General

Maggie C.Y. Lau, PhD

Professor

Laboratory of Extraterrestrial Ocean Systems (LEOS)
Institute of Deep-Sea Science and Engineering, Chinese Academy of Sciences
No. 28, Luhuitou Road, Sanya 572000, Hainan Province, P.R. China

E-mail: maglau@idsse.ac.cn

部门/实验室:深海科学研究部

Research Areas & Interests

Main areas: geobiology, microbial ecology, astrobiology

Interests: Microbial ecology and evolution; physiology and adaptation to environmental stress; biogeography; symbiosis; environmental multi-omics; geobiology; extremophiles; hot springs; arid regions; Arctic and Antarctic research; deep subsurface; aerobiology; astrobiology

Education

2007    The University of Hong Kong, HKSAR

            PhD, Microbial ecology

            Title: Ecology of natural thermophilic communities in The Tibet Autonomous Region      (China)

Advisor: Stephen B. Pointing

2002    The University of Hong Kong, HKSAR

B.Sc. (Hons.), Environmental Life Science


Publications


Papers

As the lead and senior author

Sun, E.W.-H., S. Hajirezaie, M. Dooner, T.A. Vishnivetskaya, A. Layton, A. Chauhan, S.M. Pfiffner, L.G. Whyte, T.C. Onstott, and M.C.Y. Lau (2020) Thaumarchaea genome sequences from a High Arctic active layer. Microbiology Resources Announcements 9: e00326-20. doi: 10.1128/MRA.00326-20.

Rusley, C., T.C. Onstott, T.A. Vishnivetskaya, A. Layton, A. Chauhan, S.M. Pfiffner, L.G. Whyte, and M.C.Y. Lau (2019) Metagenome-assembled genome of USCα AHI, a potential high-affinity methanotroph from Axel Heiberg Island, Canadian High Arctic. Microbiology Resources Announcements 8: e01178-19. doi: 10.1128/MRA.01178-19.

Lau, M.C.Y.R.L. HarrisY. OhM.J. Yi, Aida Behmard and T.C. Onstott. (2018) Taxonomic and functional compositions impacted by the quality of metatranscriptomic assemblies. Frontiers in Microbiology9: 1235, doi: 10.3389/fmicb.2018.01235

Edwards, C.R., T.C. Onstott, J.M. Miller, J.B. Wiggins, W. Wang, C.K. Lee, S.C. Cary, S.B. Pointing and M.C.Y. Lau (2017) Draft genome sequence of uncultured Upland Soil Cluster gammaproteobacteria (USCg) gives molecular insights into high-affinity methanotrophy. Genome Announcements 5: 17 e00047-17

Lau, M.C.Y., T.L. Kieft, O. Kuloyo, B. Linage-Alvarez, E. van Heerden, M.R. Lindsay, C. Magnabosco, W. Wang, J.B. Wiggins, L. Guo, D.H. Perlman, S. Kyin, H.H. Shwe, R.L. Harris, Y. Oh, M.J. Yi, R. Purtschert, G.F. Slater, S. Ono, S. Wei, L. Li, B. Sherwood Lollar and T.C. Onstott (2016) An oligotrophic deep subsurface community dependent on syntrophy is dominated by sulfur-driven autotrophic denitrifiers. Proceedings of the National Academy of Sciences (USA) 113: E7927–E7936, doi: 10.1073/pnas.1612244113

Lau, M.C.Y., B.T. Stackhouse, A.C. Layton, A. Chauhan, T.A. Vishnivetskaya, K. Chourey, J. Ronholm, N.C.S. Mykytczuk, P.C. Bennett, G. Lamarche-Gagnon, N. Burton, W.H. Pollard, C.R. Omelon, D.M. Medvigy, R.L. Hettich, S.M. Pfiffner, L.G. Whyte and T.C. Onstott (2015) An active atmospheric methane sink in high Arctic mineral cryosols. The ISME Journal 9: 1880-1891, doi:10.1038/ismej.2015.13

