化学和生物分析与传感，新型分析分离方法发展和应用，环境和健康相关分子的检测和识别传感，新型亲和配体的分析传感应用，纳米材料的分析检测应用

2000-09--2005-07 北京大学化学与分子工程学院 理学博士
1996-09--2000-07 北京大学化学与分子工程学院 理学学士

2005.7-2009.7 加拿大阿尔伯塔大学 博士后
2009.9-2014.7 山西大学  教授
2014.7-至今  中国科学院生态环境研究中心环境化学和生态毒理学国家重点实验室  研究员

   

[1] Hao Yu, Qiang Zhao. Competitive fluorescence assay for Cd2+ based on aptamer structure-switching. MICROCHEMICAL JOURNAL[J]. 2023, 194: http://dx.doi.org/10.1016/j.microc.2023.109348.
[2] Xu, Guohua, Chen Wang, Hao Yu, Yapiao Li, Qiang Zhao, Xin Zhou, Conggang Li, Maili Liu. Structural basis for high-affinity recognition of aflatoxin B1 by a DNA aptamer.. Nucleic Acids Res.[J]. 2023, 41(14): 7666-7674, [3] Yuan, Aijiao, Xiao, Hang, Yang, Fan, Hao, Huifang, Wang, Xiaoyan, Li, Jinhua, Jin, Minghua, Zhao, Qiang, Sha, Rui, Deng, Zhaojia, Peng, Hanyong. DNA walker for signal amplification in living cells. TRAC-TRENDS IN ANALYTICAL CHEMISTRYnull. 2023, 158: http://dx.doi.org/10.1016/j.trac.2022.116870.
[4] Zhu, Fengxi, Zhao, Qiang. Sensitive CRISPR-Cas12a-Assisted Immunoassay for Small Molecule Detection in Homogeneous Solution. ANALYTICAL CHEMISTRY[J]. 2023, 95(17): 6769-6774, http://dx.doi.org/10.1021/acs.analchem.3c00218.
[5] Li Wang, Lantian Zhou, Longyu Liu, Yu Yang, Qiang Zhao. Comparative in vitro and in silico study on the estrogenic effects of 2,2-bis(4-chlorophenyl)ethanol, 4,4′-dichlorobenzophenone and DDT analogs. SCIENCE OF THE TOTAL ENVIRONMENT. 2023, 876: http://dx.doi.org/10.1016/j.scitotenv.2023.162734.
[6] Yu, Hao, Zhao, Qiang. Sensitive microscale thermophoresis assay for rapid ochratoxin A detection with fluorescently labeled engineered aptamer. ANALYST[J]. 2023, 148(16): 3876-3882, http://dx.doi.org/10.1039/d3an00867c.
[7] Yu, Hao, Zhao, Qiang. DNAzyme-Based Microscale Thermophoresis Sensor. ANALYTICAL CHEMISTRY. 2023, [8] Zhu, Fengxi, Zhao, Qiang. CRISPR/Cas12a Powered Competitive Immunosorbent Assay for Small Molecules. Analytical Chemistry[J]. 2023, 95: 14720-14726, [9] Yu, Fangzhi, Zhang, Dapeng, Zhao, Chubin, Zhao, Qiang, Jiang, Guibin, Wang, Hailin. Flanking strand separation activity of RecA nucleoprotein filaments in DNA strand exchange reactions. NUCLEIC ACIDS RESEARCH[J]. 2023, 51(5): 2270-2283, http://dx.doi.org/10.1093/nar/gkad078.
[10] Hao Yu, Qiang Zhao. Rapid sensitive fluorescence detection of cadmium (II) with pyrene excimer switching aptasensor. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2023, 133: 1-7, http://dx.doi.org/10.1016/j.jes.2022.03.047.
