基本信息
岳华  女  硕导  中国科学院过程工程研究所
电子邮件: hyue@ipe.ac.cn
通信地址: 中国科学院过程工程研究所
邮政编码:

研究领域

新型纳微米颗粒在疫苗佐剂和肿瘤免疫中的应用

招生信息

生物材料与药物剂型
招生专业
081703-生物化工
招生方向
生物材料与药物剂型
纳微颗粒制备及应用
疫苗佐剂和肿瘤免疫

教育背景

2008-09--2012-07   中国科学院过程工程研究所   工学博士
2005-09--2008-07   山东大学微生物国家重点实验室   理学硕士

工作经历

   
工作简历
2021-01~现在, 中国科学院过程工程研究所, 青年研究员
2015-07~2021-01,中国科学院过程工程研究所, 副研究员
2012-07~2015-07,中国科学院过程工程研究所, 助理研究员
社会兼职
2015-01-01-2015-12-31,中国科学院过程工程研究所青年创新促进会, 主席
2013-01-01-今,中国科学院青年创新促进会, 会员

专利与奖励

   
奖励信息
(1) 中国颗粒学会自然科学奖, 一等奖, 省级, 2020
(2) 中国化工学会基础研究成果奖, 一等奖, 省级, 2020
(3) 中国材料大会分会优秀论文奖, 其他, 2014
(4) 中国材料研究学会首届“材料与艺术图片展”, 其他, 2014
(5) 中国科学院院长优秀奖, 院级, 2013
(6) 中国科学院青年创新促进会, 院级, 2013
(7) 北京市优秀毕业生, 省级, 2012
(8) 赛诺菲巴斯德杰出生物医学研究生奖, 院级, 2012
(9) 全国显微成像大赛一等奖, 一等奖, 其他, 2010
专利成果
[1] 魏炜, 马光辉, 岳华, 杨微, 王文婧. 一种用于低应答人群的疫苗增效剂及其制备方法和应用. 2023104316040, 2023-04-21.
[2] 马光辉, 岳华, 樊星, 胡宇宁, 周炜清, 巩方玲. 多囊脂质体及其制备方法和用途. 202211742826.6, 2022-12-30.
[3] 马光辉, 岳华, 吴颉, 吴楠, 苗春宇, 周炜清. 高分子凝胶颗粒、其制备方法、包含其的复合凝胶颗粒及用途. CN: CN107855080A, 2018-03-30.
[4] 马光辉, 魏炜, 倪德志, 岳华, 周炜清, 吕丕平. 一种疫苗制剂及其制备方法和用途. CN: CN104758944A, 2015-07-08.
[5] 马光辉, 魏炜, 倪德志, 岳华, 周炜清. 一种疏水药物的纳米晶、制备及使用方法. CN: CN104546728A, 2015-04-29.
[6] 马光辉, 岳占国, 魏炜, 苏志国, 岳华, 周炜清. 一种喜树碱类药物的新型纳米粒及其制备方法. CN: CN102091041A, 2011-06-15.

