基本信息

宓现强,中国科学院上海微系统与信息技术研究所研究员,博士生导师,课题组长,超导电子学卓越创新中心生物交叉方向负责人。国家重点研发计划项目首席科学家, 上海市优秀学术带头人。 

电子邮件:mixq@mail.sim.ac.cn
通信地址:上海市浦东新区张江高科技园区海科路100号
邮政编码:201203

研究领域

生命系统网络分析、纳米生物编码探针,微流控生物检测及器官芯片,液滴软物质,量子探测及成像

招生信息

生物学,生物工程,生物医学工程。也可以是化学,化学工程与技术,材料科学与工程
招生专业
080903-微电子学与固体电子学
083100-生物医学工程
0809Z1-生物电子学
招生方向
生物纳米编码探针
微流控生物检测及器官芯片
液滴微流控单细胞技术

教育

2001-09--2005-05   复旦大学   博士
学历
博士

学位
博士研究生

工作经历

   

专利与奖励

   

发表论文情况

近5年部分代表性论文:

2022年

1 Chenwei Xiong, Jie Li, Luyao Li, Long Chen, Rong Zhang Xianqiang Mi*,Yifan Liu.Label-free electrical monitoring of nucleic acid amplification with integrated hydrogel ionic diodes. Materials Today Bio,15 (2022) 100281

2 Shuainan Li, Chenguang Wang, Yi Xu, Wei Wang, Xiaoshuang Zhao, Qiuling Qian and Xianqiang Mi*. A designer DNA tetrahedron-based molecular beacon for tumor-related microRNA fluorescence imaging in living cells.Analyst, 2022, 147, 2231 - 2237

3 Qiuling Qian,Guifang He,Chenguang Wang,Shuainan Li,Xiaoshuang Zhao,Yi Xu,Xianqiang Mi*.Polyadeninemediated spherical nucleic acid probes for live cell fluorescence imaging of tumorrelated microRNAs.Molecular Biology Reports (2022) 49:3705–3712

4 Dongsheng Mao, Mengmeng Zheng, Wenxing Li, Yi Xu, Chengguang Wang, Qiuling Qian, Shuainan Li, Guifang Chen, Xiaoli Zhu, Xianqiang Mi*. Cubic DNA nanocage-based three-dimensional molecular beacon for accurate detection of exosomal miRNAs in confined spaces. Biosensors and Bioelectronics. 2022, 204114077

5 Chenguang Wang ,Wei Wang ,Yi Xu, Xiaoshuang Zhao, Shuainan Li, Qiuling Qian  and Xianqiang Mi*. Tetrahedral DNA Framework-Programmed Electrochemical Biosenors with Gold Nanoparticles for Ultrasensitive Cell-Free DNA Detection.Nanomaterials 2022, 12, 666. https://doi.org/10.3390/nano12040666

6Rong Tao; Shulin Zhang; Yuexia Wang; Xianqiang Mi; Jian Ma; Chengxing Shen; Guoyan Zheng.MCG-Net: End-to-end Fine-grained Delineation and Diagnostic Classification of Cardiac Events from Magnetocardiographs,IEEE J. Biomed. Health Informatics 26(3)1057-1067 ()

2021

1 Chenguang Wang,Yi Xu, Xiaoshuang Zhao, Shuainai Li, Qiuling Qian, Wei Wang and Xianqiang Mi*.A double-tetrahedral DNA framework based electrochemical biosensor for ultrasensitive detection and release of circulating tumor cells. Analyst. 2021,146(21):6474-6481DOI: 10.1039/d1an01470f

2DNA tetrahedron mediated immune sandwich assay for rapid, sensitive, and automatic detection of PSA through microfluidic electrochemical detection system.Nature microsystems and nanoengineering, 2021;7:33 

3Yi Zhang, Wei Jiang, Dezhi Feng, Chenguang Wang, Yi Xu , Yufeng Shan, Jianlu Wang , Ziwei Yin, Huiyong Deng,*, Xianqiang Mi,* and Ning Dai,* Bio-Separated and Gate-Free 2D MoS2 Biosensor Array for Ultrasensitive Detection of BRCA1. Nanomaterials 2021, 11, 545. https://doi.org/10.3390/nano11020545  

4Yi Zhang, Dezhi Feng, Yi Xu, Ziwei Yin, Wei Dou, UM E Habiba, Changyi Pan, Zongkun Zhang, Hao Mou, Huiyong Deng,*, Xianqiang Mi,*, Ning Dai.DNA-based functionalization of two-dimensional MoS2 FET biosensor for ultrasensitive detection of PSA .Applied Surface Science. 548 (2021) 149169  

2020及之前

1 A DNA Tetrahedral Structure-Mediated Ultrasensitive Fluorescent Microarray Platform for Nucleic Acids Tests.Sensors and Actuator B : Chemical.2020,321: 128538  

2 Dezhi Feng,Jing Su,Guifang He, Yi Xu,Chenguang Wang,Mengmeng Zheng,Qiuling Qian,XianQiang Mi. Electrochemical DNA Sensor for Sensitive brca1 Detection Based on DNA Tetrahedral-Structured Probe and Poly-Adenine Mediated Gold Nanoparticles.Biosensors 2020, 10, 78; doi:10.3390/bios10070078  

