081703-生物化工
081701-化学工程

蛋白质药物与疫苗工程

1999-09--2002-12   中国科学院过程工程研究所   博士
1996-09--1999-07   中国科学院武汉病毒研究所   硕士
1992-09--1996-07   湖北农学院   学士

   

2008-11~现在, 中国科学院过程工程研究所, 研究员
2003-03~2008-10,美国Albert Einstein医学院, 博士后

   

（1） 中国科学院院长奖优秀奖, 院级, 2003

[1] 胡涛, 于卫立, 申莉娟, 齐金铭. 一种基于分子内交联和聚乙二醇修饰的尿酸氧化酶及其制备方法. CN: CN112852772A, 2021-05-28.

[2] 胡涛, 齐金铭, 于卫立, 申莉娟. 一种寨卡病毒E蛋白结合疫苗及其制备方法. CN: CN111514286A, 2020-08-11.

[3] 胡涛, 颜文颖, 于卫立, 申莉娟. 一种基于双重化学修饰的血红蛋白氧载体及其制备方法和应用. CN: CN111499732A, 2020-08-07.

[4] 胡涛, 于卫立, 孙笑尉, 申莉娟. 一种基于抗原蛋白多聚体的结核分枝杆菌亚单位疫苗及其制备方法. CN: CN107096019A, 2017-08-29.

[5] 杜昱光, 张贵强, 胡涛, 贾培媛, 刘洪涛. 一种基于化学偶联的壳寡糖疫苗佐剂及其应用. CN: CN106267185A, 2017-01-04.

[6] 胡涛, 于卫立. 一种基于菊粉-壳聚糖修饰的结核分枝杆菌亚单位疫苗及其制备方法. CN: CN105944094A, 2016-09-21.

[7] 胡涛, 于卫立, 黄庆瑞. 一种基于阿拉伯半乳聚糖-聚肌苷酸胞苷酸修饰的结核分枝杆菌亚单位疫苗及其制备方法. CN: CN105903009A, 2016-08-31.

[8] 胡涛, 安文琪, 苏志国, 范蓓, 黄庆瑞, 马小伟, 潘若文. 一种以异型双功能试剂为连接桥的脑膜炎多糖结合疫苗及其制备方法. CN: CN103083652B, 2016-08-10.

[9] 胡涛, 安文琪, 范蓓, 张婷婷, 马小伟, 潘若文. 一种基于聚乙二醇修饰的脑膜炎多糖结合疫苗的制备方法. CN: CN104826104A, 2015-08-12.

[10] 胡涛, 安文琪, 苏志国, 范蓓, 黄庆瑞, 马小伟, 潘若文. 一种以异型双功能试剂为连接桥的脑膜炎多糖结合疫苗及其制备方法. CN: CN104815326A, 2015-08-05.

[11] 胡涛, 季韶洋, 吴玲. 一种PEG-长链脂肪烷定点修饰的人生长激素及其制备方法. CN: CN104592382A, 2015-05-06.

[12] 胡涛, 季韶洋, 乔卫林. 一种β-葡聚糖修饰的脑膜炎多糖结合疫苗及其制备方法. CN: CN104548090A, 2015-04-29.

[13] 胡涛, 薛晓莹, 季韶洋. 热处理提高聚乙二醇化葡激酶的生物活性的方法及应用. CN: CN103725668A, 2014-04-16.

[14] 胡涛, 季韶洋, 苏志国. 一种脑膜炎多糖结合疫苗及其制备方法. CN: CN103690944A, 2014-04-02.

[15] 胡涛, 陈薇, 于长明, 房婷, 付玲, 张金龙, 于婷. 一种具有长连接桥的聚乙二醇化ω-干扰素及其制备工艺. CN: CN103694335A, 2014-04-02.

[16] 胡涛, 王俊, 苏志国, 马光辉, 安红波. 一种聚乙二醇选择性修饰蛋白C端羧基的方法. CN: CN103626831A, 2014-03-12.

[17] 胡涛, 王俊, 苏志国, 马光辉, 刘慎翔. 一种异型双功能连接剂辅助蛋白质的PEG修饰方法. CN: CN103374559A, 2013-10-30.

[18] 胡涛, 安文琪, 苏志国, 范蓓, 吴鼎龙, 马小伟, 潘若文. 一种基于点击化学的肺炎多糖结合疫苗及其制备方法. CN: CN103110940A, 2013-05-22.