出版信息

   
发表论文
[1] Ding, Zhaowen, Zhang, Xiao, Wang, Yan, Ogino, Kenji, Wu, Yuanbin, Yue, Hua, Jiao, Zhouguang, Song, Cui, Lu, Guihong, Wang, Shuang, Gao, Xiaoyong, Gao, Yongjun, Shi, Min, Wang, Yugang, Ma, Guanghui, Wei, Wei. Nanomaterial's interfacial stimulation of vascular endothelial cells and divergent guidances for nanomedicine treating vasculature-associated diseases. NANO TODAY[J]. 2023, 49: http://dx.doi.org/10.1016/j.nantod.2023.101815.
[2] Wang, Haixin, Gao, Xiao-Dong, Yue, Hua. Lentinan-laden microspheres reprogram the tumor microenvironment and improve anti-PD-L1 efficacy. Journal of Materials Chemistry B[J]. 2023, 11: 4475-4484, [3] Huang, Liwen, Zhang, Xiao, Ding, Zhaowen, Qi, Yilin, Wang, Wenjing, Xu, Xihan, Yue, Hua, Bai, Lihuan, Wang, Heping, Feng, Leyan, Ren, Jing, Yang, Xue, Ma, Guanghui, Wei, Wei, Xue, Xue. PEGylated 2D-nanomaterials alleviate Parkinson's disease by shielding PIP2 lipids to inhibit IP3 second messenger signaling. NANO TODAY[J]. 2022, 46: http://dx.doi.org/10.1016/j.nantod.2022.101556.
[4] Zou, Jiale, Wang, Shuang, Chai, Ningli, Yue, Hua, Ye, Peng, Guo, Peilin, Li, Feng, Wei, Bo, Ma, Guanghui, Wei, Wei, Linghu, Enqiang. Construction of gastric cancer patient-derived organoids and their utilization in a comparative study of clinically used paclitaxel nanoformulations. JOURNALOFNANOBIOTECHNOLOGY[J]. 2022, 20(1): http://dx.doi.org/10.1186/s12951-022-01431-8.
[5] Wang, Changlong, Zhang, Wei, He, Yanjie, Gao, Zirui, Liu, Liyuan, Yu, Siyao, Hu, Yuxing, Wang, Shuang, Zhao, Chaochao, Li, Hui, Shi, Jinan, Zhou, Wu, Li, Feng, Yue, Hua, Li, Yuhua, Wei, Wei, Ma, Guanghui, Ma, Ding. Ferritin-based targeted delivery of arsenic to diverse leukaemia types confers strong anti-leukaemia therapeutic effects. NATURE NANOTECHNOLOGY[J]. 2021, 16(12): 1413-U164, http://dx.doi.org/10.1038/s41565-021-00980-7.
[6] Pan, Chao, Yue, Hua, Zhu, Li, Ma, Guanghui, Wang, Hengliang. Prophylactic vaccine delivery systems against epidemic infectious diseases. ADVANCED DRUG DELIVERY REVIEWSnull. 2021, 176: http://dx.doi.org/10.1016/j.addr.2021.113867.
[7] Fan, Qingze, Miao, Chunyu, Huang, Yilan, Yue, Hua, Wu, Anguo, Wu, Jianming, Wu, Jie, Ma, Guanghui. Hydroxypropyltrimethyl ammonium chloride chitosan-based hydrogel as the split H5N1 mucosal adjuvant: Structure-activity relationship. CARBOHYDRATE POLYMERS[J]. 2021, 266: http://dx.doi.org/10.1016/j.carbpol.2021.118139.
[8] Yue, Hua, Ma, Guanghui. Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect. ACTA CHIMICA SINICA[J]. 2021, 79(10): 1244-1256, [9] Lu, Ting, Hu, Fumin, Yue, Hua, Yang, Tingyuan, Ma, Guanghui. The incorporation of cationic property and immunopotentiator in poly (lactic acid) microparticles promoted the immune response against chronic hepatitis B. JOURNAL OF CONTROLLED RELEASE[J]. 2020, 321: 576-588, http://dx.doi.org/10.1016/j.jconrel.2020.02.039.
