中药色谱分离分析与纯化制备

   

070302-分析化学

基于本草物质组的新药发现
中药高效正交纯化制备方法发展

2004-09--2010-07   中国科学院大连化学物理研究所   博士
2000-09--2004-07   山西大学   学士

研究生

博士

   

2019-07~现在, 中国科学院大连化学物理研究所, 研究员
2013-07~2019-06,中国科学院大连化学物理研究所, 副研究员
2010-07~2013-07,中国科学院大连化学物理研究所, 助理研究员

   

（ 1 ） 苍术酮或苍术素作为FFA1激动剂的应用及药物组合物, 发明专利, 2022, 第 4 作者, 专利号: CN114129555A

（ 2 ） 香豆素类衍生物在制备治疗炎症性肠炎药物中应用及药物, 发明专利, 2022, 第 3 作者, 专利号: CN114129562A

（ 3 ） 一种从麻黄中提取麻黄碱的连续制备方法, 发明专利, 2022, 第 2 作者, 专利号: CN114133335A

（ 4 ） 一种木脂素类化合物及制备与应用和产品, 发明专利, 2022, 第 4 作者, 专利号: CN113880791A

（ 5 ） 双苄基异喹啉生物碱衍生物及制备和应用与药物组合物, 发明专利, 2021, 第 3 作者, 专利号: CN113730408A

（ 6 ） 一种有机酸化合物及其制备方法和用途, 发明专利, 2021, 第 4 作者, 专利号: CN111233662B

（ 7 ） 一种莪术中强极性成分的分离制备及分析方法和应用, 专利授权, 2021, 第 5 作者, 专利号: CN111610284B

（ 8 ） 一种穿山甲指纹图谱质量监测方法, 发明专利, 2021, 第 6 作者, 专利号: CN112924570A

（ 9 ） 一种胆南星定量指纹图谱质量监测方法, 发明专利, 2021, 第 5 作者, 专利号: CN112924569A

（ 10 ） 一种环状肉桂酰胺化合物及其制备方法和应用, 发明专利, 2021, 第 3 作者, 专利号: CN112898214A

（ 11 ） 一种不同厂家/或相同厂家不同批次银杏叶药物相似度的分析方法, 发明专利, 2021, 第 3 作者, 专利号: CN112858550A

（ 12 ） 无标记精氨酸加压素受体细胞模型构建和配体筛选方法, 发明专利, 2021, 第 4 作者, 专利号: CN112858673A

（ 13 ） 一种双黄连口服液定量指纹图谱质量监测方法, 发明专利, 2021, 第 4 作者, 专利号: CN112858549A

（ 14 ） 一种基于HPLC-DAD的六味地黄丸组方解析和质量分析方法, 发明专利, 2021, 第 4 作者, 专利号: CN112684091A

（ 15 ） 一种紫草液相分离时色谱峰的质量的定量分析方法, 发明专利, 2021, 第 4 作者, 专利号: CN112461939A

（ 16 ） 一种小金胶囊或小金丸或小金片质量的指纹图谱检测方法, 发明专利, 2021, 第 4 作者, 专利号: CN112444588A

（ 17 ） 磺酰胺衍生物、其药物组合物和应用, 发明专利, 2021, 第 4 作者, 专利号: CN112390734A

（ 18 ） 无标记血管紧张素Ⅱ受体细胞模型构建和筛选方法及应用, 发明专利, 2021, 第 4 作者, 专利号: CN112345745A

（ 19 ） 一种双查尔酮类化合物及其制备方法和用途, 发明专利, 2020, 第 3 作者, 专利号: CN111233648A

（ 20 ） 一种动态质量重置法检测化合物临界聚合浓度的方法, 发明专利, 2020, 第 3 作者, 专利号: CN111239053A

（ 21 ） 一种新双黄酮类化合物及其制备方法和用途, 发明专利, 2020, 第 4 作者, 专利号: CN111233808A

（ 22 ） 一种甘草中生物碱类化合物的制备方法及用途, 发明专利, 2020, 第 4 作者, 专利号: CN111228326A

（ 23 ） 一种夜交藤中极性化合物的纯化制备方法, 发明专利, 2020, 第 4 作者, 专利号: CN111233757A

（ 24 ） 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物, 发明专利, 2019, 第 3 作者, 专利号: CN110372571A