[19] 胡涛, 吴玲, 苏志国, 马光辉. 一种定点修饰N-末端的聚乙二醇化生长激素拮抗剂及其制备方法. CN: CN103087182A, 2013-05-08.

[20] 陈薇, 胡涛, 于长明, 房婷, 王俊, 付玲, 张金龙. 一种长效人干扰素及其制备方法. CN: CN103012579A, 2013-04-03.

[21] 苏志国, 马光辉, 王俊, 刘永东, 胡涛. 一种金属螯合介质辅助PEG修饰蛋白质药物的方法. CN: CN102453076A, 2012-05-16.

[22] 苏志国, 马光辉, 王俊, 刘永东, 胡涛. 聚乙二醇-葡激酶偶联物及其制备方法和应用. CN: CN102451471A, 2012-05-16.

[23] 苏志国, 彭飞, 刘永东, 胡涛. 有机溶剂辅助PEG修饰蛋白质药物的方法. CN: CN102309764A, 2012-01-11.

[24] 胡涛, 苏志国, 马光辉, 刘如艳. 重组葡激酶二聚体的制备及聚乙二醇定点修饰. CN: CN102199585A, 2011-09-28.

[25] 苏志国, 胡涛. 分子量均一的聚合血红蛋白的制备方法. CN: CN1232533C, 2005-12-21.

[26] 苏志国, 路秀玲, 郑春杨, 徐宇红, 胡涛. 血红蛋白－人血清白蛋白偶联物制备血液代用品及其制备方法. CN: CN1208346C, 2005-06-29.

   

