发表论文
(1) Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase, Sci. Rep., 2018, 通讯作者(2) Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase, Sci. Rep., 2017, 通讯作者(3) The β and γ subunits play distinct functional roles in the α2βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase, Sci. Rep., 2017, 通讯作者(4) LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis, J. Experimental Medicine, 2017, 第 10 作者(5) Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2, Nucleic Acids Res., 2017, 通讯作者(6) Molecular basis for the recognition of CCN1 by monoclonal antibody 093G9, J. Mol. Recognit., 2017, 通讯作者(7) Cbln1 and Cbln4 are structurally similar but differ in GluD2 binding interactions, Cell Rep., 2017, 通讯作者(8) Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1, Nature Commun., 2017, 通讯作者(9) Structural basis for the functional role of the Shu complex in homologous recombination, Nucleic Acids Res., 2017, 通讯作者(10) Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses, Nature Communication, 2016, 通讯作者(11) Structural insight into the arginine binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling, Cell Discovery, 2016, 通讯作者(12) Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1, J. Mol. Cell Biol., 2016, 通讯作者(13) Structural basis for Sfm1 functioning as a protein arginine methyltransferase, Cell Discovery, 2015, 通讯作者(14) Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi, Nucleic Acids Res., 2015, 通讯作者(15) Conotoxin D-GeXXA utilizes a novel strategy to antagonize nicotinic acetylcholine receptors, Sci. Rep., 2015, 通讯作者(16) Crystal structures of Arabidopsis thaliana Nudix hydrolase NUDT7 reveal a previously unobserved conformation, Mol. Plant, 2015, 通讯作者(17) Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling, Cell Res., 2015, 通讯作者(18) Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex, EMBO Rep., 2015, 通讯作者(19) Functional role of histidine in the conserved His-x-Asp motif in the catalytic core of protein kinases, Sci. Rep., 2015, 通讯作者(20) Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2, Structure, 2014, 通讯作者(21) Subdomain II of -isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition, J. Biol. Chem., 2014, 通讯作者(22) Crystal structure of the WOPR-DNA complex and implications for Wor1 function in white-opaque switching of Candida albicans, Cell Res., 2014, 通讯作者(23) Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5, eLife, 2014, 通讯作者(24) Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair, Nucleic Acids Res., 2013, 通讯作者(25) Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed lights on the search for DNA decarboxylase, Cell Res., 2013, 通讯作者(26) Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif, Biochem. J., 2013, 通讯作者(27) Crystal structure of Drosophila melanogaster tryptophan 2,3-dioxygenase reveals insights into substrate recognition and catalytic mechanism, J. Struct. Biol., 2013, 通讯作者(28) Functional and structural characterization of DNMT2 from Spodoptera frugiperda, J. Mol. Cell Biol., 2013, 通讯作者(29) Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutulicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism, Biochem. J., 2013, 通讯作者(30) Molecular basis of the acetyltransferase activity of MEC-17 towards α-tubulin, Cell Res., 2012, 通讯作者(31) Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 within the TORC1 activating EGO complex, Structure, 2012, 通讯作者(32) Crystal structures of human CaMKI reveal insights into the regulation mechanism of CaMKI, PLoS One, 2012, 通讯作者(33) Saccharomyces cerevesiae MHF complex structurally resembles the histones (H3-H4)2 heterotetramer and functions as a heterotetramer, Structure, 2012, 通讯作者(34) Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd protein, Cell Biol., 2011, 通讯作者(35) Crystal structures and kinetic studies of human kappa class glutathione transferase provide insights into the catalytic mechanism, Biochem. J., 2011, 通讯作者(36) New G-protein-coupled receptor structures provide insights into the recognition of CXCL12 and HIV-1 gp120 by CXCR4, Acta Biochem Biophys Sin, 2011, 通讯作者(37) Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274, Cell Res., 2011, 通讯作者(38) A novel calcium-binding site of von illebrand factor A2 domain regulates its cleavage by ADAMTS13, Blood, 2011, 通讯作者(39) Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal unique features of the enzyme, Nucleic Acids Res., 2011, 通讯作者(40) Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism, Biochem. J., 2011, 通讯作者(41) Molecular mechanisms of “off-on switch” of activities of human IDH1 by tumor-associated mutation R132H, Cell Res., 2010, 通讯作者(42) Structural basis of the immunosuppressive mechanism of therapeutic antibody daclizumab, Cell Res., 2010, 通讯作者(43) Crystal structure of Saccaromyces cerevisae tryptophanyl-tRNA synthetase: new insights into the mechanism of trptophan activation and implications for anti-fungal drug design, Nucleic Acids Res., 2010, 通讯作者(44) Crystal structure of P. Horikoshi tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetases, Nucleic Acids Res., 2010, 通讯作者(45) Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site, J. Struct. Biol., 2010, 通讯作者(46) Structural basis for the blockage of IL-2 signaling by therapeutic antibody Basiliximab, Structural basis for the blockage of IL-2 signaling by therapeutic antibody Basiliximab, 2010, 通讯作者(47) Molecular basis of the acceleration of the nucleotide exchange of Rheb by TCTP, J. Biol. Chem., 2009, 通讯作者(48) Structural modeling and biochemical studies reveal insights into the molecular basis of the recognition of ?-2-microglobulin by antibody BBM.1, J. Mol. Recognition, 2009, 通讯作者(49) Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20, Mol. Immonol., 2009, 通讯作者(50) Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans, Biochem. J., 2009, 通讯作者(51) Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector, Structure, 2009, 通讯作者(52) Efalizumab binding to the LFA-1 ?L I domain blocks ICAM-1 binding via steric hindrance, Proc. Natl. Acad. Sci. USA,, 2009, 通讯作者(53) Molecular basis of the interaction of Saccharomyces cerevisiae Eaf3 chromo domain with methylated H3K36, J. Biol. Chem., 2008, 通讯作者(54) Isoquinoline-1,3,4-trione derivatives inactivates caspase-3 by generation of reactive oxygen species, J. Biol. Chem., 2008, 通讯作者(55) Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid arthritis, J. Mol. Biol., 2008, 通讯作者(56) Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction, Protein Sci., 2008, 通讯作者(57) Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans, Biochem. J., 2008, 通讯作者(58) Molecular mechanism of ADPR hydrolysis by human NUDT5 from structural and kinetic studies, J. Mol. Biol., 2008, 通讯作者(59) Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide, Mol. Immunol., 2008, 通讯作者(60) Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states, Nucleic Acids Res., 2008, 通讯作者