分子影像

   

071010-生物化学与分子生物学
071011-生物物理学

分子探针的设计与构建，分子影像
肿瘤靶向治疗

1994-09--1997-06   中国原子能科学研究院   同位素技术专业博士学位
1988-09--1991-06   吉林大学   生物化学硕士学位
1984-09--1988-06   吉林大学   理学学士

   

[1] 王凡, 史继云, 高瀚男, 贾兵. 一种用于肿瘤的靶向放射与免疫联合治疗的药物组合物. CN: CN 113616818 B, 2023-04-25.

[2] 王凡, 史继云, 高宇, 罗麒, 于悦, 孙以宁. 一种白介素2突变体放射性药物的制备方法及应用. 202211594195.8, 2022-12-14.

[3] 王凡, 梁晓龙, 马晓途, 史继云, 姚美男. 一种全氟化碳硅质体及其制备方法和应用. CN: CN112546062B, 2022-08-19.

[4] 王凡, 史继云, 马晓途. 一种肿瘤靶向型放疗增敏脂质体纳米制剂及其制备方法. CN: CN110859805B, 2021-05-14.

[5] 王凡, 史继云, 罗麒, 贾兵. 一种Dar2多肽放射性药物及其制备方法. CN: CN111228521B, 2021-03-19.

[6] 王凡, 史继云, 杜帅樊, 贾兵, 高瀚男, 罗麒, 罗创维. 一种靶向HER2的D型多肽放射性药物及制备方法. CN: CN109045313B, 2020-02-18.

[7] 王凡, 史继云, 罗麒, 贾兵. 一种靶向整合素α 6 的二聚体多肽放射性药物及其制备方法. CN: CN110420337A, 2019-11-08.

[8] 王凡, 史继云, 杜帅樊, 贾兵. 一种靶向HER2的rk多肽放射性药物及其制备方法. CN: CN110339375A, 2019-10-18.

[9] 王凡, 史继云, 贾兵, 高瀚男. 一种结构修饰的RGD多肽的核医学药物. CN: CN110227169A, 2019-09-13.

[10] 王凡, 史继云, 翟洛萍. 一种双重酸敏性脂质体、以其为载体的药物及其制备方法. CN: CN110200916A, 2019-09-06.

[11] 王凡, 史继云, 高瀚男. 一种基于2PisoDGR 2 多肽的放射性药物及其制备方法. CN: CN110101880A, 2019-08-09.

[12] 王凡, 梁晓龙, 张旭, 李小达, 史继云, 马晓途, 侯睿. 一种硅质体纳米粒子药物载体及其诊断治疗制剂和制备方法. CN: CN109602907A, 2019-04-12.

[13] 王凡, 梁晓龙, 侯睿, 李小达, 史继云, 马晓途, 张旭. 一种用于超声诊断和声动力治疗的微泡制剂及其制备方法. CN: CN109529063A, 2019-03-29.

[14] 王凡, 李小达, 梁晓龙, 史继云, 贾兵, 马晓途, 高瀚男, 张欣, 姚美男, 邵楠, 张旭, 侯睿. 一种肿瘤诊断治疗制剂及其制备方法和应用. CN: CN107890566A, 2018-04-10.

[15] 王凡, 李小达, 梁晓龙, 史继云, 贾兵, 马晓途, 高瀚男, 张欣, 姚美男, 邵楠, 张旭, 侯睿. 一种纳米粒子肿瘤诊断治疗联用制剂及其制备方法和应用. CN: CN107837404A, 2018-03-27.

[16] 王凡, 梁晓龙, 马晓途, 李小达, 史继云, 姚美男, 邵楠, 张旭, 侯睿. 一种具有多重刺激响应型药物控释功能的诊断治疗制剂及其制备方法和应用. CN: CN107596366A, 2018-01-19.

[17] 王凡, 梁晓龙, 房雷, 李小达. 一种基于近红外染料‑透明质酸复合物的诊断治疗制剂. CN: CN107303388A, 2017-10-31.

[18] 王凡, 史继云, 高翰男, 梁晓龙, 贾兵. 一种卟啉脂质体放射性药物99mTc‑Texaphyrin NPs及其制备方法. CN: CN107224592A, 2017-10-03.

[19] 王凡, 史继云, 高翰男, 梁晓龙, 贾兵. 一种卟啉脂质体放射性药物64Cu‑Texaphyrin NPs及其制备方法. CN: CN107224591A, 2017-10-03.

[20] 王凡, 董诚岩, 胡志远, 史继云, 贾兵, 王子华, 李立强, 吴越, 刘昭飞, 赵慧云. 一种靶向HER2的新型多肽放射性药物及其制备方法和应用. CN: CN106581700A, 2017-04-26.

[21] 王凡, 史继云, 赵海涛, 贾兵. 一种isoDGR多肽放射性药物及其制备方法和应用. CN: CN106492237A, 2017-03-15.

[22] 王凡, 刘昭飞, 贾兵, 史继云, 董诚岩, 赵慧云. 一种肿瘤双靶点放射性分子探针及其制备方法. CN: CN103800923A, 2014-05-21.

