基本信息
魏万国 男 博导 中国科学院上海高等研究院
电子邮件: weiwanguo@hotmail.com
通信地址: 上海市浦东新区海科路99号6号楼525室
邮政编码: 201210
研究领域
有机化学、化学生物学
教育背景
2000-09--2006-03 中国科学院上海有机化学研究所 博士1996-09--2000-07 兰州大学 学士
科研活动
科研项目
( 1 ) 几个复杂Azaphilone 类天然产物的全合成及相关合成方法学研究, 主持, 国家级, 2013-01--2015-12( 2 ) 基于手性有机高价碘试剂氧化反应的活性天然产物全合成研究, 主持, 国家级, 2013-01--2015-12( 3 ) 干细胞药物的高通量筛选及优化, 参与, 国家级, 2011-01--2015-12( 4 ) 孤儿药Funapide原料药工艺开发, 主持, 院级, 2016-01--2018-12( 5 ) 抗目标疾病的小分子药物开发, 主持, 院级, 2017-06--2020-05
指导学生
现指导学生
苏小惠 02 63228
陈格 01 19183
罗木鹏 01 19132
在学研究生
李亚琴 硕士研究生(2013级)
陈 格 博士研究生(2013级)
罗木鹏 硕士研究生(2014级)
李斌 硕士研究生(2014级)
苏小慧 硕士研究生(2014级)
招生信息
招生专业
070303-有机化学085238-生物工程
招生方向
有机化学,化学生物学
出版信息
发表论文
(1) Metal-free sulfonylation of quinones with sulfonyl hydrazides in water: facile access to mono-sulfonylated hydroquinones, Tetrahedron, 2017, 通讯作者(2) Concise synthesis of polycyclic indoline scaffolds through an InIII-catalyzed formal [4+2] annulation of 2,3-disubstituted indoles with o-aminobenzyl alcohols, Eur. J. Org. Chem., 2017, 通讯作者(3) An ursolic acid-derived small molecule triggers cancer cell death through hyperstimulation of macropinocytosis, J. Med. Chem., 2017, 通讯作者(4) How to make hepatocytes by lineage reprogramming, Chemistry of Life, 2016, 通讯作者(5) TGF-beta signaling in stem cell regulation, Methods Mol. Biol., 2016, 第 2 作者(6) Ir(III)-Catalyzed arylation of spirocyclic oxindoles with phenols/naphthols toward the synthesis of spirocyclic oxindoles, Chem. Eur. J., 2016, 通讯作者(7) Self-renewal of hepatoblasts under chemically defined conditions by reiterative growth factor and chemical screening, Hepatology, 2015, 第 4 作者(8) Radical-induced metal-free alkynylation of aldehydes via direct C–H activation, Chem. Eur. J., 2015, 通讯作者(9) A combination of the telomerase inhibitor, BIBR1532, and taxol synergistically inhibit cell proliferation in breast cancer cell lines, Targeted Oncology, 2015, 通讯作者(10) Generation of self-renewing hepatoblasts from human embryonic stem cells by chemical approaches, Stem Cells Translational Medicine, 2015, 通讯作者(11) Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming, Nature Chemical Biology, 2015, 第 4 作者(12) Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts, J. Cell Mol. Med., 2014, 第 4 作者(13) Chemical approaches to studying stem cell biology, Cell Res., 2013, 第 3 作者(14) Chemical approaches to stem cell biology and therapeutics, Cell Stem Cell, 2013, 第 3 作者(15) Truncated aspidosperma alkaloid-like scaffolds: unique structures for the discovery of new bioactive compounds, Heterocycles , 2011, 第 3 作者(16) Chemical strategies for stem cell biology and regenerative medicine, Annu. Rev. Biomed. Eng., 2011, 第 2 作者(17) Discovery of new antimalarial chemotypes through chemical methodology and library development, Proc. Natl. Acad. Sci. USA, 2011, 第 1 作者(18) Rapid induction and long-term self-renew of primitive neural precursors from human embryonic stem cells by small molecule inhibitors, Proc. Natl. Acad. Sci. USA, 2011, 第 4 作者(19) Reprogramming of human primary somatic cells by Oct4 and chemical compounds, Cell Stem Cell , 2010, 第 4 作者(20) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules, Proc. Natl. Acad. Sci. USA, 2010, 第 4 作者(21) Synthesis of the cyclic nonapeptide of chlorofusin by using a convergent [3+3+3]-fragment coupling strategy, Tetrahedron, 2010, 第 3 作者(22) New Small Molecule Inhibitors of Hepatitis C Virus, Bioorg. Med. Chem. Lett., 2009, 第 1 作者(23) Total synthesis, assignment of absolute stereochemistry, and structural revision of chlorofusin, J. Am. Chem. Soc. , 2007, 第 2 作者(24) Bromoetherification-based strategy towards the spirocyclic chromophore of chlorofusin., Tetrahedron Lett., 2006, 第 1 作者(25) Synthesis studies toward chloroazaphilone and vinylogous γ-pyridones: two common natural products core structures, J. Org. Chem., 2005, 第 1 作者(26) Efficient construction of novel a-keto spiro ketal and the total synthesis of (±)-terreinol., Tetrahedron, 2005, 第 1 作者(27) A practical procedure for the multisubstituted b-naphthols and their derivatives., Tetrahedron, 2003, 第 1 作者
工作经历
工作简历
2011-07~2017-07,中国科学院上海高等研究院, 研究员 中科院"****"入选者2008-08~2011-04,美国加州斯克利普斯研究所, 博士后2006-03~2008-07,美国波士顿大学, 博士后
社会兼职
2012-12-01-今,上海科技大学教授,
专利与奖励
专利成果
( 1 ) New small molecule inhibitors of hepatitis C virus, 发明, 2013, 第 2 作者, 专利号: US 2013/0065875 A1( 2 ) 一种阿拉格列汀的合成方法, 发明, 2014, 第 1 作者, 专利号: CN201410517998.2( 3 ) 一种磺酰基氢醌类化合物的制备方法与应用, 发明, 2016, 第 1 作者, 专利号: 201610965252( 4 ) 一类含吡唑杂环的熊果酸衍生物及其合成与应用, 发明, 2017, 第 4 作者, 专利号: 201710160038.9( 5 ) 一类含吡唑杂环的熊果酰胺衍生物及其合成与应用, 发明, 2017, 第 4 作者, 专利号: 201710159962.5