应用多组学和生物信息学技术探索疾病研究中的重要科学问题，开发特色的、原创性的生物医学大数据分析方法与工具，探索具有临床应用价值的生物标志物

0710J3-生物信息学
071010-生物化学与分子生物学
0710Z2-计算生物学

生物信息学工具、算法的开发；疾病多组学研究

2000-09--2005-07   北京大学   博士
1996-09--2000-07   上海交通大学   学士

-- 研究生

-- 博士

   

2008-06~现在, 中国科学院心理研究所, 研究员
2005-07~2008-05,中国科学院北京基因组研究所, 副研究员

2020-02-01-今,中国自动化学会, 高级会员
2018-07-01-今,中国免疫学会专业分会, 常务委员
2018-07-01-今,中国医院协会临床微生物实验室管理专业委员会, 委员
2015-03-01-今,中国科学院大学, 岗位教授
2014-09-01-今,中国科学院科教融合卓越创新中心, 岗位教授
2010-10-01-今,心理科学进展, 编委
2006-05-01-今,中国遗传学会国际交流委员会, 委员

   

（1） 中国科学院优秀导师, 院级, 2013
（2） 北京市科技新星, 省级, 2007

[1] 王晶, 房柯池. 确定抗体的阴阳性及滴度的方法、设备和介质. CN: CN113902687A, 2022-01-07.
[2] 王晶, 房柯池. 预测以细胞为基质的抗体核型类别的方法、设备和介质. CN: CN113870280A, 2021-12-31.
[3] 王晶, 房柯池. 预测以细胞为基质的抗体核型类别的方法、设备和介质. CN: CN113837255A, 2021-12-24.
[4] 王晶, 郭黎媛, 关鸿志, 任海涛. 自身免疫类神经疾病的诊断. CN: CN112285363A, 2021-01-29.
[5] 王晶. 抗N-甲基-D-天冬氨酸受体脑炎的B细胞抗体基因获取方法及其免疫组库研究. CN: CN111808195A, 2020-10-23.
[6] 王晶, 郭黎媛, 林葳. 一种人类大脑基因时空表达模式在线分析系统及其方法. CN: CN110428867A, 2019-11-08.
[7] 王晶, 郭黎媛, 林葳. 一种人类大脑基因表达时空常模的建立方法. CN: CN110349625A, 2019-10-18.

   

