基本信息
刘瑞田  男  博导  中国科学院过程工程研究所
电子邮件: rtliu@home.ipe.ac.cn
通信地址: rtliu@home.ipe.ac.cn
邮政编码: 100190

招生信息

   
招生专业
081703-生物化工
085238-生物工程
100706-药理学
招生方向
生物技术药物

教育背景

2002-03--2005-02   亚利桑那州立大学   博士后
1995-08--1998-07   山东大学   博士
1987-08--1990-07   吉林大学   硕士
1982-08--1986-07   山东农业大学   学士

工作经历

   
工作简历
2012-06~现在, 中国科学院过程工程研究所, 研究员
2005-04~2012-05,清华大学, 副教授
1998-08~2002-02,山东大学, 副教授
1990-08~1995-07,济南军区军事医学研究所, 助理研究员
社会兼职
2011-05-01-2014-12-31, 国家“三重”(重大品种、重点问题、重要需求)项目评审委员会, 责任专家
2011-01-01-2014-12-31,Advances in Bioscience and Biotechnology编委会, 副编辑
2010-07-01-2014-12-31,国家重大科技专项《重大新药创制》评审委员会, 责任专家
2010-07-01-2014-12-31,国家863计划评审委员会, 责任专家
2010-07-01-2014-12-31,Journal of Alzheimer’s Disease编委会, 副编辑

专利与奖励

   
专利成果
[1] 刘瑞田, 卢帅, 谢喜秀. 新型冠状病毒抗原表位及其应用. CN: CN111848753B, 2022-03-15.

[2] 刘瑞田, 张凌宵, 刘栋群. 一种纳米颗粒及其制备方法和应用. CN: CN111603455B, 2022-02-18.

[3] 刘瑞田, 于晓琳, 查君. 一种多肽及其应用. CN: CN108341862B, 2021-04-02.

[4] 刘瑞田, 季梅, 谢喜秀. 一种重组蛋白及其制备方法和应用. CN: CN108314737B, 2021-03-16.

[5] 刘瑞田, 季梅, 谢喜秀. 疫苗通用载体及其制备方法和应用. CN: CN112062862A, 2020-12-11.

[6] 刘瑞田, 刘小歌, 于晓琳, 卢帅. 一种具有寡聚体特异性的核磁造影剂及其制备方法与应用. CN: CN109364270A, 2019-02-22.

[7] 刘瑞田, 黄亚茹, 谢喜秀. 一种天然α-syn寡聚体抗体的制备方法及其产品和应用. CN: CN109293770A, 2019-02-01.

[8] 刘瑞田, 王少伟, 刘栋群. 一种多肽及其组成的疫苗和应用. CN: CN107118260A, 2017-09-01.

[9] 宋佃卫, 谢喜秀, 马山, 刘瑞田, 菅长永, 朱孟沼, 席智赢, 刘坤, 范克明. 一种Aβ寡聚体抗体的制备工艺. CN: CN106519029A, 2017-03-22.

[10] 刘瑞田, 于晓琳, 查君. 一种多肽及其应用. CN: CN105861462A, 2016-08-17.

[11] 刘瑞田, 杨世高, 王少伟. 一种抑制β分泌酶酶切作用的多肽及其应用. CN: CN102516360A, 2012-06-27.

[12] 刘瑞田, 薛頔, 赵敏. 结合A-beta淀粉样蛋白的多肽与应用. CN: CN102516357A, 2012-06-27.

[13] 刘瑞田, 孙晓霞, 赵敏. 淀粉样蛋白纤维性寡聚体构象型抗原表位多肽及其应用. CN: CN102504016A, 2012-06-20.

[14] 刘瑞田, 王小平. 与A-beta寡聚体特异性结合的基因工程单克隆抗体. CN: CN101463085B, 2011-09-14.

[15] 刘瑞田, 赵敏. 淀粉样蛋白寡聚体构象型抗原表位多肽及其应用. CN: CN102060912A, 2011-05-18.

[16] 刘瑞田, 薛頔. 同时结合多种淀粉样蛋白单体的多肽及其应用. CN: CN102060911A, 2011-05-18.

[17] 刘瑞田, 杨世高. 抑制beta分泌酶酶切作用的多肽及其应用. CN: CN101863962A, 2010-10-20.

[18] 刘瑞田, 王小平. 与A-beta寡聚体特异性结合的基因工程单克隆抗体. CN: CN101463082A, 2009-06-24.

[19] 刘瑞田, 王小平. 与A-beta寡聚体特异性结合的基因工程单克隆抗体. CN: CN101463082A, 2009-06-24.

[20] 刘瑞田, 王小平. 与A-beta寡聚体特异性结合的基因工程单克隆抗体. CN: CN101463085A, 2009-06-24.

出版信息

   
发表论文
[1] 李凌杰, 于晓琳, 刘瑞田. 胶质细胞介导的神经突触修剪在阿尔茨海默病中的作用. 药学学报[J]. 2021, 56(2): 383-390, http://lib.cqvip.com/Qikan/Article/Detail?id=7104429572.

[2] Zhang, LingXiao, Hu, Jing, Jia, YingBo, Liu, RuiTian, Cai, Ting, Xu, Zhi Ping. Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction. NANOSCALE[J]. 2021, 13(16): 7533-7549, http://dx.doi.org/10.1039/d1nr00881a.