[10] Ma, Guanghui, Yue, Hua. Advances in Uniform Polymer Microspheres and Microcapsules: Preparation and Biomedical Applications. CHINESE JOURNAL OF CHEMISTRY[J]. 2020, 38(9): 911-923, http://lib.cqvip.com/Qikan/Article/Detail?id=7103390466.
[11] Qing, Shuang, Lyu, Chengliang, Zhu, Li, Pan, Chao, Wang, Shuang, Li, Feng, Wang, Jianghua, Yue, Hua, Gao, Xiaoyong, Jia, Rongrong, Wei, Wei, Ma, Guanghui. Biomineralized Bacterial Outer Membrane Vesicles Potentiate Safe and Efficient Tumor Microenvironment Reprogramming for Anticancer Therapy. ADVANCED MATERIALS[J]. 2020, 32(47): http://dx.doi.org/10.1002/adma.202002085.
[12] 岳华, 马光辉. 高分子纳微球在工程疫苗中的新应用. 高分子学报[J]. 2020, 125-135, http://lib.cqvip.com/Qikan/Article/Detail?id=00002HUMK9987JP0MPDO7JP1MNR.
[13] Wang, Jianghua, Wang, Shuang, Ye, Tong, Li, Feng, Gao, Xiaoyong, Wang, Yan, Ye, Peng, Qing, Shuang, Wang, Changlong, Yue, Hua, Wu, Jie, Wei, Wei, Ma, Guanghui. Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy. ADVANCED SCIENCE[J]. 2020, 7(19): https://doaj.org/article/eb7b525e7575405c8b46079997716871.
[14] Ding, Zhaowen, Luo, Nana, Yue, Hua, Gao, Yongjun, Ma, Guanghui, Wei, Wei. In vivo immunological response of exposure to PEGylated graphene oxide via intraperitoneal injection. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2020, 8(31): 6845-6856, https://www.webofscience.com/wos/woscc/full-record/WOS:000558894300020.
[15] Hu, Fumin, Yue, Hua, Lu, Ting, Ma, Guanghui. Cytosolic delivery of HBsAg and enhanced cellular immunity by pH-responsive liposome. JOURNAL OF CONTROLLED RELEASE[J]. 2020, 324: 460-470, http://dx.doi.org/10.1016/j.jconrel.2020.05.042.
[16] Pan, Chao, Wu, Jun, Qing, Shuang, Zhang, Xiao, Zhang, Lulu, Yue, Hua, Zeng, Ming, Wang, Bin, Yuan, Zheng, Qiu, Yefeng, Ye, Huahu, Wang, Dongshu, Liu, Xiankai, Sun, Peng, Liu, Bo, Feng, Erling, Gao, Xiaoyong, Zhu, Li, Wei, Wei, Ma, Guanghui, Wang, Hengliang. Biosynthesis of Self-Assembled Proteinaceous Nanoparticles for Vaccination. ADVANCED MATERIALS[J]. 2020, 32(42): https://www.webofscience.com/wos/woscc/full-record/WOS:000565425700001.
[17] Yue, Hua, Ma, Guanghui. Applications of Polymeric Micro/Nanoparticles in Engineered Vaccines. ACTA POLYMERICA SINICA[J]. 2020, 51(2): 125-135, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000518162400001.
[18] Zou, Yongjuan, Wu, Nan, Miao, Chunyu, Yue, Hua, Wu, Jie, Ma, Guanghui. A novel multiple emulsion enhanced immunity via its biomimetic delivery approach. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2020, 8(33): 7365-7374, https://www.webofscience.com/wos/woscc/full-record/WOS:000563148600003.
[19] Xiaoling Wu, Hua Yue, Yuanyu Zhang, Xiaoyong Gao, Xiaoyang Li, Licheng Wang, Yufei Cao, Miao Hou, Haixia An, Lin Zhang, Sai Li, Jingyuan Ma, He Lin, Yanan Fu, Hongkai Gu, Wenyong Lou, Wei Wei, Richard N Zare, Jun Ge. Packaging and delivering enzymes by amorphous metal-organic frameworks. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-8, http://dx.doi.org/10.1038/s41467-019-13153-x.