[1] 王晶. An automatic immunofluorescence pattern classification framework for HEp-2 image based on supervised learning. Briefings in Bioinformatics[J]. 2023, [2] Liu, Mange, Ren, Haitao, Zhu, Yicheng, Fan, Siyuan, Bai, Lin, Wang, Jing, Cui, Liying, Guan, Hongzhi. Autoimmune Cerebellar Ataxia: Etiology and Clinical Characteristics of a Case Series from China. CEREBELLUM[J]. 2022, http://dx.doi.org/10.1007/s12311-022-01412-5.
[3] He, Yukun, Fang, Kechi, Shi, Xing, Yang, Donghong, Zhao, Lili, Yu, Wenyi, Zheng, Yali, Xu, Yu, Ma, Xinqian, Chen, Li, Xie, Yu, Yu, Yan, Wang, Jing, Gao, Zhancheng. Enhanced DNA and RNA pathogen detection via metagenomic sequencing in patients with pneumonia. JOURNAL OF TRANSLATIONAL MEDICINE[J]. 2022, 20(1): http://dx.doi.org/10.1186/s12967-022-03397-5.
[4] Feng, Jingjing, Fan, Siyuan, Sun, Yinwei, Ren, Haitao, Guan, Hongzhi, Wang, Jing. Comprehensive B-Cell Immune Repertoire Analysis of Anti-NMDAR Encephalitis and Anti-LGI1 Encephalitis. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fimmu.2021.717598.
[5] Guo, Liyuan, Liu, Yushan, Wang, Jing. Preservation Analysis on Spatiotemporal Specific Co-expression Networks Suggests the Immunopathogenesis of Alzheimer's Disease. FRONTIERS IN AGING NEUROSCIENCE[J]. 2021, 13: http://dx.doi.org/10.3389/fnagi.2021.727928.
[6] Feng, Jingjing, Fan, Siyuan, Sun, Yinwei, Zhang, Zhidong, Ren, Haitao, Li, Wenhan, Cui, Liying, Peng, Bin, Ren, Xiaotun, Zhang, Weihua, Guan, Hongzhi, Wang, Jing. Study of B Cell Repertoire in Patients With Anti-N-Methyl-D-Aspartate Receptor Encephalitis. FRONTIERS IN IMMUNOLOGY[J]. 2020, 11: 10-, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403192/.
[7] Guo, Liyuan, Lin, Wei, Zhang, Yidan, Wang, Jing. A Systematic Analysis Revealed the Potential Gene Regulatory Processes of ATRA-Triggered Neuroblastoma Differentiation and Identified a Novel RA Response Sequence in the NTRK2 Gene. BIOMED RESEARCH INTERNATIONAL[J]. 2020, 2020: https://doaj.org/article/d78611b1670449c2be44746642c44016.
[8] Xu, Xiaolu, Ren, Haitao, Li, Libo, Wang, Jing, Fechner, Kai, Guan, Hongzhi. Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review. JOURNAL OF NEUROIMMUNOLOGY[J]. 2019, 330: 155-158, http://dx.doi.org/10.1016/j.jneuroim.2019.01.002.
[9] Wu Mengsi, Fang Kechi, Wang Weixiao, Lin Wei, Guo Liyuan, Wang Jing. Identification of key genes and pathways for Alzheimer’s disease via combined analysis of genome-wide expression profiling in the hippocampus. BIOPHYSICS REPORTS[J]. 2019, 5(2): 98-109, http://dx.doi.org/10.1007/s41048-019-0086-2.
[10] Liyuan Guo, Wei Lin, Yidan Zhang, Wenhan Li, Jing Wang. BEST: a web server for brain expression Spatio-temporal pattern analysis. BMC BIOINFORMATICS[J]. 2019, 20(1): 1-8, http://dx.doi.org/10.1186/s12859-019-3222-6.
[11] Guo, Liyuan, Wang, Jing. rSNPBase 3.0: an updated database of SNP-related regulatory elements, element-gene pairs and SNP-based gene regulatory networks. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(D1): D1111-D1116, http://dx.doi.org/10.1093/nar/gkx1101.
[12] Susu Qu, Yang Du, Suhua Chang, Liyuan Guo, Kechi Fang, Yongzhe Li, Fengchun Zhang, Kunlin Zhang, Jing Wang. Common variants near IKZF1 are associated with primary Sjögren's syndrome in Han Chinese.. PLOS ONE[J]. 2017, 12(5): https://doaj.org/article/b0b3ac5c85384ff18121824df4769796.
[13] Zhang, Kunlin, Qu, Susu, Chang, Suhua, Li, Gen, Cao, Chengqi, Fang, Kechi, Olff, Miranda, Wang, Li, Wang, Jing. An overview of posttraumatic stress disorder genetic studies by analyzing and integrating genetic data into genetic database PTSDgene. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWSnull. 2017, 83: 647-656, http://dx.doi.org/10.1016/j.neubiorev.2017.08.021.