[3] Sun, Xiaoying, Li, Lingjie, Dong, QuanXiu, Zhu, Jie, Huang, Yaru, Hou, Shengjie, Yu, Xiaolin, Liu, Ruitian. Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease. JOURNAL OF NEUROINFLAMMATION[J]. 2021, 18(1): 1-14, http://dx.doi.org/10.1186/s12974-021-02182-3.

[4] Zhang, LingXiao, Jia, YingBo, Huang, YaRu, Liu, HuiNa, Sun, XiaMei, Cai, Ting, Liu, RuiTian, Xu, Zhi Ping. Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma. NANO RESEARCH[J]. 2021, 14(5): 1326-1334, https://www.webofscience.com/wos/woscc/full-record/WOS:000590923600003.

[5] Lu, Shuai, Xie, Xixiu, Zhao, Lei, Wang, Bin, Zhu, Jie, Yang, Tingrui, Yang, Guangwen, Ji, Mei, Lv, Cuiping, Xue, Jian, Dai, Erhei, Fu, Ximing, Liu, Dongqun, Zhang, Lun, Hou, Shengjie, Yu, Xiaolin, Wang, Yuling, Gao, Huixia, Shi, Xuehan, Ke, Changwen, Ke, Bixia, Jiang, Chunguo, Liu, Ruitian. The immunodominant and neutralization linear epitopes for SARS-CoV-2. CELL REPORTS[J]. 2021, 34(4): 108666-108666, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837128/.

[6] Liu,Xiaoge, Zhang,Lun, Lu,Shuai, Liu,Dongqun, Huang,Yaru, Zhu,Jie, Zhou,Weiwei, Yu,Xiaolin, Liu,Ruitian. Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer’s Disease. Journal of Nanobiotechnology[J]. 2020, 18(1): 1-13, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648289/.

[7] Ruitian Liu. A conditionally releasable "don’t eat me" CD47 signal facilitates microglia-targeted drug delivery for the treatment of Alzheimer's disease. Advanced Functional Materials. 2020, 
[8] Liu, Dongqun, Lu, Shuai, Zhang, Lun, Huang, Yaru, Ji, Mei, Sun, Xiaoying, Liu, Xiaoge, Liu, Ruitian. Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice. VACCINES[J]. 2020, 8(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000579955200001.

[9] Zhang, Lingxiao, Sun, Xiamei, Jia, Yingbo, Liu, Xiaoge, Dong, Mingdong, Xu, Zhi Ping, Liu, Ruitian. Nanovaccine's rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy. NANO TODAY[J]. 2020, 35: http://dx.doi.org/10.1016/j.nantod.2020.100923.

[10] Liu, Dongqun, Lu, Shuai, Zhang, Lun, Zhang, Lingxiao, Ji, Mei, Liu, XiaoGe, Yu, Zhuo, Liu, Ruitian. A biomimetic yeast shell vaccine coated with layered double hydroxides induces a robust humoral and cellular immune response against tumors. NANOSCALE ADVANCES[J]. 2020, 2(8): 3494-3506, http://dx.doi.org/10.1039/d0na00249f.

[11] Huang, Yaru, Liu, Ruitian. The Toxicity and Polymorphism of beta-Amyloid Oligomers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 21(12): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000550123500001.

[12] Yu, XiaoLin, Zhu, Jie, Liu, Xiangmeng, Xu, Pengxin, Zhang, Yue, Liu, Ruitian. Vaccines targeting the primary amino acid sequence and conformational epitope of amyloid-beta had distinct effects on neuropathology and cognitive deficits in EAE/AD mice. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2020, 177(12): 2860-2871, https://www.webofscience.com/wos/woscc/full-record/WOS:000520724900001.

[13] Liu, XiaoGe, Zhang, Lun, Lu, Shuai, Liu, DongQun, Zhang, LingXiao, Yu, XiaoLin, Liu, RuiTian. Multifunctional Superparamagnetic Iron Oxide Nanoparticles Conjugated with A beta Oligomer-Specific scFv Antibody and Class A Scavenger Receptor Activator Show Early Diagnostic Potentials for Alzheimer's Disease. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2020, 15: 4919-4932, https://www.webofscience.com/wos/woscc/full-record/WOS:000548715400002.

[14] Yaru Huang, Ruitian Liu. The Toxicity and Polymorphism of β-Amyloid Oligomers. International Journal of Molecular Sciences[J]. 2020, 21(12): https://doaj.org/article/c79b52295e6d4658945606223e30dd85.

[15] Ji, Mei, Xie, Xixiu, Liu, Dongqun, Lu, Shuai, Zhang, Lingxiao, Huang, Yaru, Liu, Ruitian. Engineered hepatitis B core virus-like particle carrier for precise and personalized Alzheimer's disease vaccine preparation via fixed-point coupling. APPLIED MATERIALS TODAY[J]. 2020, 19: http://dx.doi.org/10.1016/j.apmt.2020.100575.

