基本信息

王言  男  博士生导师 

专利代理师资格

​知识产权管理体系内审员资格


中国科学院深圳先进技术研究院
电子邮件: yan.wang@siat.ac.cn
通信地址: 深圳南山区学苑大道1068号
邮政编码:518055

研究领域

利用生物信息学和化学信息学,开发和优化药物筛选模型,进而开展现有药物的药效学再评价、毒副作用机制和预警研究,以及现有药物的二次开发研究。曾开发10个基于靶点的药物筛选平台,其中包括首个针对 HCMV terminase 的药物评价筛选平台,获得 NIH资助 300 万美元开发 HCMV terminase 抑制剂。在药物筛选领域发表 SCI 文章 50余篇,i10指数30。作为主要执行人完成了美国NIH项目、香港卫生署项目等多个药物研究项目。回国后主持国家自然科技基金、广东省自然科技基金和高水平医院登峰计划以及深圳市科创委项目。现为国家自然科技基金评审专家,深圳市海外引进高层次人才,深圳南山区领航人才。


招生信息

   
招生专业
071010-生物化学与分子生物学
招生方向
药物筛选

教育背景

2010-08--2014-12   香港中文大学   博士
2007-09--2010-06   中国药科大学   硕士
2003-09--2007-06   南京中医药大学   学士
学位
博士 香港中文大学

工作经历

   
工作简历
2018-09~现在, 中国科学院深圳先进技术研究院, 副研究员
2015-11~2018-08,美国明尼苏达大学, 博士后研究员
2013-12~2015-10,香港中文大学, 助理研究员
社会兼职
2023-07-01-今,香港中文大学深圳研究院创业导师,
2022-07-01-今,Chinese Medicine青年编委,

专利与奖励

深圳市海外高层次人才孔雀计划”C类引进人才,2019


专利成果
( 1 ) Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening, 发明, 2018, 第 2 作者, 专利号: US9968616B2