[14] 王晶. A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorde. Molecular psychiatry. 2017, [15] Wang, Jinglu, Qu, Susu, Wang, Weixiao, Guo, Liyuan, Zhang, Kunlin, Chang, Suhua, Wang, Jing, S Chang, J Wang. A combined analysis of genome-wide expression profiling of bipolar disorder in human prefrontal cortex. JOURNAL OF PSYCHIATRIC RESEARCH[J]. 2016, 82: 23-29, http://dx.doi.org/10.1016/j.jpsychires.2016.07.016.
[16] Guo, Liyuan, Du, Yang, Qu, Susu, Wang, Jing. rVarBase: an updated database for regulatory features of human variants. NUCLEIC ACIDS RESEARCH[J]. 2016, 44(D1): D888-D893, http://dx.doi.org/10.1093/nar/gkv1107.
[17] Ott, Jurg, Wang, Jing, Leal, Suzanne M. Genetic linkage analysis in the age of whole-genome sequencing. NATURE REVIEWS GENETICS[J]. 2015, 16(5): 275-284, http://dx.doi.org/10.1038/nrg3908.
[18] Du, Y, Gao, L, Zhang, K, Wang, J. Association of the IL6 polymorphism rs1800796 with cancer risk: a meta-analysis. GENETICS AND MOLECULAR RESEARCH[J]. 2015, 14(4): 13236-13246, http://dx.doi.org/10.4238/2015.October.26.20.
[19] Chang, Suhua, Fang, Kechi, Zhang, Kunlin, Wang, Jing. Network-Based Analysis of Schizophrenia Genome-Wide Association Data to Detect the Joint Functional Association Signals. PLOS ONE[J]. 2015, 10(7): http://dx.doi.org/10.1371/journal.pone.0133404.
[20] Chang, Suhua, Wang, Jinglu, Zhang, Kunlin, Wang, Jing. Pathway-based analysis for genome-wide association study data of bipolar disorder provides new insights for genetic study. PROTEIN & CELL[J]. 2015, 6(12): 912-915, http://dx.doi.org/10.1007/s13238-015-0201-1.
[21] Guo, Liyuan, Du, Yang, Wang, Jing. Network analysis reveals a stress-affected common gene module among seven stress-related diseases/systems which provides potential targets for mechanism research. SCIENTIFIC REPORTS[J]. 2015, 5: http://dx.doi.org/10.1038/srep12939.
[22] Kechi Fang, Kunlin Zhang, Jing Wang. Network-assisted analysis of primary Sjögren’s syndrome GWAS data in Han Chinese. SCIENTIFIC REPORTS. 2015, 5: [23] Liyuan Guo, Du, Yang, Chang, Suhua, Zhang, Weina, Jing Wang. Applying differentially expressed genes from rodent models of chronic stress to researches of stress-related disease: an online database. Psychosomatic Medicine.[J]. 2014, [24] Li, Zhao, Chang, Suhua, Zhang, Liuyan, Gao, Lei, Wang, Jing. Molecular genetic studies of ADHD and its candidate genes: A review. PSYCHIATRY RESEARCHnull. 2014, 219(1): 10-24, http://dx.doi.org/10.1016/j.psychres.2014.05.005.
[25] 王晶. I-GSEA4GWAS v2 a web server for functional analysis of SNPs in trait associated pathways identified from genome-wide association study.. Protein Cell. 2014, [26] Guo, Liyuan, Du, Yang, Chang, Suhua, Zhang, Kunlin, Wang, Jing. rSNPBase: a database for curated regulatory SNPs. NUCLEIC ACIDS RESEARCH[J]. 2014, 42(D1): D1033-D1039, http://dx.doi.org/10.1093/nar/gkt1167.
[27] Gao, Lei, Li, Zhao, Chang, Suhua, Wang, Jing. Association of Interleukin-10 Polymorphisms with Schizophrenia: A Meta-Analysis. PLOS ONE[J]. 2014, 9(3): http://dx.doi.org/10.1371/journal.pone.0090407.
[28] Zhang, WeiNa, Chang, SuHua, Guo, LiYuan, Zhang, KunLin, Wang, Jing, Wang, J reprint author, Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing , Peoples R China. The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies. JOURNAL OF AFFECTIVE DISORDERS[J]. 2013, 151(2): 531-539, http://dx.doi.org/10.1016/j.jad.2013.06.039.
[29] 王晶. A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sj?gren’s syndrome at 7q11.23. Nature Genetics. 2013, [30] Chang, SuHua, Gao, Lei, Li, Zhao, Zhang, WeiNa, Du, Yang, Wang, Jing. BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder. BIOLOGICAL PSYCHIATRY[J]. 2013, 74(10): 727-733, http://dx.doi.org/10.1016/j.biopsych.2013.04.016.
