100701-药物化学

活性天然产物的合成以及结构修饰改造

2000-07--2004-06   兰州大学   博士学位

   

2009-12~现在, 中国科学院昆明植物研究所, 副研究员
2004-06~2009-12,郑州大学, 讲师

   

（ 1 ） 韧革菌素二级醇酸酯衍生物及其药物组合物和其应用, 发明, 2017, 第 1 作者, 专利号: ZL 2014 1 0128748.X
（ 2 ） 韧革菌素酰胺衍生物及其制备方法和应用, 发明, 2017, 第 2 作者, 专利号: ZL 20141 0128300.8
（ 3 ） 韧革菌素一级醇酸酯衍生物及其药物组合物和其制备方法与应用, 发明, 2017, 第 2 作者, 专利号: ZL 2014 1 0128811.X
（ 4 ） 秋水仙碱和别秋水仙碱的不对称合成方法, 发明, 2019, 第 4 作者, 专利号: 201911245381 .9

   

[1] Zhang, Tian-Yuan, Zhang,Lu-Yue, Liang, Xiao, Wei, Kun, Yang, Yu-Rong. Catalytic, Asymmetric Total Synthesis of (+)-α , (+)-β , (+)-γ , and (−)-δ-Lycorane. ORGANICLETTERS[J]. 2022, 24: 2905-2909, https://pubs.acs.org/doi/pdf/10.1021/acs.orglett.2c00905.
[2] Liang, Xiao, Li, Lei, Wei, Kun, Yang, YuRong. Gram-Scale, Seven-Step Total Synthesis of (-)-Colchicine. ORGANIC LETTERS[J]. 2021, 23(7): 2731-2735, http://dx.doi.org/10.1021/acs.orglett.1c00638.
[3] Deng, Yi, Liang, Xiao, Wei, Kun, Yang, YuRong. Ir-Catalyzed Asymmetric Total Syntheses of Bisdehydrotuberostemonine D, Putative Bisdehydrotuberostemonine E and Structural Revision of the Latter. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2021, 143(49): 20622-20627, http://dx.doi.org/10.1021/jacs.1c11265.
[4] Zhang, TianYuan, Deng, Yi, Wei, Kun, Yang, YuRong. Enantioselective Iridium-Catalyzed Allylic Alkylation of Racemic Branched Alkyl-Substituted Allylic Acetates with Malonates. ORGANIC LETTERS[J]. 2021, 23(3): 1086-1089, http://dx.doi.org/10.1021/acs.orglett.0c04309.
[5] Li, Lei, Shi, Li, Wei, Kun, Yang, YuRong. Asymmetric Total Synthesis of (+)-Quinocarcinamide. ORGANIC LETTERS[J]. 2021, 23(20): 7972-7975, http://dx.doi.org/10.1021/acs.orglett.1c02970.
[6] Zheng, Yu, Yang, HongDou, Wei, Kun, Yang, YuRong. Synthetic Studies toward Parvistemoline Using Asymmetric Ir/Amine-Catalyzed Allylation. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(8): 6025-6029, http://dx.doi.org/10.1021/acs.joc.1c00390.
[7] Zheng, Yu, Li, XueDan, Sheng, PengZhen, Yang, HongDou, Wei, Kun, Yang, YuRong. Asymmetric Total Syntheses of (-)-Fennebricin A, (-)-Renieramycin J, (-)-Renieramycin G, (-)-Renieramycin M, and (-)- Jorunnamycin A via C-H Activation. ORGANIC LETTERS[J]. 2020, 22(11): 4489-4493, http://ir.kib.ac.cn/handle/151853/72118, http://www.irgrid.ac.cn/handle/1471x/6927931, http://ir.kib.ac.cn/handle/151853/72119, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000538848600084&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[8] Meng, ChunYan, Liang, Xiao, Wei, Kun, Yang, YuRong. Enantioselective Ir-Catalyzed Allylic Alkylation of Racemic Allylic Alcohols with Malonates. ORGANIC LETTERS[J]. 2019, 21(3): 840-843, http://ir.kib.ac.cn/handle/151853/64241.
[9] Yao, JianNeng, Liang, Xiao, Wei, Kun, Yang, YuRong. Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine. ORGANIC LETTERS[J]. 2019, 21(20): 8485-8487, [10] Meng, ChunYan, Liang, Xiao, Zhang, Hongbin, Wei, Kun, Yang, YuRong. Stereocontrolled concise synthesis of (+/-)-halosaline through intramolecular C-H amination. TETRAHEDRON LETTERS[J]. 2019, 60(27): 1781-1783, [11] Yue, BeiBei, Deng, Yi, Zheng, Yu, Wei, Kun, Yang, YuRong. Iridium-Catalyzed Enantioselective Allylation of Aryl Enamides and Enecarbamates. ORGANIC LETTERS[J]. 2019, 21(7): 2449-2452, https://www.webofscience.com/wos/woscc/full-record/WOS:000464247500110.
