课题组建立了生物材料可控和规模制备的平台，针对核酸药物治疗的多元化需求，通过调控生物材料载体（脂质、聚合物等）与治疗性药物（单核酸药物、核酸-化学药物等）、预防性疫苗（mRNA、DNA疫苗等）以及医学成像示踪剂（磁共振示踪剂等）的构效关系，进行重大疾病“预防-诊断-治疗”的研究（代谢类疾病、恶性肿瘤、神经退行性疾病等）。

研究方向:

核酸药物治疗；

核酸疫苗免疫；

多药治疗；

联合诊疗。

主页：http://www.zhangxinlab.cn/

   

080502-材料学
080501-材料物理与化学
081704-应用化学

生物高分子材料，药物剂型
生物材料制备，药物剂型
纳米生物材料

2004-10--2008-02   法国斯特拉斯堡大学   博士

   

2010-07~现在, 中国科学院过程工程研究所生化工程国家重点实验室, 研究员
2008-03~2010-03,法国国家健康与医学研究院, 助理研究员

2017-10-30-2021-10-31,中国生物物理学会纳米生物学分会理事, 理事
2015-06-30-今,中国生物医学工程学会纳米医学分会委员, 委员
2015-06-06-今,中国生物材料学会转化医学材料分会委员, 委员
2015-01-01-今,Theranostics编委, 编委

高分子物理学专题

   

（1） 中国生物材料学会青年科学家奖, 省级, 2018
（2） 中国生物材料学会年度杰出贡献奖, 其他, 2013

[1] 张欣, 卢治国, 张田露, 王建泽, 阳俊, 李燕. 一种活性基团修饰的介孔二氧化硅纳米香料及其制备方法. CN: CN113969211A, 2022-01-25.

[2] 张欣, 代凤英. 一种免疫磁珠及其制备方法和应用. CN: CN113933501A, 2022-01-14.

[3] 张欣, 阳俊, 申奇, 刘瑞瑗. 氧化锌、抗原共载药物纳米疫苗、其制备方法与应用. CN: CN110755607B, 2021-12-28.

[4] 张欣. 一种CRISPRCas9递送体系及其制备方法和应用. 202110262193.8, 2021-03-10.

[5] 张欣. 一种口服胶囊及其制备方法和应用. 202110126503.3, 2021-01-19.

[6] 张欣, 李燕, 籍伟红, 刘霖颖, 彭欢. 阳离子聚前药聚合物、其制备方法及应用. CN: CN110974973A, 2020-04-10.

[7] 张欣, 卢治国, 王向宇, 张田露, 阳俊. 温度和pH双重响应缓释芳香纳米凝胶、制备方法及应用. CN: CN110982623A, 2020-04-10.

[8] 张欣, 张田露, 刘霖颖, 李燕, 卢治国. 姜黄素香料体系、制备方法及应用. CN: CN109771662A, 2019-05-21.

[9] 张欣, 沈洁, 张田露, 卢治国. pH响应缓控释的聚合物纳米香料及其制备方法. CN: CN109518463A, 2019-03-26.

[10] 张欣, 籍伟红, 张田露, 卢治国. 温控缓释的介孔二氧化硅纳米香料及其制备方法. CN: CN109504537A, 2019-03-22.

[11] 张欣, 张田露, 卢治国. 光响应缓释的聚合物纳米香料及其制备方法. CN: CN108546595A, 2018-09-18.

[12] 张欣, 张田露, 卢治国. 光控缓释的球形二氧化硅纳米香料及其制备方法. CN: CN108531292A, 2018-09-14.

[13] 张欣, 卢治国, 张田露. 光控缓释的棒状二氧化硅纳米香料及其制备方法. CN: CN108441323A, 2018-08-24.

[14] 张欣, 代凤英, 胡冰冰. 一种超顺磁性纳米颗粒及其制备方法和应用. CN: CN104906600B, 2018-01-05.

[15] 张欣, 张田露, 李燕, 李彦辉, 庆宏. 一种用于治疗帕金森病的EGCG香料药及其制备方法. CN: CN107496416A, 2017-12-22.

[16] 张欣, 李燕. 一种聚羧基甜菜碱基因转染制剂及其制备方法和用途. CN: CN105238819A, 2016-01-13.

[17] 张欣, 阳俊, 乔晨萌. 一种脂质体核酸疫苗佐剂及其制备方法和应用. CN: CN105106116A, 2015-12-02.

[18] 张欣, 代凤英, 胡冰冰. 一种超顺磁性纳米颗粒及其制备方法和应用. CN: CN104922702A, 2015-09-23.