[11] Yu, Hao, Zhao, Qiang. Profiling Additional Effects of Aptamer Fluorophore Modification on Microscale Thermophoresis Characterization of Aptamer-Target Binding. Analytical Chemistry[J]. 2023, [12] Xu, Guohua, Zhao, Jiajing, Yu, Hao, Wang, Chen, Huang, Yangyu, Zhao, Qiang, Zhou, Xin, Li, Conggang, Liu, Maili. Structural Insights into the Mechanism of High-Affinity Binding of Ochratoxin A by a DNA Aptamer br. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144(17): 7731-7740, http://dx.doi.org/10.1021/jacs.2c00478.
[13] Yu, Hao, Zhao, Qiang. Sensitive Microscale Thermophoresis Assay Using Aptamer Thermal Switch. ANALYTICAL CHEMISTRY[J]. 2022, 94(48): 1-7, http://dx.doi.org/10.1021/acs.analchem.2c0306816685Anal.
[14] Liying Liu, Hao Yu, Qiang Zhao. The Characterization of Binding between Aptamer and Bisphenol A and Developing Electrochemical Aptasensors for Bisphenol A with Rationally Engineered Aptamers. BIOSENSORS[J]. 2022, 12(11): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688307/.
[15] Liu, Liying, Yu, Hao, Zhao, Qiang. The Characterization of Binding between Aptamer and Bisphenol A and Developing Electrochemical Aptasensors for Bisphenol A with Rationally Engineered Aptamers. BIOSENSORS-BASEL[J]. 2022, 12(11): 913-1, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000881001300001.
[16] Yu, Hao, Zhao, Qiang. Aptamer Molecular Beacon Sensor for Rapid and Sensitive Detection of Ochratoxin A. MOLECULES[J]. 2022, 27(23): 8267-1, http://dx.doi.org/10.3390/molecules27238267.
[17] Hao, Jinghua, Cao, Dong, Zhao, Qiang, Zhang, Dapeng, Wang, Hailin. Intramolecular Folding of PolyT Oligonucleotides Induced by Cooperative Binding of Silver(I) Ions. MOLECULES[J]. 2022, 27(22): 7842-1, http://dx.doi.org/10.3390/molecules27227842.
[18] Guohua Xu, Jiajing Zhao, Hao Yu, Chen Wang, Yangyu Huang, Qiang Zhao, Xin Zhou, Conggang Li, Maili Liu. Structural Insights into the Mechanism of High-Affinity Binding of Ochratoxin A by a DNA Aptamer. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2022, 144(17): 7731-7740, https://pubs.acs.org/doi/10.1021/jacs.2c00478.
[19] Wang, Li, Qie, Yu, Yang, Yu, Zhao, Qiang. Binding and Activation of Estrogen-Related Receptor γ: A Novel Molecular Mechanism for the Estrogenic Disruption Effects of DDT and Its Metabolites. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2022, 56(17): 12358-12367, http://dx.doi.org/10.1021/acs.est.1c08624.
[20] Li, Yapiao, Yu, Hao, Zhao, Qiang. Aptamer fluorescence anisotropy assays for detection of aflatoxin B1 and adenosine triphosphate using antibody to amplify signal change. RSC ADVANCES[J]. 2022, 12(12): 7464-7468, http://dx.doi.org/10.1039/d2ra00843b.
[21] Yu, Hao, Zhao, Qiang. A Sensitive Aptamer Fluorescence Anisotropy Sensor for Cd2+ Using Affinity-Enhanced Aptamers with Phosphorothioate Modification. BIOSENSORS-BASEL[J]. 2022, 12(10): 887-1, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000872154600001.
[22] Wang, Chao, Yu, Hao, Zhao, Qiang. A Simple Structure-Switch Aptasensor Using Label-Free Aptamer for Fluorescence Detection of Aflatoxin B1. MOLECULES[J]. 2022, 27(13): [23] Gao, Lu, Liu, Liying, Tian, Yunfei, Yang, Qianfan, Wu, Peng, Fan, Chunhai, Zhao, Qiang, Li, Feng. Probing the Formation Kinetics and Thermodynamics with Rationally Designed Analytical Tools Enables One-Pot Synthesis and Purification of a Tetrahedral DNA Nanostructure. ANALYTICAL CHEMISTRY[J]. 2021, 93(18): 7045-7053, http://dx.doi.org/10.1021/acs.analchem.1c00363.