[12] Yue, BeiBei, Deng, Yi, Zheng, Yu, Wei, Kun, Yang, YuRong. Iridium-Catalyzed Enantioselective Allylation of Aryl Enamides and Enecarbamates. ORGANIC LETTERS[J]. 2019, 21(7): 2449-2452, https://www.webofscience.com/wos/woscc/full-record/WOS:000464247500110.
[13] Zheng, Yu, Yue, BeiBei, Wei, Kun, Yang, YuRong. Short Synthesis of the Monoterpene Indole Alkaloid (+/-)-Arbornamine. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 83(8): 4867-4870, https://www.webofscience.com/wos/woscc/full-record/WOS:000430898500056.
[14] Zheng, Yu, Yue, BeiBei, Wei, Kun, Yang, YuRong. Iridium-Catalyzed Enantioselective Allyl-Allyl Cross-Coupling of Racemic Allylic Alcohols with Allylboronates. ORGANIC LETTERS[J]. 2018, 20(24): 8035-8038, http://ir.kib.ac.cn/handle/151853/64370.
[15] Liang, Xiao, Zhang, TianYuan, Meng, ChunYan, Li, XueDan, Wei, Kun, Yang, YuRong. Total Synthesis of (-)-Actinophyllic Acid Enabled by a Key Dual Ir/Amine-Catalyzed Allylation. ORGANIC LETTERS[J]. 2018, 20(15): 4575-4578, https://www.webofscience.com/wos/woscc/full-record/WOS:000441112700042.
[16] Liang, Xiao, Zhang, TianYuan, Zeng, XueYi, Zheng, Yu, Wei, Kun, Yang, YuRong. Ir-Catalyzed Asymmetric Total Synthesis of (-)-Communesin F. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(9): 3364-3367, http://ir.kib.ac.cn/handle/151853/50996.
[17] Zheng, Yu, Wei, Kun, Yang, YuRong. Total Synthesis of (-)-Geissoschizol through Ir-Catalyzed Allylic Amidation as the Key Step. ORGANIC LETTERS[J]. 2017, 19(23): 6460-6462, https://www.webofscience.com/wos/woscc/full-record/WOS:000417229000050.
[18] Luo, Ji, Wei, Kun, Wang, Shuanghua, Zhao, Weiye, Ma, Canrong, Hettenhausen, Christian, Wu, Jinsong, Cao, Guoyan, Sun, Guiling, Baldwin, Ian T, Wu, Jianqiang, Wang, Lei. COI1-Regulated Hydroxylation of Jasmonoyl-L-isoleucine Impairs Nicotiana attenuata's Resistance to the Generalist Herbivore Spodoptera litura. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2016, 64(14): 2822-2831, http://ir.kib.ac.cn/handle/151853/26212.
[19] Jiang, ShiZhi, Zeng, XueYi, Liang, Xiao, Lei, Ting, Wei, Kun, Yang, YuRong. Iridium-Catalyzed Enantioselective Indole Cyclization: Application to the Total Synthesis and Absolute Stereochemical Assignment of (-)-AspidophyllineA. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(12): 4044-4048, http://ir.kib.ac.cn/handle/151853/26181.
[20] Liang, Xiao, Jiang, ShiZhi, Wei, Kun, Yang, YuRong. Enantioselective Total Synthesis of (-)-Alstoscholarisine A. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 138(8): 2560-2562, http://ir.kib.ac.cn/handle/151853/26005.
[21] 韦堃. Iridium-catalyzed enantioselective allylation of silyl enol ethers derived from ketones and a,b-unsaturated ketones. Chemical Communications. 2015, [22] Liang, Xiao, Wei, Kun, Yang, YuRong. Iridium-catalyzed enantioselective allylation of silyl enol ethers derived from ketones and alpha,beta-unsaturated ketone. CHEMICAL COMMUNICATIONS[J]. 2015, 51(98): 17471-17474, http://www.irgrid.ac.cn/handle/1471x/1029002.
[23] Kun Wei, Gang-Qiang Wang, Xue Bai, Yan-Fen Niu, He-Ping Chen, Chun-Nan Wen, Zheng-Hui Li, Ze-Jun Dong, Zhi-Li Zuo, Wen-Yong Xiong, Ji-Kai Liu. Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2015, 5(3): 129-157, http://ir.kib.ac.cn/handle/151853/33812.
[24] Wang, SuRui, Zhang, Ling, Chen, HePing, Li, ZhengHui, Dong, ZeJun, Wei, Kun, Liu, JiKai. Four new spiroaxane sesquiterpenes and one new rosenonolactone derivative from cultures of Basidiomycete Trametes versicolor. FITOTERAPIA[J]. 2015, 105: 127-131, http://www.irgrid.ac.cn/handle/1471x/1028958.