[19] 张欣, 代凤英, 邓恒. 一种金纳米粒子光热疗剂及其制备方法和应用. CN: CN104888214A, 2015-09-09.

[20] 张欣, 李燕, 刘瑞瑗. 一种避免加速血液清除现象的长循环脂质体、制备方法及应用. CN: CN104644555A, 2015-05-27.

[21] 张欣, 董雅琼, 阳俊. 一种阳离子脂质分子及其制备方法和用途. CN: CN104447365A, 2015-03-25.

[22] 张欣, 董雅琼, 阳俊. 一种阳离子脂质体核酸类药物制剂及其制备方法和应用. CN: CN104352440A, 2015-02-18.

[23] 张欣, 阳俊, 乔晨萌. 一种微胶囊日用香精及其制备方法. CN: CN104293486A, 2015-01-21.

[24] 翁杰, 张欣, 乔晨萌, 阳俊. 一种纳米脂质体食用香精的制备方法. CN: CN103960634A, 2014-08-06.

[25] 张欣, 代凤英, 钟砚琦, 何艳, 刘颖果. 一种具有类风湿性关节炎部位靶向作用的超顺磁性颗粒、制备方法及其用途. CN: CN103690971A, 2014-04-02.

[26] 张欣, 代凤英, 钟砚琦. 一种高分子原位修饰的超顺磁性颗粒、制备方法及其用途. CN: CN103405790A, 2013-11-27.

[27] 张欣, 梁子才, 梁兴杰, 代凤英, 李燕, 程强. 新型阳离子脂质体核酸类药物制剂,及其制备方法和应用. CN: CN103194489A, 2013-07-10.

[28] 张欣, 李燕, 代凤英. 一种抗吸附、长循环脂质分子、其制备方法及其在医药和化妆品领域的应用. CN: CN102653573A, 2012-09-05.

   

