1. 经皮新剂型与新技术：包括化学药物/中药有效成分经皮新剂型与新技术，经皮疫苗给药研究。

2. 生物技术药物输送系统研究：包括新型载体材料的制备，载体与大分子药物的相互作用，载体给药系统与生物屏障的相互作用，生物大分子黏膜给药研究，以及大分子药物靶向给药研究。

3. 环境响应型肿瘤分子探针及影像。

综合应用化学，生物，制药及材料学等交叉学科的理论基础，研究高效的生物技术药物给药系统。研究内容包括新型药物载体合成、制备与表征，载体与大分子药物的相互作用，载体与生物屏障的作用，细胞学及动物学实验评价，以及DNA重组蛋白的构建、表达和纯化，蛋白药物的化学修饰等。

欢迎上述专业的同学报考。

100702-药剂学

   

浙江大学 -- 研究生

浙江大学 -- 博士

2008-2010 Senior Research Fellow, University of Michigan College of Pharmacy
2005-2008 Research Fellow, University of Michigan College of Pharmacy

2010 至今 中国科学院上海药物研究所，研究员，课题组长

   

[1] Tang, Yisi, Liang, Jianming, Wu, Aihua, Chen, Yingzhi, Zhao, Pengfei, Lin, Tingting, Zhang, Meng, Xu, Qin, Wang, Jianxin, Huang, Yongzhuo. Co-Delivery of Trichosanthin and Albendazole by Nano-Self-Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis (vol 9, pg 26648, 2017). ACS APPLIED MATERIALS & INTERFACESnull. 2020, 12(2): 3275-3275, https://www.webofscience.com/wos/woscc/full-record/WOS:000508464500143.
[2] Chen, Yingzhi, Zhang, Meng, Min, Kyoung Ah, Wang, Huiyuan, Shin, Meong Cheol, Li, Feng, Yang, Victor C, Huang, Yongzhuo. Improved Protein Toxin Delivery Based on ATTEMPTS Systems. CURRENT DRUG TARGETSnull. 2018, 19(4): 380-392, http://dx.doi.org/10.2174/1389450118666170302094758.
[3] Xu, Fan, Zhong, Huihai, Chang, Ya, Li, Dongdong, Jin, Hongyue, Zhang, Meng, Wang, Huiyuan, Jiang, Chen, Shen, Youqing, Huang, Yongzhuo. Targeting death receptors for drug-resistant cancer therapy: Codelivery of pTRAIL and monensin using dual-targeting and stimuli-responsive self-assembling nanocomposites. BIOMATERIALS[J]. 2018, 158: 56-73, http://www.corc.org.cn/handle/1471x/2172106.
[4] Yongzhuo Huang. Dual-Targeting Biomimetic Delivery for Antiglioma via Remodeling Tumor Microenvironment and Directing Macrophage-Mediated Immunotherapy. Chemical Science. 2018, [5] Kang, Xuejia, Zheng, Zenin, Liu, Zehua, Wang, Huiyuan, Zhao, Yuge, Zhang, Wenyuan, Shi, Mingjie, He, Yang, Cao, Yang, Xu, Qin, Peng, Chengyuan, Huang, Yongzhuo. Liposomal Codelivery of Doxorubicin and Andrographolide Inhibits Breast Cancer Growth and Metastasis. MOLECULAR PHARMACEUTICS[J]. 2018, 15(4): 1618-1626, http://dx.doi.org/10.1021/acs.molpharmaceut.7b01164.
[6] Li, Dongdong, Zhang, Meng, Xu, Fan, Chen, Yingzhi, Chen, Binfan, Chang, Ya, Zhong, Huihai, Jin, Hongyue, Huang, Yongzhuo. Biomimetic albumin-modified gold nanorods for photothermo-chemotherapy and macrophage polarization modulation. ACTA PHARMACEUTICA SINICA B[J]. 2018, 8(1): 74-84, http://lib.cqvip.com/Qikan/Article/Detail?id=89886689504849564849484949.
[7] Yongzhuo Huang. Mannosylated Liposomal Codelivery of Dihydroartemisinin and Doxorubicin for Drug-Resistant Colon Cancer Therapy. Acta Pharmacologica Sinica. 2017, [8] Chen, Yingzhi, Zhang, Meng, Jin, Hongyue, Li, Dongdong, Xu, Fan, Wu, Aihua, Wang, Jinyu, Huang, Yongzhuo. Glioma Dual-Targeting Nanohybrid Protein Toxin Constructed by Intein-Mediated Site-Specific Ligation for Multistage Booster Delivery. THERANOSTICS[J]. 2017, 7(14): 3489-3503, https://www.webofscience.com/wos/woscc/full-record/WOS:000407855900007.