出版信息

   
发表论文
[1] Kuangyang Yang, Qian Xie, Jiaxin Liao, Na Zhao, Jianhui Liang, Ben Liu, Jianhai Chen, Wenxiang Cheng, Xueling Bai, Peng Zhang, Qian Liu, Bing Song, Junyi Danny Wang, Fanghao Zheng, Chun Hu, Lichu Liu, Lei Chen, Yan Wang. Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2023, 311: http://dx.doi.org/10.1016/j.jep.2023.116476.
[2] Yanni Shen, Qian Xie, Yiling Wang, Jianhui Liang, Cuilu Jiang, Xiaoping Liu, Yan Wang, Chun Hu. Design, synthesis and anti-osteosarcoma activity study of novel pyrido2,3-dpyrimidine derivatives by inhibiting DKK1-Wnt/β-catenin pathway. BIOORGANIC CHEMISTRY. 2023, 141: http://dx.doi.org/10.1016/j.bioorg.2023.106848.
[3] He, MingFeng, Liang, JianHui, Shen, YanNi, Zhang, ChaoWei, Yang, KuangYang, Liu, LiChu, Xie, Qian, Hu, Chun, Song, Xun, Wang, Yan. Coptisine Inhibits Influenza Virus Replication by Upregulating p21. MOLECULES[J]. 2023, 28(14): http://dx.doi.org/10.3390/molecules28145398.
[4] Yang, Kuangyang, Xie, Qian, Tang, Tingting, Zhao, Na, Liang, Jianhui, Shen, Yanni, Li, Ziqi, Liu, Ben, Chen, Jianhai, Cheng, Wenxiang, Bai, Xueling, Zhang, Peng, Liu, Qian, Song, Bing, Hu, Chun, Liu, Lichu, Wang, Yan. Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. PHYTOMEDICINE[J]. 2023, 108: http://dx.doi.org/10.1016/j.phymed.2022.154506.
[5] Lei Chen, Xia Qiu, Abigail Dupre, Oscar PellonCardenas, Xiaojiao Fan, Xiaoting Xu, Prateeksha Rout, Katherine D Walton, Joseph Burclaff, Ruolan Zhang, Wenxin Fang, Rachel Ofer, Alexandra Logerfo, Kiranmayi Vemuri, Sheila Bandyopadhyay, Jianming Wang, Gaetan Barbet, Yan Wang, Nan Gao, Ansu O Perekatt, Wenwei Hu, Scott T Magness, Jason R Spence, Michael P Verzi. TGFB1 induces fetal reprogramming and enhances intestinal regeneration. CELL STEM CELL. 2023, 30(11): 1520-1537.e8, http://dx.doi.org/10.1016/j.stem.2023.09.015.
[6] Xie, Qian, Yang, Kuangyang, Liang, Jianhui, Shen, Yanni, Liu, Lichu, Wang, Yan. Spheroid culture of chondrocytes exhibits elevated levels of inflammation: A better approach for investigating the mechanisms of osteoarthritis?. PHARMACOLOGICAL RESEARCH[J]. 2023, 191: http://dx.doi.org/10.1016/j.phrs.2023.106762.
[7] Qian Liu, Vsevolod Telezhkin, Wenkai Jiang, Yu Gu, Yan Wang, Wei Hong, Weiming Tian, Polina Yarova, Gaofeng Zhang, Simon Mingyuen Lee, Peng Zhang, Min Zhao, Nicholas D Allen, Emilio Hirsch, Josef Penninger, Bing Song. Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation. CELL & BIOSCIENCE[J]. 2023, 13(1): 1-17, https://doaj.org/article/797ccd32264d468c927a159ef5755817.
[8] Yang, Kuangyang, Xie, Qian, Liang, Jianhui, Shen, Yanni, Li, Ziqi, Zhao, Na, Wu, Yuanyan, Liu, Lichu, Zhang, Peng, Hu, Chun, Chen, Lei, Wang, Yan. Identification of Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment. PHYTOMEDICINE[J]. 2023, 118: http://dx.doi.org/10.1016/j.phymed.2023.154939.
[9] Wenxin Fang, Ruolan Zhang, Jianhui Liang, Wanrong Xie, Youtao Zhang, Lei Chen, Yan Wang. Cereblon: A promising E3 ligase for broad-spectrum anticancer PROTAC drug development?. PHARMACOLOGICAL RESEARCH[J]. 2023, 196: 106901-, http://dx.doi.org/10.1016/j.phrs.2023.106901.
[10] Qian Xie, Yanni Shen, Yanli Meng, Jianhui Liang, Jing Xu, Shishao Liang, Xiaoping Liu, Yan Wang, Chun Hu. Pyrido2,3-dpyrimidine-2,4(1H,3H)-dione derivatives as RAF-MEK-ERK pathway signaling pathway blockers: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2022, 240: http://dx.doi.org/10.1016/j.ejmech.2022.114579.
[11] Senaweera, Sameera, Edwards, Tiffany C, Kankanala, Jayakanth, Wang, Yan, Sahani, Rajkumar Lalji, Xie, Jiashu, Geraghty, Robert J, Wang, Zhengqiang. Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV). ACTA PHARMACEUTICA SINICA B[J]. 2022, 12(4): 1671-1684, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7222772&detailType=1.
[12] Zhang, Jinwen, He, Mingfeng, Xie, Qian, Su, Ailing, Yang, Kuangyang, Liu, Lichu, Liang, Jianhui, Li, Ziqi, Huang, Xiuxin, Hu, Jianshu, Liu, Qian, Song, Bing, Hu, Chun, Chen, Lei, Wang, Yan. Predicting In Vitro and In Vivo Anti-SARS-CoV-2 Activities of Antivirals by Intracellular Bioavailability and Biochemical Activity. ACS OMEGA[J]. 2022, 7(49): 45023-45035, http://dx.doi.org/10.1021/acsomega.2c05376.