（ 25 ） β 2 -肾上腺素受体拮抗剂及应用, 发明专利, 2019, 第 5 作者, 专利号: CN109893651A

（ 26 ） 一种枸杞子中二咖啡酰亚精胺类化合物选择性富集方法, 发明专利, 2019, 第 4 作者, 专利号: CN109810014A

（ 27 ） 一种莪术中β 2 -肾上腺素受体激动剂及其应用, 发明专利, 2019, 第 3 作者, 专利号: CN109806254A

（ 28 ） 柴胡活性成分在制备抗三阴性乳腺癌药物中的应用, 发明专利, 2019, 第 4 作者, 专利号: CN109549945A

（ 29 ） 一种高效分离纯化高纯度甘草酸的方法, 专利授权, 2018, 第 3 作者, 专利号: CN107759655A

（ 30 ） 一种化合物、毒蕈碱M受体拮抗剂、组合物及应用, 发明专利, 2017, 第 3 作者, 专利号: CN107129439A

（ 31 ） 化合物、毒蕈碱M受体拮抗剂、组合物及应用, 专利授权, 2017, 第 3 作者, 专利号: CN107129453A

（ 32 ） 一种黑果枸杞中花色苷类化合物异构体的分离纯化方法, 发明专利, 2016, 第 3 作者, 专利号: CN106188180A

（ 33 ） 一种黑果枸杞中花色苷类化合物的选择性富集方法, 专利授权, 2016, 第 3 作者, 专利号: CN106198172A

（ 34 ） 蟾蜍二烯内酯类化合物在制备抗胃癌药物中的应用, 发明专利, 2016, 第 4 作者, 专利号: CN106138067A

（ 35 ） 一种蟾蜍二烯内酯类化合物选择性分离纯化方法, 发明专利, 2015, 第 3 作者, 专利号: CN104774234A

（ 36 ） 一种基于亲水固相萃取技术的蟾蜍二烯内酯类化合物类分离纯化方法, 发明专利, 2015, 第 3 作者, 专利号: CN104774235A

（ 37 ） 一种嚏根草配基空间异构体化合物及其制备和应用, 发明专利, 2011, 第 2 作者, 专利号: CN102101878A

（ 38 ） 一种沙蟾毒精空间异构体化合物及其制备和应用, 发明专利, 2011, 第 2 作者, 专利号: CN102101879A

（ 39 ） 一类蟾蜍内酯类化合物在抑制肿瘤生长药物中的应用, 发明专利, 2010, 第 1 作者, 专利号: CN101829123A

（ 40 ） 一种蟾蜍内酯类化合物及其在制备抗肿瘤药物中的应用, 发明专利, 2010, 第 4 作者, 专利号: CN101830963A

   