[24] Li, Yapiao, Zhao, Qiang. Antibody- and aptamer-based competitive fluorescence polarization/anisotropy assays for ochratoxin A with tetramethylrhodamine-labeled ochratoxin A. ANALYTICAL METHODS[J]. 2021, 13(13): 1612-1617, https://www.webofscience.com/wos/woscc/full-record/WOS:000637901300008.
[25] Li, Yapiao, Yu, Fangzhi, Chen, Shaokun, Zhang, Ning, Wang, Hailin, Zhao, Qiang. Immunoassay of Small Molecule Mediated by a Triply Functional DNA. ANALYTICAL CHEMISTRY[J]. 2021, 93(11): 4794-4799, http://dx.doi.org/10.1021/acs.analchem.0c05386.
[26] Wang, Chao, Sun, Yang, Zhao, Qiang. A sensitive thrombin-linked sandwich immunoassay for protein targets using high affinity phosphorodithioate modified aptamer for thrombin labeling. TALANTA[J]. 2020, 207: http://dx.doi.org/10.1016/j.talanta.2019.120280.
[27] Li, Yapiao, Zhang, Ning, Wang, Hailin, Zhao, Qiang. Fluorescence Anisotropy-Based Signal-Off and Signal-On Aptamer Assays Using Lissamine Rhodamine B as a Label for Ochratoxin A. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2020, 68(14): 4277-4283, http://dx.doi.org/10.1021/acs.jafc.0c00549.
[28] Wang, Chao, Liu, Liying, Zhao, Qiang. Low Temperature Greatly Enhancing Responses of Aptamer Electrochemical Sensor for Aflatoxin B1 Using Aptamer with Short Stem. ACS SENSORS[J]. 2020, 5(10): 3246-3253, https://www.webofscience.com/wos/woscc/full-record/WOS:000585974600031.
[29] 余方志, 章大鹏, 袁征, 赵强, 汪海林. 亲和毛细管电泳技术在蛋白质-DNA相互作用研究中的应用. 色谱[J]. 2020, 38(10): 1133-1142, https://www.chrom-china.com/CN/10.3724/SP.J.1123.2020.03007.
[30] Li, Yapiao, Zhang, Ning, Wang, Hailin, Zhao, Qiang. An immunoassay for ochratoxin A using tetramethylrhodamine-labeled ochratoxin A as a probe based on a binding-induced change in fluorescence intensity. ANALYST[J]. 2020, 145(2): 651-655, https://www.webofscience.com/wos/woscc/full-record/WOS:000508560800033.
[31] Zhao, Qiang, Bai, Yunlong, Wang, Hailin. Directing a rational design of aptamer-based fluorescence anisotropy assay for sensitive detection of immunoglobulin E by site-specific binding study. TALANTA[J]. 2020, 217: http://dx.doi.org/10.1016/j.talanta.2020.121018.
[32] Liu, Liying, Zhao, Qiang. A simple fluorescence anisotropy assay for detection of bisphenol A using fluorescently labeled aptamer. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2020, 97(11): 19-24, http://lib.cqvip.com/Qikan/Article/Detail?id=7103261805.
[33] Yu, Fangzhi, Yuan, Zheng, Zhang, Dapeng, Liu, Yan, Zhao, Qiang, Wang, Hailin. High-affinity and undissociated capillary electrophoresis for DNA strand exchange analysis. CHEMICAL COMMUNICATIONS[J]. 2020, 56(54): 7403-7406, https://www.webofscience.com/wos/woscc/full-record/WOS:000545820900031.
[34] Li, Yapiao, Zhao, Qiang. Aptamer structure switch fluorescence anisotropy assay for aflatoxin B1 using tetramethylrhodamine-guanine interaction to enhance signal change. CHINESE CHEMICAL LETTERS[J]. 2020, 31(7): 1982-1985, https://www.webofscience.com/wos/woscc/full-record/WOS:000548928800055.