[1] Wenying Yan, Ming Sheng, Weili Yu, Lijuan Shen, Jinming Qi, Hong Zhou, Tao Hu, Lian Zhao. Hydroxyethyl Starch–Bovine Hemoglobin Conjugateas an Effective Oxygen Carrier with the Ability to Expand Plasma. ACS OMEGA. 2023, 8(12): 11447-11456, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061510/.
[2] Yu, Weili, Shen, Lijuan, Qi, Jinming, Hu, Tao. Conjugation with loxoribine and mannan improves the immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 fusion protein. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS[J]. 2022, 172: 193-202, http://dx.doi.org/10.1016/j.ejpb.2022.02.011.
[3] He, Yunxia, Yu, Weili, Shen, Lijuan, Yan, Wenying, Xiao, Lucheng, Qi, Jinming, Hu, Tao. A SARS-CoV-2 vaccine based on conjugation of SARS-CoV-2 RBD with IC28 peptide and mannan. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2022, 222: 661-670, http://dx.doi.org/10.1016/j.ijbiomac.2022.09.180.
[4] Tang, Xiaozhao, Yu, Weili, Shen, Lijuan, Qi, Jinming, Hu, Tao. Conjugation with 8-arm PEG and CRM(197 )enhances the immunogenicity of SARS-CoV-2 ORF8 protein. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2022, 109: http://dx.doi.org/10.1016/j.intimp.2022.108922.
[5] He, Yunxia, Qi, Jinming, Xiao, Lucheng, Shen, Lijuan, Yu, Weili, Hu, Tao. Purification and characterization of the receptor-binding domain of SARS-CoV-2 spike protein from Escherichia coli. ENGINEERING IN LIFE SCIENCES[J]. 2021, 21(6): 453-460, http://dx.doi.org/10.1002/elsc.202000106.
[6] Qi, Jinming, He, Yunxia, Shen, Lijuan, Yu, Weili, Hu, Tao. Conjugation of Hemoglobin and Mannan Markedly Improves the Immunogenicity of Domain III of the Zika Virus E Protein: Structural and Immunological Study. BIOCONJUGATE CHEMISTRY[J]. 2021, 32(2): 328-338, http://dx.doi.org/10.1021/acs.bioconjchem.0c00700.
[7] Wang, Meiqi, Yu, Weili, Shen, Lijuan, Zheng, He, Guo, Xuan, Zhong, Jinyi, Hu, Tao. Conjugation of haloalkane dehalogenase DhaA with arabinogalactan to increase its stability. JOURNAL OF BIOTECHNOLOGY[J]. 2021, 335: 47-54, http://dx.doi.org/10.1016/j.jbiotec.2021.06.002.
[8] Rui Yu, Junjie Xu, Tao Hu, Wei Chen. The Pneumococcal Polysaccharide-Tetanus Toxin Native C-Fragment Conjugate Vaccine: The Carrier Effect and Immunogenicity. MEDIATORS OF INFLAMMATION[J]. 2020, 2020: https://doaj.org/article/3734f2c1df014fa9933f32906a089e6c.
[9] Qi, Jinming, Yin, Ying, Yu, Weili, Shen, Lijuan, Xu, Junjie, Hu, Tao. Conjugation of beta-Glucan with the Hydrazone and Disulfide Linkers Markedly Improves the Immunogenicity of Zika Virus E Protein. MOLECULAR PHARMACEUTICS[J]. 2020, 17(6): 1933-1944, https://www.webofscience.com/wos/woscc/full-record/WOS:000538337600014.
[10] Yan, Wenying, Shen, Lijuan, Yu, Weili, Wang, Ying, Wang, Quan, You, Guoxing, Zhao, Lian, Zhou, Hong, Hu, Tao. A triply modified human adult hemoglobin with low oxygen affinity, rapid autoxidation and high tetramer stability. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2020, 159: 236-242, http://dx.doi.org/10.1016/j.ijbiomac.2020.05.007.
[11] Yin, Ying, Yu, Weili, Li, Yujie, Liu, Kun, Zai, Xiaodong, Zhang, Jun, Fu, Ling, Hu, Tao, Xu, Junjie, Chen, Wei. Self-conjugated protective antigen elicits strong and durable protective antibody response against anthrax. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 137: 790-800, http://dx.doi.org/10.1016/j.ijbiomac.2019.06.233.
[12] Zheng, He, Yu, WeiLi, Guo, Xuan, Zhao, YuanZhong, Cui, Yan, Hu, Tao, Zhong, JinYi. An effective immobilized haloalkane dehalogenase DhaA from Rhodococcus rhodochrous by adsorption, crosslink and PEGylation on meso-cellular foam. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 125: 1016-1023, http://ir.ipe.ac.cn/handle/122111/27849.