1 Framework Nucleic Acid-Enabled Programming of Electrochemical Catalytic Properties of Artificial Enzymes. ACS Appl. Mater.Interfaces.2019,11(24):21859-21864 

2 Au NFs flower modified disposable 16-SPCE electrochemical biosensor for label-free and multiplex detection of Glycated hemoglobin.Tanlanta. 2019,201,119-125  

3 Poly-adenine-mediated Spherical Nucleic Acids for Strand Displacement-based DNA/RNA Detection.Biosensors and Bioelectronics. 2019,127:85–91  

4Microfluidic cap-to-dispense (μCD): a universal microfluidic–robotic interface for automated pipette-free high-precision liquid handling. Lab on Chip,2019,19,3405–3415  


1 Fluorescent biosensors enabled by graphene and graphene oxide.Biosensors and Bioelectronics. 2017;89(Pt 1):96-106. (ESI 1%高被引论文)  

2 Universal fluorescence biosensor platform based on graphene quantum dots and pyrene-functionalized molecular beacons for detection of microRNAs.ACS Appl Mater&Interfaces. 2015;7(30):16152-6  

3 Elaborately designed diblock nanoprobes for simultaneous multicolor detection of microRNAs.Nanoscale2015,7(38):15822-15829年度“hot paper” 

4 DNA Tetrahedral Nanostructure-Based Electrochemical miRNA Biosensor for Simultaneous Detection of Multiple miRNAs in Pancreatic Carcinoma. ACS Appl Mater Interfaces.2017, 9(28):24118-2412  

5 A novel ultrasensitive electrochemical DNA sensor based on double DNA tetrahedral nanostructures. Biosensors and Bioelectronics  2015,71434-438 

6 An electrochemical immunosensor for quantitative detection of ficolin-3.Nanotechnology.2016;27(25):254003. doi: 10.1088/0957-4484/27/25/254003  

7 DNA nanotechnology mediated gold nanoparticle conjugates and their applications in biomedicine. Chinese Journal of Chemistry. 2016,34(3):299–307 

 




科研活动

   
科研项目
( 1 ) 近红外808nm激光对ATP敏感性钾通道的作用及其机制研究, 主持, 国家级, 2011-01--2013-12
( 2 ) 不同波长的LED光照与ATP敏感性钾通道的相互作用探讨, 主持, 省级, 2009-07--2012-07
( 3 ) 糖网病光学治疗装置, 主持, 研究所(学校), 2010-09--2012-09
( 4 ) 国际医疗器械安全性信息监测 , 主持, 省级, 2010-06--2011-12
( 5 ) 糖尿病、心血管疾病模型的研究, 主持, 研究所(学校), 2009-01--2011-10
( 6 ) 中欧医疗器械管理对比研究 , 主持, 国家级, 2006-09--2009-08
( 7 ) 上海市优秀青年教师科研专项基金, 主持, 国家级, 2006-09--2008-12
( 8 ) 中国博士后科学基金A类资助, 主持, 国家级, 2006-09--2008-09
( 9 ) 中国博士后科学基金特别资助, 主持, 国家级, 2009-01--2010-12
( 10 ) 全球医疗器械命名规则和命名系统研究 , 参与, 国家级, 2006-09--2007-12
( 11 )  基于分子信标的胰腺癌筛检技术开发, 主持, 省级, 2013-07--2015-09
( 12 ) 中医诊疗设备注册审批标准研究, 主持, 国家级, 2012-05--2014-12
( 13 ) 中国科学院上海高等研究院纳米医学平台建设 , 主持, 国家级, 2011-04--2012-04
( 14 ) 新型乳腺癌多指标分子分型及转移预测技术开发研究, 参与, 省级, 2012-09--2014-09
( 15 )  新型抗结肠癌棉酚衍生物的临床前研究, 参与, 省级, 2011-11--2014-09
( 16 ) 近红外808nm激光对ATP敏感性钾通道的作用及其机制研究, 主持, 省级, 2009-07--2012-07
( 17 ) 医疗器械研发服务网络.中国科学院科技服务网络计划(STS计划)项目, 参与, 部委级, 2015-01--2016-12
( 18 ) 个人移动健康监护监管技术方法与标准研究, 参与, 部委级, 2015-01--2016-12
( 19 ) 用于肿瘤筛检的智能电化学微流控芯片检测仪实验室样机, 主持, 省级, 2015-07--2018-09
( 20 ) 新型城镇化下的智慧城市智慧健康关键技术及应用研究, 参与, 部委级, 2015-06--2017-06
( 21 ) POCT糖化血红蛋白检测仪关键技术及产品开发研究, 参与, 国家级, 2015-12--2017-12
( 22 ) 基于随机采样的快速超分辨荧光成像技术研究及其样机实现, 主持, 国家级, 2016-07--2018-12
( 23 ) 高FRET效率的荧光纳米探针的设计及制备, 主持, 国家级, 2016-07--2018-12
( 24 ) 微流控芯片检测分析装置的研制及其对循环肿瘤细胞的应用研究., 主持, 省级, 2016-10--2019-09
( 25 ) 面向先天性心脏病早期筛查的胎儿心磁图仪及应用示范, 参与, 部委级, 2020-01--2021-12
( 26 ) 肿瘤分子诊断试剂盒及检测仪器研制, 主持, 部委级, 2021-01--2022-12