Lau, M.C.Y., C. Cameron, C. Magnabosco, C.T. Brown, F. Schilkey, S. Grim, S. Hendrickson, M. Pullin, B. Sherwood Lollar, Esta van Heerden, T.L. Kieft and T.C. Onstott (2014) Phylogeny and phylogeography of functional genes shared among seven terrestrial subsurface metagenomes reveal N-cycling and microbial evolutionary relationships. Frontiers in Microbiology 5: 531. doi:10.3389/fmicb.2014.00531

Bahl, J.*, M.C.Y. Lau*, G.J.D. Smith, V. Dhanesakaran, S.C. Cary, D.C. Lacap, C.K. Lee, R.T. Papke, K.A. Warren-Rhodes, F.K.Y. Wong, C.P. McKay and S.B. Pointing (2010) Ancient origins determine global biogeography of hot and cold desert cyanobacteria. Nature Communications 2:163. doi:10.1038/ncomms1167 (*co-first authors)

Lau, M.C.Y. and S.B. Pointing (2009) Vertical partitioning and expression of primary metabolic genes in a thermophilic microbial mat. Extremophiles 13: 533-540. doi: 10.1007/s00792-009-0240-8

Lau, M.C.Y., J.C. Aitchison and S.B. Pointing (2009) Bacterial community composition in thermophilic microbial mats from five hot springs in central Tibet. Extremophiles 13: 139-149. doi: 10.1007/s00792-008-0205-3

Lau, M.C.Y., J.C. Aitchison and S.B. Pointing (2008) Early colonization of thermal niches in a silica-depositing hot spring in central Tibet. Geobiology 6: 136-146. doi: 10.1111/j.1472-4669.2007.00124.x

Lau, C.Y., H.M. Jing, J.C. Aitchison and S.B. Pointing (2006) Highly diverse community structure in a remote central Tibetan geothermal spring does not display monotonic variation to thermal stress. FEMS Microbiology Ecology 57: 80-91. doi: 10.1111/j.1574-6941.2006.00104.x


Co-authored

Oh, Y., Q. Zhuang, L. Liu, L.R. Welp, M.C.Y. Lau, T.C. Onstott, D. Medvigy, L. Bruhwiler, E.J. Dlugokencky, G. Hugelius, L. D’Imperio and B. Elberling (2020) Reduced net methane emissions due to microbial methane oxidation in a warmer Arctic. Nature Climate Change 10: 317-321. doi: 10.1038/s41558-020-0734-z.

Liang R., M.C.Y. Lau, E.T. Saitta, Z.K. Garvin and T.C. Onstott (2020) Genome-centric resolution of novel microbial lineages in an excavated Centrosaurus dinosaur fossil bone from the Late Cretaceous of North America. Environmental Microbiome 15: 8. doi: 10.1186/s40793-020-00355-w.

Weinstein, D.J., S.E. Allen, M.C.Y. Lau, M. Erasmus, K.C. Asalone, K. Walters-Conte, G. Deikus, R. Sebra, G. Borgonie, E. van Heerden, T.C. Onstott and J.R. Bracht (2019) The genome of a subterrestrial nematode reveals adaptations to heat. Nature Communications 10: 5268. doi: 10.1038/s41467-019-13245-8.

Tracey, J.C., M. Coronado, T.W. Giessen, M.C .Y. Lau, P.A. Silver and B.B. Ward (2019) The discovery of twenty-eight new encapsulin sequences, including three in anammox bacteria. Scientific Reports 9: 20122. doi: /10.1038/s41598-019-56533-5.

Liang R., M.C.Y. Lau, O. Baars, F.T. Robb and T.C. Onstott (2019) Aspartic acid racemization constrains long-term viability and longevity of endospores. FEMS Microbiology Ecology 95: fiz132. doi: 10.1093/femsec/fiz132.