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[2] Li, Yan, Ji, Weihong, Peng, Huan, Zhao, Ruichen, Zhang, Tianlu, Lu, Zhiguo, Yang, Jun, Liu, Ruiyuan, Zhang, Xin. Charge-switchable zwitterionic polycarboxybetaine particle as an intestinal permeation enhancer for efficient oral insulin delivery. THERANOSTICS[J]. 2021, 11(9): 4452-4466, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7977443/.
[3] Zhang, Tianlu, Lu, Zhiguo, Wang, Jianze, Shen, Jie, Hao, Qiulian, Li, Yan, Yang, Jun, Niu, Yunwei, Xiao, Zuobing, Chen, Lei, Zhang, Xin. Preparation of mesoporous silica nanoparticle with tunable pore diameters for encapsulating and slowly releasing eugenol. CHINESE CHEMICAL LETTERS[J]. 2021, 32(5): 1755-1758, http://dx.doi.org/10.1016/j.cclet.2020.12.033.
[4] Ji, Weihong, Li, Yan, Peng, Huan, Zhao, Ruichen, Shen, Jie, Wu, Yanyue, Wang, Jianze, Hao, Qiulian, Lu, Zhiguo, Yang, Jun, Zhang, Xin. Self-Catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases. ADVANCED MATERIALS[J]. 2021, [5] Ji, Weihong, Li, Yan, Liu, Ruiyuan, Lu, Zhiguo, Liu, Linying, Shi, Zhuyan, Shen, Jie, Zhang, Xin. Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies. MATERIALS HORIZONS[J]. 2021, 8(4): 1199-1206, https://www.webofscience.com/wos/woscc/full-record/WOS:000639328100022.
[6] Shen, Jie, Lu, Zhiguo, Wang, Jianze, Hao, Qiulian, Ji, Weihong, Wu, Yanyue, Peng, Huan, Zhao, Ruichen, Yang, Jun, Li, Yan, Shi, Zhuyan, Zhang, Xin. Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment. ADVANCED MATERIALS[J]. 2021, 33(27): http://dx.doi.org/10.1002/adma.202101993.
[7] Zhang, Tianlu, Lu, Zhiguo, Wang, Xiangyu, Shen, Jie, Wang, Jianze, Niu, Yunwei, Xiao, Zuobing, Zhang, Xin. Zwitterionic comb-like lipid polymers encapsulating linalool for increasing the fragrance retention time. CHINESE CHEMICAL LETTERS[J]. 2021, 32(1): 573-576, http://dx.doi.org/10.1016/j.cclet.2020.01.041.
[8] Ma, Wenjing, Peng, Huan, Liu, Kewei, Wang, Yaguo, Wang, Wei, Qu, Shilin, Li, Yan, Bi, Lijun, Zhang, Xin, Zhang, Liqun. Efficacy of Dual-Targeting Combined Anti-Tuberculosis Drug Delivery System in the Treatment of Tuberculous Meningitis. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY[J]. 2021, 17(10): 2034-2042, [9] Peng, Huan, Ji, Weihong, Zhao, Ruichen, Lu, Zhiguo, Yang, Jun, Li, Yan, Zhang, Xin. pH-sensitive zwitterionic polycarboxybetaine as a potential non-viral vector for small interfering RNA delivery. RSC ADVANCES[J]. 2020, 10(73): 45059-45066, http://dx.doi.org/10.1039/d0ra09359a.
[10] Lu, Zhiguo, Wang, Xiangyu, Zhang, Tianlu, Zhang, Luyao, Yang, Jun, Li, Yan, Shen, Jie, Wang, Jianze, Niu, Yunwei, Xiao, Zuobing, Liu, Guiying, Zhang, Xin. Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk. CHINESE CHEMICAL LETTERS[J]. 2020, 31(12): 3139-3142, http://lib.cqvip.com/Qikan/Article/Detail?id=7103955078.
[11] Linying Liu, Yan Li, Huan Peng, Ruiyuan Liu, Weihong Ji, Zhuyan Shi, Jie Shen, Guanghui Ma, Xin Zhang. Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing α-synuclein and immune activation of Parkinson’s disease. SCIENCE ADVANCES. 2020, 6(50): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732192/.
[12] Wang, Xiangyu, Lu, Zhiguo, Shen, Jie, Niu, Yunwei, Xiao, Zuobing, Chen, Lei, Hao, Jifu, Zhang, Xin. Nano-Fragrance with pH-Sensitive Release Property for Improvement of Central Nervous System. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY[J]. 2020, 16(2): 193-200, https://www.webofscience.com/wos/woscc/full-record/WOS:000524973800005.
[13] Lu, Zhiguo, Zhang, Tianlu, Yang, Jun, Wang, Jianze, Shen, Jie, Wang, Xiangyu, Xiao, Zuobing, Niu, Yunwei, Liu, Guiying, Zhang, Xin. Effect of mesoporous silica nanoparticles-based nano-fragrance on the central nervous system. ENGINEERING IN LIFE SCIENCES[J]. 2020, 20(11): 535-540, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7645641/.
[14] Lu, Zhiguo, Wang, Jianze, Qu, Lina, Kan, Guanghan, Zhang, Tianlu, Shen, Jie, Li, Yan, Yang, Jun, Niu, Yunwei, Xiao, Zuobing, Li, Yinghui, Zhang, Xin. Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition. BIOACTIVE MATERIALS[J]. 2020, 5(4): 1127-1137, http://lib.cqvip.com/Qikan/Article/Detail?id=7103847788.
[15] Liu, Ruiyuan, Yang, Jun, Liu, Linying, Lu, Zhiguo, Shi, Zhuyan, Ji, Weihong, Shen, Jie, Zhang, Xin. An "Amyloid-beta Cleaner" for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction. ADVANCED SCIENCE[J]. 2020, 7(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000497900400001.
[16] Peng, Huan, Ji, Weihong, Zhao, Ruichen, Yang, Jun, Lu, Zhiguo, Li, Yan, Zhang, Xin. Exosome: a significant nano-scale drug delivery carrier. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2020, 8(34): 7591-7608, https://www.webofscience.com/wos/woscc/full-record/WOS:000565996500002.
[17] Liu, Linying, Li, Yan, Peng, Huan, Liu, Ruiyuan, Ji, Weihong, Shi, Zhuyan, Shen, Jie, Ma, Guanghui, Zhang, Xin. Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease. SCIENCE ADVANCES[J]. 2020, 6(50): http://dx.doi.org/10.1126/sciadv.aba3967.
[18] Li, Yan, Liu, Linying, Ji, Weihong, Peng, Huang, Zhao, Ruichen, Zhang, Xin. Strategies and materials of SMARTnon-viral vectors: Overcoming the barriers for brain gene therapy. NANOTODAY[J]. 2020, 35: http://dx.doi.org/10.1016/j.nantod.2020.101006.
[19] Ruiyuan Liu, Jun Yang, Linying Liu, Zhiguo Lu, Zhuyan Shi, Weihong Ji, Jie Shen, Xin Zhang. An "Amyloid‐β Cleaner" for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction. ADVANCED SCIENCE[J]. 2020, 7(2): n/a-n/a, https://doaj.org/article/3fe6a359cf594caf8352e9939f7de2f6.