[13] Wan, Jiangfan, Wang, Gang, Qin, Fuying, Huang, Danling, Wang, Yan, Su, Ailing, Zhang, Haiping, Liu, Yang, Zeng, Shaoyin, Wei, Chaoliang, Cheng, Yongxian, Liu, Jie. Z16b, a natural compound from Ganoderma cochlear is a novel RyR2 stabilizer preventing catecholaminergic polymorphic ventricular tachycardia. ACTA PHARMACOLOGICA SINICA[J]. 2022, 43(9): 2340-2350, http://dx.doi.org/10.1038/s41401-022-00870-1.
[14] Hu, Ziwei, Hu, Hao, Hu, Zhili, Zhong, Xiaojun, Guan, Yifu, Zhao, Yunshi, Wang, Lu, Ye, Liang, Ming, Liliang, Rajoka, Muhammad Shahid Riaz, He, Zhendan, Wang, Yan, Song, Xun. Sanguinarine, Isolated From Macleaya cordata, Exhibits Potent Antifungal Efficacy Against Candida albicans Through Inhibiting Ergosterol Synthesis. FRONTIERS IN MICROBIOLOGY[J]. 2022, 13: https://doaj.org/article/190cd5e3daea45a288a63c83b4d36302.
[15] He, MingFeng, Liang, JianHui, Shen, YanNi, Zhang, JinWen, Liu, Ying, Yang, KuangYang, Liu, LiChu, Wang, Junyi, Xie, Qian, Hu, Chun, Song, Xun, Wang, Yan. Glycyrrhizin Inhibits SARS-CoV-2 Entry into Cells by Targeting ACE2. LIFE-BASEL[J]. 2022, 12(11): http://dx.doi.org/10.3390/life12111706.
[16] Wang, Yan, SotoAcosta, Ruben, Ding, Rui, Chen, Liqiang, Geraghty, Robert J. Anti-HCMV activity by an irreversible p97 inhibitor LC-1310. MEDICINAL CHEMISTRY RESEARCH[J]. 2021, 30(2): 440-448, http://dx.doi.org/10.1007/s00044-020-02679-1.
[17] 陈建海, 张鹏. Notch-1 and Notch-3 Mediates Hypoxia-Induced Synovial Fibroblasts Activation in Rheumatoid Arthritis. Arthritis & Rheumatology[J]. 2021, [18] Wang, Yan, Chen, Lei. Lung tissue distribution of drugs as a key factor for COVID-19 treatment. BRITISH JOURNAL OF PHARMACOLOGYnull. 2020, 177(21): 4995-4996, https://www.doi.org/10.1111/bph.15102.
[19] Hu, Yiping, Zhang, Tiantian, Chen, Jingqin, Cheng, WenXiang, Chen, Jianhai, Zheng, Zhengtan, Lin, Jietao, Zhu, Guoyuan, Zhang, Yong, Bai, Xueling, Wang, Yan, Song, Bing, Wang, Qingwen, Qin, Ling, Zhang, Peng. Downregulation of Hypoxia-Inducible Factor-1 alpha by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2020, 19: 1330-1342, https://www.webofscience.com/wos/woscc/full-record/WOS:000519557700109.
[20] Qin, FuYing, Zhang, HaoXing, Di, QianQian, Wang, Yan, Yan, YongMing, Chen, WeiLin, Cheng, YongXian. Ganoderma cochlear Metabolites as Probes to Identify a COX-2 Active Site and as in Vitro and in Vivo Anti-Inflammatory Agents. ORGANIC LETTERS[J]. 2020, 22(7): 2574-2578, https://www.webofscience.com/wos/woscc/full-record/WOS:000526335800015.
[21] Wang, Yan, Chen, Lei. Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2020, 889: http://dx.doi.org/10.1016/j.ejphar.2020.173634.
[22] Wang, Yan, Xiao, ChuYing, Lin, HuangQuan, Hu, JianShu, Ip, TszMing, Wan, David ChiCheong. Development of an enzyme-linked immunosorbent assay for Keap1-Nrf2 interaction inhibitors identification. REDOX BIOLOGY[J]. 2020, 34: http://dx.doi.org/10.1016/j.redox.2020.101573.
[23] Cheng, WenXiang, Huang, Huan, Chen, JianHai, Zhang, TianTian, Zhu, GuoYuan, Zheng, ZhengTan, Lin, JieTao, Hu, YiPing, Zhang, Yong, Bai, XueLing, Wang, Yan, Xu, ZhanWang, Song, Bing, Mao, YiYing, Yang, Fei, Zhang, Peng. Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2020, 22: 92-100, http://dx.doi.org/10.1016/j.jot.2019.07.007.
[24] Yan, YongMing, Zhang, HaoXing, Liu, Huan, Wang, Yan, Wu, JingBo, Li, YanPeng, Cheng, YongXian. (+/-)-Lucidumone, a COX-2 InhibitoryCaged Fungal Meroterpenoid from Ganoderma lucidum. ORGANIC LETTERS[J]. 2019, 21(21): 8523-8527, https://www.webofscience.com/wos/woscc/full-record/WOS:000494553300004.
[25] Wang, Yan, Geraghty, Robert J. FRET-based assay using a three-way junction DNA substrate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES[J]. 2019, 127: 29-37, http://dx.doi.org/10.1016/j.ejps.2018.10.016.
[26] Yan YongMing, Zhang HaoXing, Liu Huan, Wang Yan, Wu JingBo, Li YanPeng, Cheng YongXian. ( plus /-)-Lucidumone, a COX-2 Inhibitory Caged Fungal Meroterpenoid from Ganoderma lucidum. ORGANIC LETTERS[J]. 2019, 21(21): 8523-8527, [27] Wen Liang Pan, Yan Wang, Yuan Hao, Jack Ho Wong, Wing Cheong Chan, David ChiCheong Wan, Tzi Bun Ng. Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells. BBA - MOLECULAR BASIS OF DISEASE. 2018, 1864(11): 3837-3846, http://dx.doi.org/10.1016/j.bbadis.2018.09.008.