[16] Ji, Mei, Zhu, Jie, Xie, Xixiu, Liu, Dongqun, Wang, Bin, Yu, Zhuo, Liu, Ruitian. A novel rapid modularized hepatitis B core virus-like particle-based platform for personalized cancer vaccine preparation via fixed-point coupling. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE[J]. 2020, 28: http://dx.doi.org/10.1016/j.nano.2020.102223.

[17] Ruitian Liu. Yeast-Based Aβ1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer’s Disease Transgenic Mice. Vaccines (Basel). 2020, 
[18] Xiaoyu Du, Xixiu Xie, Ruitian Liu. The Role of α-Synuclein Oligomers in Parkinson’s Disease. International Journal of Molecular Sciences[J]. 2020, 21(22): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697105/.

[19] Ruitian Liu. Vaccines targeting the primary amino acid sequence and conformational epitope of amyloid-β had distinct effects on neuropathology and cognitive deficits in EAE/AD mice. Br J Pharmacol. 2020, 
[20] Zhang, Lun, Liu, Xiaoge, Liu, Dongqun, Yu, Xiaolin, Zhang, Lingxiao, Zhu, Jie, Lu, Shuai, Liu, Ruitian. A Conditionally Releasable "Do not Eat Me" CD47 Signal Facilitates Microglia-Targeted Drug Delivery for the Treatment of Alzheimer's Disease. ADVANCED FUNCTIONAL MATERIALS[J]. 2020, 30(24): https://www.webofscience.com/wos/woscc/full-record/WOS:000529145600001.

[21] Liu, Xiaoge, Zhang, Lun, Lu, Shuai, Liu, Dongqun, Huang, Yaru, Zhu, Jie, Zhou, Weiwei, Yu, Xiaolin, Liu, Ruitian. Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease. JOURNAL OF NANOBIOTECHNOLOGY[J]. 2020, 18(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000590702000001.

[22] Ruitian Liu. A Biomimetic yeast shell vaccine coated with layered double hydroxides induces robust humoral and cellular immune response against tumor. Nanoscale Adv. 2020, 
[23] Du, Xiaoyu, Xie, Xixiu, Liu, Ruitian. The Role of alpha-Synuclein Oligomers in Parkinson's Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 21(22): https://www.webofscience.com/wos/woscc/full-record/WOS:000594886400001.

[24] Ruitian Liu. Multifunctional Superparamagnetic Iron Oxide Nanoparticles Conjugated with Aβ Oligomer-Specific scFv Antibody and Class A Scavenger Receptor Activator Show Early Diagnostic Potentials for Alzheimer’s Disease. International Journal of Nanomedicine. 2020, 
[25] Ruitian Liu. Engineered Hepatitis B core Virus-Like Particle carrier for precise and personalized Alzheimer’s disease vaccines via SpyCatcher/SpyTag technology. Applied Materials Today. 2020, 
[26] Sun, Xun, Zhu, Jie, Sun, Xiaoying, Ji, Mei, Yu, Xiaolin, Liu, Ruitian. Ellagic acid rescues motor and cognitive deficits in the R6/2 mouse model of Huntington's disease by lowering mutant huntingtin protein. FOOD & FUNCTION[J]. 2020, 11(2): 1334-1348, https://www.webofscience.com/wos/woscc/full-record/WOS:000518566700012.

[27] Liu, Xiaoge, Lu, Shuai, Liu, Dongqun, Zhang, Lun, Zhang, Lingxiao, Yu, Xiaolin, Liu, Ruitian. ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson's and Huntington's diseases. BRAIN RESEARCH[J]. 2019, 1707: 141-153, http://ir.ipe.ac.cn/handle/122111/28289.

[28] Zhang, Lingxiao, Sun, Xiamei, Xu, Zhi Ping, Liu, Ruitian. Development of Multifunctional Clay-Based Nanomedicine for Elimination of Primary Invasive Breast Cancer and Prevention of Its Lung Metastasis and Distant Inoculation. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(39): 35566-35576, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000489001900006.

[29] Huang, Yaru, Xie, Xixiu, Ji, Mei, Yu, Xiaolin, Zhu, Jie, Zhang, Lingxiao, Liu, Xiaoge, Wei, Chen, Li, Gang, Liu, Ruitian. Naturally occurring autoantibodies against alpha-synuclein rescues memory and motor deficits and attenuates alpha-synuclein pathology in mouse model of Parkinson's disease. NEUROBIOLOGY OF DISEASE[J]. 2019, 124: 202-217, http://ir.ipe.ac.cn/handle/122111/28086.

[30] Yaru Huang, Xixiu Xie, Mei Ji, Xiaolin Yu, Jie Zhu, Lingxiao Zhang, Xiaoge Liu, Chen Wei, Gang Li, Ruitian Liu. Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease. Neurobiology of Disease[J]. 2019, 124: 202-217, http://dx.doi.org/10.1016/j.nbd.2018.11.024.

[31] Sun, XiaoYing, Dong, QuanXiu, Zhu, Jie, Sun, Xun, Zhang, LiFan, Qiu, Mandy, Yu, XiaoLin, Liu, RuiTian. Resveratrol Rescues Tau-Induced Cognitive Deficits and Neuropathology in a Mouse Model of Tauopathy. CURRENT ALZHEIMER RESEARCH[J]. 2019, 16(8): 710-722, http://dx.doi.org/10.2174/1567205016666190801153751.