[20] Ding, Mingzhu, Chen, Biqiang, Ji, Xiaojun, Zhou, Jingwen, Wang, Huiyuan, Tian, Xiwei, Feng, Xudong, Yue, Hua, Zhou, Yongjin, Wang, Hailong, Wu, Jianping, Yang, Pengpeng, Jiang, Yu, Mao, Xuming, Xiao, Gang, Zhong, Cheng, Xiao, Wenhai, Li, Bingzhi, Qin, Lei, Cheng, Jingsheng, Yao, Mingdong, Wang, Ying, Liu, Hong, Zhang, Lin, Yu, Linling, Chen, Tao, Dong, Xiaoyan, Jia, Xiaoqiang, Zhang, Songping, Liu, Yanfeng, Chen, Yong, Chen, Kequan, Wu, Jinglan, Zhu, Chenjie, Zhuang, Wei, Xu, Sheng, Jiao, Pengfei, Zhang, Lei, Song, Hao, Yang, Sheng, Xiong, Yan, Li, Yongquan, Zhang, Youming, Zhuang, Yingping, Su, Haijia, Fu, Weiping, Huang, Yingming, Li, Chun, Zhao, Zongbao K, Sun, Yan, Chen, GuoQiang, Zhao, Xueming, Huang, He, Zheng, Yuguo, Yang, Lirong, Su, Zhiguo, Ma, Guanghui, Ying, Hanjie, Chen, Jian, Tan, Tianwei, Yuan, Yingjin. Biochemical engineering in China. REVIEWS IN CHEMICAL ENGINEERINGnull. 2019, 35(8): 929-993, http://dx.doi.org/10.1515/revce-2017-0035.
[21] Chen, Pengyu, Yue, Hua, Zhai, Xiaobo, Huang, Zihan, Ma, GuangHui, Wei, Wei, Yan, LiTang. Transport of a graphene nanosheet sandwiched inside cell membranes. SCIENCE ADVANCES[J]. 2019, 5(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000473798500072.
[22] Wang, Shuang, Ni, Dezhi, Yue, Hua, Luo, Nana, Xi, Xiaobo, Wang, Yugang, Shi, Min, Wei, Wei, Ma, Guanghui. Exploration of Antigen Induced CaCO3 Nanoparticles for Therapeutic Vaccine. SMALL[J]. 2018, 14(14): http://www.irgrid.ac.cn/handle/1471x/1764245.
[23] Wu, Sihua, Yue, Hua, Wu, Jie, Zhang, Wenming, Jiang, Min, Ma, Guanghui. The interacting role of physical stiffness and tumor cells on the macrophages polarization. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2018, 552: 81-88, http://dx.doi.org/10.1016/j.colsurfa.2018.04.026.
[24] Yue, Hua, Yuan, Lan, Zhang, Weiwei, Zhang, Shujia, Wei, Wei, Ma, Guanghui. Macrophage responses to the physical burden of cell-sized particles. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(3): 393-400, https://www.webofscience.com/wos/woscc/full-record/WOS:000422871100005.
[25] Xia, Yufei, Wu, Jie, Wei, Wei, Du, Yiqun, Wan, Tao, Ma, Xiaowei, An, Wenqi, Guo, Aiying, Miao, Chunyu, Yue, Hua, Li, Shuoguo, Cao, Xuetao, Su, Zhiguo, Ma, Guanghui. Exploiting the pliability and lateral mobility of Pickering emulsion for enhanced vaccination. NATURE MATERIALS[J]. 2018, 17(2): 187-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000423153800019.
[26] Nana Luo, Jeffrey K Weber, Shuang Wang, Binquan Luan, Hua Yue, Xiaobo Xi, Jing Du, Zaixing Yang, Wei Wei, Ruhong Zhou, Guanghui Ma. PEGylated graphene oxide elicits strong immunological responses despite surface passivation. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/a128b2d6b00b4f8f896db220436e5a4a.