[9] Xu, Jiaojiao, Xu, Beihua, Tao, Jin, Yang, Yunxu, Hu, Ying, Huang, Yongzhuo. Microneedle-Assisted, DC-Targeted Codelivery of pTRP-2 and Adjuvant of Paclitaxel for Transcutaneous Immunotherapy. SMALL[J]. 2017, 13(28): https://www.webofscience.com/wos/woscc/full-record/WOS:000405913400006.
[10] Peng, Huige, Chen, Binfan, Huang, Wei, Tang, Yubo, Jiang, Yifan, Zhang, Wenyuan, Huang, Yongzhuo. Reprogramming Tumor-Associated Macrophages To Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat. NANO LETTERS[J]. 2017, 17(12): 7684-7690, https://www.webofscience.com/wos/woscc/full-record/WOS:000418393300070.
[11] Tan Jiao, Wang Huiyuan, Xu Fan. Poly-γ-glutamic acid-based GGT-targeting and surface camouflage strategy for improving cervical cancer gene therapy.. 2017, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=SJPD&dbname=SJPDLAST&filename=SJPD94C3ABD61364381FD88871158578EA71&v=MjcxODdlQ0pVYUYxdVFVci9QSmxjU2JtS0NHWUNHUWxmQnJMVTk1dDlpeExtK3hLRT1OaWZiYXJxOGJkSzkzZnREWmVnSkNIOHh6bUJuNGpkMVQzN2pxUm93ZnJyaE5MMg==.
[12] Chen, Yingzhi, Zhang, Meng, Jin, Hongyue, Tang, Yisi, Wu, Aihua, Huang, Yongzhuo. Prodrug-Like, PEGylated Protein Toxin Trichosanthin for Reversal of Chemoresistance. MOLECULAR PHARMACEUTICS[J]. 2017, 14(5): 1429-1438, https://www.webofscience.com/wos/woscc/full-record/WOS:000400633300011.
[13] Chen, Yingzhi, Zhang, Meng, Jin, Hongyue, Tang, Yisi, Wang, Huiyuan, Xu, Qin, Li, Yaping, Li, Feng, Huang, Yongzhuo. Intein-mediated site-specific synthesis of tumor-targeting protein delivery system: Turning PEG dilemma into prodrug-like feature. BIOMATERIALS[J]. 2017, 116: 57-68, http://dx.doi.org/10.1016/j.biomaterials.2016.11.033.
[14] Zhao, Pengfei, Yin, Weimin, Wu, Aihua, Tang, Yisi, Wang, Jinyu, Pan, Zhenzhen, Lin, Tingting, Zhang, Meng, Chen, Binfan, Duan, Yifei, Huang, Yongzhuo. Dual-Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug-Resistant Cancer Therapy. ADVANCED FUNCTIONAL MATERIALS[J]. 2017, 27(44): http://dx.doi.org/10.1002/adfm.201700403.
[15] Lin, Tingting, Zhao, Pengfei, Jiang, Yifan, Tang, Yisi, Jin, Hongyue, Pan, Zhenzhen, He, Huining, Yang, Victor C, Huang, Yongzhuo. Blood-Brain-Barrier-Penetrating Albumin Nanoparticles for Biomimetic Drug Delivery via Albumin-Binding Protein Pathways for Antiglioma Therapy. ACS NANO[J]. 2016, 10(11): 9999-10012, https://www.webofscience.com/wos/woscc/full-record/WOS:000388913100028.
[16] Yongzhuo Huang. Nuclear-targeting TAT-PEG-Asp8-Doxorubicin Polymeric Nanoassembly for Overcoming Drug-resistant Colon Cancer. ACTAPHARMACOLOGICASINICA. 2016, [17] Cui, Yanna, Zhang, Meng, Zeng, Feng, Jin, Hongyue, Xu, Qin, Huang, Yongzhuo. Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(47): 32159-32169, http://dx.doi.org/10.1021/acsami.6b10175.
[18] Hu, Ying, Xu, Beihua, Xu, Jiaojiao, Shou, Dan, Liu, Ergang, Gao, Jianqing, Liang, Wenquan, Huang, Yongzhuo. Microneedle-assisted dendritic cell-targeted nanoparticles for transcutaneous DNA immunization. POLYMER CHEMISTRY[J]. 2015, 6(3): 373-379, https://www.webofscience.com/wos/woscc/full-record/WOS:000346422300006.
[19] Wang, Yaping, Lin, Tingting, Zhang, Wenyuan, Jiang, Yifan, Jin, Hongyue, He, Huining, Yang, Victor C, Chen, Yi, Huang, Yongzhuo. A Prodrug-type, MMP-2-targeting Nanoprobe for Tumor Detection and Imaging. THERANOSTICS[J]. 2015, 5(8): 787-795, https://www.webofscience.com/wos/woscc/full-record/WOS:000354959900001.