[23] 王凡, 刘昭飞, 贾兵, 史继云, 董诚岩, 赵慧云. 一种靶向整合素α v β 6 的多肽放射性药物及其制备方法. 中国: CN103784981A, 2014-05-14.

[24] 王凡, 刘昭飞, 贾兵, 史继云, 董诚岩, 赵慧云. 一种靶向整合素α v β 6 的多肽放射性药物及其制备方法. CN: CN103784981A, 2014-05-14.

[25] 王凡, 史继云, 贾兵, 刘昭飞, 赵慧云. 一种新型VQ多肽放射性药物及其制备方法. CN: CN103330951A, 2013-10-02.

[26] 王凡, 贾兵, 杨志. 一种用于胃癌治疗的药物及其制备方法. CN: CN101091799B, 2010-04-14.

[27] 王凡, 贾兵, 杨志. 一种用于胃癌诊断的药物及其制备方法. CN: CN101670120A, 2010-03-17.

[28] 王凡, 史继云, 贾兵. 放射性核素标记的RGD多肽药物及其制备方法. CN: CN101485891A, 2009-07-22.

[29] 王凡, 史继云, 贾兵. 用于integrinα v β 3 阳性肿瘤的RGD多肽放射性药物及其制备方法. CN: CN101474415A, 2009-07-08.

[30] 王凡, 贾兵, 史继云. 一种RGD多肽放射性药物及其制备方法. CN: CN101428148A, 2009-05-13.

[31] 王凡, 贾兵, 杨志. 一种用于胃癌诊断的药物及其制备方法. 中国: CN101091800, 2007-12-26.

   

