Chemical biology and synthetic biology of nucleic acids
Chemical biology and synthetic biology
1. H. Mei*, J. C. Chaput*, Synthesis of a Fluorescent Cytidine TNA Triphosphate Analogue. Methods Mol. Biol. 2019, 1973, 27-37. (Invited Book Chapter)
2 X. Guo, P. Leonard, S. A. Ingale, J. Liu, H. Mei, M. Sieg, F. Seela, 5-Aza-7-deaza-2’-deoxyguanosine and 2'-Deoxycytidine form Programmable Silver-Mediated Base Pairs with Metal Ions in the Core of the DNA Double Helix. Chem. Eur. J. 2018, 24, 8883-8892.
3 H. Mei#, R. Liao#, J. Randi, Y. Wang, S. Bala, C. McCloskey, C. Switzer, J. C. Chaput*, Synthesis and Evolution of a Threose Nucleic Acid Aptamer Bearing 7‑Deaza-7-Substituted Guanosine Residues. J. Am. Chem. Soc. 2018, 140, 5706-5713. (Hot Papers selected by Oligonucleotide Therapeutics Society)
4 H. Mei, J. C. Chaput*, Expanding the Chemical Diversity of TNA with tUTP Derivatives that are Substrates for a TNA Polymerase. Chem. Commun. 2018, 54, 1237-1240.
5 H. Mei#, C. Shi#, J. Randi, Y. Wang, M. Kardouh, J. C. Chaput*, Synthesis and Polymerase Activity of a Fluorescent Cytidine TNA Triphosphate Analogue. Nucleic Acids Res. 2017, 45, 5629-5638.
6 S. Bala, J. Liao, H. Mei, J. C. Chaput*, Synthesis of α-L-threofuranosyl Nucleoside 3'-Monophosphates, 3'-Phosphoro(2-methyl)imidazolides, and 3'-Triphosphates. J. Org. Chem. 2017, 82, 5910-5916.
7 S. K. Jana, X. Guo, H. Mei, F. Seela*, Robust Silver-mediated Imidazolo-dC Base Pairs in Metal DNA: Dinuclear Silver Bridges with Exceptional Stability in Double Helices with Parallel and Antiparallel Strand Orientation. Chem. Commun. 2015, 51, 17301-17304.
8 H. Mei, S. A. Ingale, F. Seela*, 3-Phenyl-5,6,7,8-tetrahydropyrimido[4,5-c]pyridazin-7-one as Nucleobase Substitute in DNA: Synthesis of the 2'-Deoxyribonucleoside, Cyclonucleoside Formation and Base Pairing in Oligonucleotides. 2015, Tetrahedron, 2015, 71, 6170-6175.
9 H. Yang, H. Mei, F. Seela*, Pyrrolo-dC Metal Base Pairs in the Reverse Watson-Crick Double Helix: Capturing of Silver-Ions, Enhanced Stability of Parallel DNA and Impact of 6-Pyridinyl Residues on Fluorescence and Metal Ion Binding. Chem. Eur. J. 2015, 21, 10207-10219.
10 H. Mei, S. A. Ingale, F. Seela*, Imidazolo-dC Metal-Mediated Base Pairs: Purine Nucleosides Capture Two Ag+ Ions and Form a Duplex with the Stability of a Covalent DNA Cross-Link, Chem. Eur. J. 2014, 20, 16248-16257.
11 H. Mei, I. Röhl and F. Seela*, Ag+-mediated DNA Base Pairing: Extraordinary Stable Pyrrolo-dC – Pyrrolo-dC Pairs Binding Two Silver Ions. J. Org. Chem. 2013, 78, 9457-9563. (Selected as one of the exciting papers from ACS publications in 2013 about nucleic acids)
12 H. Mei, H.Yang, I. Röhl, F. Seela*, Silver Arrays Inside DNA Duplexes Constructed from Ag+-mediated Pyrrolo-dC – Pyrrolo-dC Base Pairs. ChemPlusChem, 2014, 79, 914-918.
13 H. Mei, S. A. Ingale, F. Seela*, Pyrene and Bis-Pyrene DNA Nucleobase Conjugates: Excimer and Monomer Fluorescence of Linear and Dendronized Cytosine and 7-Deazaguanine Click Adducts. Tetrahedron 2013, 69, 4731-4742.
14 S. Ingale, H. Mei, P. Leonard, F. Seela*, Ethynyl Side Chain Hydration During Synthesis and Work up of “Clickable” Oligonucleotides: Bypassing Acetyl Group Formation by Triisopropylsilyl Protection. J. Org. Chem. 2013, 78, 11271-11282.
15 H. Mei, S. Budow, F. Seela*, Construction and Assembly of Chimeric DNA: Oligonucleotide Hybrid Molecules Composed of Parallel or Antiparallel Duplexes and Tetrameric i-Motifs. Biomacromolecules, 2012, 13, 4196-4204.
16 S. A. Ingale, S. S. Pujari, V. R. Sirivolu, P. Ding, H. Xiong, H. Mei, F. Seela*, 7-Deazapurine and 8-Aza-7-deazapurine Nucleoside and Oligonucleotide Pyrene “Click” Conjugates: Synthesis, Nucleobase Controlled Fluorescence Quenching, and Duplex Stability. J. Org. Chem. 2012, 77, 188-199.
17 F. Seela*, H. Mei, H. Xiong, S. Budow, H. Eickmeier, H. Reuter, 5-Ethynyl-2'-deoxycytidine: A DNA Building Block with a "Clickable" Side Chain. Acta Cryst. 2012, C68, o395-0398.
18. H. Mei, L. Xing, L. Cai, H.-W. Jin, P. Zhao, Z.-J. Yang*, L.-R. Zhang, L.-H. Zhang, Studies on the Synthesis of Neamine-dinucleosides and Neamine-PNA Conjugates and their Interaction with RNA. Bioorg. Med. Chem. Lett. 2008, 18, 5335-5338.