[13] Wang, Tingting, Li, Guang, Wang, Dianbing, Li, Feng, Men, Dong, Hu, Tao, Xi, Yan, Zhang, XianEn. Quantitative profiling of integrin alpha v beta 3 on single cells with quantum dot labeling to reveal the phenotypic heterogeneity of glioblastoma. NANOSCALE[J]. 2019, 11(39): 18224-18231, https://www.webofscience.com/wos/woscc/full-record/WOS:000512634500030.
[14] 胡瞬, 易有金, 胡涛, 李福胜. mRNA疫苗的开发及临床研究进展. 中国生物工程杂志[J]. 2019, 39(11): 105-, https://manu60.magtech.com.cn/biotech/CN/10.13523/j.cb.20191112.
[15] 胡瞬, 胡涛, 贺丽萍, 易有金. 菊糖作为结核分枝杆菌和人乳头瘤病毒疫苗佐剂的免疫原性研究. 现代预防医学[J]. 2019, 46(8): 1478-1482, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849928.
[16] Qi, Fangbing, Qi, Jinming, Hu, Chunyang, Shen, Lijuan, Yu, Weili, Hu, Tao. Conjugation of staphylokinase with the arabinogalactan-PEG conjugate: Study on the immunogenicity, in vitro bioactivity and pharmacokinetics. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 131: 896-904, http://ir.ipe.ac.cn/handle/122111/28152.
[17] 李海霞, 刘坤璐, 贾培媛, 于卫立, 武军华, 胡涛, 王勃, 王玉霞, 单俊杰. 板蓝根多糖IIP-A-1和IIP-2作为疫苗佐剂的免疫原性. 中国药理学与毒理学杂志[J]. 2019, 22-29, http://lib.cqvip.com/Qikan/Article/Detail?id=89766683504849574849484852.
[18] Zhang, Guiqiang, Jia, Peiyuan, Liu, Hongtao, Hu, Tao, Du, Yuguang. Conjugation of chitosan oligosaccharides enhances immune response to porcine circovirus vaccine by activating macrophages. IMMUNOBIOLOGY[J]. 2018, 223(11): 663-670, http://dx.doi.org/10.1016/j.imbio.2018.07.012.
[19] Zhang, Guiqiang, Jia, Peiyuan, Liu, Hongtao, Hu, Tao, Du, Yuguang. Conjugation of chitosan oligosaccharides via a carrier protein markedly improves immunogenicity of porcine circovirus vaccine. GLYCOCONJUGATE JOURNAL[J]. 2018, 35(5): 451-459, http://ir.ipe.ac.cn/handle/122111/26162.
[20] Qi, Fangbing, Hu, Chunyang, Yu, Weili, Hu, Tao. Conjugation with Eight-Arm PEG Markedly Improves the In Vitro Activity and Prolongs the Blood Circulation of Staphylokinase. BIOCONJUGATE CHEMISTRY[J]. 2018, 29(2): 451-458, https://www.webofscience.com/wos/woscc/full-record/WOS:000426144300026.
[21] Wei, Dong, Yu, Weili, Hu, Chunyang, Shen, Lijuan, Hu, Tao. The phenyl linker markedly increases the immunogenicity of the pneumococcal polysaccharide conjugate vaccine. BIOTECHNOLOGY LETTERS[J]. 2018, 40(8): 1263-1270, http://ir.ipe.ac.cn/handle/122111/26696.
[22] Zhang, Jun, Wang, Ying, You, GuoXing, Wang, Quan, Zhang, Shan, Yu, WeiLi, Hu, Tao, Zhao, Lian, Zhou, Hong. Conjugation with 20kDa dextran decreases the autoxidation rate of bovine hemoglobin. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY[J]. 2018, 46(7): 1436-1443, http://ir.ipe.ac.cn/handle/122111/26813.
[23] Zhang, Jun, Wang, Ying, Zhang, Shan, You, GuoXing, Li, PengLong, Wang, Quan, Yu, WeiLi, Hu, Tao, Zhou, Hong, Zhao, Lian. In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY[J]. 2018, 46: S133-S137, http://ir.ipe.ac.cn/handle/122111/28632.
[24] Hua, Shun, Yu, Weili, Hu, Chunyang, Wei, Dong, Shen, Lijuan, Hu, Tao, Yi, Youjin. Conjugation of the CRM197-inulin conjugate significantly increases the immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 fusion protein. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2017, 25(21): 5968-5974, http://dx.doi.org/10.1016/j.bmc.2017.09.027.
[25] Zhao, YuanZhong, Yu, WeiLi, Zheng, He, Guo, Xuan, Guo, Nan, Hu, Tao, Zhong, JinYi. PEGylation with the thiosuccinimido butylamine linker significantly increases the stability of haloalkane dehalogenase DhaA. JOURNAL OF BIOTECHNOLOGY[J]. 2017, 254: 25-33, http://dx.doi.org/10.1016/j.jbiotec.2017.05.022.
[26] Wang, Ying, Wang, Linli, Yu, Weili, Gao, Dawei, You, Guoxing, Li, Penglong, Zhang, Shan, Zhang, Jun, Hu, Tao, Zhao, Lian, Zhou, Hong. A PEGylated bovine hemoglobin as a potent hemoglobin-based oxygen carrier. BIOTECHNOLOGY PROGRESS[J]. 2017, 33(1): 252-260, https://www.webofscience.com/wos/woscc/full-record/WOS:000394889400029.
[27] Wan, Xue, Zhang, Juankun, Yu, Weili, Shen, Lijuan, Ji, Shaoyang, Hu, Tao. Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins. PROCESS BIOCHEMISTRY[J]. 2017, 52: 183-191, http://dx.doi.org/10.1016/j.procbio.2016.09.029.