[27] Ni, Dezhi, Qing, Shuang, Ding, Hui, Yue, Hua, Yu, Di, Wang, Shuang, Luo, Nana, Su, Zhiguo, Wei, Wei, Ma, Guanghui. Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer. ADVANCED SCIENCE[J]. 2017, 4(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000413166700004.
[28] 吴楠, 吴晶晶, 岳华, 吴颉, 马光辉. 壳聚糖季铵盐微球作为注射疫苗佐剂的安全性评价. 2016年全国高分子材料科学与工程研讨会论文摘要集null. 2016, 1-, http://www.irgrid.ac.cn/handle/1471x/6898742.
[29] Fan, Qingze, Qi, Feng, Miao, Chunyu, Yue, Hua, Gong, Fangling, Wu, Jie, Ma, Guanghui, Su, Zhiguo. Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2016, 500: 177-185, http://dx.doi.org/10.1016/j.colsurfa.2016.04.028.
[30] Xiong, Ke, Wei, Wei, Jin, Yongjie, Wang, Shumin, Zhao, Dongxu, Wang, Shuang, Gao, Xiaoyong, Qiao, Chenmeng, Yue, Hua, Ma, Guanghui, Xie, HaiYan. Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells. ADVANCED MATERIALS[J]. 2016, 28(36): 7929-7935, http://ir.ipe.ac.cn/handle/122111/21478.
[31] Wei, Wei, Zhu, Dan, Wang, Zhenhua, Ni, Dezhi, Yue, Hua, Wang, Shuang, Tao, Yong, Ma, Guanghui. Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2016, 4(15): 2548-2552, http://ir.ipe.ac.cn/handle/122111/21000.
[32] 吴晶晶, 吴楠, 岳华, 吴兴兰, 中西秀树, 高晓冬, 马光辉. 壳聚糖季铵盐微球作为注射疫苗佐剂的安全性评价. 过程工程学报[J]. 2016, 16(4): "647-653", http://www.irgrid.ac.cn/handle/1471x/1188119.
[33] Liu, Shan, Wei, Wei, Xie, Bo, Yue, Hua, Ni, Dezhi, Bao, Yali, Ma, Guanghui, Su, Zhiguo G. Breaching the Hyaluronan Barrier with PH20-Fc Facilitates Intratumoral Permeation and Enhances Antitumor Efficiency: A Comparative Investigation of Typical Therapeutic Agents in Different Nanoscales. ADVANCED HEALTHCARE MATERIALS[J]. 2016, 5(22): 2872-2881, http://www.irgrid.ac.cn/handle/1471x/1179148.
[34] Wang, YueQi, Fan, QingZe, Liu, Yan, Yue, Hua, Ma, XiaoWei, Wu, Jie, Ma, GuangHui, Su, ZhiGuo. Improving adjuvanticity of quaternized chitosan-based microgels for H5N1 split vaccine by tailoring the particle properties to achieve antigen dose sparing effect. INTERNATIONAL JOURNAL OF PHARMACEUTICS[J]. 2016, 515(1-2): 84-93, http://dx.doi.org/10.1016/j.ijpharm.2016.09.082.
[35] Yue, Hua, Wei, Wei, Gu, Zonglin, Ni, Dezhi, Luo, Nana, Yang, Zaixing, Zhao, Lin, Garate, Jose Antonio, Zhou, Ruhong, Su, Zhiguo, Ma, Guanghui. Exploration of graphene oxide as an intelligent platform for cancer vaccines. NANOSCALE[J]. 2015, 7(47): 19949-19957, http://dx.doi.org/10.1039/c5nr04986e.
[36] Luo, Nana, Ni, Dezhi, Yue, Hua, Wei, Wei, Ma, Guanghui. Surface-Engineered Graphene Navigate Divergent Biological Outcomes toward Macrophages. ACS APPLIED MATERIALS & INTERFACES[J]. 2015, 7(9): 5239-5247, http://www.irgrid.ac.cn/handle/1471x/945590.
[37] Fu, Qiang, Lv, Piping, Chen, Zhongke, Ni, Dezhi, Zhang, Lijun, Yue, Hua, Yue, Zhanguo, Wei, Wei, Ma, Guanghui. Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane. NANOSCALE[J]. 2015, 7(9): 4020-4030, http://www.irgrid.ac.cn/handle/1471x/944916.