[20] Wang, Huiyuan, Jiang, Yifan, Peng, Huige, Chen, Yingzhi, Zhu, Peizhi, Huang, Yongzhuo. Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors. ADVANCED DRUG DELIVERY REVIEWSnull. 2015, 81: 142-160, http://dx.doi.org/10.1016/j.addr.2014.10.031.
[21] Liang, Jianming, Zeng, Feng, Zhang, Meng, Pan, Zhenzhen, Chen, Yingzhi, Zeng, Yuaner, Xu, Yong, Xu, Qin, Huang, Yongzhuo. Green synthesis of hyaluronic acid-based silver nanoparticles and their enhanced delivery to CD44(+) cancer cells. RSC ADVANCES[J]. 2015, 5(54): 43733-43740, https://www.webofscience.com/wos/woscc/full-record/WOS:000354964600080.
[22] Wang, Huixin, Zhao, Yongxing, Wang, Huiyuan, Gong, Junbo, He, Huining, Shin, Meong Cheol, Yang, Victor C, Huang, Yongzhuo. Low-molecular-weight protamine-modified PLGA nanoparticles for overcoming drug-resistant breast cancer. JOURNAL OF CONTROLLED RELEASE[J]. 2014, 192: 47-56, http://dx.doi.org/10.1016/j.jconrel.2014.06.051.
[23] Jiang, Yifan, Lu, Junyan, Wang, Yaping, Zeng, Feng, Wang, Huiyuan, Peng, Huige, Huang, Min, Jiang, Hualiang, Luo, Cheng, Huang, Yongzhuo. Molecular-Dynamics-Simulation-Driven Design of a Protease-Responsive Probe for In-Vivo Tumor Imaging. ADVANCED MATERIALS[J]. 2014, 26(48): 8174-8178, https://www.webofscience.com/wos/woscc/full-record/WOS:000346480800014.
[24] Tan, Jiao, Cheong, Heesun, Park, Yoon Shin, Kim, Hangun, Zhang, Meng, Moon, Cheol, Huang, Yongzhuo. Cell-Penetrating Peptide-Mediated Topical Delivery of Biomacromolecular Drugs. CURRENT PHARMACEUTICAL BIOTECHNOLOGY[J]. 2014, 15(3): 231-239, https://www.webofscience.com/wos/woscc/full-record/WOS:000340715300006.
[25] Wang, Zhao, Chen, Yingzhi, Liu, Ergang, Gong, Junbo, Shin, Meong Cheol, Huang, Yongzhuo. CPP-mediated Protein Delivery in a Noncovalent Form: Proof-of-Concept for Percutaneous and Intranasal Delivery. PROTEIN AND PEPTIDE LETTERS[J]. 2014, 21(11): 1129-1136, https://www.webofscience.com/wos/woscc/full-record/WOS:000343235900005.
[26] Wang, Yaping, Jiang, Yifan, Zhang, Meng, Tan, Jiao, Liang, Jianming, Wang, Huixin, Li, Yaping, He, Huining, Yang, Victor C, Huang, Yongzhuo. Protease-Activatable Hybrid Nanoprobe for Tumor Imaging. ADVANCED FUNCTIONAL MATERIALS[J]. 2014, 24(34): 5443-5453, https://www.webofscience.com/wos/woscc/full-record/WOS:000341834000015.
[27] Wang, Huiyuan, Li, Feng, Du, Chengan, Wang, Huixin, Mahato, Ram I, Huang, Yongzhuo. Doxorubicin and Lapatinib Combination Nanomedicine for Treating Resistant Breast Cancer. MOLECULAR PHARMACEUTICS[J]. 2014, 11(8): 2600-2611, https://www.webofscience.com/wos/woscc/full-record/WOS:000339982900010.
[28] Wang, Huiyuan, Wang, Huixin, Liang, Jianming, Jiang, Yifan, Guo, Qianqian, Peng, Huige, Xu, Qin, Huang, Yongzhuo. Cell-Penetrating Apoptotic Peptide/p53 DNA Nanocomplex as Adjuvant Therapy for Drug-Resistant Breast Cancer. MOLECULAR PHARMACEUTICS[J]. 2014, 11(10): 3352-3360, https://www.webofscience.com/wos/woscc/full-record/WOS:000342857000014.