[1] Jiyun Shi, Shuaifan Du, Rongxi Wang, Hannan Gao, Qi Luo, Guozhu Hou, Yidong Zhou, Zhaohui Zhu, Fan Wang. Molecular imaging of HER2 expression in breast cancer patients using a novel peptide-based tracer 99m Tc-HP-Ark2: a pilot study. JOURNAL OF TRANSLATIONAL MEDICINE[J]. 2023, 21(1): 1-17, http://dx.doi.org/10.1186/s12967-022-03865-y.
[2] Yu Gao, Qi Luo, Zhichen Sun, Hannan Gao, Yue Yu, Yining Sun, Xiaotu Ma, Chuanhui Han, Jiyun Shi, Fan Wang. Implication of 99mTc-sum IL-2 SPECT/CT in immunotherapy by imaging of tumor-infiltrating T cells. JOURNAL FOR IMMUNOTHERAPY OF CANCER[J]. 2023, 11(3): https://doaj.org/article/ad84fce022a64279a6c58dc1361591a2.
[3] Shi, Linqing, Chen, Bo, Liu, Tianyu, Li, Liqiang, Hu, Biao, Li, Chenzhen, Jia, Bing, Wang, Fan. Tc-99m-CD3813: A Nanobody-Based Single Photon Emission Computed Tomography Radiotracer with Clinical Potential for Myeloma Imaging and Evaluation of CD38 Expression. MOLECULAR PHARMACEUTICS[J]. 2022, 19(7): 2583-2594, http://dx.doi.org/10.1021/acs.molpharmaceut.2c00279.
[4] Yang, Guangjie, Gao, Hannan, Luo, Chuangwei, Zhao, Xiaoyu, Luo, Qi, Shi, Jiyun, Wang, Fan. Palmitic Acid-Conjugated Radiopharmaceutical for Integrin alpha(v)beta(3)-Targeted Radionuclide Therapy. PHARMACEUTICS[J]. 2022, 14(7): [5] Liu Tianyu, Wu Yue, Shi Linqing, Li Liqiang, Hu Biao, Wang Yanpu, Gao Hannan, Yu Xiaolu, Zhang Xin, Zhao Huiyun, Wan Yakun, Jia Bing, Wang Fan. Preclinical evaluation of [99mTc]Tc-labeled anti-EpCAM nanobody for EpCAM receptor expression imaging by immuno-SPECT/CT. EOROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING[J]. 2022, 49: 1810-1821, https://link.springer.com/article/10.1007/s00259-021-05670-z.
[6] Qi Luo, Yunwei Zhang, Zihua Wang, Yining Sun, Linqing Shi, Yue Yu, Jiyun Shi, Zhiyuan Hu, Fan Wang. A novel peptide-based probe^(99m)Tc-PEG_(6)-RD-PDP2 for the molecular imaging of tumor PD-L2 expression. 中国化学快报:英文版[J]. 2022, 33(7): 3497-3501, http://lib.cqvip.com/Qikan/Article/Detail?id=7107696973.
[7] Zhai Luoping, Luo Chuangwei, Gao Hannan, Du Shuaifan, Shi Jiyun, Wang Fan. A Dual pH-Responsive DOX-Encapsulated Liposome Combined with Glucose Administration Enhanced Therapeutic Efficacy of Chemotherapy for Cancer. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2021, 16: 3185-3199, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121622/.
[8] Zhao Haitao, Gao Hannan, Luo Chuangwei, Yang Guangjie, Zhao Xiaoyu, Gao Shi, Ma Qingjie, Jia Bing, Shi Jiyun, Wang Fan. An Integrin-αvβ6/α5β1-Bitargeted Probe for the SPECT Imaging of Pancreatic Adenocarcinoma in Preclinical and Primary Clinical Studies. BIOCONJUGATE CHEMISTRY[J]. 2021, 32(7): 1298-1305, https://pubs.acs.org/doi/abs/10.1021/acs.bioconjchem.1c00296.
[9] Zhang, Changlu, Gao, Yanan, Du, Chengzhi, Markowitz, Geoffrey J, Fu, Jing, Zhang, Zhenxing, Liu, Chunliang, Qin, Wenhao, Wang, Hongyang, Wang, Fan, Yang, Pengyuan. Hepatitis B-Induced IL8 Promotes Hepatocellular Carcinoma Venous Metastasis and Intrahepatic Treg Accumulation. CANCER RESEARCH[J]. 2021, 81(9): 2386-2398, http://dx.doi.org/10.1158/0008-5472.CAN-20-3453.
[10] Gao, Yu, Luo, Qi, Luo, Chuangwei, Ma, Xiaotu, Shi, Jiyun, Wang, Fan. Tc-99m-labeled Mutant Interleukin-2 as a Promising SPECT Probe for in vivo Imaging of Tumor-Infiltrating T Cells. JOURNAL OF NUCLEAR MEDICINEnull. 2020, 61: https://www.webofscience.com/wos/woscc/full-record/WOS:000568290500144.
[11] Wu, Yue, Li, Liqiang, Wang, Zihua, Shi, Jiyun, Hu, Zhiyuan, Gao, Shi, Miao, Weibing, Ma, Qingjie, Dong, Chengyan, Wang, Fan. Imaging and monitoring HER2 expression in breast cancer during trastuzumab therapy with a peptide probe(99m)Tc-HYNIC-H10F. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING[J]. 2020, 47(11): 2613-2623, [12] Gao, Hannan, Yang, Guangjie, Luo, Chuangwei, Jia, Bing, Shi, Jiyun, Wang, Fan. A long-acting radiolabeled RGD analogue Lu-177-AB-3PRGD2 for targeted radiotherapy of tumor. JOURNALOFLABELLEDCOMPOUNDSRADIOPHARMACEUTICALSnull. 2019, 62: S43-S44, https://www.webofscience.com/wos/woscc/full-record/WOS:000468965200026.