[28] Kankanala, Jayakanth, Wang, Yan, Geraghty, Robert J, Wang, Zhengqiang. Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease. CHEMMEDCHEM[J]. 2018, 13(16): 1658-1663, https://www.webofscience.com/wos/woscc/full-record/WOS:000442341900006.
[29] Pan, Wen Liang, Wang, Yan, Hao, Yuan, Wong, Jack Ho, Chan, Wing Cheong, Wan, David ChiCheong, Ng, Tzi Bun. Overexpression of CXCR4 synergizes with LL-37 in the metastasis of breast cancer cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE[J]. 2018, 1864(11): 3837-3846, http://ir.siat.ac.cn:8080/handle/172644/14430.
[30] Wang Yan. Synthesis, β-catenin Translocation Capability and ALP Activation Activity of 7H-thiazolo [3, 2-b]-1, 2, 4-triazin-7-one Derivatives. Medicinal Chemistry. 2018, [31] Wang, Yan, Tang, Jing, Wang, Zhengqiang, Geraghty, Robert J. Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication. ANTIVIRAL RESEARCH[J]. 2018, 152: 10-17, http://dx.doi.org/10.1016/j.antiviral.2018.01.015.
[32] Zhou, Wenbo, Wang, Yan, Xie, Jiashu, Geraghty, Robert J. A fluorescence-based high-throughput assay to identify inhibitors of tyrosylprotein sulfotransferase activity. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 482(4): 1207-1212, http://dx.doi.org/10.1016/j.bbrc.2016.12.013.
[33] Wang, Yan, Qi, Wei, Zhang, Li, Ying, Zhenguang, Sha, Ou, Li, Chunman, Lu, Lanhai, Chen, Xiangyan, Li, Zhenzhong, Niu, Feng, Xue, Fang, Wang, Dong, Ng, TziBun, Zhang, Lihong. The novel targets of DL-3-n-butylphthalide predicted by similarity ensemble approach in combination with molecular docking study. QUANTITATIVE IMAGING IN MEDICINE AND SURGERY[J]. 2017, 7(5): 532-536, https://www.webofscience.com/wos/woscc/full-record/WOS:000419046000005.
[34] Wang, Yan, Mao, Lili, Kankanala, Jayakanth, Wang, Zhengqiang, Geraghty, Robert J. Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage. JOURNAL OF VIROLOGY[J]. 2017, 91(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000393194600033.
[35] Wang, Yan, Lin, HuangQuan, Wang, Ping, Hu, JianShu, Ip, TszMing, Yang, LiuMeng, Zheng, YongTang, Wan, David ChiCheong. Discovery of a Novel HIV-1 Integrase/p75 Interacting Inhibitor by Docking Screening, Biochemical Assay, and in Vitro Studies. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2017, 57(9): 2336-2343, https://www.webofscience.com/wos/woscc/full-record/WOS:000411914200021.
[36] Wang, Winston Yan, Wong, Jack Ho, Ip, Denis Tsz Ming, Wan, David Chi Cheong, Cheung, Randy Chifai, Ng, Tzi Bun. Bovine Lactoferrampin, Human Lactoferricin, and Lactoferrin 1-11 Inhibit Nuclear Translocation of HIV Integrase. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2016, 179(7): 1202-1212, https://www.webofscience.com/wos/woscc/full-record/WOS:000381594500006.
[37] Wang, Yan, Lin, HuangQuan, Xiao, ChuYing, Law, WaiKit, Hu, JianShu, Ip, TszMing, Wan, David ChiCheong. Using molecular docking screening for identifying hyperoside as an inhibitor of fatty acid binding protein 4 from a natural product database. JOURNAL OF FUNCTIONAL FOODS[J]. 2016, 20: 159-170, http://dx.doi.org/10.1016/j.jff.2015.10.031.
[38] Wang, Yan, Hu, JianShu, Lin, HuangQuan, Ip, TszMing, Wan, David ChiCheong. Herbalog: A tool for target-based identification of herbal drug efficacy through molecular docking. PHYTOMEDICINE[J]. 2016, 23(12): 1469-1474, http://dx.doi.org/10.1016/j.phymed.2016.08.008.
[39] Wang, Yan, Lin, HuangQuan, Law, WaiKit, Liang, WeiCheng, Zhang, JinFang, Hu, JianShu, Ip, TszMing, Waye, Mary MiuYee, Wan, David ChiCheong. Pimozide, a Novel Fatty Acid Binding Protein 4 Inhibitor, Promotes, Adipogenesis of 3T3-L1 Cells by Activating PPAR gamma. ACS CHEMICAL NEUROSCIENCE[J]. 2015, 6(2): 211-218, https://www.webofscience.com/wos/woscc/full-record/WOS:000349813700003.