[20] Wang, Xiangyu, Lu, Zhiguo, Zhang, Jimei, Zhao, Baochang, Wang, Jianze, Shen, Jie, Niu, Yunwei, Xiao, Zuobing, Liu, Guiying, Hao, Jifu, Zhang, Xin. Cationic Nano-Fragrance with Sustained Release Property for Neuroregulation. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY[J]. 2020, 16(3): 344-351, https://www.webofscience.com/wos/woscc/full-record/WOS:000538938700006.
[21] Yang, Jun, Shi, Zhuyan, Liu, Ruiyuan, Wu, Yanyue, Zhang, Xin. Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology. THERANOSTICS[J]. 2020, 10(7): 3223-3239, https://www.webofscience.com/wos/woscc/full-record/WOS:000514452800023.
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[23] Shen, Jie, Lu, Zhiguo, Wang, Jianze, Zhang, Tianlu, Yang, Jun, Li, Yan, Liu, Guiying, Zhang, Xin. Advances of Nanoparticles for Leukemia Treatment. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2020, 6(12): 6478-6489, https://www.webofscience.com/wos/woscc/full-record/WOS:000599989300002.
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[25] Wu, Yanyue, Lu, Zhiguo, Li, Yan, Yang, Jun, Zhang, Xin. Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection. NANOMATERIALS[J]. 2020, 10(8): https://doaj.org/article/fe7a7bee4c6145c8b3809d912b42f6c0.
[26] Zhao, Ruichen, Lu, Zhiguo, Yang, Jun, Zhang, Liqun, Li, Yan, Zhang, Xin. Drug Delivery System in the Treatment of Diabetes Mellitus. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2020, 8: https://doaj.org/article/ce1866ea02c84510bbf023ec02e4729f.
[27] Zhang, Tianlu, Lu, Zhiguo, Zhang, Luyao, Li, Yan, Yang, Jun, Shen, Jie, Wang, Jianze, Niu, Yunwei, Xiao, Zuobing, Chen, Lei, Zhang, Xin. Preparation of hollow mesoporous silica nanorods for encapsulating and slowly releasing eugenol. CHINESECHEMICALLETTERS[J]. 2020, 31(12): 3135-3138, http://lib.cqvip.com/Qikan/Article/Detail?id=7103955077.
[28] Wang, Jianze, Lu, Zhiguo, Shen, Jie, Peng, Huan, Zhang, Tianlu, Niu, Yunwei, Xiao, Zuobing, Hao, Jifu, Zhang, Xin. Hollow Mesoporous Silica Nanoparticles Loaded with Eugenol for Regulating the Central Nervous System. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY[J]. 2020, 16(5): 652-658, https://www.webofscience.com/wos/woscc/full-record/WOS:000573055400001.
[29] Weihong Ji, Tianlu Zhang, Zhiguo Lu, Jie Shen, Jing Hu, Yunwei Niu, Zuobing Xiao, Xin Zhang. Mesoporous silica nanospheres with the ability of photo-driven releasing sandela 803 for the application to wallpaper. 中国化学快报:英文版[J]. 2019, 30(3): 747-749, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849632.
[30] Zhang, Tianlu, Lu, Zhiguo, Shen, Jie, Hu, Jing, Niu, Yunwei, Xiao, Zuobing, Chen, Lei, Zhang, Xin. Preparation of Photo-Responsive Nanomicelles Loaded with Sandela 803 for Wallpaper Application. NANOSCIENCE AND NANOTECHNOLOGY LETTERS[J]. 2019, 11(1): 22-30, http://ir.ipe.ac.cn/handle/122111/27985.
[31] Shen, Qi, Yang, Jun, Liu, Ruiyuan, Liu, Linying, Zhang, Jinchao, Shen, Shigang, Zhang, Xin. Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy. MATERIALSHORIZONS[J]. 2019, 6(4): 810-816, http://ir.ipe.ac.cn/handle/122111/28261.
[32] Weihong Ji, Tianlu Zhang, Zhiguo Lu, Jie Shen, Zuobing Xiao, Xin Zhang. Synthesis and characterization of novel biocompatible nanocapsules encapsulated lily fragrance. 中国化学快报(英文版)[J]. 2019, 30(3): 739-742, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849630.
[33] Ji, Weihong, Zhang, Tianlu, Lu, Zhiguo, Shen, Jie, Hu, Jing, Niu, Yunwei, Xiao, Zuobing, Zhang, Xin. Mesoporous silica nanospheres with the ability of photo-driven releasing sandela 803 for the application to wallpaper. CHINESE CHEMICAL LETTERS[J]. 2019, 30(3): 747-749, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849632.
[34] 周珠贤, 胡静, 江黎明, 朱为宏, 张欣, 肖作兵, 申有青. 纳米香料技术的现状与发展. 中国科学:化学[J]. 2019, 49(4): 575-580, https://www.sciengine.com/doi/10.1360/N032018-00168.
[35] 沈洁, 卢红霞, 卢治国, 张田露, 朱为宏, 江黎明, 申有青, 肖作兵, 张欣. 高分子纳米香精制备的研究进展. 中国科学:化学[J]. 2019, 49(4): 591-596, https://www.sciengine.com/doi/10.1360/N032018-00195.
[36] Zhang, Tianlu, Li, Jian, Zhang, Mengying, Lu, Zhiguo, Wang, Zhen, Shen, Jie, Hu, Jing, Niu, Yunwei, Xiao, Zuobing, Chen, Lei, Mansmann, Ulrich R, Zhang, Xin. Light-Activated Nanoparticles Encapsulated with Santalum Album: A Potential Therapeutic Agent for Neurodegenerative Disease. NANOSCIENCE AND NANOTECHNOLOGY LETTERS[J]. 2019, 11(3): 312-321, http://ir.ipe.ac.cn/handle/122111/28303.
[37] Ji, Weihong, Zhang, Tianlu, Lu, Zhiguo, Shen, Jie, Xiao, Zuobing, Zhang, Xin. Synthesis and characterization of novel biocompatible nanocapsules encapsulated lily fragrance. CHINESE CHEMICAL LETTERS[J]. 2019, 30(3): 739-742, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849630.
[38] Liu, Linying, Li, Yan, Liu, Ruiyuan, Shen, Qi, Li, Yanhui, Shi, Zhuyan, Shen, Jie, Ji, Weihong, Zhang, Xin. Switchable nanoparticle for programmed gene-chem delivery with enhanced neuronal recovery and CT imaging for neurodegenerative disease treatment. MATERIALS HORIZONS[J]. 2019, 6(9): 1923-1929, https://www.webofscience.com/wos/woscc/full-record/WOS:000490535600014.
[39] 沈洁, 卢红霞, 卢治国, 张田露, 肖作兵, 张欣. 光敏纳米香料应用于壁纸及香气缓控释的研究. 中国科学:化学[J]. 2019, 49(4): 613-618, https://www.sciengine.com/doi/10.1360/N032018-00194.
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（1） 分子仿生, Molecular Biomimics, 科学出版社, 2013-06, 第 3 作者
（2） 肿瘤靶向诊疗的纳米材料, Nanomaterials for Tumor Targeting Theranostics, 高等教育出版社, 2015-07, 第 3 作者