[13] Liu, Tianyu, Wu, Yue, Gao, Hannan, Jia, Bing, Wang, Fan. Stable site-specific labeling of nanobodies with Tc-99m for SPECT imaging. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALSnull. 2019, 62: S423-S425, [14] Feng, Xun, Liu, Hao, Gao, Liquan, Shi, Jiyun, Jia, Bing, Liu, Zhaofei, Wang, Fan. A Tc-99m-labeled cyclic peptide for integrin alpha v beta 6-targeted SPECT/CT imaging of tumor and pulmonary fibrosis in preclinical mouse models. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALSnull. 2019, 62: S464-S465, [15] Liu, Tianyu, Wu, Yue, Shi, Linqing, Wang, Yanpu, Gao, Hannan, Hu, Biao, Zhang, Xin, Zhao, Huiyun, Wan, Yakun, Jia, Bing, Wang, Fan. Preclinical evaluation of Tc-99m-labeled anti-EpCAM nanobody conjugates for imaging EpCAM receptor expression by immuno-SPECT. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS[J]. 2019, 62: S60-S62, [16] Wu, Yue, Gao, Hannan, Liu, Tianyu, Hu, Biao, Zhang, Xin, Wan, Yakun, Shi, Jiyun, Jia, Bing, Wang, Fan. Imaging-guided anti-PD-L1 immunotherapy with SPECT/CT of Tc-99m-labeled nanobody. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS[J]. 2019, 62: S443-S444, https://www.webofscience.com/wos/woscc/full-record/WOS:000468965200367.
[17] Liu Hao, Gao Liquan, Yu Xinhe, Zhong Lijun, Shi Jiyun, Jia Bing, Li Nan, Liu Zhaofei, Wang Fan. Small-animal SPECT/CT imaging of cancer xenografts and pulmonary fibrosis using a ~(99m)Tc-labeled integrin avb6-targeting cyclic peptide with improved in vivo stability. BIOPHYSICS REPORTS[J]. 2018, 4(5): 254-264, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6380053&detailType=1.
[18] Fan, Di, Shi, Jiyun, Zhai Luoping, Gao, Hannan, Zhang, Xin, Wang, Kai, Qiao, Zhen, Chen, Qian, Zhao, Xiaobin, Ai, Lin, Wang, Fan. Lu-177-labeled Payloaded Liposome for SPECT/Optical Dual-modality Imaging and Combined Radio- and Chemotherapy in LLC Mice Model. JOURNAL OF NUCLEAR MEDICINEnull. 2018, 59: https://www.webofscience.com/wos/woscc/full-record/WOS:000467489901306.
[19] 李立强, 董诚岩, 杨志, 贾兵, 王凡. 肿瘤阳离子显像剂~（111）In-TPP类似物的制备与生物学评价. 中华核医学与分子影像杂志[J]. 2017, 37(1): 20-24, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5906943&detailType=1.
[20] 刘昭飞, 杨志, 王凡. 精准医学时代的SPECT显像探针：挑战与机遇. 中华核医学与分子影像杂志[J]. 2017, 37(1): 2-4, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5906939&detailType=1.
[21] Wang Fan. SPECT/CT Imaging of the Novel HER2-Targeted Peptide Probe 99mTc-HYNIC-H6F in Breast Cancer Mouse Models.. J Nucl Med.. 2017, [22] Zhang, Xin, Chen, Muhua, Dong, Chengyan, Wang, Bing, Wang, Shu, Ji, Bing, Wang, Fan. Radiolabeled PTP Derivative for Pre- and Intraoperative Mapping of Lymph Nodes by SPECT/Optical Dual-Modality Imaging. JOURNAL OF NUCLEAR MEDICINEnull. 2016, 57: https://www.webofscience.com/wos/woscc/full-record/WOS:000442211001375.
[23] Ma Teng, Liu Hao, Sun Xianlei, Gao Liquan, Shi Jiyun, Zhao Huiyun, Jia Bing, Wan Fan, Liu Zhaofei, Ma Teng, Liu Hao, Sun Xianlei, Gao Liquan, Jia Bing, Wan Fan, Liu Zhaofei, Shi Jiyun, Zhao Huiyun. Serial in Vivo Imaging Using a Fluorescence Probe Allows Identification of Tumor Early Response to Cetuximab Immunotherapy. 2016, http://www.chinaxiv.org/abs/201605.01245.
[24] Wang Fan. Small-Animal SPECT/CT of the Progression and Recovery of Rat Liver Fibrosis by Using an Integrin αvβ3-targeting Radiotracer.. Radiology. 2016, [25] Chengyan Dong, Zhaofei Liu, Fan Wang. Radioligand saturation binding for quantitative analysis of ligand-receptor interactions. BIOPHYSICS REPORTS. 2016, 1(3): 148-155, http://dx.doi.org/10.1007/s41048-016-0016-5.
[26] Zhang, Zhaoqi, Zhao, Xinming, Ding, Cuimin, Wang, Jianfang, Zhang, Jingmian, Wang, Fan. Tc-99m-3PRGD2 SPECT/CT Imaging for Monitoring Early Response of EGFR-TKIs Therapy in Patients with Advanced-Stage Lung Adenocarcinoma. CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS[J]. 2016, 31(7): 238-245, https://www.webofscience.com/wos/woscc/full-record/WOS:000383587300002.
[27] Wang Fan. (99m)Tc-HisoDGR as a Potential SPECT Probe for Orthotopic Glioma Detection via Targeting of Integrin α5β1.. Bioconjug Chem. 2016, [28] Lijia Jing, Jiyun Shi, Yaqian Li, Di Fan, Renfa Liu, Zhifei Dai, Fan Wang, Jie Tian. 177Lu -Labeled Cerasomes Encapsulating Indocyanine Green for Cancer Theranostics. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201804160009532LZ.
[29] Yu, Xinhe, Wu, Yue, Liu, Hao, Gao, Liquan, Zhang, Chenran, Shi, Jiyun, Jia, Bing, Liu, Zhaofei, Wang, Fan. Integrin alpha v beta 3-targeted small-animal SPECT/CT of the progression and recovery of liver fibrosis in a rat model. JOURNAL OF NUCLEAR MEDICINEnull. 2015, 56(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000358738801306.
[30] Li, Peng, Wu, Ping, Xin, Xue, Fan, YunLi, Wang, GuiBin, Wang, Fan, Ma, MengYing, Xue, MingMing, Luo, YiXiao, Yang, FuDe, Bao, YanPing, Shi, Jie, Sun, HongQiang, Lu, Lin. Incubation of alcohol craving during abstinence in patients with alcohol dependence. ADDICTION BIOLOGY[J]. 2015, 20(3): 513-522, https://www.webofscience.com/wos/woscc/full-record/WOS:000352652200009.
