基本信息
刘洪涛  男  博导  中国科学院过程工程研究所
电子邮件: liuhongtao@ipe.ac.cn
通信地址: 北京市海淀区中关村北二街1号
邮政编码: 100190

招生信息

   
招生专业
071020-生物技术与医药
招生方向
营养糖生物学

教育背景

2006-09--2010-06   中国科学院大连化学物理研究所   博士
2003-09--2006-06   解放军军事医学科学院   硕士
1995-09--1998-06   第一军医大学   本科

工作经历

   
工作简历
2014-10~现在, 中国科学院过程工程研究所, 研究员
2010-10~2014-09,美国俄克拉荷马大学, 博士后
1998-07~2003-08,解放军第154医院, 文职干部
社会兼职
2015-07-01-2020-06-30,中国生物工程糖生物工程专业委员会, 委员
2014-11-12-2018-11-11,中国生物化学与分子生物学会脂质与脂蛋白专业委员会, 青年委员

出版信息

   
发表论文
(1) Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-κB and endothelial inflammatory response, Carbohydr Polym, 2014, 第 1 作者
(2) Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response, Cardiovasc Res, 2014, 第 1 作者
(3) Identification of nitric oxide as an endogenous inhibitor of 26S proteasomes in vascular endothelial cells, Plos One, 2014, 第 1 作者
(4) Upregulation of Unc-51-Like Kinase 1 by Nitric Oxide Stabilizes SIRT1, Independent of Autophagy, PLoS One, 2014, 第 2 作者
(5) Enhancement of 26S proteasome functionality connects oxidative stress and vascular endothelial inflammatory response in diabetes, Arterioscl Throm Vas, 2012, 第 1 作者
(6) Angiogenesis impairment in diabetes: Role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2, PLoS ONE, 2012, 第 1 作者
(7) Chitosan oligosaccharides suppress lipopolysaccharide-induced interleukin-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases, Acta Pharmacol Sin, 2011, 第 1 作者
(8) Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-α in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways, Carbohydrate Polymers, 2011, 第 2 作者
(9) Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species, Journal of Ethnopharmacology, 2010, 第 1 作者
(10) Chitosan oligosaccharides inhibit TNF-α-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways, Carbohydrate Polymer, 2010, 第 1 作者
(11) Chitosan oligosaccharides protect human umbilical vein endothelial cells from hydrogen peroxide-induced apoptosis, Carbohydrate Polymer, 2010, 第 1 作者
(12) Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways,  Inflammation Research, 2010, 第 1 作者
(13) Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-κB signaling pathways., Journal of Ethnopharmacology, 2009, 第 3 作者
(14) The effect of Tetramethylpyrazine on hydrogen peroxide-induced oxidative damage in human umbilical vein endothelial cells, Basic Clinical Pharmacology Toxicology, 2009, 第 2 作者
(15) Chitosan oligosaccharides inhibit the expression of interleukin-6 in lipopolysaccharide-induced human umbilical vein endothelial cells through p38 and ERK1/2 protein kinases, Basic Clinical Pharmacology Toxicology, 2009, 第 1 作者
(16) Chitosan oligosaccharides attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells, Pharmacol Res, 2009, 第 1 作者

科研活动

   
科研项目
( 1 ) 海洋糖工程技术研发联合实验室, 主持, 院级, 2015-06--2018-05
( 2 ) O-GLcNAc修饰、泛素-蛋白酶体系统与糖尿病胰岛素抵抗之间的相互作用及潜在的分子调控机制研究, 主持, 国家级, 2016-01--2019-12
( 3 ) 基于糖、脂代谢紊乱及炎性损伤研究的功能寡糖筛选平台构建, 主持, 市地级, 2015-01--2017-12