（1） 基于定量指纹图谱技术的经典名方清骨散基准样品量值传递分析, Analysis on quality value transmitting of Qinggusan reference sample of classical prescription based on quantitative fingerprint technology, 色谱, 2023, 第 10 作者
（2） A guide of column selection for two-dimensional liquid chromatography method development of natural alkaloids, TALANTA, 2023, 通讯作者
（3） 基于超高效液相色谱-紫外检测定量指纹图谱结合化学模式识别的复方金钱草颗粒质量评价, Quality evaluation of Fufang Jinqiancao granules based on ultra performance liquid chromatography-ultraviolet detection quantitative fingerprint combined with chemical pattern recognition, 色谱, 2022, 第 8 作者
（4） 天然产物中FFA1受体新激动剂的发现与研究, Discovery and study of new FFA1 receptor agonists from natural products, 上海中医药大学学报, 2021, 第 6 作者
（5） Offline preparative three-dimensional HPLC for systematic and efficient purification of alkaloids from Gelsemium elegans Benth, JOURNAL OF CHROMATOGRAPHY A, 2021, 通讯作者
（6） 基于HPLC-Q-TOF-MS/MS的分子网络技术快速分析夏天无生物碱, Rapid Identification of Alkaloids in the Rhizomes of Corydalis decumbens by Molecular Networking Base on HPLC-Q-TOF-MS/MS, 质谱学报, 2021, 第 5 作者
（7） Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 pharmacotherapy, FOOD AND CHEMICAL TOXICOLOGY, 2021, 第 5 作者
（8） Computer-Aided Rapid Establishment of Fingerprint of Xiaojin Capsule by HPLC, INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY, 2021, 通讯作者
（9） Analgesic bisbenzylisoquinoline alkaloids from the rhizoma of Menispermum dauricum DC, BIOORGANIC CHEMISTRY, 2021, 通讯作者
（10） 基于化学模式识别技术的枳实HPLC定量指纹图谱研究, An HPLC Fingerprint Research on Citrus aurantium Based on Chemical Pattern Recognition Technology, 分析测试学报, 2021, 第 6 作者
（11） Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products, JOURNAL OF ETHNOPHARMACOLOGY, 2021, 通讯作者
（12） Identification and target-pathway deconvolution of FFA4 agonists with anti-diabetic activity from Arnebia euchroma (Royle) Johnst, PHARMACOLOGICAL RESEARCH, 2021, 通讯作者
（13） 超高效液相色谱-质谱法同时测定舒血宁注射剂中20种黄酮醇苷与萜类内酯成分, Simultaneous Determination of 20 Flavonoid Glycosides and Terpenoid Lactones in Shuxuening Injection by Ultra-high Performance Liquid Chromatography-Mass Spectrometry, 分析测试学报, 2020, 第 4 作者
（14） Scocycamides, a Pair of Macrocyclic Dicaffeoylspermidines with Butyrylcholinesterase Inhibition and Antioxidation Activity from the Roots of Scopolia tangutica, ORGANIC LETTERS, 2020, 通讯作者
（15） 穿山甲色谱指纹谱的建立及其在基源鉴别和质量等级区分方面的应用, Establishment of chromatographic fingerprint of Squama Manis and its applications in animal source identification and quality grade discrimination, 色谱, 2020, 第 5 作者
（16） An offline two-dimensional supercritical fluid chromatography × reversed phase liquid chromatography tandem quadrupole time-of-flight mass spectrometry system for comprehensive gangliosides profiling in swine brain extract, TALANTA, 2020, 第 2 作者
（17） Combination of multi-model statistical analysis and quantitative fingerprinting in quality evaluation of Shuang-huang-lian oral liquid (vol 412, pg 7073, 2020), ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 第 5 作者
（18） An offline two-dimensional supercritical fluid chromatography x reversed phase liquid chromatography tandem quadrupole time-of-flight mass spectrometry system for comprehensive gangliosides profiling in swine brain extract, TALANTA, 2020, 通讯作者
（19） Integration of micro-fractionation, high-performance liquid chromatography-ultraviolet detector-charged aerosol detector-mass spectrometry analysis and cellular dynamic mass redistribution assay to accelerate alkaloid drug discovery, JOURNAL OF CHROMATOGRAPHY A, 2020, 通讯作者
（20） Chemical profiling of spermidines in goji berry by strong cation exchange solid-phase extraction (SCX-SPE) combined with ultrahigh-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS/MS), JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2020, 第 3 作者
（21） Phytochemical and chemotaxonomic study on Saussurea medusa Maxim. (Compositae), BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2020, 第 2 作者
（22） Combination of multi-model statistical analysis and quantitative fingerprinting in quality evaluation of Shuang-huang-lian oral liquid, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 第 5 作者
（23） 基于化学模式识别的栀子UPLC定量指纹图谱研究, UPLC quantitative fingerprint research on Gardeniae Fructus based on chemical pattern recognition technology, 中国中药杂志, 2020, 第 8 作者
（24） Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 通讯作者
（25） Inhibition of miR-93 promotes interferon effector signaling to suppress influenza A infection by upregulating JAK1, INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 第 4 作者