[31] Wang Fan. (68)Ga-labeled 3PRGD2 for dual PET and Cerenkov luminescence imaging of orthotopic human glioblastoma.. Bioconjug Chem.. 2015, [32] Zhu, Zhaohui, Zhao, Xinming, Li, Mei, Yang, Aimin, Xin, Jun, Zhao, Zhoushe, Wang, Fan, Li, Fang. Tc-99m-3PRGD2 SPECT/CT integrin receptor imaging in response evaluation of non-small cell lung cancer: a multicenter clinical study. JOURNAL OF NUCLEAR MEDICINEnull. 2015, 56(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000358738800129.
[33] Liu, Kaiyu, Liu, Xujie, Peng, Zhiping, Sun, Haojie, Zhang, Mingzhi, Zhang, Jianning, Liu, Shuang, Hao, Limin, Lu, Guoqiu, Zheng, Kangcheng, Gong, Xikui, Wu, Di, Wang, Fan, Shen, Li. Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging. ONCOTARGET[J]. 2015, 6(27): 23735-23747, https://www.webofscience.com/wos/woscc/full-record/WOS:000363157700051.
[34] Shi, Jiyun, Fan, Di, Zhang, Xin, Yang, Li, Sun, Yi, Zhao, Huiyun, Zhu, Zhaohui, Jia, Bing, Wang, Fan. PET imaging of tumor metastasis using 68Ga-labeled a novel tumor-homing peptide TMTP1. JOURNAL OF NUCLEAR MEDICINEnull. 2014, 55: https://www.webofscience.com/wos/woscc/full-record/WOS:000361438101250.
[35] Wang Fan. 177Lu-labeled antibodies for EGFR-targeted SPECT/CT imaging and radioimmunotherapy in a preclinical head and neck carcinoma model. Mol Pharm. 2014, [36] Liu, Zhaofei, Sun, Xianlei, Liu, Hao, Ma, Teng, Shi, Jiyun, Jia, Bing, Zhao, Huiyun, Wang, Fan. Early Assessment of Tumor Response to Gefitinib Treatment by Noninvasive Optical Imaging of Tumor Vascular Endothelial Growth Factor Expression in Animal Models. JOURNAL OF NUCLEAR MEDICINE[J]. 2014, 55(5): 818-823, http://dx.doi.org/10.2967/jnumed.113.133660.
[37] Wang, Chao, Chen, Muhua, Dong, Chengyan, Zhao, Huiyun, Shi, Jiyun, Liu, Zhaofei, Jia, Bing, Wang, Fan. Improving stability of IF 10 peptide based Annexin 1 targeting probes for colon cancer detection. JOURNAL OF NUCLEAR MEDICINEnull. 2014, 55: https://www.webofscience.com/wos/woscc/full-record/WOS:000361438101176.
[38] Wang Fan. PET Imaging of Neovascularization with (68)Ga-3PRGD2 for Assessing Tumor Early Response to Endostar Antiangiogenic Therapy. Mol Pharm. 2014, [39] Yu, Qingsong, Dong, Chengyan, Zhang, Jiajing, Shi, Jiyun, Jia, Bing, Wang, Fan, Gan, Zhihua. Synthesis of poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl) methacrylamide) block copolymers with well-defined structures and their influence on in vivo circulation and biodistribution. POLYMER CHEMISTRY[J]. 2014, 5(19): 5617-5627, http://dx.doi.org/10.1039/c4py00681j.
[40] Jiyun Shi, Di Fan, Chengyan Dong, Hao Liu, Bing Jia, Huiyun Zhao, Xiaona Jin, Zhaofei Liu, Fang Li, Fan Wang. Anti-tumor Effect of Integrin Targeted 177 Lu-3PRGD 2 and Combined Therapy with Endostar. THERANOSTICS. 2014, 4(3): 256-266, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915089/.
[41] Dong, C, Liu, Z, Wang, F. Peptide-based Radiopharmaceuticals for Targeted Tumor Therapy. CURRENT MEDICINAL CHEMISTRY[J]. 2014, 21(1): 139-152, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000327778900010.
[42] 王凡. 新型肿瘤特异性核医学分子探针及应用展望. 生物产业技术[J]. 2014, 24-28, http://lib.cqvip.com/Qikan/Article/Detail?id=662719825.
[43] Liu, Zhaofei, Ma, Teng, Sun, Xianlei, Liu, Hao, Shi, Jiyun, Wang, Fan. Near-infrared fluorescence imaging for assessing the early tumor response to cetuximab. JOURNAL OF NUCLEAR MEDICINEnull. 2014, 55: https://www.webofscience.com/wos/woscc/full-record/WOS:000361438102104.
[44] Li, Yang, Liu, Zhaofei, Dong, Chengyan, He, Peng, Liu, Xujie, Zhu, Zhaohui, Jia, Bing, Li, Fang, Wang, Fan. Noninvasive Detection of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Teratoma with an Integrin-Targeting Agent Tc-99m-3PRGD2. MOLECULAR IMAGING AND BIOLOGY[J]. 2013, 15(1): 58-67, http://dx.doi.org/10.1007/s11307-012-0571-1.
[45] Shi, Jiyun, Cui, Liyang, Jia, Bing, Liu, Zhaofei, He, Peng, Dong, Chengyan, Jin, Xiaona, Zhao, Huiyun, Li, Fang, Wang, Fan. Technetium 99m-Labeled VQ Peptide: A New Imaging Agent for the Early Detection of Tumors or Premalignancies. MOLECULAR IMAGING[J]. 2013, 12(5): https://doaj.org/article/f135027d62c14091a0180537da77cf6b.
[46] Cui, Liyang, Liu, Zhaofei, Jin, Xiaona, Jia, Bing, Li, Fang, Wang, Fan. Evaluation of Re-188-MAG(2)-RGD-bombesin for potential prostate cancer therapy. NUCLEAR MEDICINE AND BIOLOGY[J]. 2013, 40(2): 182-189, http://dx.doi.org/10.1016/j.nucmedbio.2012.11.002.
[47] Liu, Zhaofei, Cui, Liyang, Liu, Xujie, Wang, Fan. Noninvasive small-animal PET of trastuzumab-mediated EGFR downregulation with Ga-68-Vec(Fab'). JOURNAL OF NUCLEAR MEDICINEnull. 2012, 53: https://www.webofscience.com/wos/woscc/full-record/WOS:000443680200330.
