基本信息

蔡新霞
中科院电子学研究所传感技术国家重点实验室研究员、博导
中国科学院核心骨干特聘研究员、中国科学院大学岗位教授
2011年任国家纳米研究重大科学研究计划项目首席科学家
2012年国家杰出青年基金获得者
2014年入选国家百千万人才工程,获“有突出贡献中青年专家”荣誉称号
入选2016年度科技北京领军人才工程
专业:080920生物电子学; 080903微电子学与固体电子学
电邮:xxcai@mail.ie.ac.cn ;电话:010-58887193
地址:北京市中关村北一条9号科电大厦1109,邮编100190

研究领域

    长期从事微纳生物传感器及其检测系统研究,目前主要研究方向如下:
1、基于纳米技术的神经信息检测相关基础研究
  电生理和递质化学双模微电极阵列
  细胞/组织切片离体微电极阵列
  活体微电极阵列
  电极纳米功能材料与敏感材料
2、便携式生化快速检测技术
  电化学免疫快速检测技术  (肺癌、激素等疾病标志物检测)
  佩戴式脑神经检测电极与芯片系统
3、生物信息检测分析系统
  
脑神经信息检测科学仪器
  多参数生化检测分析仪器

教育背景

1998-10--2001-11   英国格拉斯哥大学电子与电气工程系生物电子学研究中心   博 士
1988-09--1991-07   中国科学院半导体所   工学硕士
1984-09--1988-07   北京理工大学电子工程系   工学学士
出国学习工作
作为客座研究员,于1995.04~1995.07,在日本东京工业大学生命科学与技术系相泽生物传感器实验室开展合作研究 

工作经历

   
工作简历

1991.08~1996.12 中国科学院电子学研究所 研究实习员 助理研究员 
1997.01~2002.03 中国科学院电子学研究所 副研究员
2002.04~2004.03 中国科学院电子学研究所 研究员 
2004.04~至今       中国科学院电子学研究所 博士生导师、研究员 
                             中国科学院大学教授

社会兼职
2014.03~至今 中国科学院大学微电子学位评定委员会 委员
2012.09~至今 中国科学院电子学研究所学术委员会 委员
2010.09~至今 中国科学院电子学研究所学位委员会 委员
2010.10~至今 中国生物医学工程学会神经工程分会 委员
2006.10~至今 中国仪器仪表学会传感器分会 常务理事
2006.09~至今 中国生物医学工程学会生物电子学分会 委员
 
2005.10~至今 传感技术联合国家重点实验室学术委员会 委员 

主要进展

       先后承担了多项国家科研项目,发表论文160篇,获授权国家发明专利26项,获2013年度国家技术发明二等奖和2012年度北京市科技奖二等奖各1项;曾获中国科学院大学优秀教师荣誉称号,先后培养研究生32人,获中科院院长优秀奖等奖励15人次;指导研究生毕业后有三分之一到研究机构和高校任职,三分之一到高新技术公司任职,三分之一出国深造。

 

Main Publications in Recent Years (*corresponding author):

1)       Yang Wang, Jinping Luo, Juntao Liu, Xinrong Li, Zhuang Kong, Hongyan Jin*, Xinxia Cai*, Electrochemical integrated paper-based immunosensor modified with multi-walled carbon nanotubes nanocomposites for point-of-care testing of 17β-estradiol. Biosensors and Bioelectronics, Volume 107, 1 June 2018, Pages 47-53

2)       Song Zhang, Yilin Song, Mixia Wang, Guihua Xiao, Fei Gao, Ziyue Li, Guoxian Tao, Ping Zhuang, Feng Yue*, Piu Chan*,Xinxia Cai*, Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays, Microsystems & Nanoengineering (2018) 4, 17070; 17070; doi:10.1038/micronano.2017.70, www.nature.com/micronano

3)       Juntao Liu, Yan Fan, Zhuang Kong, Yang Wang, Jinping Luo, Shengwei Xu, Hongyan Jin*, Xinxia Cai*, Smartphone-based rapid quantitative detection of luteinizing hormone using gold immunochromatographic strip, Sensors and Actuators B: Chemical, Volume 259, 15 April 2018, Pages 1073-1081.

4)       Guihua Xiao, Yilin Song, Song Zhang, Lili Yang, Xinxia Cai*, A high-sensitive nano-modified biosensor for dynamic monitoring of glutamate and neural spike covariation from rat cortex to hippocampal sub-regions, Journal of Neuroscience Methods, Volume 291, 1 November 2017, Pages 122-130

5)       Xinyi Fan, Yilin Song, Yuanlin Ma, Song Zhang, Guihua Xiao, Lili Yang, Huiren Xu, Dai Zhang, Xinxia Cai*, In Situ Real-Time Monitoring of Glutamate and Electrophysiology from Cortex to Hippocampus in Mice Based on a Microelectrode Array, Sensors 2017, 17, 61; doi:10.3390/s17010061

6)       Xinyang Liu, Juntao Liu, Feng Duan, Rui Liu, Shuping Gai, Shengwei Xu, Jianhui Sun, Xinxia Cai*, Neuroscience Letters 653 (2017) 326–331. https://authors.elsevier.com/a/1VHs~15DX1HV4p

7)       Yan Fan, Juntao Liu, Yang Wang, Jinping Luo, Huiren Xu, Shengwei Xu, Xinxia Cai*, Biosensors and Bioelectronics, 2017,  95:60–66. https://authors.elsevier.com/a/1UtWK3PVtpZ0AF

8)       Song Zhang, Yilin Song, Mixia Wang, Zhiming Zhang, XinyiFan, Xianteng Song, Ping Zhuang, Feng Yue, Piu Chan*, Xinxia Cai*. A silicon based implantable microelectrode array for electrophysiological and dopamine recording from cortex to striatum in the non-human primate brain. Biosensors and Bioelectronics, 2016, 85:53-61.