[28] Wang, Ying, Zhang, Shan, Zhang, Jun, Yu, WeiLi, Gao, DaWei, Wang, Quan, You, GuoXing, Hu, Tao, Zhao, Lian, Zhou, Hong. Structural, functional and physiochemical properties of dextran-bovine hemoglobin conjugate as a hemoglobin-based oxygen carrier. PROCESS BIOCHEMISTRY[J]. 2017, 60: 67-73, https://www.webofscience.com/wos/woscc/full-record/WOS:000413377400009.
[29] Zhang, Guiqiang, Cheng, Gong, Jia, Peiyuan, Jiao, Siming, Feng, Cui, Hu, Tao, Liu, Hongtao, Du, Yuguang. The Positive Correlation of the Enhanced Immune Response to PCV2 Subunit Vaccine by Conjugation of Chitosan Oligosaccharide with the Deacetylation Degree. MARINE DRUGS[J]. 2017, 15(8): https://doaj.org/article/79a8a19d166c41f584a3d7ab87292484.
[30] Zhang, Guiqiang, Cheng, Gong, Jia, Peiyuan, Jiao, Siming, Feng, Cui, Hu, Tao, Liu, Hongtao, Du, Yuguang. The Positive Correlation of the Enhanced Immune Response to PCV2 Subunit Vaccine by Conjugation of Chitosan Oligosaccharide with the Deacetylation Degree (vol 15, 236, 2017). MARINE DRUGS. 2017, 15(9): http://www.irgrid.ac.cn/handle/1471x/1763801.
[31] Chang, Xin, Yu, Weili, Ji, Shaoyang, Shen, Lijuan, Tan, Aijuan, Hu, Tao. Conjugation of PEG-hexadecane markedly increases the immunogenicity crossMark of pneumococcal polysaccharide conjugate vaccine. VACCINE[J]. 2017, 35(13): 1698-1704, http://ir.ipe.ac.cn/handle/122111/22081.
[32] Zhang, Guiqiang, Jia, Peiyuan, Cheng, Gong, Jiao, Siming, Ren, Lishi, Ji, Shaoyang, Hu, Tao, Liu, Hongtao, Du, Yuguang. Enhanced immune response to inactivated porcine circovirus type 2 (PCV2) vaccine by conjugation of chitosan oligosaccharides. CARBOHYDRATE POLYMERS[J]. 2017, 166: 64-72, http://dx.doi.org/10.1016/j.carbpol.2017.02.058.
[33] Sun, Xiaowei, Yu, Weili, Pang, Quanhai, Hu, Tao. Conjugation Reaction with 8-Arm PEG Markedly Improves the Immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 Fusion Protein. BIOCONJUGATE CHEMISTRY[J]. 2017, 28(6): 1658-1668, http://ir.ipe.ac.cn/handle/122111/22700.
[34] Huang, Qingrui, Yu, Weili, Hu, Tao. Potent Antigen-Adjuvant Delivery System by Conjugation of Mycobacterium tuberculosis Ag85B-HspX Fusion Protein with Arabinogalactan-Poly(I:C) Conjugate. BIOCONJUGATE CHEMISTRY[J]. 2016, 27(4): 1165-1174, http://ir.ipe.ac.cn/handle/122111/21012.
[35] Yu, Weili, He, Tao. Conjugation with an Inulin-Chitosan Adjuvant Markedly Improves the Immunogenicity of Mycobacterium tuberculosis CFP10-TB10.4 Fusion Protein. MOLECULAR PHARMACEUTICS[J]. 2016, 13(11): 3626-3635, http://ir.ipe.ac.cn/handle/122111/21652.
[36] Tao Hu. A potent antigen-adjuvant delivery system by conjugation of Mycobacterium tuberculosis Ag85B-HspX fusion protein with arabinogalactan-poly(I:C) conjugate. Bioconjugate Chemistry. 2016, [37] Zhang, Tingting, Yu, Weili, Wang, Yanfei, Hu, Tao. Moderate PEGylation of the carrier protein improves the polysaccharide-specific immunogenicity of meningococcal group A polysaccharide conjugate vaccine. VACCINE[J]. 2015, 33(28): 3208-3214, http://dx.doi.org/10.1016/j.vaccine.2015.04.094.
[38] Wang, Qingqing, Hu, Tao, Sun, Lijing, Ji, Shaoyang, Zhao, Dawei, Liu, Jiaxin, Ma, Guanghui, Su, Zhiguo. CO binding improves the structural, functional, physical and anti-oxidation properties of the PEGylated hemoglobin. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY[J]. 2015, 43(1): 18-25, http://www.irgrid.ac.cn/handle/1471x/945033.
[39] Wu, Ling, Ji, Shaoyang, Hu, Tao. N-Terminal Modification with Pseudo-Bifunctional PEG-Hexadecane Markedly Improves the Pharmacological Profile of Human Growth Hormone. MOLECULAR PHARMACEUTICS[J]. 2015, 12(5): 1402-1411, http://www.irgrid.ac.cn/handle/1471x/960011.
[40] Xu, Mengfang, Xing, Xueqing, Wu, Zhonghua, Du, Yuguang, Hu, Tao. Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine. VACCINE[J]. 2015, 33(43): 5815-5821, http://dx.doi.org/10.1016/j.vaccine.2015.09.021.
