生物化学与分子生物学  

邢宣宣  博士研究生  071010-生物化学与分子生物学  

孙飞  硕士研究生  071010-生物化学与分子生物学  

王海纳  硕士研究生  071010-生物化学与分子生物学  

郎士伟  博士研究生  071010-生物化学与分子生物学  

刘兵  博士研究生  071010-生物化学与分子生物学  

夏秋  博士研究生  071010-生物化学与分子生物学  

张俊华  博士研究生  071010-生物化学与分子生物学