[29] Huang, Yongzhuo, Jiang, Yifan, Wang, Huiyuan, Wang, Jianxin, Shin, Meong Cheol, Byun, Youngro, He, Huining, Liang, Yanqin, Yang, Victor C. Curb challenges of the "Trojan Horse" approach: Smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery. ADVANCED DRUG DELIVERY REVIEWSnull. 2013, 65(10): 1299-1315, http://dx.doi.org/10.1016/j.addr.2012.11.007.
[30] Yan, Lu, Wang, Huiyuan, Jiang, Yifan, Liu, Jinhua, Wang, Zhao, Yang, Yongxin, Huang, Shengwu, Huang, Yongzhuo. Cell-Penetrating Peptide-Modified PLGA Nanoparticles for Enhanced Nose-to-Brain Macromolecular Delivery. MACROMOLECULAR RESEARCH[J]. 2013, 21(4): 435-441, https://www.webofscience.com/wos/woscc/full-record/WOS:000318177400016.
[31] Wang, Ye, Liu, Ergang, Sun, Xiaoyi, Huang, Pengyu, Long, Hao, Wang, Hua, Yu, Xin, Zheng, Caihong, Huang, Yongzhuo. Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs. POLYMER CHEMISTRY[J]. 2013, 4(10): 2958-2962, https://www.webofscience.com/wos/woscc/full-record/WOS:000317936500005.
[32] Sun, Yajuan, Dong, Weibing, Wang, Huiyuan, Huang, Yongzhuo, Gu, Huike, Yang, Victor C, Gong, Junbo. Template synthesis of PMAA@chitosan hollow nanorods for docetaxel delivery. POLYMER CHEMISTRY[J]. 2013, 4(8): 2489-2495, http://dx.doi.org/10.1039/c3py21157f.
[33] Wang, Huiyuan, Guo, Qianqian, Jiang, Yifan, Liu, Ergang, Zhao, Yongxing, Wang, Huixin, Li, Yaping, Huang, Yongzhuo. Co-delivery of Cell-permeable Chimeric Apoptosis AVPIR(8) Peptide/p53 DNA for Cocktail Therapy. ADVANCED FUNCTIONAL MATERIALS[J]. 2013, 23(48): 6068-6075, https://www.webofscience.com/wos/woscc/full-record/WOS:000328733800012.
[34] Guo, Qianqian, Wang, Huiyuan, Zhao, Yongxing, Wang, Huixin, Zeng, Feng, Hua, Haiying, Xu, Qin, Huang, Yongzhuo. Cell-penetrating albumin conjugates for enhanced doxorubicin delivery. POLYMER CHEMISTRY[J]. 2013, 4(17): 4584-4587, https://www.webofscience.com/wos/woscc/full-record/WOS:000323361300007.
[35] Liu, Jinhua, Zhao, Yongxing, Guo, Qianqian, Wang, Zhao, Wang, Huiyuan, Yang, Yongxin, Huang, Yongzhuo. TAT-modified nanosilver for combating multidrug-resistant cancer. BIOMATERIALS[J]. 2012, 33(26): 6155-6161, http://dx.doi.org/10.1016/j.biomaterials.2012.05.035.
[36] Wang, Shuo, Wang, Hua, Liang, Wenquan, Huang, Yongzhuo. An injectable hybrid nanoparticle-in-oil-in-water submicron emulsion for improved delivery of poorly soluble drugs. NANOSCALE RESEARCH LETTERS[J]. 2012, 7(1): 219-219, http://dx.doi.org/10.1186/1556-276X-7-219.
[37] Yang, Yongxin, Jiang, Yifan, Wang, Zhao, Liu, Jinhua, Yan, Lu, Ye, Junxiao, Huang, Yongzhuo. Skin-permeable quaternary nanoparticles with layer-by-layer structure enabling improved gene delivery. JOURNAL OF MATERIALS CHEMISTRY[J]. 2012, 22(19): 10029-10034, https://www.webofscience.com/wos/woscc/full-record/WOS:000303207100085.
[38] Yongzhuo Huang. In vivo delivery of cell permeable antisense-HIF1a-oligonucleotide to adipose tissue reduces adiposity in obese mice. Journal of Controlled Release. 2012, [39] Yongzhuo Huang. Magnetic nanoparticles for brain tumors imaging.. Current Pharmaceutical Biotechnology. 2012, [40] Yongzhuo Huang. Multidisciplinary drug delivery system for targeting tumor and its acidic microenvironment. Journal of Controlled Release. 2012, [41] Huang, Yongzhuo, Rao, Yuefeng, Chen, Jinliang, Yang, Victor C, Liang, Wenquan. Polysorbate cationic synthetic vesicle for gene delivery. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A[J]. 2011, 96A(3): 513-519, https://www.webofscience.com/wos/woscc/full-record/WOS:000286953000002.