[35] Yu Fangzhi, Zhang Dapeng, Yuan Zheng, Zhao Qiang, Wang Hailin. Application of affinity capillary electrophoresis in the study of protein-DNA interactions. CHINESE JOURNAL OF CHROMATOGRAPHY[J]. 2020, 38(10): 1133-1142, [36] Wang, Chao, Zhao, Qiang. A reagentless electrochemical sensor for aflatoxin B1 with sensitive signal-on responses using aptamer with methylene blue label at specific internal thymine. BIOSENSORS & BIOELECTRONICS[J]. 2020, 167: http://dx.doi.org/10.1016/j.bios.2020.112478.
[37] Zhao, Qiang, Tao, Jeffrey, Feng, Wei, Uppal, Jagdeesh S, Peng, Hanyong, Le, X Chris. Aptamer binding assays and molecular interaction studies using fluorescence anisotropy - A review. ANALYTICA CHIMICA ACTA[J]. 2020, 1125: 267-278, http://dx.doi.org/10.1016/j.aca.2020.05.061.
[38] Yuan, Zheng, Xu, Peng, Yu, Fangzhi, Zhang, Dapeng, Zhao, Qiang, Yu, Wenqiang, Wang, Hailin. An electroosmotic flow-free two-direction migration strategy enables fast affinity capillary electrophoresis to study the weak interactions between basic peptides and RNA. ANALYTICAL METHODS[J]. 2020, 12(48): 5833-5838, https://www.webofscience.com/wos/woscc/full-record/WOS:000603082600006.
[39] Wang, Chao, Li, Yapiao, Zhao, Qiang. A competitive electrochemical aptamer-based method for aflatoxin B1 detection with signal-off response. ANALYTICAL METHODS[J]. 2020, 12(5): 646-650, https://www.webofscience.com/wos/woscc/full-record/WOS:000512005000005.
[40] Chao Wang, Linlin Sun, Qiang Zhao. A simple aptamer molecular beacon assay for rapid detection of aflatoxin B1. 中国化学快报:英文版[J]. 2019, 30(5): 1017-1020, http://lib.cqvip.com/Qikan/Article/Detail?id=7002346667.
[41] Wang, Chao, Li, Yapiao, Zhou, Ce, Zhao, Qiang. Fluorometric determination of aflatoxin B1 using a labeled aptamer and gold nanoparticles modified with a complementary sequence acting as a quencher. MICROCHIMICA ACTA[J]. 2019, 186(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000497699000001.
[42] Li, Yapiao, Zhao, Qiang. Aptamer Structure Switch Fluorescence Anisotropy Assay for Small Molecules Using Streptavidin as an Effective Signal Amplifier Based on Proximity Effect. ANALYTICAL CHEMISTRY[J]. 2019, 91(11): 7379-7384, [43] Wang, Chao, Sun, Linlin, Zhao, Qiang. A simple aptamer molecular beacon assay for rapid detection of aflatoxin B1. CHINESE CHEMICAL LETTERS[J]. 2019, 30(5): 1017-1020, http://lib.cqvip.com/Qikan/Article/Detail?id=7002346667.
[44] Yu, Fangzhi, Zhao, Qiang, Zhang, Dapeng, Yuan, Zheng, Wang, Hailin. Affinity Interactions by Capillary Electrophoresis: Binding, Separation, and Detection. ANALYTICAL CHEMISTRY[J]. 2019, 91(1): 372-387, http://dx.doi.org/10.1021/acs.analchem.8b04741.
[45] Qiang Zhao, Jeffrey Tao, Jagdeesh S Uppal, Hanyong Peng, Hailin Wang, X Chris Le. Nucleic acid aptamers improving fluorescence anisotropy and fluorescence polarization assays for small molecules. TRENDS IN ANALYTICAL CHEMISTRY. 2019, 110: 401-409, http://dx.doi.org/10.1016/j.trac.2018.11.018.