（26） Application of two-dimensional liquid chromatography in the separation of traditional Chinese medicine, JOURNAL OF SEPARATION SCIENCE, 2020, 通讯作者
（27） Establishment of chromatographic fingerprint of Squama Manis and its applications in animal source identification and quality grade discrimination, CHINESE JOURNAL OF CHROMATOGRAPHY, 2020, 第 5 作者
（28） 基于HPLC-Q-TOF/MS的白屈菜生物碱化学组成快速辨识研究, Rapid identification of the alkaloids of Chelidonium majus L.by HPLC-Q-TOF/MS, 药学学报, 2020, 第 4 作者
（29） Purification of tertiary and quaternary alkaloids from Rhizoma Corydalis using reversed-phase/weak cation-exchange mixed-mode class separation combined with preparative C18 and silica based strong cation-exchange chromatography, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2019, 第 6 作者
（30） Offline preparative 2-D polar-copolymerized reversed-phase chromatography × zwitterionic hydrophilic interaction chromatography for effective purification of polar compounds from Caulis Polygoni Multiflori, JOURNALOFCHROMATOGRAPHYB, 2019, 通讯作者
（31） Offline preparative 2-D polar-copolymerized reversed-phase chromatography x zwitterionic hydrophilic interaction chromatography for effective purification of polar compounds from Caulis Polygoni Multiflori, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2019, 通讯作者
（32） Resonant waveguide grating based assays for colloidal aggregate detection and promiscuity characterization in natural products, RSC ADVANCES, 2019, 通讯作者
（33） 生物碱的高效液相色谱分离分析与纯化制备研究进展, Research Progress on High Performance Liquid Chromatography in Analysis and Preparation of Alkaloids, 分析测试学报, 2019, 第 2 作者
（34） Characterization of tropane and cinnamamide alkaloids from Scopolia tangutica by high-performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry, JOURNAL OF SEPARATION SCIENCE, 2019, 通讯作者
（35） Strong electrostatic repulsive interaction used for fast and effective alkaloid enrichment from plants, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2019, 通讯作者
（36） Identification of Alkaloids from Corydalis yanhusuo W. T. Wang as Dopamine D-1 Receptor Antagonists by Using CRE-Luciferase Reporter Gene Assay, MOLECULES, 2018, 第 5 作者
（37） 离线二维液相色谱法分离巴天酸模根的化学成分, Separation of chemical compositions in root of Rumex patientia L. with off-line two-dimensional liquid chromatography, 色谱, 2018, 第 3 作者
（38） Discovery of beta(2)-adrenoceptor agonists in curcuma zedoaria rosc using label-free cell phenotypic assay combined with two-dimensional liquid chromatography, JOURNAL OF CHROMATOGRAPHY A, 2018, 通讯作者
（39） Discovery of novel antagonists on beta(2)-adrenoceptor from natural products using a label-free cell phenotypic assay, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2018, 第 10 作者
（40） Saikosaponin d from radix bupleuri suppresses triple-negative breast cancer cell growth by targeting beta-catenin signaling, BIOMEDICINE & PHARMACOTHERAPY, 2018, 第 10 作者
（41） Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3, FASEB JOURNAL, 2018, 第 2 作者
（42） Simultaneous determination of free and total choline and l-carnitine in infant formula using hydrophilic interaction liquid chromatography with tandem mass spectrometry, JOURNAL OF SEPARATION SCIENCE, 2018, 第 5 作者
（43） Enzyme-assisted extraction and liquid chromatography-inductively coupled plasma mass spectrometry for the determination of arsenic species in fish, JOURNAL OF CHROMATOGRAPHY A, 2018, 第 6 作者
（44） On-line comprehensive two-dimensional liquid chromatography tandem mass spectrometry for the analysis of Curcuma kwangsiensis, TALANTA, 2018, 通讯作者
（45） Purification of high-purity glycyrrhizin from licorice using hydrophilic interaction solid phase extraction coupled with preparative reversed-phase liquid chromatography, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2017, 通讯作者
（46） Construction of an off-line two dimensional reversed-phase liquid chromatography/ultra-high performance supercritical fluid chromatography method for rapid and comprehensive analysis of Piper kadsura, JOURNAL OF SUPERCRITICAL FLUIDS, 2017, 第 4 作者
（47） Construction of an off-line two dimensional reversed-phase liquid chromatography/ultra-high performance supercritical fluid chromatography method for rapid and comprehensive analysis of Piper kadsura, THE JOURNAL OF SUPERCRITICAL FLUIDS, 2017, 第 4 作者
（48） Discovery of new muscarinic acetylcholine receptor antagonists from Scopolia tangutica., SCIENTIFIC REPORTS, 2017, 通讯作者