[48] Liu, Zhaofei, Huang, Jinming, Dong, Chengyan, Cui, Liyang, Jin, Xiaona, Jia, Bing, Zhu, Zhaohui, Li, Fang, Wang, Fan. Tc-99m-Labeled RGD-BBN Peptide for Small-Animal SPECT/CT of Lung Carcinoma. MOLECULAR PHARMACEUTICS[J]. 2012, 9(5): 1409-1417, http://dx.doi.org/10.1021/mp200661t.
[49] Liu, Zhaofei, Huang, Jinming, Dong, Chengyan, Cui, Liyang, Jia, Bing, Wang, Fan. Small-animal SPECT/CT of lung carcinoma with Tc-99m-labeled RGD-BBN peptide. JOURNAL OF NUCLEAR MEDICINEnull. 2012, 53: https://www.webofscience.com/wos/woscc/full-record/WOS:000443680203271.
[50] Dong, Chengyan, Fan, Di, Liu, Hao, Shi, Jiyun, Zhao, Huiyun, Liu, Zhaofei, Jia, Bing, Wang, Fan. Gefitinib pre-treatment increases the tumor uptake of Tc-99m-3PRGD2. JOURNAL OF NUCLEAR MEDICINEnull. 2012, 53: https://www.webofscience.com/wos/woscc/full-record/WOS:000443680200321.
[51] Shi, Ximin, Wu, Chenxi, Zhu, Zhaohui, Wang, Fan, Li, Fang. High-quality imaging of angiogenesis in rat myocardial infarction and stroke models using 99mTc-3PRGD2 nanoSPECT/CT. JOURNAL OF NUCLEAR MEDICINEnull. 2012, 53: https://www.webofscience.com/wos/woscc/full-record/WOS:000443680203341.
[52] Liu, Zhaofei, Li, Yang, Dong, Chengyan, Jia, Bing, Wang, Fan. Tc-99m-3PRGD2 SPECT/CT allows noninvasive detection of human induced pluripotent stem cell (hiPSC)-derived teratoma. JOURNAL OF NUCLEAR MEDICINEnull. 2012, 53: https://www.webofscience.com/wos/woscc/full-record/WOS:000443680200216.
[53] Liu, Zhaofei, He, Peng, Zhao, Huiyun, Jia, Bing, Wang, Fan. Improving tumor responses by combining EGFR tyrosine kinase inhibitor gefitinib with I-131-hEGF radionuclide therapy. JOURNAL OF NUCLEAR MEDICINEnull. 2012, 53: https://www.webofscience.com/wos/woscc/full-record/WOS:000443680200169.
[54] 王凡. 99Tcm放射性药物的发展与机遇. 中华核医学杂志[J]. 2011, 31(1): 2-3, http://lib.cqvip.com/Qikan/Article/Detail?id=37009328.
[55] Liu, Zhaofei, He, Peng, Liu, Xujie, Wang, Fan. EGFR tyrosine kinase inhibitor ZD1839 mediates significantly increased tumor uptake of hEGF in nude mouse models. JOURNAL OF NUCLEAR MEDICINEnull. 2011, 52: https://www.webofscience.com/wos/woscc/full-record/WOS:000443798902188.
[56] Liu, Zhaofei, Shi, Jiyun, Jia, Bing, Yu, Zilin, Liu, Yan, Zhao, Huiyun, Li, Fang, Tian, Jie, Chen, Xiaoyuan, Liu, Shuang, Wang, Fan. Two Y-90-Labeled Multimeric RGD Peptides RGD4 and 3PRGD2 for Integrin Targeted Radionuclide Therapy. MOLECULAR PHARMACEUTICS[J]. 2011, 8(2): 591-599, http://dx.doi.org/10.1021/mp100403y.
[57] Liu, Zhaofei, Jia, Bing, Zhao, Huiyun, Chen, Xiaoyuan, Wang, Fan. Specific Targeting of Human Integrin alpha(v)beta(3) with In-111-Labeled Abegrin (TM) in Nude Mouse Models. MOLECULAR IMAGING AND BIOLOGY[J]. 2011, 13(1): 112-120, http://dx.doi.org/10.1007/s11307-010-0302-4.
[58] Yang, Sujuan, Dong, Chengyan, Zhao, Huiyun, Huang, Jinming, Cui, Liyang, Shi, Jiyun, Liu, Zhaofei, Jia, Bing, Wang, Fan. A novel dual-modality biotinated SPECT/NIR probe for pretargeted tumor imaging. JOURNAL OF NUCLEAR MEDICINEnull. 2011, 52: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000443798902046.
[59] Dong, Chengyan, Zhao, Huiyun, Cui, Liyang, Shi, Jiyun, Huang, Jinming, Yang, Sujuan, Liu, Zhaofei, Jia, Bing, Wang, Fan. Preparation and evaluation of Tc-99m-labeled dimeric Tyr(3)-Octreotide in the AR42J tumor model. JOURNAL OF NUCLEAR MEDICINEnull. 2011, 52: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000443798901547.
[60] Liu, Zhaofei, Jin, Cunjing, Yu, Zilin, Zhang, Jing, Liu, Yan, Zhao, Huiyun, Jia, Bing, Wang, Fan. Radioimmunotherapy of Human Colon Cancer Xenografts with I-131-Labeled Anti-CEA Monoclonal Antibody. BIOCONJUGATE CHEMISTRY[J]. 2010, 21(2): 314-318, http://dx.doi.org/10.1021/bc9003603.
[61] Liu, Zhaofei, Liu, Yan, Jia, Bing, Zhao, Huiyun, Jin, Xiaona, Li, Fang, Chen, Xiaoyuan, Wang, Fan. Epidermal Growth Factor Receptor-Targeted Radioimmunotherapy of Human Head and Neck Cancer Xenografts Using Y-90-Labeled Fully Human Antibody Panitumumab. MOLECULAR CANCER THERAPEUTICS[J]. 2010, 9(8): 2297-2308, http://dx.doi.org/10.1158/1535-7163.MCT-10-0444.
[62] Shi, Jiyun, Liu, Zhaofei, Jia, Bing, Yu, Zilin, Zhao, Huiyun, Wang, Fan. Potential therapeutic radiotracers: preparation, biodistribution and metabolic characteristics of Lu-177-labeled cyclic RGDfK dimer. AMINO ACIDS[J]. 2010, 39(1): 111-120, http://dx.doi.org/10.1007/s00726-009-0382-0.
[63] Liu, Zhaofei, Jia, Bing, Shi, Jiyun, He, Peng, Wang, Fan. gamma Imaging of colon cancer in tumor-bearing mice using a Tc-99m-labeled peptide identified by phage display. JOURNAL OF NUCLEAR MEDICINEnull. 2010, 51: https://www.webofscience.com/wos/woscc/full-record/WOS:000447387100295.