[46] Xu, Guohua, Zhao, Jiajing, Liu, Na, Yang, Minghui, Zhao, Qiang, Li, Conggang, Liu, Maili. Structure-guided post-SELEX optimization of an ochratoxin A aptamer. NUCLEIC ACIDS RESEARCH[J]. 2019, 47(11): 5963-5972, http://dx.doi.org/10.1093/nar/gkz336.
[47] Wang, Chao, Zhao, Qiang. A competitive thrombin-linked aptamer assay for small molecule: aflatoxin B-1. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2019, 411(25): 6637-6644, https://www.webofscience.com/wos/woscc/full-record/WOS:000486030400014.
[48] Sun, Linlin, Li, Yapiao, Wang, Hailin, Zhao, Qiang. An aptamer assay for aflatoxin B1 detection using Mg2+ mediated free zone capillary electrophoresis coupled with laser induced fluorescence. TALANTA[J]. 2019, 204: 182-188, http://dx.doi.org/10.1016/j.talanta.2019.05.069.
[49] Chao Wang, Yapiao Li, Qiang Zhao. A signal-on electrochemical aptasensor for rapid detection of aflatoxin B1 based on competition with complementary DNA. BIOSENSORS AND BIOELECTRONICS. 2019, 144: http://dx.doi.org/10.1016/j.bios.2019.111641.
[50] Li, Yapiao, Sun, Linlin, Zhao, Qiang. Aptamer-Structure Switch Coupled with Horseradish Peroxidase Labeling on a Microplate for the Sensitive Detection of Small Molecules. ANALYTICAL CHEMISTRY[J]. 2019, 91(4): 2615-2619, [51] Wang, Chao, Li, Yapiao, Zhao, Qiang. A signal-on electrochemical aptasensor for rapid detection of aflatoxin B1 based on competition with complementary DNA. BIOSENSORS & BIOELECTRONICS[J]. 2019, 144: http://dx.doi.org/10.1016/j.bios.2019.111641.
[52] Sun, Linlin, Zhao, Qiang. Competitive horseradish peroxidase-linked aptamer assay for sensitive detection of Aflatoxin B1. TALANTA[J]. 2018, 179: 344-349, http://ir.rcees.ac.cn/handle/311016/40904.
[53] Sun, Linlin, Zhao, Qiang. Direct fluorescence anisotropy approach for aflatoxin B1 detection and affinity binding study by using single tetramethylrhodamine labeled aptamer. TALANTA[J]. 2018, 189: 442-450, http://ir.rcees.ac.cn/handle/311016/40924.
[54] Dolot, Rafal, Lam, Curtis H, Sierant, Malgorzata, Zhao, Qiang, Liu, FengWu, Nawrot, Barbara, Egli, Martin, Yang, Xianbin. Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(9): 4819-4830, http://ir.rcees.ac.cn/handle/311016/40909.
[55] Li, Yapiao, Sun, Linlin, Zhao, Qiang. Development of aptamer fluorescent switch assay for aflatoxin B1 by using fluorescein-labeled aptamer and black hole quencher 1-labeled complementary DNA. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2018, 410(24): 6269-6277, http://ir.rcees.ac.cn/handle/311016/40917.
[56] Sun, Linlin, Zhao, Qiang. A simple fluorescent aptamer based assay coupled with fluorescence scanning capillary array for aflatoxin B1. ANALYST[J]. 2018, 143(19): 4600-4605, http://ir.rcees.ac.cn/handle/311016/40866.
[57] Bai, Yunlong, Zhao, Qiang. Rapid fluorescence detection of immunoglobulin E using an aptamer switch based on a binding-induced pyrene excimer. ANALYTICAL METHODS[J]. 2017, 9(26): 3962-3967, http://ir.rcees.ac.cn/handle/311016/39397.
[58] Liu, Yingxiong, Zhao, Qiang. Direct fluorescence anisotropy assay for cocaine using tetramethylrhodamine-labeled aptamer. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2017, 409(16): 3993-4000, http://ir.rcees.ac.cn/handle/311016/39295.