Saitta, E.T., R. Liang, M.C.Y. Lau, C.M. Brown, N.R. Longrich, T.G. Kaye, B.J. Novak, S.L. Salzberg, M.A. Norell, G.D. Abbott, M.R. Dickinson, J. Vinther, I.D. Bull, R.A. Brooker, P. Martin, P. Donohoe, T.D.J. Knowles, K.E.H. Penkman and T.C. Onstott (2019) Cretaceous dinosaur bone contains recent organic material and provides an environment conducive to microbial communities. eLife 8: e40205. doi: 10.7554/eLife.46205

Sun, X., L.F.M. Kop, M.C.Y. Lau, J. Frank, A. Jayakumar, S. Lücker and B.B. Ward (2019) Uncultured Nitrospina-like species are major nitrite oxidizing bacteria in oxygen minimum zones. The ISME Journal 13: 2391–2402. doi: 10.1038/s41396-019-0443-7

Liang R., M.C.Y. Lau, T. Vishnivetskaya, K.G. Lloyd, W. Wang, J. Wiggins, J. Miller, S. Pfiffner, E.M. Rivkina, T.C. Onstott (2019) Predominance of anaerobic, spore-forming bacteria in metabolically active microbial communities from ancient Siberian permafrost. Applied and Environmental Microbiology 85: e00560-19. doi: 10.1128/AEM.00560-19.

Magnabosco, C., P.H.A. Timmers, M.C.Y. Lau, G. Borgonie, B. Linage-Alvarez, O. Kuloyo, R. Alleva, T.L. Kieft, G.F. Slater, E. van Heerden, B. Sherwood Lollar and T.C. Onstott (2018) Fluctuations in populations of subsurface methane oxidizers in coordination with changes in electron acceptor availability. FEMS Microbiology Ecology94: fiy089. doi: 10.1093/femsec/fiy089

Harris, R.L., M.C.Y. Lau, A. Cadar, D.H. Bartlett, E. Cason, E. van Heerden, T.C. Onstott (2018) Draft genome sequence of “Candidatus Bathyarchaeota” archaeon BE326-BA-RLH, an uncultured denitrifier and putative anaerobic methanotroph from South Africa’s deep continental biosphere. Microbiology Resources Announcements 7: e01295-18. doi: 10.1128/MRA.01295-18.

Heard, A.W., O. Warr, G. Borgonie, B. Linage, O. Kuloyo, J.W. Fellowes, C. Magnabosco, M.C.Y. Lau, M. Erasmus, E.D. Cason, E. van Heerden, T.L. Kieft, J.C. Mabry, T.C. Onstott, B. Sherwood Lollar and C.J. Ballentine (2018) South African crustal fracture fluids preserve paleometeoric water signatures for up to tens of millions of years. Chemistry Geology 493: 379-395, doi: 10.1016/j.chemgeo.2018.06.011

Kieft, T.L., C.W. Clifford, M.B. Higgins, A.S. Mennito, C.F.M. Clewett, V. Heuer, M.J. Pullin, S. Hendrickson, E. van Heerden, B. Sherwood Lollar. M.C.Y. Lau and T.C. Onstott. (2018) Dissolved organic matter compositions in 0.6–3.4 km deep fracture waters, Kaapvaal Craton, South Africa. Organic Geochemistry 118: 116-131, doi.org/10.1016/j.orggeochem.2018.02.003

Becraft, E.D, T. Woyke, J. Jarett J, N. Ivanova, F. Godoy-Vitorino, N. Poulton, J. M. Brown, J. Brown, M.C.Y. Lau, T. Onstott, J.A. Eisen, D. Moser and R. Stepanauskas (2017) Rokubacteria: Genomic Giants among the Uncultured Bacterial Phyla. Frontiers in Microbiology 8: 2264, doi: 10.3389/fmicb.2017.02264

Lacap-Bugler, D.C., K.K. Lee, S. Archer, L.N. Gillman, M.C.Y. Lau, S. Leuzinger, C.K. Lee, T. Maki, C.P. McKay, J.K. Perrott, A. de los Rios-Murillo, K.A. Warren-Rhodes, D.W. Hopkins and S.B. Pointing. Global diversity of desert hypolithic cyanobacteria. Frontiers in Microbiology 8: 867, doi: 10.3389/fmicb.2017.00867