[25] Chen, ZiMing, Yang, XiaoYan, Fan, QiongYing, Li, ZhengHui, Wei, Kun, Chen, HePing, Feng, Tao, Liu, JiKai. Three novel degraded steroids from cultures of the Basidiomycete Antrodiella albocinnamomea. STEROIDS[J]. 2014, 87: 21-25, http://dx.doi.org/10.1016/j.steroids.2014.05.008.
[26] Jiang, ShiZhi, Lei, Ting, Wei, Kun, Yang, YuRong. Collective Total Synthesis of Tetracyclic Diquinane Lycopodium Alkaloids (+)-Paniculatine, (-)-Magellanine, (+)-Magellaninone and Analogues Thereof. ORGANIC LETTERS[J]. 2014, 16(21): 5612-5615, http://www.irgrid.ac.cn/handle/1471x/929643.
[27] Wang, GangQiang, Wei, Kun, Zhang, Ling, Li, ZhengHui, Wang, QiuAn, Liu, JiKai. Three new vibralactone-related compounds from cultures of Basidiomycete Boreostereum vibrans. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2014, 16(5): 447-452, http://www.irgrid.ac.cn/handle/1471x/845925.
[28] Ding, JianHai, Feng, Tao, Cui, BaoKai, Wei, Kun, Li, ZhengHui, Liu, JiKai. Novel sesquiterpenoids from cultures of the basidiomycete Irpex lacteus. TETRAHEDRON LETTERS[J]. 2013, 54(21): 2651-2654, http://dx.doi.org/10.1016/j.tetlet.2013.03.038.
[29] Wang, GangQiang, Wei, Kun, Li, ZhengHui, Feng, Tao, Ding, JianHai, Wang, QiuAn, Liu, JiKai. Three new compounds from the cultures of basidiomycete Boreostereum vibrans. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2013, 15(9): 950-955, http://www.irgrid.ac.cn/handle/1471x/784364.
[30] Huang, JiuZhong, Jie, XiaoKe, Wei, Kun, Zhang, Hongbin, Wang, MinCai, Yang, YuRong. Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization. SYNLETT[J]. 2013, 24(10): 1303-1306, https://www.webofscience.com/wos/woscc/full-record/WOS:000320576300028.
[31] Gao, Yuan, Wang, GangQiang, Wei, Kun, Hai, Ping, Wang, Fei, Liu, JiKai. Isolation and Biomimetic Synthesis of (+/-)-Guajadial B, a Novel Meroterpenoid from Psidium guajava. ORGANIC LETTERS[J]. 2012, 14(23): 5936-5939, https://www.webofscience.com/wos/woscc/full-record/WOS:000311926000032.
[32] Zhou, ZhongYu, Shi, GuoQing, Fontaine, Robert, Wei, Kun, Feng, Tao, Wang, Fang, Wang, GangQiang, Qu, Yan, Li, ZhengHui, Dong, ZeJun, Zhu, HuaJie, Yang, ZhuLiang, Zeng, Guang, Liu, JiKai. Evidence for the Natural Toxins from the Mushroom Trogia venenata as a Cause of Sudden Unexpected Death in Yunnan Province, China. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2012, 51(10): 2368-2370, http://www.irgrid.ac.cn/handle/1471x/448477.
[33] Yang, YuRong, Shen, Liang, Huang, JiuZhong, Xu, Tao, Wei, Kun. Application of the Helquist Annulation in Lycopodium Alkaloid Synthesis: Unified Total Syntheses of (-)-8-Deoxyserratinine, (-)-Fawcettimine, and (+)-Lycoflexine. JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 76(10): 3684-3690, http://www.irgrid.ac.cn/handle/1471x/392924.
[34] Wang, GangQiang, Wei, Kun, Zhang, Lin, Feng, Tao, Wang, Fei, Wang, QiuAn, Liu, JiKai. One-step biomimetic synthesis of (+/-)-linderaspirone A and (+/-)-bi-linderone. TETRAHEDRON LETTERS[J]. 2011, 52(21): 2719-2721, http://dx.doi.org/10.1016/j.tetlet.2011.03.081.

   

（ 1 ） 天然产物韧革菌素衍生物的药物设计合成研究, 主持, 国家级, 2012-01--2014-12
（ 2 ） 中国特有植物和微生物药用活性物质的基础研究（第四组）, 参与, 国家级, 2009-01--2013-08
（ 3 ） 吲哚生物碱不对称合成 新策略研究, 参与, 部委级, 2016-01--2020-12

已指导学生

王苏锐  硕士研究生  078001-药物化学  

现指导学生

杨红豆  硕士研究生  078001-药物化学  

石莉  硕士研究生  078001-药物化学  

龙向熙  硕士研究生  105500-药学