​研究方向包括计算机辅助结构优化设计的抗体药物、设计新型治疗性药物载体以及生物药临床前研究。正在研究的项目包含针对阿尔兹海默症等多种淀粉样蛋白疾病的抗体和疫苗等免疫治疗药物的研发。承担或参与多项国家新药创制重大专项、国家自然科学基金和中科院先导专项项目。

   

083100-生物医学工程

生物工程药物

2008-08--2013-11   美国堪萨斯大学   博士研究生
2005-09--2008-07   清华大学   硕士研究生

   

2017-07~现在, 中国科学院过程工程研究所, 副研究员
2014-03~2017-07,中国科学院过程工程研究所, 助理研究员

   

[1] Ruitian Liu. A conditionally releasable "don’t eat me" CD47 signal facilitates microglia-targeted drug delivery for the treatment of Alzheimer's disease. Advanced Functional Materials. 2020, [2] Liu, Dongqun, Lu, Shuai, Zhang, Lingxiao, Ji, Mei, Liu, Shuying, Wang, Shaowei, Liu, Ruitian. An indoleamine 2, 3-dioxygenase siRNA nanoparticle-coated and Trp2-displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice. JOURNAL OF CONTROLLED RELEASE[J]. 2018, 273: 1-12, http://dx.doi.org/10.1016/j.jconrel.2018.01.013.
[3] Liu, ShuYing, Lu, Shuai, Yu, XiaoLin, Yang, ShiGao, Liu, Wen, Liu, XiangMeng, Wang, ShaoWei, Zhu, Jie, Ji, Mei, Liu, DongQun, Zhang, ZiPing, Liu, RuiTian. Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice. CURRENT ALZHEIMER RESEARCH[J]. 2018, 15(9): 856-868, http://ir.ipe.ac.cn/handle/122111/26816.
[4] Huang, Na, Lu, Shuai, Liu, XiaoGe, Zhu, Jie, Wang, YuJiong, Liu, RuiTian. PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering A beta generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer's disease mice. ONCOTARGET[J]. 2017, 8(46): 81001-81013, https://www.webofscience.com/wos/woscc/full-record/WOS:000412465700078.
[5] Yang Shigao, Liu Wen, Tian Yongzhen, Wang Weiyun, Ling Tiejun, Liu Ruitian. A Novel Multifunctional Compound Camellikaempferoside B Decreases Aβ Production, Interferes with Aβ Aggregation, and Prohibits Aβ-Mediated Neurotoxicity and Neuroinflammation. ACS CHEMICAL NEUROSCIENCE[J]. 2016, [6] Ruitian Liu. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer’s disease. Free Radical Biology Medicine. 2014, [7] Lu, Shuai, Lee, Kenneth K, Harris, Bethany, Xiong, Bo, Bose, Tania, Saraf, Anita, Hattem, Gaye, Florens, Laurence, Seidel, Chris, Gerton, Jennifer L. The cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription. EMBO REPORTS[J]. 2014, 15(5): 609-617, https://www.webofscience.com/wos/woscc/full-record/WOS:000335579900027.

   

（ 1 ） Cohesin调控DNA复制和基因组稳定性机制的研究, 主持, 国家级, 2015-01--2017-12
（ 2 ） Cohesin与组蛋白去甲基化酶共同调控肿瘤发生的分子机制研究, 主持, 市地级, 2015-12--2018-11
（ 3 ） 治疗APOE-e4型阿尔茨海默病的特异识别淀粉样蛋白寡聚体抗体的临床前研究, 参与, 部委级, 2017-01--2019-12
（ 4 ） 治疗阿尔茨海默病的寡聚体特异性抗体药物研发, 主持, 国家级, 2018-01--2020-12