[32] Zhang, Lingxiao, Xie, Xixiu, Liu, Dongqun, Xu, Zhi Ping, Liu, Ruitian. Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy. BIOMATERIALS[J]. 2018, 174: 54-66, http://dx.doi.org/10.1016/j.biomaterials.2018.05.015.

[33] Ji, Mei, Xie, Xixiu, Liu, Dongqun, Yu, Xiaolin, Zhang, Yue, Zhang, Lingxiao, Wang, Shaowei, Huang, Yaru, Liu, Ruitian. Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau. P301S mouse model of Alzheimer's disease and frontotemporal dementia. ALZHEIMERS RESEARCH & THERAPY[J]. 2018, 10(1): http://ir.ipe.ac.cn/handle/122111/26690.

[34] Shuying Liu, Xiaolin Yu, Jie Zhu, Xiangmeng Liu, Yue Zhang, Quanxiu Dong, Shan Ma, Ruitian Liu. Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington’s disease by decreasing mutant huntingtin protein level and normalizing NF-κB signaling pathway. Brain Research. 2018, 1697: 21-33, http://dx.doi.org/10.1016/j.brainres.2018.06.009.

[35] Zhang, Lifan, Yu, Xiaolin, Ji, Mei, Liu, Shuying, Wu, Xiaoling, Wang, Yujiong, Liu, Ruitian. Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T-synuclein mouse model of Parkinson's disease. FOOD & FUNCTION[J]. 2018, 9(12): 6415-6427, http://ir.ipe.ac.cn/handle/122111/27592.

[36] Zhang, Yue, Yu, Xiaolin, Zhu, Jie, Liu, Shuying, Liu, Xiangmeng, Dong, Quanxiu, Chai, Jiaqian, Liu, Ruitian. Intravenous immunoglobulin improves glucose control and beta-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2018, 54: 145-152, http://www.irgrid.ac.cn/handle/1471x/1764159.

[37] Yue Zhang, Xiaolin Yu, Jun Zha, Lizhen Mao, Jiaqian Chai, Ruitian Liu. Therapeutic vaccine against IL-1β improved glucose control in a mouse model of type 2 diabetes. Life Sciences. 2018, 192: 68-74, http://dx.doi.org/10.1016/j.lfs.2017.11.021.

[38] Liu, Dongqun, Lu, Shuai, Zhang, Lingxiao, Ji, Mei, Liu, Shuying, Wang, Shaowei, Liu, Ruitian. An indoleamine 2, 3-dioxygenase siRNA nanoparticle-coated and Trp2-displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice. JOURNAL OF CONTROLLED RELEASE[J]. 2018, 273: 1-12, http://dx.doi.org/10.1016/j.jconrel.2018.01.013.

[39] Dong, Quanxiu, Zhu, Jie, Liu, Shuying, Yu, Xiaolin, Liu, Ruitian. An oligomer-specific antibody improved motor function and attenuated neuropathology in the SOD1-G93A transgenic mouse model of ALS. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2018, 65: 413-421, http://dx.doi.org/10.1016/j.intimp.2018.10.032.

[40] Zhang Yue, Yu Xiaolin, Zhu Jie, Liu Shuying, Liu Xiangmeng, Dong Quanxiu, Chai Jiaqian, Liu Ruitian. Intravenous immunoglobulin improves glucose control and β-cell function in human IAPP transgenic mice by attenuating islet inflammation and reducing IAPP oligomers. International Immunopharmacology[J]. 2018, 54: 145-152, http://dx.doi.org/10.1016/j.intimp.2017.11.012.

[41] Zhang, Yue, Yu, Xiaolin, Zha, Jun, Mao, Lizhen, Chai, Jiaqian, Liu, Ruitian. Therapeutic vaccine against IL-1 beta improved glucose control in a mouse model of type 2 diabetes. LIFE SCIENCES[J]. 2018, 192: 68-74, https://www.webofscience.com/wos/woscc/full-record/WOS:000418477800010.

[42] Liu, Shuying, Yu, Xiaolin, Zhu, Jie, Liu, Xiangmeng, Zhang, Yue, Dong, Quanxiu, Ma, Shan, Liu, Ruitian. Intravenous immunoglobulin ameliorates motor and cognitive deficits and neuropathology in R6/2 mouse model of Huntington's disease by decreasing mutant huntingtin protein level and normalizing NF-kappa B signaling pathway. BRAIN RESEARCH[J]. 2018, 1697: 21-33, http://ir.ipe.ac.cn/handle/122111/26697.

[43] Liu, ShuYing, Lu, Shuai, Yu, XiaoLin, Yang, ShiGao, Liu, Wen, Liu, XiangMeng, Wang, ShaoWei, Zhu, Jie, Ji, Mei, Liu, DongQun, Zhang, ZiPing, Liu, RuiTian. Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice. CURRENT ALZHEIMER RESEARCH[J]. 2018, 15(9): 856-868, http://ir.ipe.ac.cn/handle/122111/26816.