Stackhouse, B.T., M.C.Y. Lau, T.A. Vishnivetskaya, N. Burton, R. Wang, A. Southworth, L.G. Whyte and T.C. Onstott (2017) Atmospheric CH4 oxidation by Arctic permafrost and mineral cryosols as a function of water saturation and temperature. Geobiology 15: 94-111, doi: 10:1111/gbi.12193

Oh, Youmi, B.T. Stackhouse, M.C.Y. Lau, X. Xu, A.T. Trugman, J. Moch, T.C. Onstott, C.J. Jørgensen, L. D’Imperio, B. Elberling, C.A. Emmerton, V.L. St. Louis and D. Medvigy (2016) A scalable model for methane consumption in arctic mineral soils. Geophysical Research Letters 43: 5143-5150. doi: 10.1002/2016GL069049

D.A. Pearce, I.A. Alekhina, A. Terauds, A. Wilmotte, A. Quesada, A. Edwards, A. Dommergue, B. Sattler, B.J. Adams, C. Magalhães, W.-L. Chu, M.C.Y. Lau, C. Cary, D.J. Smith, D.H. Wall, G. Eguren, G. Matcher, J.A. Bradley, J.-P. de Vera, J. Elster, K.A. Hughes, L. Cuthbertson, L.G. Benning, N. Gunde-Cimerman, P. Convey, S.G. Hong, S.B. Pointing, V.H. Pellizari and W.F. Vincent (2016) Aerobiology over Antarctica – A new initiative for atmospheric ecology. Frontiers in Microbiology 7: 16. doi: 10.3389/fmicb.2016.00016

Simkus, D.N., G.F. Slater, B. Sherwood Lollar, K. Wilkie, T.L. Kieft, C. Magnabosco, M.C.Y. Lau, M.J. Pullin, S.B. Hendrickson, K.E. Wommack, E.G. Sakowski, E. van Heerdeen, O. Kuloyo, B. Linage, G. Borgonie and T.C. Onstott (2016) Variations in microbial carbon sources and cycling in the deep continental subsurface. Geochimica et Cosmochimica Acta 173: 264-283, doi:10.1016/j.gca.2015.10.003

Magnabosco, C.M., K. Ryan, M.C.Y. Lau, O. Kuloyo, B. Sherwood Lollar, T.L. Kieft, E. van Heerdeen and T.C. Onstott (2016) A metagenomic window into carbon metabolism at 3 km depth in Precambrian continental crust. The ISME Journa10:730-41. doi:10.1038/ismej.2015.150

Labonté, J.M., E.K. Field, M.C.Y. Lau, D. Chivian, E. van Heerden, K. Eric Wommack, T.L. Kieft, T.C. Onstott and R. Stepanauskas (2015) Single cell genomics indicates horizontal gene transfer and viral infections in a deep subsurface Firmicutes population. Frontiers in Microbiology 6: 349. doi:10.3389/fmicb.2015.00349

Magnabosco, C., M. Tekere, M.C.Y. Lau, B. Linage, O. Kuloyo, M. Erasmus, E. Cason, E. van Heerden, G. Borgonie, T.L. Kieft, J. Oliver and T.C. Onstott (2014) Comparisons of the composition and biogeographic distribution of the bacterial communities occupying South African thermal springs with those inhabiting deep subsurface fracture water. Frontiers in Microbiology 5: 679

Chauhan, A., A.C. Layton, T.A. Vishnivetskaya, D. Williams, S.M. Pfiffner, B. Rekepalli, B. Stackhouse, M.C.Y. Lau, T.J. Phelps, N. Mykytczuk, J. Ronholm, L. Whyte, T.C. Onstott, G.S. Sayler (2014) Metagenomes from thawing low-soil-organic-carbon mineral cryosols and permafrost of the Canadian high Arctic. Genome Announcements 2: e01217-14. doi:10.1128/genomeA.01217-14