[38] 马光辉. Exploration of Graphene Oxide as Intelligent Platform for Cancer Vaccine. Nanoscale. 2015, [39] Yue, Hua, Ma, Guanghui. Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications. VACCINE[J]. 2015, 33(44): 5927-5936, http://dx.doi.org/10.1016/j.vaccine.2015.07.100.
[40] 岳华, 马光辉. 基于纳微米颗粒和凝胶佐剂的新型疫苗传递体系. 中国材料进展[J]. 2015, 34(3): 216-224, http://lib.cqvip.com/Qikan/Article/Detail?id=664197243.
[41] Ni, Dezhi, Ding, Hui, Liu, Shan, Yue, Hua, Bao, Yali, Wang, Zhenhua, Su, Zhiguo, Wei, Wei, Ma, Guanghui. Superior Intratumoral Penetration of Paclitaxel Nanodots Strengthens Tumor Restriction and Metastasis Prevention. SMALL[J]. 2015, 11(21): 2518-2526, http://www.irgrid.ac.cn/handle/1471x/975484.
[42] Yin, Zhen, Zhang, Wei, Fu, Qiang, Yue, Hua, Wei, Wei, Tang, Pei, Li, Wenjing, Li, Weizhen, Lin, Lili, Ma, Guanghui, Ma, Ding. Construction of Stable Chainlike Au Nanostructures via Silica Coating and Exploration for Potential Photothermal Therapy. SMALL[J]. 2014, 10(18): 3619-3624, http://www.irgrid.ac.cn/handle/1471x/904003.
[43] 张微微, 魏炜, 马光辉, 袁兰, 张殊佳, 岳华. 纳米载体的理化性质对细胞学效应及抗肿瘤效果的影响. 癌症进展[J]. 2014, 256-260, http://www.irgrid.ac.cn/handle/1471x/945674.
[44] Yue Hua. Porous quaternized chitosan nanoparticles improve the therapeutic effect of paclitaxel on non-small cell lung cancer following oral administration. Biomacromolecules. 2013, [45] Wei, Wei, Lv, PiPing, Chen, XiaoMing, Yue, ZhanGuo, Fu, Qiang, Liu, ShiYing, Yue, Hua, Ma, GuangHui. Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression. BIOMATERIALS[J]. 2013, 34(15): 3912-3923, http://dx.doi.org/10.1016/j.biomaterials.2013.02.030.
[46] Yue, Zhanguo, You, Zuoxiang, Yang, Qinzheng, Lv, Piping, Yue, Hua, Wang, Bin, Ni, Dezhi, Su, Zhiguo, Wei, Wei, Ma, Guanghui. Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2013, 1(26): 3239-3247, http://ir.ipe.ac.cn/handle/122111/13406.
[47] Liu, ShiYing, Wei, Wei, Yue, Hua, Ni, DeZhi, Yue, ZhanGuo, Wang, Shuang, Fu, Qiang, Wang, YueQi, Ma, GuangHui, Su, ZhiGuo. Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy. BIOMATERIALS[J]. 2013, 34(33): 8291-8300, http://dx.doi.org/10.1016/j.biomaterials.2013.07.020.
[48] Yue, Zhanguo, Lv, Piping, Yue, Hua, Gao, Yongjun, Ma, Ding, Wei, Wei, Ma, Guanghui. Inducible graphene oxide probe for high-specific tumor diagnosis. CHEMICAL COMMUNICATIONS[J]. 2013, 49(37): 3902-3904, http://ir.ipe.ac.cn/handle/122111/13354.
[49] Yue, Hua, Wei, Wei, Fan, Bei, Yue, Zhanguo, Wang, Lianyan, Ma, Guanghui, Su, Zhiguo. The orchestration of cellular and humoral responses is facilitated by divergent intracellular antigen trafficking in nanoparticle-based therapeutic vaccine. PHARMACOLOGICAL RESEARCH[J]. 2012, 65(2): 189-197, http://dx.doi.org/10.1016/j.phrs.2011.09.008.
[50] Lv, PiPing, Ma, YuFeng, Yu, Rong, Yue, Hua, Ni, DeZhi, Wei, Wei, Ma, GuangHui. Targeted Delivery of Insoluble Cargo (Paclitaxel) by PEGylated Chitosan Nanoparticles Grafted with Arg-Gly-Asp (RGD). MOLECULAR PHARMACEUTICS[J]. 2012, 9(6): 1736-1747, http://www.irgrid.ac.cn/handle/1471x/735828.