[59] Bai, Yunlong, Zhao, Qiang. Investigation of the effects of metal ions in sample buffer on capillary electrophoresis coupled with laser-induced fluorescence analysis of thrombin using a dye-labeled 29-mer DNA aptamer. ANALYTICAL METHODS[J]. 2017, 9(38): 5684-5690, http://ir.rcees.ac.cn/handle/311016/39345.
[60] Sun, Linlin, Wu, Liqing, Zhao, Qiang. Aptamer based surface plasmon resonance sensor for aflatoxin B1. MICROCHIMICA ACTA[J]. 2017, 184(8): 2605-2610, http://ir.rcees.ac.cn/handle/311016/39249.
[61] Bai, Yunlong, Li, Yapiao, Zhang, Dapeng, Wang, Hailin, Zhao, Qiang. Enhancing the Affinity of Anti-Human alpha-Thrombin 15-mer DNA Aptamer and Anti-Immunoglobulin E Aptamer by PolyT Extension. ANALYTICAL CHEMISTRY[J]. 2017, 89(17): 9467-9473, http://ir.rcees.ac.cn/handle/311016/39306.
[62] Bai, Yunlong, Wang, Hailin, Zhao, Qiang. Detection of human neutrophil elastase by aptamer affinity capillary electrophoresis coupled with laser-induced fluorescence using specified site fluorescently labeled aptamer. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2017, 409(29): 6843-6849, http://ir.rcees.ac.cn/handle/311016/39286.
[63] Li, Yapiao, Sun, Linlin, Zhao, Qiang. Competitive fluorescence anisotropy/polarization assay for ATP using aptamer as affinity ligand and dye-labeled ATP as fluorescence tracer. TALANTA[J]. 2017, 174: 7-13, http://ir.rcees.ac.cn/handle/311016/39276.
[64] Guo, Limin, Zhao, Qiang. Thrombin-linked aptamer assay for detection of platelet derived growth factor BB on magnetic beads in a sandwich format. TALANTA[J]. 2016, 158: 159-164, http://dx.doi.org/10.1016/j.talanta.2016.05.037.
[65] Hao, Lihua, Bai, Yunlong, Wang, Hailin, Zhao, Qiang. Affinity capillary electrophoresis with laser induced fluorescence detection for thrombin analysis using nuclease-resistant RNA aptamers. JOURNAL OF CHROMATOGRAPHY A[J]. 2016, 1476: 124-129, http://dx.doi.org/10.1016/j.chroma.2016.11.011.
[66] Hao, Lihua, Zhao, Qiang. Using fluoro modified RNA aptamers as affinity ligands on magnetic beads for sensitive thrombin detection through affinity capture and thrombin catalysis. ANALYTICAL METHODS[J]. 2016, 8(3): 510-516, http://ir.rcees.ac.cn/handle/311016/35980.
[67] Guo, Limin, Hao, Lihua, Zhao, Qiang. An aptamer assay using rolling circle amplification coupled with thrombin catalysis for protein detection. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2016, 408(17): 4715-4722, https://www.webofscience.com/wos/woscc/full-record/WOS:000378725200020.
[68] Hao, Lihua, Zhao, Qiang. Microplate based assay for thrombin detection using an RNA aptamer as affinity ligand and cleavage of a chromogenic or a fluorogenic peptide substrate. MICROCHIMICA ACTA[J]. 2016, 183(6): 1891-1898, http://www.irgrid.ac.cn/handle/1471x/1176630.
[69] Guo, Limin, Zhao, Qiang. Determination of the platelet-derived growth factor BB by a competitive thrombin-linked aptamer-based Fluorometric assay. MICROCHIMICA ACTA[J]. 2016, 183(12): 3229-3235, http://ir.rcees.ac.cn/handle/311016/35834.
[70] Liu, Yingxiong, Zhao, Qiang. Fluorescence anisotropy assay for D-vasopressin with a tetramethylrhodamine-labeled aptamer. ANALYTICAL METHODS[J]. 2016, 8(11): 2383-2390, http://ir.rcees.ac.cn/handle/311016/35857.