[44] Zhang, Yangxin, Wang, Shaowei, Lu, Shuai, Zhang, Lingxiao, Liu, Dongqun, Ji, Mei, Wang, Weiyun, Liu, Ruitian. A mimotope of A beta oligomers may also behave as a beta-sheet inhibitor. FEBS LETTERS[J]. 2017, 591(21): 3615-3624, https://www.webofscience.com/wos/woscc/full-record/WOS:000415051300013.

[45] Shaowei Wang, Dongqun Liu, Lingxiao Zhang, Mei Ji, Yangxin Zhang, Quanxiu Dong, Shuying Liu, Xixiu Xie, Ruitian Liu. A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease. Alzheimer’s Research & Therapy[J]. 2017, 9(1): 1-14, http://dx.doi.org/10.1186/s13195-017-0267-5.

[46] Huang, Na, Lu, Shuai, Liu, XiaoGe, Zhu, Jie, Wang, YuJiong, Liu, RuiTian. PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A beta generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice. ONCOTARGET[J]. 2017, 8(46): 81001-81013, https://www.webofscience.com/wos/woscc/full-record/WOS:000412465700078.

[47] Wang, Shaowei, Liu, Dongqun, Zhang, Lingxiao, Ji, Mei, Zhang, Yangxin, Dong, Quanxiu, Liu, Shuying, Xie, Xixiu, Liu, Ruitian. A vaccine with A beta oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer's disease. ALZHEIMERS RESEARCH & THERAPY[J]. 2017, 9: https://www.webofscience.com/wos/woscc/full-record/WOS:000403027200001.

[48] Zhang, Lingxiao, Liu, Dongqun, Wang, Shaowei, Yu, Xiaolin, Ji, Mei, Xie, Xixiu, Liu, Shuying, Liu, Ruitian. MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide effectively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2017, 5(31): 6266-6276, http://www.irgrid.ac.cn/handle/1471x/1763716.

[49] Zha, Jun, Chi, Xiaowei, Yu, Xiaolin, Liu, Xiangmeng, Liu, Dongqun, Zhu, Jie, Ji, Hui, Liu, Ruitian. Interleukin-1 beta-Targeted Vaccine Improves Glucose Control and beta-Cell Function in a Diabetic KK-A(y) Mouse Model. PLOS ONE[J]. 2016, 11(5): http://ir.ipe.ac.cn/handle/122111/21056.

[50] Ruitian Liu. Naturally occurring autoantibodies against Ab oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin. Neuropharmacology. 2016, 
[51] Wang, Teng, Xie, Xixiu, Ji, Mei, Wang, Shaowei, Zha, Jun, Zhou, Weiwei, Yu, Xiaolin, Wei, Chen, Ma, Shan, Xi, Zhiying, Pang, Guangli, Liu, Ruitian. Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin. NEUROPHARMACOLOGY[J]. 2016, 105(JUNE): 561-576, http://ir.ipe.ac.cn/handle/122111/20955.

[52] Wang, Shaowei, Yang, Shigao, Liu, Wen, Zhang, Yangxin, Xu, Pengxin, Wang, Teng, Ling, Tiejun, Liu, Ruitian. Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease. BEHAVIOURAL BRAIN RESEARCH[J]. 2016, 296: 109-117, http://dx.doi.org/10.1016/j.bbr.2015.09.003.

[53] Jun Zha, XiaoWei Chi, XiaoLin Yu, XiangMeng Liu, DongQun Liu, Jie Zhu, Hui Ji, RuiTian Liu. Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-Ay Mouse Model.. PLOS ONE[J]. 2016, 11(5): https://doaj.org/article/6988aa9205a84346aa546a0c2d6afc20.

[54] Zha, Jun, Liu, Xiangmeng, Zhu, Jie, Liu, Shuying, Lu, Shuai, Xu, Pengxin, Yu, Xiaolin, Liu, Ruitian. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses. SCIENTIFIC REPORTS[J]. 2016, 6(NOV): http://ir.ipe.ac.cn/handle/122111/21654.

[55] Yang, Shigao, Liu, Wen, Lu, Shuai, Tian, Yongzhen, Wang, Weiyun, Ling, Tiejun, Liu, Ruitian. A Novel Multifunctional Compound Camellikaempferoside B Decreases A beta Production, Interferes with A beta Aggregation, and Prohibits A beta-Mediated Neurotoxicity and Neuroinflammation. ACS CHEMICAL NEUROSCIENCE[J]. 2016, 7(4): 505-518, http://ir.ipe.ac.cn/handle/122111/21032.

[56] Yang Shigao, Liu Wen, Tian Yongzhen, Wang Weiyun, Ling Tiejun, Liu Ruitian. A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation. ACS Chemical Neuroscience[J]. 2016, 
[57] Yu, XiaoLin, Li, YaNan, Zhang, He, Su, YaJing, Zhou, WeiWei, Zhang, ZiPing, Wang, ShaoWei, Xu, PengXin, Wang, YuJiong, Liu, RuiTian. Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress. FOOD & FUNCTION[J]. 2015, 6(10): 3296-3306, http://www.irgrid.ac.cn/handle/1471x/1010242.