[41] Weilin Qiao, Shaoyang Ji, Yubao Zhao, Tao Hu. Conjugation of β-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine. VACCINE. 2015, 33(17): 2066-2072, http://dx.doi.org/10.1016/j.vaccine.2015.02.045.
[42] Qiao, Weilin, Ji, Shaoyang, Zhao, Yubao, Hu, Tao. Conjugation of beta-glucan markedly increase the immunogencity of meningococcal group Y polysaccharide conjugate vaccine. VACCINE[J]. 2015, 33(17): 2066-2072, http://www.irgrid.ac.cn/handle/1471x/945555.
[43] Xue, Xiaoying, Ji, Shaoyang, Mu, Qimeng, Hu, Tao. Heat treatment increases the bioactivity of C-terminally PEGylated staphylokinase. PROCESS BIOCHEMISTRY[J]. 2014, 49(7): 1092-1096, http://dx.doi.org/10.1016/j.procbio.2014.04.001.
[44] Yu, Weili, Yu, Changming, Wu, Ling, Fang, Ting, Qiu, Rui, Zhang, Jinlong, Yu, Ting, Fu, Ling, Chen, Wei, Hu, Tao. PEGylated recombinant human interferon-omega as a long-acting antiviral agent: Structure, antiviral activity and pharmacokinetics. ANTIVIRAL RESEARCH[J]. 2014, 108(AUG): 142-147, http://www.irgrid.ac.cn/handle/1471x/862566.
[45] Wang, Qingqing, Sun, Lijing, Ji, Shaoyang, Zhao, Dawei, Liu, Jiaxin, Su, Zhiguo, Hu, Tao. Reversible protection of Cys-93(beta) by PEG alters the structural and functional properties of the PEGylated hemoglobin. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS[J]. 2014, 1844(7): 1201-1207, http://www.irgrid.ac.cn/handle/1471x/857771.
[46] Qingqing Wang, Lijing Sun, Shaoyang Ji, Dawei Zhao, Jiaxin Liu, Zhiguo Su, Tao Hu. Reversible protection of Cys-93(β) by PEG alters the structural and functional properties of the PEGylated hemoglobin. BBA - PROTEINS AND PROTEOMICS. 2014, 1844(7): 1201-1207, http://dx.doi.org/10.1016/j.bbapap.2014.04.005.
[47] Tao Hu. PEGylated recombinant human interferon-w as a long-acting antiviral agent: Structure, antiviral activity and pharmacokinetics.. Antiviral Research. 2014, [48] Wu, Ling, Ji, Shaoyang, Shen, Lijuan, Hu, Tao. Phenyl Amide Linker Improves the Pharmacokinetics and Pharmacodynamics of N-Terminally Mono-PEGylated Human Growth Hormone. MOLECULAR PHARMACEUTICS[J]. 2014, 11(9): 3080-3089, http://www.irgrid.ac.cn/handle/1471x/862528.
[49] Wu, Dinglong, Ji, Shaoyang, Hu, Tao. Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm. VACCINE[J]. 2013, 31(48): 5623-5626, http://dx.doi.org/10.1016/j.vaccine.2013.09.065.
[50] Huang, Qingrui, Li, Dongxia, Kang, Aijun, An, Wenqi, Fan, Bei, Ma, Xiaowei, Ma, Guanghui, Su, Zhiguo, Hu, Tao. PEG as a spacer arm markedly increases the immunogenicity of meningococcal group Y polysaccharide conjugate vaccine. JOURNAL OF CONTROLLED RELEASE[J]. 2013, 172(1): 382-389, http://dx.doi.org/10.1016/j.jconrel.2013.03.008.
[51] Mu, Qimeng, Hu, Tao, Yu, Jingkai. Molecular Insight into the Steric Shielding Effect of PEG on the Conjugated Staphylokinase: Biochemical Characterization and Molecular Dynamics Simulation. PLOS ONE[J]. 2013, 8(7): http://ir.ipe.ac.cn/handle/122111/13563.
[52] Xue, Xiaoying, Li, Dongxia, Yu, Jingkai, Ma, Guanghui, Su, Zhiguo, Hu, Tao. Phenyl Linker-Induced Dense PEG Conformation Improves the Efficacy of C-Terminally MonoPEGylated Staphylokinase. BIOMACROMOLECULES[J]. 2013, 14(2): 331-341, http://ir.ipe.ac.cn/handle/122111/13559.
[53] Wu, Ling, Ho, Sa V, Wang, Wei, Gao, Jianping, Zhang, Guifeng, Su, Zhiguo, Hu, Tao. N-terminal mono-PEGylation of growth hormone antagonist: Correlation of PEG size and pharmacodynamic behavior. INTERNATIONALJOURNALOFPHARMACEUTICS[J]. 2013, 453(2): 533-540, http://ir.ipe.ac.cn/handle/122111/13531.
[54] Liu, Ruyan, Li, Dongxia, Wang, Jun, Qiu, Rui, Lin, Qixun, Zhang, Guifeng, Ma, Guanghui, Su, Zhiguo, Hu, Tao. Preparation, characterization and in vitro bioactivity of N-terminally PEGylated staphylokinase dimers. PROCESS BIOCHEMISTRY[J]. 2012, 47(1): 41-46, http://dx.doi.org/10.1016/j.procbio.2011.10.004.