[64] Liu, Zhaofei, Wang, Fan. Dual-Targeted Molecular Probes for Cancer Imaging. CURRENT PHARMACEUTICAL BIOTECHNOLOGYnull. 2010, 11(6): 610-619, http://dx.doi.org/10.2174/138920110792246546.
[65] Jia, Bing, Liu, Zhaofei, Zhu, Zhaohui, Shi, Jiyun, Li, Fang, Liu, Shuang, Wang, Fan. Blood clearance kinetics, biodistribution and radiation dosimetry of a kit-formulated integrin alpha(v)beta(3)-selective radiotracer Tc-99m-3PRGD2 in non-human primates. JOURNAL OF NUCLEAR MEDICINEnull. 2010, 51: https://www.webofscience.com/wos/woscc/full-record/WOS:000447387101019.
[66] Liu, Zhaofei, Jia, Bing, Shi, Jiyun, Jin, Xiaona, Zhao, Huiyun, Li, Fang, Liu, Shuang, Wang, Fan. Tumor Uptake of the RGD Dimeric Probe Tc-99m-G(3)-2P(4)-RGD2 is Correlated with Integrin alpha(v)beta(3) Expressed on both Tumor Cells and Neovasculature. BIOCONJUGATE CHEMISTRY[J]. 2010, 21(3): 548-555, http://dx.doi.org/10.1021/bc900547d.
[67] Shi, Jiyun, Kim, YoungSeung, Chakraborty, Sudipta, Jia, Bing, Wang, Fan, Liu, Shuang. 2-Mercaptoacetylglycylglycyl (MAG(2)) as a Bifunctional Chelator for Tc-99m-Labeling of Cyclic RGD Dimers: Effect of Technetium Chelate on Tumor Uptake and Pharmacokinetics. BIOCONJUGATE CHEMISTRY[J]. 2009, 20(8): 1559-1568, http://dx.doi.org/10.1021/bc9001739.
[68] Jin, Cunjing, Zhang, Jing, Yu, Zilin, Liu, Yan, Liu, Zhaofei, Zhao, Huiyun, Jia, Bing, Wang, Fan. Radioimmunotherapy of colon cancer with 131I-labeled anti-CEA monoclonal antibody CL58. JOURNAL OF NUCLEAR MEDICINEnull. 2009, 50: https://www.webofscience.com/wos/woscc/full-record/WOS:000444145701672.
[69] Liu, Yan, Jia, Bing, Liu, Zhaofei, Zhao, Huiyun, Chen, Xiaoyuan Shawn, Wang, Fan. Radioimmunotherapy of EGFR-positive tumors with 90Y-labeled panitumumab. JOURNAL OF NUCLEAR MEDICINEnull. 2009, 50: https://www.webofscience.com/wos/woscc/full-record/WOS:000444145701671.
[70] Shi, Jin, Kim, YoungSeung, Zhai, Shizhen, Jia, Bing, Wang, Fan, Liu, Shuang. Improving tumor uptake and biodistribution characteristics of In-111-labeled cyclic RGD dimers with triglycine and PEG4 linkers. JOURNAL OF NUCLEAR MEDICINEnull. 2009, 50: https://www.webofscience.com/wos/woscc/full-record/WOS:000444145700570.
[71] Shi, Jiyun, Kim, YoungSeung, Chakraborty, Sudipta, Zhai, Shizhen, Jia, Bing, Zhao, Huiyun, Wang, Fan, Liu, Shuang. 99mTc-Labeled cyclic RGD dimers with high tumor uptake and favorable pharmacokinetics for imaging tumor integrin avb3 expression. JOURNAL OF NUCLEAR MEDICINEnull. 2009, 50: https://www.webofscience.com/wos/woscc/full-record/WOS:000444145700566.
[72] Jia, Bing, Yu, Zilin, Liu, Zhaofei, Shi, Jiyun, Zhao, Huiyun, Chen, Xiaoyuan Shawn, Wang, Fan. Targeted radiotherapy of integrin alpha v beta 3-positive tumors with 90Y-labeled RGD tetramer. JOURNAL OF NUCLEAR MEDICINEnull. 2009, 50: https://www.webofscience.com/wos/woscc/full-record/WOS:000444145700506.
[73] Jia, Bing, Liu, Zhaofei, Shi, Jiyun, Zhao, Huiyun, Liu, Shuang, Wang, Fan. Expression levels of integrin alpha v beta 3 versus tumor uptake of 99mTc-labeled RGD peptide. JOURNAL OF NUCLEAR MEDICINEnull. 2009, 50: https://www.webofscience.com/wos/woscc/full-record/WOS:000444145700271.
[74] 余子璘, 贾兵, 刘昭飞, 史继云, 赵慧云, 杨志, 王凡. 99^Tc^m标记RGD环肽四聚体在神经胶质瘤裸鼠模型中的显像研究. 中华核医学杂志[J]. 2009, 29(2): 103-108, http://lib.cqvip.com/Qikan/Article/Detail?id=30033849.
[75] Shi, Jiyun, Jia, Bing, Liu, Zhaofei, Yang, Zhi, Yu, Zilin, Chen, Kai, Chen, Xiaoyuan, Liu, Shuang, Wang, Fan. (99m)Tc-labeled bombesin(7-14)NH(2) with favorable properties for SPECT imaging of colon cancer. BIOCONJUGATE CHEMISTRY[J]. 2008, 19(6): 1170-1178, [76] 贾兵, 刘昭飞, 赵慧云, 王凡. γ计数器定量测定^90Y标记化合物在动物体内的生物分布. 同位素[J]. 2008, 21(1): 36-39, http://lib.cqvip.com/Qikan/Article/Detail?id=26711355.
[77] 赵慧云, 贾兵, 史纪云, 王凡. ^90Y标记的不同氨基酸序列的RGD环肽的制备及在荷人神经胶质瘤动物模型中的评价. 核化学与放射化学[J]. 2008, 30(1): 17-22, http://lib.cqvip.com/Qikan/Article/Detail?id=26852870.
[78] 全欣, 张燕, 贾兵, 赵慧云, 余子磷, 史纪云, 王凡. ^99Tc^m-HYNIC-β-Ala-BBN（7-14）NH2的制备及其初步生物分布. 同位素[J]. 2007, 20(2): 77-82, http://lib.cqvip.com/Qikan/Article/Detail?id=24787522.
[79] 史继云, 余子璘, 贾兵, 赵慧云, 王凡. ^177Lu—DoTA—Bz—RGDdimer和^177Lu-DOTA-Bz-PEG4-RGD dimer的制备及生物评价. 同位素[J]. 2007, 20(4): 214-218,223, http://lib.cqvip.com/Qikan/Article/Detail?id=26105494.
[80] 刘昭飞, 贾兵, 史继云, 杨志, 赵慧云, 王凡. ^99Tc^m—RGD环肽二聚体的制备及其体内外评价. 中华核医学杂志[J]. 2007, 27(4): 205-209, http://lib.cqvip.com/Qikan/Article/Detail?id=25570200.
[81] SHEN Lang-tao, ZHAO Hui-yun, DU Jin, WANG Fan. Anti-tumor Activities of Four Chelating Agents Against Human Neuroblastoma Cells. 中国原子能科学研究院年报：英文版[J]. 2004, 122-122, http://lib.cqvip.com/Qikan/Article/Detail?id=18028691.