（49） "Two-dimensional" molecularly imprinted solid-phase extraction coupled with crystallization and high performance liquid chromatography for fast semi-preparative purification of tannins from pomegranate husk extract, JOURNAL OF CHROMATOGRAPHY A, 2017, 第 2 作者
（50） Purification of lignans from Fructus Arctii using off-line two-dimensional supercritical fluid chromatography/reversed-phase liquid chromatography, JOURNAL OF SEPARATION SCIENCE, 2017, 第 5 作者
（51） Anti-gastric cancer activity in three-dimensional tumor spheroids of bufadienolides, SCIENTIFIC REPORTS, 2016, 第 9 作者
（52） Separation and characterization of bufadienolides in toad skin using two-dimensional normal-phase liquid chromatography x reversed-phase liquid chromatography coupled with mass spectrometry, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 通讯作者
（53） Identification and characterization of naturally occurring inhibitors against human carboxylesterase 2 in White Mulberry Root-bark, FITOTERAPIA, 2016, 第 4 作者
（54） Recent development in liquid chromatography stationary phases for separation of Traditional Chinese Medicine components, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 通讯作者
（55） Identification of miRNomes in human stomach and gastric carcinoma reveals miR-133b/a-3p as therapeutic target for gastric cancer, CANCER LETTERS, 2015, 第 1 作者
（56） 基于Thiol-Click-COOH 固相萃取的蟾蜍二烯内酯的类分离研究, 中国科学 化学, 2015, 第 3 作者
（57） Characterisation of oligosaccharides from Baizhu by HILIC-MS, NATURAL PRODUCT RESEARCH, 2015, 第 2 作者
（58） High-Performance Liquid Chromatography Separation of cis-trans Anthocyanin Isomers from Wild Lycium ruthenicum Murr. Employing a Mixed-Mode Reversed-Phase/Strong Anion-Exchange Stationary Phase, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2015, 通讯作者
（59） ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling, ONCOTARGET, 2015, 第 5 作者
（60） Evaluation of a silicon oxynitride hydrophilic interaction liquid chromatography column in saccharide and glycoside separations, JOURNAL OF SEPARATION SCIENCE, 2015, 第 6 作者
（61） High-Performance Liquid Chromatography Separation of cis−trans Anthocyanin Isomers from Wild Lycium ruthenicum Murr. Employing a Mixed-Mode Reversed-Phase/Strong Anion-Exchange Stationary Phase, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2015, 第 2 作者
（62） Double Off-line Two-dimensional Liquid Chromatography for Separation and Identification of Compounds in Salvia Miltiorrhiza (Danshen), 世界中医药, 2015, 第 7 作者
（63） psi-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling, ONCOTARGET, 2015, 第 5 作者
（64） Characterization of anthocyanins in wild Lycium ruthenicum Murray by HPLC-DAD/QTOF-MS/MS, ANALYTICAL METHODS, 2015, 通讯作者
（65） The influence of organic sample solvents on the separation efficiency of basic compounds under strong cation exchange mode, ANALYTICA CHIMICA ACTA, 2015, 第 3 作者
（66） Preparative separation of a challenging anthocyanin from Lycium ruthenicum Murr. by two-dimensional reversed-phase liquidchromatography/hydrophilic interaction chromatography, RSC ADVANCES, 2015, 通讯作者
（67） Efficient purification of low molecular weight nitrogen polar compounds from the skin of Bufo bufo gargarizans Cantor by reversed-phase high performance liquid chromatography with a polar-copolymerized C18 stationary phase, ANALYTICAL METHODS, 2014, 通讯作者
（68） Purification of bufadienolides from the skin of Bufo bufo gargarizans Cantor with positively charged C18 column, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 第 5 作者
（69） Hydrophilic interaction chromatography for selective separation of isomeric saponins, JOURNAL OF CHROMATOGRAPHY A, 2014, 第 4 作者
（70） Efficient purification of active bufadienolides by a class separation method based on hydrophilic solid-phase extraction and reversed-phase high performance liquid chromatography, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 通讯作者
（71） 蟾毒配基磺酸化及基于自制串联固相萃取对磺酸化产物富集的研究, Study of Bufogenins on Sulfonation Reaction and Enrichment of Sulfated Bufogenins via a Homemade RP/HILIC -SPE, 分析测试学报, 2014, 第 2 作者
（72） Efficient purification of active bufadienolides by a class separation method based on hydrophilic solid-phase extraction from toad skin, the 3rd annual meeting of the gp-tcm research association & the 5th annual meeting of the tcm pharmaceutical analysis specialty committee of wfcms, 2014, 第 2 作者