Vishnivetskaya, T.A., A.C. Layton, M.C.Y. Lau, A. Chauhan, K.R. Cheng, A.J. Meyers, J.R. Murphy, A.W. Rogers, G.S. Saarunya, D.E. Williams, S.M. Pfiffner, J.P. Biggerstaff, B.T. Stackhouse, T.J. Phelps, L. Whyte, G.S. Sayler and T.C. Onstott (2014) Commercial DNA extraction kits impact observed microbial community composition in permafrost samples. FEMS Microbiology Ecology 87: 217-230. doi: 10.1111/1574-6941.12219

Woo, A.C., M.S. Brar, Y. Chan, M.C.Y. Lau, F.C.C. Leung, J.A. Scott, L.P.P. Vrijmoed, P. Zawar-Reza and S.B. Pointing (2013) Temporal variation in airborne microbial populations and microbially-derived allergens in a tropical urban landscape. Atmospheric Environment 74: 291-300. doi: 10.1016/j.atmosenv.2013.03.047

Chan, Y., D.C. Lacap, M.C.Y. Lau, K.Y. Ha, K.A. Warren-Rhodes, C.S. Cockell, D.A. Cowan, C.P. McKay and S.B. Pointing (2012) Hypolithic microbial communities: between a rock and a hard place. Environmental Microbiology 14: 2272-2282. doi: 10.1111/j.1462-2920.2012.02821.x

Caruso, T., Y. Chan, D.C. Lacap, M.C.Y. Lau, C.P. McKay and S.B. Pointing (2011) Stochastic and deterministic processes interact in the assembly of desert microbial communities on a global scale. The ISME Journal 5: 1406-1413. doi:10.1038/ismej.2011.21

Wong, F.K.Y., M.C.Y. Lau, D.C. Lacap, J.C. Aitchison, D.A. Cowan and S.B. Pointing (2010) Hypolithic colonization of quartz pavement in the high altitude tundra of central Tibet. Microbial Ecology 60: 730-739. doi: 10.1007/s00248-010-9653-2

Wong, F.K.Y., M.C.Y. Lau, D.C. Lacap, J.C. Aitchison, D.A. Cowan and S.B. Pointing (2010) Endolithic microbial colonization of limestone in a high-altitude arid environment. Microbial Ecology 59: 689-699. doi: 10.1007/s00248-009-9607-8

Pointing, S.B., Y. Chan, D.C. Lacap, M.C.Y. Lau, J. Jurgens and R.L. Farrell (2009) Highly specialized microbial diversity in hyper-arid polar desert. Proceedings of the National Academy of Sciences (USA). 106: 19964-19969. doi:10.1073/pnas.0908274106

Purcell, D., U. Sompong, C.Y. Lau, T.G. Barraclough, Y. Peerapornpisal and S.B. Pointing (2007) The effects of temperature, pH and sulphide on the community structure of hyperthermophilic streamers in hot springs of northern Thailand. FEMS Microbiology Ecology 60: 456-466. doi: 10.1111/j.1574-6941.2007.00302.x

Jing, H.M., D.C. Lacap, C.Y. Lau and S.B. Pointing (2006) Community phylogenetic diversity of cyanobacterial mats associated with geothermal springs along a tropical intertidal gradient. Extremophiles 10: 159-163. doi: 10.1007/s00792-005-0477-9


(underlined are students who were mentored by me for the piece of work)

Research Interests

Microbial ecology and evolution; physiology and adaptation to environmental stress; biogeography; symbiosis; environmental multi-omics; geobiology; extremophiles; hot springs; arid regions; Arctic and Antarctic research; deep subsurface; aerobiology; astrobiology

Conferences

Invited talks

2018

  • "Fluorescent in situ hybridization of transcript-annealing molecular beacons (FISH-TAMB) – an innovative method to tag active, low-abundance prokaryotic cells" at International Symposium on Deep Earth Exploration and Practices (DEEP-2018), October 24-26, Beijing, China