   

（ 1 ） 基于Porphysome的新型分子探针的研究, 负责人, 国家任务, 2015-01--2019-12
（ 2 ） 新型多功能有机纳米分子探针的研究, 负责人, 地方任务, 2014-07--2017-06
（ 3 ） 基于多模态分子影像技术的新型肿瘤放射性分子探针的在体评价研究, 负责人, 国家任务, 2012-01--2016-12
（ 4 ） 新型用于integrin αvβ3阳性肿瘤早期诊断和治疗的放射性药物, 负责人, 国家任务, 2012-01--2015-12
（ 5 ） 用于肿瘤诊断、分期及疗效监测的特异性肿瘤显像剂一类新药临床前研究, 负责人, 中国科学院计划, 2016-01--2018-12
（ 6 ） 为乳腺癌精准诊治提供多参数影像学信息的分子探针的构建及评价, 负责人, 国家任务, 2017-01--2022-12

已指导学生

杜成志  博士研究生  071011-生物物理学  

高宇  博士研究生  071011-生物物理学  

罗麒  博士研究生  071009-细胞生物学  

马晓途  博士研究生  071011-生物物理学  

现指导学生

孙以宁  博士研究生  071011-生物物理学  

张夏雯  硕士研究生  071009-细胞生物学  

张宁  硕士研究生  071011-生物物理学  

李怡馨  博士研究生  071011-生物物理学  

于悦  博士研究生  071011-生物物理学