[40] Liang, WeiCheng, Wang, Yan, Liang, PuPing, Pan, XuQing, Fu, WeiMing, Yeung, Venus SaiYing, Lu, YingFei, Wan, David ChiCheong, Tsui, Stephen KwokWing, Tsang, SukYing, Ma, WenBin, Zhang, JinFang, Waye, Mary MiuYee. MiR-25 Suppresses 3T3-L1 Adipogenesis by Directly Targeting KLF4 and C/EBP. JOURNAL OF CELLULAR BIOCHEMISTRY[J]. 2015, 116(11): 2658-2666, http://dx.doi.org/10.1002/jcb.25214.
[41] Liang, WeiCheng, Fu, WeiMing, Wong, CheukWa, Wang, Yan, Wang, WeiMao, Hu, GuoXin, Zhang, Li, Xiao, LiJia, Wan, David ChiCheong, Zhang, JinFang, Waye, Mary MiuYee. The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer. ONCOTARGET[J]. 2015, 6(26): 22513-22525, http://ir.foo.ac.cn/handle/2SETSVCV/18.
[42] Ng, Tzi Bun, Cheung, Randy Chi Fai, Wong, Jack Ho, Wang, Yan, Ip, Denis Tsz Ming, Wan, David Chi Cheong, Xia, Jiang. Antiviral activities of whey proteins. APPLIED MICROBIOLOGY AND BIOTECHNOLOGYnull. 2015, 99(17): 6997-7008, https://www.webofscience.com/wos/woscc/full-record/WOS:000359739600004.
[43] Lin, HuangQuan, Wang, Yan, Chan, KamLeung, Ip, TszMing, Wan, ChiCheong David. Differential Regulation of Lipid Metabolism Genes in the Brain of Acetylcholinesterase Knockout Mice. JOURNAL OF MOLECULAR NEUROSCIENCE[J]. 2014, 53(3): 397-408, https://www.webofscience.com/wos/woscc/full-record/WOS:000339956700016.
[44] Wang, Yan, Law, WaiKit, Hu, JianShu, Lin, HuangQuan, Ip, TszMing, Wan, David ChiCheong. Discovery of FDA-Approved Drugs as Inhibitors of Fatty Acid Binding Protein 4 Using Molecular Docking Screening. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2014, 54(11): 3046-3050, https://www.webofscience.com/wos/woscc/full-record/WOS:000345551000002.
[45] Gu, Wangang, Ip, Denis TszMing, Liu, Sijie, Chan, Joseph H, Wang, Yan, Zhang, Xuan, Zheng, Yongtang, Wan, David ChiCheong. 1,4-Bis(5-(naphthalen-1-yl)thiophen-2-yl)naphthalene, a small molecule, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular Lens epithelium-derived growth factor. CHEMICO-BIOLOGICAL INTERACTIONS[J]. 2014, 213(X): 21-27, http://dx.doi.org/10.1016/j.cbi.2014.01.011.
[46] Wang, Yan, Liang, WeiCheng, Pan, WenLiang, Law, WaiKit, Hu, JianShu, Ip, Deriis TszMing, Waye, Mary MiuYee, Ng, TziBun, Wan, David ChiCheong. Silibinin, a novel chemokine receptor type 4 antagonist, inhibits chemokine ligand 12-induced migration in breast cancer cells. PHYTOMEDICINE[J]. 2014, 21(11): 1310-1317, http://dx.doi.org/10.1016/j.phymed.2014.06.018.
[47] Liang, WeiCheng, Wang, Yan, Xiao, LiJia, Wang, YuBing, Fu, WeiMing, Wang, WeiMao, Jiang, HuiQing, Qi, Wei, Wan, David ChiCheong, Zhang, JinFang, Waye, Mary MiuYee. Identification of miRNAs that specifically target tumor suppressive KLF6-FL rather than oncogenic KLF6-SV1 isoform. RNA BIOLOGY[J]. 2014, 11(7): 845-854, http://ir.gibh.ac.cn/handle/344009/315.
[48] Wang, Yan, Pan, WenLiang, Liang, WeiCheng, Law, WaiKit, Ip, Denis TszMing, Ng, TziBun, Waye, Mary MiuYee, Wan, David ChiCheong. Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE[J]. 2013, 2013: https://doaj.org/article/9f19b4bf1d62436989b8e651b91785ff.
[49] Liang, WeiCheng, Wang, Yan, Wan, David ChiCheong, Yeung, Venus SaiYing, Waye, Mary MiuYee. Characterization of miR-210 in 3T3-L1 Adipogenesis. JOURNAL OF CELLULAR BIOCHEMISTRY[J]. 2013, 114(12): 2699-2707, http://dx.doi.org/10.1002/jcb.24617.
[50] Xu, Henan, Zhang, Lan, Liu, Hongmin, Liu, Sijie, Lin, Huangquan, Wang, Yan, Wan, David ChiCheong, Hu, Chun. Synthesis, Characterization and Biological Activity of 3-aryl-6-(4-fluorobenzyl)-7H-thiazolo3,2-b-1,2,4-triazin-7-one Derivatives as Novel Acetylcholinesterase Inhibitors. LATIN AMERICAN JOURNAL OF PHARMACY[J]. 2013, 32(7): 953-959, https://www.webofscience.com/wos/woscc/full-record/WOS:000330930100001.
[51] Zhou, Xuelin, Wang, Yan, Hu, Tao, Or, Penelope M Y, Wong, John, Kwan, Yiu Wa, Wan, David C C, Hoi, Pui Man, Lai, Paul B S, Yeung, John H K. Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes. PHYTOMEDICINE[J]. 2013, 20(3-4): 367-374, http://dx.doi.org/10.1016/j.phymed.2012.09.021.
[52] Zhou, Xuelin, Wang, Yan, Or, Penelope M Y, Wan, David C C, Kwan, Yiu Wa, Yeung, John H K. Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes. PHYTOMEDICINE[J]. 2012, 19(7): 648-657, http://dx.doi.org/10.1016/j.phymed.2012.01.005.