   

（ 1 ） 兼具高效分区包载、程序可控释放功能的药物输递系统改善肿瘤耐药性的研究, 主持, 国家级, 2014-01--2017-12
（ 2 ） 基因治疗药物肿瘤靶向递送关键技术及成药性研究, 主持, 国家级, 2014-01--2016-12
（ 3 ） 超顺磁性造影剂增强的功能磁共振成像系统的研制, 主持, 部委级, 2014-01--2015-12
（ 4 ） 核酸纳米化药物, 主持, 部委级, 2012-06--2017-06
（ 5 ） 香料纳米化与缓控释, 主持, 国家级, 2016-07--2021-06
（ 6 ） 生物材料, 主持, 国家级, 2016-01--2018-12
（ 7 ） 一种高特异性用于帕金森病诊疗的MRI对比剂研究, 主持, 省级, 2017-10--2020-10

已指导学生

钟砚琦  硕士研究生  085238-生物工程  

孙丹丹  硕士研究生  430117-化学工程  

邓恒  硕士研究生  085204-材料工程  

刘洪梅  博士研究生  081703-生物化工  

李燕  博士研究生  081703-生物化工  

卢治国  硕士研究生  085238-生物工程  

现指导学生

石竹砚  博士研究生  081703-生物化工  

刘霖颖  博士研究生  081703-生物化工  

刘瑞瑗  博士研究生  081703-生物化工  

籍伟红  硕士研究生  081703-生物化工  

沈洁  硕士研究生  081703-生物化工