  • “Atmospheric CH4 oxidation by Arctic and Antarctic soils” at Institute of Tibetan Plateau Research, CAS and Institute of Botany, CAS, March 19, Beijing, China

  • “What “Big Data” has taught us about the continental subsurface?” at Chinese Academy of Sciences “Forum on Science and Technology Frontiers” – The deep biosphere in China, March 18, Beijing, China

  • “Sequence the deep biosphere: the norm and time to go beyond?” at Deep Volatiles, Energy & Environments Summit, Center for High Pressure Science & Technology Advanced Research, March 14, Shanghai, China

  • “Revelation of the biogeochemical cycles in the deep continental subsurface by cross-disciplinary research” at The International College of University of Chinese Academy of Sciences (IC-UCAS) Winter School, Institute of Deep-sea Science and Engineering, CAS, January 16, Sanya, China

2017

  • “Minority populations matter: methane-cycling organisms are important ecosystem engineers” at Department of Microbiology, The University of Tennessee, October 23, Knoxville, Tennessee, USA
  • “Microbial syntrophy: implications on diversity, stability, biogeography and evolution of the deep biosphere”. The 4th International Conference of Geobiology – Rocks, life and climate, June 24-26, Wuhan, China
  • Award lecture “Microbial syntrophy: implications on diversity, stability, biogeography and evolution of the deep biosphere” at The 3rd DCO International Science Meeting, March 23-25, St. Andrews, Scotland, UK
  • “How microorganisms overcome the challenges of living in extreme environments: an example from the deep subsurface” at Department of Microbiology and Immunology, Montana State University, February 7, Bozeman, Montana, USA

2016

  • “Deep life evolution” at the Center for Dark Energy Biosphere Investigations/Deep Carbon Observatory Origins and Movements Workshop, May 9-10, Los Angeles, California, USA

2015

  • “Microbial CH4 production and oxidation at a 1.34-km deep subterranean site in South Africa” at Deep Carbon Observatory Deep Life Community Workshop, May 7-9, Lisbon, Portugal
  • “Insights into deep terrestrial biosphere: from molecule to ecosystem level” at the Second Deep Carbon Observatory International Science Meeting, March 26-28, Munich, Germany

Oral presentations

2017

  • “Physiology of uncultivated atmospheric CH4 oxidizing bacteria informed by genome from metagenome” at XIIth SCAR Biology Symposium, July 10-14, Leuven, Belgium

  • “Using HTSEQ to understand the life in extreme environments” at HTSEQ Users group meeting, Princeton University, January 10, Princeton, NJ, USA

2016

  • “Atmospheric methane-oxidizing bacteria in Antarctic cryosols” at 2016 SCAR Open Science Conference, August 22-26, Kuala Lumpur, Malaysia 

2015

  • “Living on the dark side of the Earth” at Proks Luncheon Seminar, Princeton University, December 04, Princeton, NJ, USA

  • “The methane sinks at the Polar Regions” at the Princeton Postdoctoral Council Seminar, Princeton University, August 20, Princeton, NJ, USA

  • “Mineral cryosols in the High Arctic consume CH4 from the atmosphere” at Environmental Geology & Geochemistry Seminar, Department of Geosciences, Princeton University, April 30, Princeton, NJ, USA

2014

  • “Hallelujah! The in situ nitrogen cycle within the subterranean crust” at AGU 2014 Fall Meeting, December 15-19, San Francisco, California, USA

2012

  • “Impact of permafrost thawing on global climate: a battle among microorganisms” at IPY 2012 “From Knowledge to Action” Conference, April 22-27, Montréal, Canada

2011

  • “Evaluating PCR primers for environmental microbiology by in-silico analysis of genome data” at Environmental Geology & Geochemistry Seminar, Department of Geosciences, Princeton University, November 11, Princeton, NJ, USA

2005

  • “Application of Taxonomic Distinctness indices to molecular biodiversity data derived from thermophilic communities” at The 8th International Thermophiles Conference: From Evolution to Revolution, September 18-22, Gold Coast, Queensland, Australia