[55] Li, Chunju, Lin, Qixun, Wang, Jun, Shen, Lijuan, Ma, Guanghui, Su, Zhiguo, Hu, Tao. Preparation, structural analysis and bioactivity of ribonuclease A-albumin conjugate: Tetra-conjugation or PEG as the linker. JOURNAL OF BIOTECHNOLOGY[J]. 2012, 162(2-3): 283-288, http://dx.doi.org/10.1016/j.jbiotec.2012.09.008.
[56] Wang, Jun, Wang, Yinjue, Hu, Tao, Li, Xiunan, Huang, Yongdong, Liu, Yongdong, Ma, Guanghui, Su, Zhiguo. An oriented adsorption strategy for efficient solid phase PEGylation of recombinant staphylokinase by immobilized metal-ion affinity chromatography. PROCESS BIOCHEMISTRY[J]. 2012, 47(1): 106-112, http://dx.doi.org/10.1016/j.procbio.2011.10.016.
[57] Peng, Fei, Wang, Yinjue, Sun, Lijing, Liu, Yongdong, Hu, Tao, Zhang, Guifeng, Ma, Guanghui, Su, Zhiguo. PEGylation of Proteins in Organic Solution: A Case Study for Interferon beta-1b. BIOCONJUGATE CHEMISTRY[J]. 2012, 23(9): 1812-1820, http://www.irgrid.ac.cn/handle/1471x/779130.
[58] 马洪梅, 张贵锋, 李春, 孔英俊, 高飞, 胡涛, 马光辉, 苏志国. 界面上配基种类对BSA吸附行为的影响. 中国生物工程杂志[J]. 2012, 32(7): 53-59, http://lib.cqvip.com/Qikan/Article/Detail?id=42578308.
[59] Hu, Tao, Li, Dongxia, Wang, Jun, Wang, Qingqing, Liang, Yangui, Su, Yanlei, Ma, Guanghui, Su, Zhiguo, Wang, Shihua. Propylbenzmethylation at Val-1(alpha) markedly increases the tetramer stability of the PEGylated hemoglobin: A comparison with propylation at Val-1(alpha). BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS[J]. 2012, 1820(12): 2044-2051, http://www.irgrid.ac.cn/handle/1471x/725183.
[60] Liu, Shenxiang, Sun, Lijing, Wang, Jun, Ma, Guanghui, Su, Zhiguo, Hu, Tao. Mono-PEGylation of ribonuclease A: High PEGylation efficiency by thiolation with small molecular weight reagent. PROCESS BIOCHEMISTRY[J]. 2012, 47(9): 1364-1370, http://dx.doi.org/10.1016/j.procbio.2012.05.003.
[61] Wang, Jun, Hu, Tao, Liu, Yongdong, Zhang, Guifeng, Ma, Guanghui, Su, Zhiguo. Kinetic and stoichiometric analysis of the modification process for N-terminal PEGylation of staphylokinase. ANALYTICAL BIOCHEMISTRY[J]. 2011, 412(1): 114-116, http://dx.doi.org/10.1016/j.ab.2010.12.030.
[62] Tao Hu. Increased inter dimeric interaction of oxy hemoglobin is necessary for attenuation of reductive Pegylation promoted dissociation of tetramer. Artificial Cells, Blood Substitutes, and Biotechnology. 2011, [63] Wang, YinJue, Liu, YongDong, Chen, Jing, Hao, SuJuan, Hu, Tao, Ma, GuangHui, Su, ZhiGuo. Efficient preparation and PEGylation of recombinant human non-glycosylated erythropoietin expressed as inclusion body in E. coli. INTERNATIONAL JOURNAL OF PHARMACEUTICS[J]. 2010, 386(1-2): 156-164, http://www.irgrid.ac.cn/handle/1471x/778891.
[64] Li, Suping, Hu, Tao, Chen, Yali, Zheng, Chunyang, Liu, Tao, Ma, Guanghui, Su, Zhiguo. Cross-linked inulin as a potential plasma expander: Biochemical properties and physiological characterization in a rabbit model. CARBOHYDRATE POLYMERS[J]. 2010, 82(4): 1054-1060, http://dx.doi.org/10.1016/j.carbpol.2010.06.018.
[65] Li, Suping, Hu, Tao, Chen, Yali, Wang, Xianwei, Liu, Tao, Ma, Guanghui, Su, Zhiguo. Chemically modified konjac glucomannan with high colloid osmotic pressure: Physiological evaluation in a rabbit model as a plasma substitute. GLYCOBIOLOGY[J]. 2010, 20(8): 950-958, http://www.irgrid.ac.cn/handle/1471x/740235.
[66] Wang, YinJue, Hao, SuJuan, Liu, YongDong, Hu, Tao, Zhang, GuiFeng, Zhang, Xuan, Qi, QingSheng, Ma, GuangHui, Su, ZhiGuo. PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin. JOURNAL OF CONTROLLED RELEASE[J]. 2010, 145(3): 306-313, http://dx.doi.org/10.1016/j.jconrel.2010.04.021.
[67] Suo, Xiaoyan, Lu, Xiuling, Hu, Tao, Ma, Guanghui, Su, Zhiguo. A solid-phase adsorption method for PEGylation of human serum albumin and staphylokinase: preparation, purification and biochemical characterization. BIOTECHNOLOGY LETTERS[J]. 2009, 31(8): 1191-1196, http://www.irgrid.ac.cn/handle/1471x/778919.