[58] Ruitian Liu. utin improves spatial memory in Alzheimer’s disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behavioural Brain Research. 2014, 
[59] Zhang, Junbo, Guo, Fei, Huang, Xiaoqiang, Chen, Chuangfu, Liu, Ruitian, Zhang, Hui, Wang, Yuanzhi, Yin, Shuanghong, Li, Zhiqiang. A novel Omp25-binding peptide screened by phage display can inhibit Brucella abortus 2308 infection in vitro and in vivo. JOURNAL OF MEDICAL MICROBIOLOGY[J]. 2014, 63(Pt 6): 780-787, https://www.webofscience.com/wos/woscc/full-record/WOS:000338815500002.

[60] Xu, Pengxin, Wang, Shaowei, Yu, Xiaolin, Su, Yajing, Wang, Teng, Zhou, Weiwei, Zhang, He, Wang, Yujiong, Liu, Ruitian. Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A beta oligomer level and attenuating oxidative stress and neuroinflammation. BEHAVIOURAL BRAIN RESEARCH[J]. 2014, 264(1): 173-180, http://www.irgrid.ac.cn/handle/1471x/837097.

[61] Ruitian Liu. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer’s disease. Free Radical Biology Medicine. 2014, 
[62] Zhang, He, Su, Yajing, Zhou, Weiwei, Wang, Shaowei, Xu, Pengxin, Yu, Xiaolin, Liu, Ruitian. Activated Scavenger Receptor A Promotes Glial Internalization of A beta. PLOS ONE[J]. 2014, 9(4): http://www.irgrid.ac.cn/handle/1471x/857816.

[63] He Zhang, Yajing Su, Weiwei Zhou, Shaowei Wang, Pengxin Xu, Xiaolin Yu, Ruitian Liu. Activated scavenger receptor A promotes glial internalization of aβ.. PLOS ONE[J]. 2014, 9(4): https://doaj.org/article/e46534170fbd40b09635e3eeb653f6f1.

[64] Zhao, Min, Wang, Shaowei, Wang, Yujiong, Zhang, Ran, Li, Yanan, Su, Yajing, Zhou, Weiwei, Yu, Xiaolin, Liu, Ruitian. Pan-Amyloid Oligomer Specific scFv Antibody Attenuates Memory Deficits and Brain Amyloid Burden in Mice with Alzheimer's Disease. CURRENT ALZHEIMER RESEARCH[J]. 2014, 11(1): 69-78, http://www.irgrid.ac.cn/handle/1471x/837058.

[65] Zhou, Weiwei, Lu, Shuai, Su, Yajing, Xue, Di, Yu, Xiaolin, Wang, Shaowei, Zhang, He, Xu, Pengxin, Xie, Xixiu, Liu, Ruitian. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2014, 74(SEP.): 50-63, http://dx.doi.org/10.1016/j.freeradbiomed.2014.06.013.

[66] Min Zhao Shaowei Wang Yajing Su Weiwei Zhou Xiaolin Yu Ruitian Liu. Oligomer-specific single chain variable fragment antibody attenuates memory deficits and brain amyloid burden in Alzheimer disease transgenic mice. 中国药理通讯[J]. 2013, 30(2): 35-37, http://lib.cqvip.com/Qikan/Article/Detail?id=46461209.

[67] 周维维, 汪维云, 刘瑞田, 于晓琳. 抗淀粉样蛋白寡聚体单链抗体融合蛋白在真核细胞中表达的初步研究. 安徽农业大学学报[J]. 2013, 40(4): 685-689, http://www.irgrid.ac.cn/handle/1471x/857643.

[68] Shigao Yang, Shaowei Wang, Min Zhao, Ran Zhang, Weiwei Zhou, Yanan Li, Yajing Su, He Zhang, Xiaolin Yu, Ruitian Liu. A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.. PLOS ONE[J]. 2012, 7(11): https://doaj.org/article/58a0526d4f8244bbad4355bb720da5f0.

[69] Di Xue, Min Zhao, Yujiong Wang, Li Wang, Yang Yang, Shaowei Wang, Ran Zhang, Yang Zhao, Ruitian Liu. A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis. Neurobiology of Disease[J]. 2012, 46(3): 701-709, http://dx.doi.org/10.1016/j.nbd.2012.03.013.

[70] Yang, Shigao, Wang, Shaowei, Zhao, Min, Zhang, Ran, Zhou, Weiwei, Li, Yanan, Su, Yajing, Zhang, He, Yu, Xiaolin, Liu, Ruitian. A Peptide Binding to the beta-Site of APP Improves Spatial Memory and Attenuates A beta Burden in Alzheimer's Disease Transgenic Mice. PLOS ONE[J]. 2012, 7(11): http://www.irgrid.ac.cn/handle/1471x/725177.

[71] Wang, Shaowei, Wang, YuJiong, Su, Yajing, Zhou, Weiwei, Yang, Shigao, Zhang, Ran, Zhao, Min, Li, Yanan, Zhang, Ziping, Zhan, Dawei, Liu, Ruitian. Rutin inhibits beta-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. NEUROTOXICOLOGY[J]. 2012, 33(3): 482-490, https://www.webofscience.com/wos/woscc/full-record/WOS:000304730100026.