[42] Yang, Yongxin, Gao, Yu, Chen, Lingli, Huang, Yongzhuo, Li, Yaping. Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles. INTERNATIONAL JOURNAL OF PHARMACEUTICS[J]. 2011, 405(1-2): 188-195, https://www.webofscience.com/wos/woscc/full-record/WOS:000287279400022.
[43] He, Huining, David, Allan E, Zhang, Jian, Park, Yoon Shin, Wang, Jianxin, Huang, Yongzhuo, Wang, Jingkang, Yang, Victor C. Low molecular weight protamine/insulin formulation with potential to attenuate protamine-masqueraded insulin allergy. MACROMOLECULAR RESEARCHnull. 2011, 19(12): 1224-1226, https://www.webofscience.com/wos/woscc/full-record/WOS:000296517300003.
[44] Dong, Siyu, Wang, Shuo, Zheng, Caihong, Liang, Wenquan, Huang, Yongzhuo. An in situ-forming, solid lipid/PLGA hybrid implant for long-acting antipsychotics. SOFT MATTER[J]. 2011, 7(12): 5873-5878, https://www.webofscience.com/wos/woscc/full-record/WOS:000291354200050.
[45] Zheng, Xiaoling, Huang, Yongzhuo, Zheng, Caihong, Dong, Siyu, Liang, Wenquan. Alginate-Chitosan-PLGA Composite Microspheres Enabling Single-Shot Hepatitis B Vaccination. AAPS JOURNAL[J]. 2010, 12(4): 519-524, https://www.webofscience.com/wos/woscc/full-record/WOS:000288426100004.
[46] Huang, Yongzhuo, Park, Yoon Shin, Moon, Cheol, David, Allan E, Chung, Hee Sun, Yang, Victor C. Synthetic Skin-Permeable Proteins Enabling Needleless Immunization. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2010, 49(15): 2724-2727, http://dx.doi.org/10.1002/anie.200906153.
[47] Huang, Yongzhuo, Park, Yoon Shin, Wang, Jianxin, Moon, Cheol, Kwon, Young Min, Chung, Hee Sun, Park, Yoon Jeong, Yang, Victor C. ATTEMPTS System: A Macromolecular Prodrug Strategy for Cancer Drug Delivery. CURRENT PHARMACEUTICAL DESIGNnull. 2010, 16(21): 2369-2376, http://dx.doi.org/10.2174/138161210791920441.
[48] Yoon Shin Park, Yongzhuo Huang, Yoon Jeong Park, Allan E. David, Lindsay White, Huining He, Hee Sun Chung, Victor C. Yang. Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1α-oligonucleotide. JOURNAL OF CONTROLLED RELEASE. 2010, 144(1): 82-90, http://dx.doi.org/10.1016/j.jconrel.2010.01.026.
[49] Yu, Faquan, Zhang, Lei, Huang, Yongzhuo, Sun, Kai, David, Allan E, Yang, Victor C. The magnetophoretic mobility and superparamagnetism of core-shell iron oxide nanoparticles with dual targeting and imaging functionality. BIOMATERIALS[J]. 2010, 31(22): 5842-5848, http://dx.doi.org/10.1016/j.biomaterials.2010.03.072.
[50] Huang, Yongzhuo, Yu, Faquan, Park, YoonShin, Wang, Jianxin, Shin, MeongCheol, Chung, Hee Sun, Yang, Victor C. Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery. BIOMATERIALS[J]. 2010, 31(34): 9086-9091, http://dx.doi.org/10.1016/j.biomaterials.2010.08.046.
[51] Yu, Faquan, Huang, Yongzhuo, Cole, Adam J, Yang, Victor C. The artificial peroxidase activity of magnetic iron oxide nanoparticles and its application to glucose detection. BIOMATERIALS[J]. 2009, 30(27): 4716-4722, http://dx.doi.org/10.1016/j.biomaterials.2009.05.005.