9)       Yang Wang, HuirenXu, JinpingLuo, Juntao Liu, Li Wang, Yan Fan, Shi Yan, Yue Yang, Xinxia Cai*. A novel label-free microfluidic paper-based immunosensor for highly sensitive electrochemical detection of carcinoembryonic antigen. Biosensors and Bioelectronics, 2016, 83:319-326.

10)    Wenjing Wei, Yilin Song, Xinyi Fan, Song Zhang, Li Wang, Shengwei Xu, Mixia Wang, Xinxia Cai*. Simultaneous recording of brain extracellular glucose, spike and LFP in real time using an implantablemicroelectrode array with nano-materials. Nanotechnology, 2016, 27(11):114001.

11)    Huiren Xu, Yang Wang, Li Wang, Yilin Song, Jinping Luo, Xinxia Cai*. A label-free microelectrode array based on one-step synthesis of chitosan–multi-walled carbon nanotube–thionine for ultrasensitive detection of carcinoembryonic antigen. Nanomaterials, 2016, 6,132.

12)    Xinyang Liu, Juntao Liu, Shuping Gai, Kristina Meyer, Shengwei Xu, Xinxia Cai*. Time-frequency distribution properties of event-related potentials in mental fatigue induced by visual memory tasks. Neuro Report, 2016, 27(14):1031-1036.

13)    Wenjing Wei, Yilin Song, Li Wang, Song Zhang, Jinping Luo, Shengwei Xu, Xinxia Cai*, An implantable microelectrode array for simultaneous L-glutamate and electrophysiological recordings in vivo    Microsystems & Nanoengineering, 2015, 1, 15002, dio:10.1038/micronano.2015.2

14)    Li Wang, Huiren Xu, Jinping Luo, Chunxiu Liu, Shengwei Xu, Xinxia Cai*,   Highly Sensitive Detection of Quantal Dopamine Secretion from Pheochromocytoma Cells Using Neural Microelectrode Array Electrodeposited with Polypyrrole Graphene, ACS Applied materials & Interface, 2015, 7, 7619-7626

15)    Shuxue Qu, Juntao Liu, Jinping Luo, Bin Wang, Xinxia Cai*. A rapid and highly sensitive portable chemiluminescent immunosensor of carcinoembryonic antigen based on immunomagnetic separation in human serum, Analytica Chimica Acta, 2013, 766: 94-99.

16)    Huiren Xu, Li Wang, Jinping Luo,  Chunxiu Liu, Juntao Liu,  Song Zhang, Xinxia Cai*. Selective recognition of 5-Hydroxytryptamine and dopamine on multi-walled carbon nanotubes-chitosan hybrid film modified microelectrode array. Sensors, 2015, 15(1): 1008-1021.

17)    Quan Zhou, Shuping Gai, Nansen Lin, Jingjing Zhang, Lu Zhang, Renhuan Yu, Juntao Liu, Xinxia Cai*. Power spectral differences of electrophysiological signals detected at acupuncture points and non-acupuncture points. Acupunct Electrother Res., 2014, 39(2):169-181.

18)    Wenjing Wei, Yilin Song, Wentao Shi,Nansen Lin, Tingjun Jiang, Xinxia Cai*, A high sensitivityMEA probefor measuring real time rat brain glucose flux, Biosensors and Bioelectronics, 2014, 55, 66-71

19)    Li Wang, Tingjun Jiang, Yilin Song, Wentao Shi, Xinxia Cai*, Dopamine detection using a patchclamp system on a planar microeletrode array  electrodeposited by polypyrrole/graphene nanocomposites, Science China, 2014, 57, 1-5

20)    Chunxiu Liu, Yilin Song, Nansen Lin, Shuai Zhou, Mixia Wang, Xinxia Cai*,  Planar Microelectrode Chip for Synchronous Simulative Neurochemical and Neuroelectrial Monitoring, Journal of Nanoscience and Nanotechnology, 2013, 13(2), 736-740.

21)    Shuai Zhou, Chunxiu Liu, Yilin Song, Xinxia Cai*,  Highly Selective and Sensitive Determination of Dopamine Using Nafion Coated Microelectrode Arrays, Journal of Nanoscience and Nanotechnology, 2013, 13(2), 1598-1601

22)    Jinping Luo, Shuxue Qu, Juntao Liu, Bin Wang, Xinxia Cai*, Rapid detection of Cyfra 21-1 by optical-biosensing based on chemiluminescence immunoassay using bio-functionlized magnetic nanocomposites, Chinese Science Bulletin, 2013, 58(16), 1-3

23)    Wentao Shi, Chunxiu Liu, Yilin Song, Nansen Lin, Shuai Zhou, Xinxia Cai*, An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites, Biosensors and Bioelectronics, 2012, 38, 100-106

24)    Yilin Song, Nansen Lin, Chunxiu Liu, Hong Jiang, Guogang Xing, Xinxia Cai*,  A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro, Biosensors and Bioelectronics, 2012, 38, 416-420.

25)    Jinping Luo, Weiwei Yue, Xiaohong Liu, Qing Tian, Xinxia Cai*, Bioluminescence-based biosensor for food contamination, Biosensors and Environmental Health, 2012,  Science Publishers, 18, 336-354

奖励信息
(1) 基于生物敏感膜的便携式传感器及关键技术及应用, 二等奖, 国家级, 2013
(2) 基于新型敏感膜的便携式生物传感器关键技术及应用, 二等奖, 省级, 2012

教授课程

生物电子学