   

（ 1 ） 中国科学院****择优支持, 主持, 部委级, 2011-01--2013-12
（ 2 ） 聚乙二醇修饰血红蛋白四聚体的稳定性研究, 主持, 国家级, 2010-01--2012-12
（ 3 ） 关于多糖结合疫苗研究的合作开发, 主持, 研究所（学校）, 2009-06--2011-05
（ 4 ） 长效w-干扰素的合作开发, 主持, 研究所（学校）, 2010-10--2012-09
（ 5 ） 基于分子识别的肺炎多糖结合疫苗的制备及其免疫学性质的研究, 主持, 省级, 2014-01--2016-12
（ 6 ） 多糖结合疫苗的研究与开发, 主持, 部委级, 2014-01--2016-12
（ 7 ） 登革病毒免疫原的化学偶联技术, 主持, 部委级, 2015-01--2017-12
（ 8 ） 多糖结合疫苗的研究与开发, 主持, 研究所（学校）, 2014-07--2017-06

已指导学生

刘如艳  硕士研究生  081703-生物化工  

刘慎翔  硕士研究生  430117-化学工程  

吴玲  博士研究生  081703-生物化工  

薛晓莹  博士研究生  081703-生物化工  

许孟芳  硕士研究生  085238-生物工程  

黄庆瑞  博士研究生  081703-生物化工  

现指导学生

祁芳冰  博士研究生  081703-生物化工  

于卫立  博士研究生  081703-生物化工  

卫东  硕士研究生  085238-生物工程  

齐金铭  博士研究生  081703-生物化工  

贺云霞   博士研究生  081703-生物化工