科研活动

   
科研项目
( 1 ) 黄芪甲苷通过抑制CXCR4/SDF1信号轴对抗骨关节炎的作用机制研究, 负责人, 国家任务, 2020-01--2022-12
( 2 ) 脂肪酸结合蛋白4诱导软骨基质降解的机制研究, 负责人, 地方任务, 2019-10--2022-09
( 3 ) 天然小分子FABP4抑制剂的发现及其对抗骨关节炎的机制研究, 负责人, 地方任务, 2020-05--2023-04
( 4 ) 伤科黄水治疗膝骨关节炎作用机理研究, 负责人, 地方任务, 2020-07--2023-06
( 5 ) 发现一种有美白作用的植物提取物, 负责人, 企业委托, 2021-02--2021-07
( 6 ) 穿心莲内酯通过抑制FABP4介导的脂毒性对抗类风湿性关节炎的作用机制研究, 负责人, 国家任务, 2022-01--2024-12
( 7 ) 清热解毒中药对抗类风湿性关节炎机制研究, 负责人, 地方任务, 2021-09--2022-12
( 8 ) 中药复方对抗新冠病毒的物质基础和网络药理学研究, 负责人, 地方任务, 2021-09--2022-12

合作情况

   
项目协作单位

佛山市中医院

沈阳药科大学

东南大学

深圳大学

深圳技术大学