[71] Qiang Zhao, Jie Gao. Sensitive and selective detection of thrombin by using a cyclic peptide as affinity ligand. BIOSENSORS AND BIOELECTRONICS. 2015, 63: 21-25, http://dx.doi.org/10.1016/j.bios.2014.07.010.
[72] Zhao, Qiang, Gao, Jie. Sensitive and selective detection of thrombin by using a cyclic peptide as affinity ligand. BIOSENSORS & BIOELECTRONICS[J]. 2015, 63: 21-25, http://dx.doi.org/10.1016/j.bios.2014.07.010.
[73] Zhao, Qiang, Lv, Qin, Wang, Hailin. Aptamer fluorescence anisotropy sensors for adenosine triphosphate by comprehensive screening tetramethylrhodamine labeled nucleotides. BIOSENSORS & BIOELECTRONICS[J]. 2015, 70(1): 188-193, http://dx.doi.org/10.1016/j.bios.2015.03.031.
[74] Qiang Zhao, Qin Lv, Hailin Wang. Aptamer fluorescence anisotropy sensors for adenosine triphosphate by comprehensive screening tetramethylrhodamine labeled nucleotides. BIOSENSORS AND BIOELECTRONICS. 2015, 70: 188-193, http://dx.doi.org/10.1016/j.bios.2015.03.031.
[75] Lv, Li, Guo, Limin, Zhao, Qiang. Aptamer and rolling circle amplification-involved sandwich assay for platelet-derived growth factor-BB with absorbance analysis. ANALYTICAL METHODS[J]. 2015, 7(5): 1855-1859, http://ir.rcees.ac.cn/handle/311016/32515.
[76] Zhang, Dapeng, Fu, Rong, Zhao, Qiang, Rong, Haiqin, Wang, Hailin. Nanoparticles-Free Fluorescence Anisotropy Amplification Assay for Detection of RNA Nucleotide-Cleaving DNAzyme Activity. ANALYTICAL CHEMISTRY[J]. 2015, 87(9): 4903-4909, http://ir.rcees.ac.cn/handle/311016/32628.
[77] Hao, Lihua, Zhao, Qiang. A fluorescein labeled aptamer switch for thrombin with fluorescence decrease response. ANALYTICAL METHODS[J]. 2015, 7(9): 3888-3892, http://ir.rcees.ac.cn/handle/311016/32500.
[78] Zhao, Qiang, Lv, Qin, Wang, Hailin. Identification of Allosteric Nucleotide Sites of Tetramethylrhodamine-Labeled Aptamer for Noncompetitive Aptamer-Based Fluorescence Anisotropy Detection of a Small Molecule, Ochratoxin A. ANALYTICAL CHEMISTRY[J]. 2014, 86(2): 1238-1245, http://www.irgrid.ac.cn/handle/1471x/936464.
[79] Zhao, Qiang, Geng, Xia, Wang, Hailin. Fluorescent sensing ochratoxin A with single fluorophore-labeled aptamer. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2013, 405(19): 6281-6286, http://www.irgrid.ac.cn/handle/1471x/844404.
[80] Zhao, Qiang, Cheng, Lin. Detection of thrombin using an excimer aptamer switch labeled with dual pyrene molecules. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2013, 405(25): 8233-8239, https://www.webofscience.com/wos/woscc/full-record/WOS:000324587400029.
[81] Zhao, Qiang, Gao, Jie. Fluorogenic assays for activated protein C using aptamer modified magnetic beads. MICROCHIMICA ACTA[J]. 2013, 180(9-10): 813-819, https://www.webofscience.com/wos/woscc/full-record/WOS:000320862100011.
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（1） 国家自然科学基金重点项目，参与，国家级，2015-01--2019-12
（2） 国家自然科学基金委优秀青年基金，主持，国家级，2013-01--2015-12
（3） 山西省青年拔尖人才支持计划项目，主持，省级，2013-01--2015-12
（4） 核酸适配体在环境分析检测中的应用，主持，部委级，2012-01--2015-12