[72] Du, Xueting, Wang, Li, Wang, Yujiong, Andreasen, Maria, Zhan, Dawei, Feng, Ying, Li, Min, Zhao, Min, Otzen, Daniel, Xue, Di, Yang, Yang, Liu, Ruitian. A beta(1-16) Can Aggregate and Induce the Production of Reactive Oxygen Species, Nitric Oxide, and Inflammatory Cytokines. JOURNAL OF ALZHEIMERS DISEASE[J]. 2011, 27(2): 401-413, https://www.webofscience.com/wos/woscc/full-record/WOS:000297215900016.

[73] Xi Zhang, Xiao-xia Sun, Di Xue, Dong-ge Liu, Xiao-yan Hu, Min Zhao, Shi-gao Yang, Yang Yang, Yong-jing Xia, Ying Wang, Rui-tian Liu. Conformation-dependent scFv antibodies specifically recognize the oligomers assembled from various amyloids and show colocalization of amyloid fibrils with oligomers in patients with amyloidoses. BBA - Proteins and Proteomics. 2011, 1814(12): 1703-1712, http://dx.doi.org/10.1016/j.bbapap.2011.09.005.

[74] Yang, Shigao, Wang, Weiyun, Ling, Tiejun, Feng, Ying, Du, Xueting, Zhang, Xi, Sun, Xiaoxia, Zhao, Min, Xue, Di, Yang, Yang, Liu, Ruitian. Alpha-tocopherol quinone inhibits beta-amyloid aggregation and cytotoxicity, disaggregates preformed fibrils and decreases the production of reactive oxygen species, NO and inflammatory cytokines. NEUROCHEMISTRY INTERNATIONAL[J]. 2010, 57(8): 914-922, http://dx.doi.org/10.1016/j.neuint.2010.09.011.

[75] Yang, ShiGao, Zhang, Xi, Sun, XiaoSia, Ling, TieJun, Feng, Ying, Du, XueYing, Zhao, Min, Yang, Yang, Xue, Di, Wang, Li, Liu, RuiTian. Diverse Ecdysterones Show Different Effects on Amyloid-beta(42) Aggregation but All Uniformly Inhibit Amyloid-beta(42)-Induced Cytotoxicity. JOURNAL OF ALZHEIMERS DISEASE[J]. 2010, 22(1): 107-117, https://www.webofscience.com/wos/woscc/full-record/WOS:000283294100009.

[76] Feng, Ying, Yang, Shigao, Du, Xueting, Zhang, Xi, Sun, Xiaoxia, Zhao, Min, Sun, Guiyuan, Liu, Ruitian. Ellagic acid promotes A beta 42 fibrillization and inhibits A beta 42-induced neurotoxicity. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2009, 390(4): 1250-1254, https://www.webofscience.com/wos/woscc/full-record/WOS:000272650800032.

[77] Feng, Ying, Wang, Xiaoping, Yang, Shigao, Wang, Yujiong, Zhang, Xi, Du, Xueting, Sun, Xiaoxia, Zhao, Min, Huang, Lei, Liu, Ruitian. Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation. NEUROTOXICOLOGY[J]. 2009, 30(6): 986-995, http://dx.doi.org/10.1016/j.neuro.2009.08.013.

[78] Wang, Xiaoping, Zhang, Junhua, Wang, Yujiong, Feng, Ying, Zhang, Xi, Sun, Xiaoxia, Li, Jiliang, Du, Xueting, Lambert, Mary P, Yang, Shigao, Zhao, Min, Klein, William L, Liu, Ruitian. Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers. FEBS LETTERS[J]. 2009, 583(3): 579-584, http://dx.doi.org/10.1016/j.febslet.2008.12.064.

[79] 邵锴, 姜海燕, 张国利, 岳玉环, 朱平, 吴广谋, 刘瑞田. 从噬菌体抗体库中筛选抗HIV-Tat蛋白单链抗体. 中国实验诊断学[J]. 2008, 12(5): 592-594, http://lib.cqvip.com/Qikan/Article/Detail?id=27361402.

[80] Liu, R, Barkhordarian, H, Emadi, S, Park, CB, Sierks, MR. Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42. NEUROBIOLOGY OF DISEASE[J]. 2005, 20(1): 74-81, http://dx.doi.org/10.1016/j.nbd.2005.02.003.

[81] Liu, RT, Yuan, B, Emadi, S, Zameer, A, Schulz, P, McAllister, C, Lyubchenko, Y, Goud, G, Sierks, MR. Single chain variable fragments against beta-amyloid (A beta) can inhibit A beta aggregation and prevent A beta-induced neurotoxicity. BIOCHEMISTRY[J]. 2004, 43(22): 6959-6967, https://www.webofscience.com/wos/woscc/full-record/WOS:000221807500014.

[82] Ruitian Liu. Single chain Fv antibodies against 25-35 peptide fragment of amyloid-?: potential therapeutic for Alzheimer’s disease. Neurobiology Aging. 2004, 
[83] Emadi, S, Liu, RT, Yuan, B, Schulz, P, McAllister, C, Lyubchenko, Y, Messer, A, Sierks, MR. Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments. BIOCHEMISTRY[J]. 2004, 43(10): 2871-2878, https://www.webofscience.com/wos/woscc/full-record/WOS:000220143300021.