[51] Yue, Hua, Wei, Wei, Yue, Zhanguo, Wang, Bin, Luo, Nana, Gao, Yongjun, Ma, Ding, Ma, Guanghui, Su, Zhiguo. The role of the lateral dimension of graphene oxide in the regulation of cellular responses. BIOMATERIALS[J]. 2012, 33(16): 4013-4021, http://dx.doi.org/10.1016/j.biomaterials.2012.02.021.
[52] Liu, Xiangyou, Wei, Wei, Wang, Chunlei, Yue, Hua, Ma, Ding, Zhu, Cheng, Ma, Guanghui, Du, Yuguang. Apoferritin-camouflaged Pt nanoparticles: surface effects on cellular uptake and cytotoxicity. JOURNAL OF MATERIALS CHEMISTRY[J]. 2011, 21(20): 7105-7110, http://www.irgrid.ac.cn/handle/1471x/735979.
[53] Yue, ZhanGuo, Wei, Wei, Lv, PiPing, Yue, Hua, Wang, LianYan, Su, ZhiGuo, Ma, GuangHui. Surface Charge Affects Cellular Uptake and Intracellular Trafficking of Chitosan-Based Nanoparticles. BIOMACROMOLECULES[J]. 2011, 12(7): 2440-2446, http://www.irgrid.ac.cn/handle/1471x/735937.
[54] Lv, PiPing, Wei, Wei, Yue, Hua, Yang, TingYuan, Wang, LianYan, Ma, GuangHui. Porous Quaternized Chitosan Nanoparticles Containing Paclitaxel Nanocrystals Improved Therapeutic Efficacy in Non-Small-Cell Lung Cancer after Oral Administration. BIOMACROMOLECULES[J]. 2011, 12(12): 4230-4239, http://www.irgrid.ac.cn/handle/1471x/735900.
[55] Yue, ZhanGuo, Wei, Wei, You, ZuoXiang, Yang, QinZheng, Yue, Hua, Su, ZhiGuo, Ma, GuangHui. Iron Oxide Nanotubes for Magnetically Guided Delivery and pH-Activated Release of Insoluble Anticancer Drugs. ADVANCED FUNCTIONAL MATERIALS[J]. 2011, 21(18): 3446-3453, http://www.irgrid.ac.cn/handle/1471x/735913.
[56] Yue, Hua, Wei, Wei, Yue, Zhanguo, Lv, Piping, Wang, Lianyan, Ma, Guanghui, Su, Zhiguo. Particle size affects the cellular response in macrophages. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES[J]. 2010, 41(5): 650-657, http://dx.doi.org/10.1016/j.ejps.2010.09.006.
[57] Wei, Wei, Yue, ZhanGuo, Qu, JianBo, Yue, Hua, Su, ZhiGuo, Ma, GuangHui. Galactosylated nanocrystallites of insoluble anticancer drug for liver-targeting therapy: an in vitro evaluation. NANOMEDICINE[J]. 2010, 5(4): 589-596, http://www.irgrid.ac.cn/handle/1471x/740245.
发表著作
(1) New Microsphere and Microcapsule Materials in Biotechnology: design, preparation and application (Microsphere for targeting delivery of anticancer drug, Pan Stanford Publishing Pte Ltd, 2013-05, 第 4 作者

科研活动

   
科研项目
( 1 ) 壳聚糖纳微球作为EV71手足口病疫苗佐剂的研究, 主持, 国家级, 2014-01--2016-12
( 2 ) 基于氧化石墨烯多种特性构建的 “One but all”肿瘤疫苗体系, 主持, 国家级, 2014-01--2016-12
( 3 ) 中国科学院青年创新促进会, 主持, 部委级, 2013-01--2016-12
( 4 ) 高效持久的2D-3D复合型免疫递送体系的构建及机制研究, 主持, 省级, 2020-01--2022-12
( 5 ) 耐药菌多糖结合疫苗的免疫原及佐剂研究, 主持, 国家级, 2021-01--2024-12
( 6 ) 具有脂质调控作用的二维纳米材料对神经退行性疾病的修复及机制研究, 主持, 市地级, 2021-01--2023-12
( 7 ) 氧化石墨烯纳米片对帕金森症的治疗作用及其机制研究, 主持, 市地级, 2020-01--2021-12
参与会议
(1)Exploration of graphene oxide (GO) as vaccine delivery system   第五届疫苗中国发展国际峰会   2015-03-25
(2)Exploration of micro-sized graphene oxide as “One but All” tumor vaccine delivery system   2013-10-27