（73） Efficient purification of high-purity compounds from the stem of Lonicera japonica Thunb using two-dimensional preparative chromatography, JOURNAL OF SEPARATION SCIENCE, 2013, 第 2 作者
（74） Comprehensive characterization of Stevia Rebaudiana using two-dimensional reversed-phase liquid chromatography/hydrophilic interaction liquid chromatography, JOURNAL OF SEPARATION SCIENCE, 2012, 第 4 作者
（75） The herbalome-an attempt to globalize Chinese herbal medicine, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 第 2 作者
（76） Natural products purification and drug discovery, THE 6TH SHANGHAI INTERNATIONAL SYMPOSIUM ON ANALYTICAL CHEMISTRY, 2012, 第 2 作者
（77） Chromatographic Methodology and Technology for Developing TCM, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES　, 2011, 第 3 作者
（78） Purification of active bufadienolides from toad skin by preparative reversed-phase liquid chromatography coupled with hydrophilic interaction chromatography, JOURNAL OF SEPARATION SCIENCE, 2010, 第 1 作者
（79） 复杂样品分离分析方法学, Methodology for Separation and Analysis of Complex Samples, analytica china conference 2010, 2010, 第 2 作者
（80） 本草物质结构组方法学研究, 2010, 第 1 作者
（81） Systematic screening and characterization of novel bufadienolides from toad skin using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2010, 第 1 作者
（82） 复杂样品分离分析方法学, Methodology for Separation and Analysis of Complex Samples, Analytica china conference 2010, 2010, 第 2 作者
（83） Two-dimensional RPLC-RPLC system with different pH in two dimensions for separation of alkaloids from Corydalis yanhusuo W. T. Wang, JOURNAL OF SEPARATION SCIENCE, 2009, 第 3 作者
（84） 中药物质基础的高效液相色谱分离分析方法研究, The study of high-performance liquid chromatography methods for the separation and analysis of traditional chinese medicines, 中国科学：B辑, 2009, 第 1 作者
（85） Synthesis; chromatographic evaluation and hydrophilic interaction/reversed-phase mixed-mode behavior of a "Click β-cyclodextrin" stationary phase, JOURNAL OF CHROMATOGRAPHY A, 2009, 第 4 作者
（86） Synthesis, chromatographic evaluation and hydrophilic interaction/reversed-phase mixed-mode behavior of a "Click beta-cyclodextrin" stationary phase, JOURNAL OF CHROMATOGRAPHY A, 2009, 第 4 作者
（87） 中药物质基础的高效液相色谱分离分析方法研究, 中国科学 B, 2009, 第 1 作者
（88） Purification of alkaloids from Corydalis yanhusuo W. T. Wang using preparative 2-D HPLC, JOURNAL OF SEPARATION SCIENCE, 2009, 第 3 作者
（89） 中药物质基础研究的思路与方法, Approaches to the Study on Material Foundation of Chinese Medicines, 中国天然药物, 2009, 第 4 作者
（90） Improved concentration technique for purified preparative fractions via solid phase extraction using oasis HLB as sorbent, JOURNAL OF BIOTECHNOLOGY, 2008, 第 1 作者
（91） Purification of chitooligosaccharides by using purification factory, JOURNAL OF BIOTECHNOLOGY, 2008, 第 3 作者
（92） 中药筛选组分的高通量制备和表征方法, High-throughput method for preparation and characterization of screening multi-components of TCMs, 4th shanghai international symposium on analytical chemistry, 2008, 第 2 作者
（93） A novel method of prediction and optimization for preparative high-performance liquid chromatography separation, JOURNAL OF CHROMATOGRAPHY A, 2008, 第 3 作者
（94） Purification of chitooligosaccharides by using purification factory, 13th international biotechnology symposium & exhibition, 2008, 第 3 作者
（95） 中药筛选组分的高通量制备和表征方法, High-throughput method for preparation and characterization of screening multi-components of TCMs, 4th shanghai international symposium on analytical chemistry, 2008, 第 2 作者
（96） Investigation of alkaloids concentration using solid phase extraction, JOURNAL OF BIOTECHNOLOGY, 2008, 第 2 作者
（97） Novel reversed-phase high-performance liquid chromatography stationary phase with oligo(ethylene glycol) "click" to silica, JOURNAL OF CHROMATOGRAPHY A, 2008, 第 2 作者
（98） Investigation of alkaloids concentration using solid phase extraction, JOURNALOFBIOTECHNOLOGY, 2008, 第 2 作者
（99） Improved concentration technique for purified preparative fractions via solid phase extraction using oasis HLB as sorbent, 13th international biotechnology symposium & exhibition, 2008, 第 1 作者
（100） "Click oligomeric ethylene glycol": complementary stationary phases for RP-HPLC, Dalian International Symposia and Exhibition on Chromatography, 2007, 第 4 作者
（101） Studies of iridoid glycosides using liquid chromatography/electrospray ionization tandem mass spectrometry, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2007, 第 5 作者

   

（ 1 ） 唐古特山莨菪生物碱的高效制备与毒蕈碱型受体活性的构效研究, 负责人, 国家任务, 2017-01--2020-12

已指导学生

张羽  硕士研究生  070302-分析化学  

现指导学生

徐林莉  硕士研究生  070302-分析化学