[84] Ruitian Liu. nti beta-amyloid (A?) ScFv inhibits A? aggregation and neurotoxicity. Neurobiology Aging. 2004, 
[85] Liu, RT, McAllister, C, Lyubchenko, Y, Sierks, MR. Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation. JOURNAL OF NEUROSCIENCE RESEARCH[J]. 2004, 75(2): 162-171, https://www.webofscience.com/wos/woscc/full-record/WOS:000187939100002.

[86] Liu, R, McAllister, C, Lyubchenko, Y, Sierks, MR. Proteolytic antibody light chains alter beta-amyloid aggregation and prevent cytotoxicity. BIOCHEMISTRYnull. 2004, 43(31): 9999-10007, https://www.webofscience.com/wos/woscc/full-record/WOS:000223121200007.

[87] Rangan, SK, Liu, RT, Brune, D, Planque, S, Paul, S, Sierks, MR. Degradation of beta-amyloid by proteolytic antibody light chains. BIOCHEMISTRY[J]. 2003, 42(48): 14328-14334, https://www.webofscience.com/wos/woscc/full-record/WOS:000186986700027.

[88] 宋欣, 魏留梅, 刘瑞田, 曲音波. 脂肪酶高产菌株选育和菌种库的建立. 微生物学通报[J]. 2002, 29(1): 6-10, http://lib.cqvip.com/Qikan/Article/Detail?id=6233715.

[89] 康从宝, 李清心, 刘瑞田, 曲音波. 一株白腐菌产生的漆酶对RB宙蓝的脱色作用. 应用与环境生物学报[J]. 2002, 8(3): 298-301, http://lib.cqvip.com/Qikan/Article/Detail?id=6525324.

[90] 杨素萍, 赵春贵, 刘瑞田, 曲音波, 钱新民. 沼泽红假单胞菌乙酸光合放氢研究. 生物工程学报[J]. 2002, 18(4): 486-491, http://lib.cqvip.com/Qikan/Article/Detail?id=6597780.

[91] 刘瑞田, 宋欣, 刘相梅, 康从宝, 曲音波. 假单孢菌碱性木聚糖酶分子活性部位的研究. 应用与环境生物学报[J]. 2002, 8(5): 520-524, http://lib.cqvip.com/Qikan/Article/Detail?id=7140884.

[92] 刘瑞田, 曲音波. 木聚糖酶生物学特性及其诱导产生的研究进展. 西安体育学院学报[J]. 2001, http://lib.cqvip.com/Qikan/Article/Detail?id=1000022094.

[93] 刘瑞田, 姜英辉, 高培基, 曲音波. 假单胞菌碱性木聚糖酶的纯化及性质. 微生物学报[J]. 1999, 39(2): 132-, http://lib.cqvip.com/Qikan/Article/Detail?id=3424654.

[94] Liu, RT, Qu, YB, Wang, BM, Zhen, JC, Gao, PJ, Jiang, YH, Yang, GH, Li, ZC, Laskin, AI, Li, GX, Yu, YT. Enzymatic modification of straw pulp and characterization of alkaline xylanases from Pseudomonas sp.. ENZYME ENGINEERING XIV[J]. 1998, 864: 474-478, https://www.webofscience.com/wos/woscc/full-record/WOS:000078305800081.

[95] 刘瑞田, 曲音波. 木聚糖酶分子的结构区域. 生物工程进展[J]. 1998, 18(6): 26-, http://lib.cqvip.com/Qikan/Article/Detail?id=3345353.

[96] 刘瑞田, 曲音波. 木聚糖酶生物学特性及其诱导产生的研究进展. 工业微生物[J]. 1998, http://lib.cqvip.com/Qikan/Article/Detail?id=1000021722.

[97] 刘瑞田, 曲音波. 木聚麦酶基因克隆,表达及序列分析研究. 微生物学通报[J]. 1997, 24(5): 293-296, http://lib.cqvip.com/Qikan/Article/Detail?id=2759026.

[98] 刘瑞田, 曲音波. 木聚糖酶分子结构研究进展. 纤维素科学与技术[J]. 1997, 5(3): 1-6, http://lib.cqvip.com/Qikan/Article/Detail?id=2711201.

科研活动

   
科研项目
( 1 ) 生物药候选药物研究, 主持, 国家级, 2012-01--2015-12
( 2 ) 应用淀粉样蛋白单体过渡态抗原表位治疗和预防阿兹海默病的动物实验研究, 主持, 国家级, 2011-01--2015-12
( 3 ) 淀粉样蛋白聚集结合位点特性及其对实验动物的治疗研究, 主持, 国家级, 2014-01--2017-12
( 4 ) 治疗老年性痴呆多肽药物XD5的临床前研究, 主持, 院级, 2015-06--2017-12
( 5 ) 应用静丙中A-beta寡聚体抗体治疗老年性痴呆的研究, 主持, 院级, 2013-10--2016-12

指导学生

现指导学生

王少伟  博士研究生  081703-生物化工  

季梅  硕士研究生  081703-生物化工  

刘小歌  博士研究生  081703-生物化工  

张凌宵  硕士研究生  081703-生物化工  

刘栋群  博士研究生  081703-生物化工  

黄亚茹   博士研究生  081703-生物化工