[31] 王晶. ADHDgene: a genetic database for attention deficit hyperactivity discorder. Nucleic Acids Research. 2012, [32] Guo, Liyuan, Zhang, Weina, Chang, Suhua, Zhang, Liuyan, Ott, Jurg, Wang, Jing, Wang, J reprint author, Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing , Peoples R China. MK4MDD: A Multi-Level Knowledge Base and Analysis Platform for Major Depressive Disorder. PLOS ONE[J]. 2012, 7(10): http://dx.doi.org/10.1371/journal.pone.0046335.
[33] 王晶. Identification of a new nanoRNase in Bartonella. Microbiology. 2012, [34] Zhao, Hansheng, Li, Mao, Fang, Kechi, Chen, Wenfeng, Wang, Jing, Zhao, HS reprint author, China Agr Univ, Coll Biol Sci, State Key Lab Agrobiotechnol, Beijing , Peoples R China. In Silico Insights into the Symbiotic Nitrogen Fixation in Sinorhizobium meliloti via Metabolic Reconstruction. PLOS ONE[J]. 2012, 7(2): http://dx.doi.org/10.1371/journal.pone.0031287.
[35] Chang, Suhua, Zhang, Weina, Gao, Lei, Wang, Jing. Prioritization of candidate genes for attention deficit hyperactivity disorder by computational analysis of multiple data sources. PROTEIN & CELL[J]. 2012, 3(7): 526-534, http://lib.cqvip.com/Qikan/Article/Detail?id=7105128633.
[36] Panda Gurudutta, Zhang Kunlin, Chang Suhua, Lam Carolyn M C, Sun Changyue, Zhao Hansheng, Fang Kechi, Godinho Miguel, Martins dos Santos Vtor A P, Wang Jing. Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. BMC SYSTEMS BIOLOGY[J]. 2011, 5(1): https://doaj.org/article/32270dbbbcba4eaca06c3a42c3a1720d.
[37] Zhang, Kunlin, Chang, Suhua, Cui, Sijia, Guo, Liyuan, Zhang, Liuyan, Wang, Jing, Wang, J reprint author, Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing , Peoples R China. ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. NUCLEIC ACIDS RESEARCH[J]. 2011, 39(Web Server issue): W437-W443, http://dx.doi.org/10.1093/nar/gkr391.
[38] Ott, Jurg, Wang, Jing, Ott, J reprint author, Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing , Peoples R China. Multiple phenotypes in genome-wide genetic mapping studies. PROTEIN & CELL[J]. 2011, 2(7): 519-522, http://www.irgrid.ac.cn/handle/1471x/970934.
[39] Yang, Liu, Zhang, Kunlin, Dai, Wei, He, Ximiao, Zhao, Qian, Wang, Jing, Sun, Zhong Sheng, Wang, J reprint author, Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing , Peoples R China. Systematic evaluation of genome-wide methylated DNA enrichment using a CpG island array. BMC GENOMICS[J]. 2011, 12(1): http://dx.doi.org/10.1186/1471-2164-12-10.
[40] Zhang KunLin, Zhang LiuYan, Zhang WeiNa, Wang Jing, Wang, J reprint author, Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing , Peoples R China. Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study. CHINESE SCIENCE BULLETIN[J]. 2011, 56(32): 3398-3402, http://dx.doi.org/10.1007/s11434-011-4742-2.
[41] Yan, HaiQin, Chang, SuHua, Tian, ZheXian, Zhang, Le, Sun, YiCheng, Li, Yan, Wang, Jing, Wang, YiPing. Novel AroA from Pseudomonas putida Confers Tobacco Plant with High Tolerance to Glyphosate. PLOSONE[J]. 2011, 6(5): http://dx.doi.org/10.1371/journal.pone.0019732.
[42] Zhang, Jiajie, Mamlouk, Amir Madany, Martinetz, Thomas, Chang, Suhua, Wang, Jing, Hilgenfeld, Rolf, Hilgenfeld, R reprint author, Med Univ Lubeck, Ctr Struct Cell Biol Med, Inst Biochem, Ratzeburger Allee , D Lubeck, Germany. PhyloMap: an algorithm for visualizing relationships of large sequence data sets and its application to the influenza A virus genome. BMC BIOINFORMATICS[J]. 2011, 12(1): http://dx.doi.org/10.1186/1471-2105-12-248.
[43] 张柳燕, 常素华, 王晶. 从首个合成细胞看合成生物学的现状与发展. 科学通报[J]. 2010, 55(1): 001-012, http://lib.cqvip.com/Qikan/Article/Detail?id=37349255.
[44] Zhang, Kunlin, Cui, Sijia, Chang, Suhua, Zhang, Liuyan, 王晶. i-GSEA4GWAS: a web server for identification of pathways/gene sets associated with traits by applying an improved gene set enrichment analysis to genome-wide association study. NUCLEIC ACIDS RESEARCH[J]. 2010, 38(Suppl 2): W90-W95, https://www.webofscience.com/wos/woscc/full-record/WOS:000284148900016.

   

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