有机合成方法学研究
催化不对称合成

有机合成
药物合成

070303-有机化学

有机合成方法学研究，催化不对称合成

2001-09--2006-07   中科院成都有机化学研究所   有机化学专业，获博士学位
1994-09--1998-07   四川大学   四川大学化学系有机化学专业，获学士学位

2006年8月-2007年9月，美国科罗拉多州立大学化学系，博士后

-- 研究生

-- 博士

1998年8月-2001年8月，中国航天工业总公司第四研究院，助理工程师
2006年8月-2007年9月，美国科罗拉多州立大学化学系，博士后
2007年10月至今， 中国科学院成都有机化学研究所，研究员，博士生导师
2010年5月-2011年2月，手性药物国家工程研究中心，研发部经理
2011年3月至今， 手性药物国家工程研究中心副主任
2011年3月至今， 成都丽凯手性技术有限公司常务副总

1、中国科学院“西部之光”人才培养计划，2010年
2、四川省直机关工委优秀共产党员， 2010年
3、四川省学术与技术带头人后备人选，2011年

2015-10~现在, 手性药物国家工程研究中心, 主任
2015-10~现在, 成都丽凯手性技术有限公司，手性药物国家工程研究中心, 董事长
2011-03~2011-07,成都丽凯手性技术有限公司，手性药物国家工程研究中心, 常务副总经理，研究中心副主任
2010-05~2011-02,成都丽凯手性技术有限公司，手性药物国家工程研究中心, 研发部经理
2007-10~2011-07,中国科学院成都有机化学研究所, 研究员，博士生导师
2006-08~2007-09,美国科罗拉多州立大学, 美国科罗拉多州立大学化学系，博士后
1998-08~2001-08,中国航天工业总公司第四研究院, 助理工程师

已指导学生

陈文兵  博士研究生  070303-有机化学  

孙宏伟  博士研究生  070303-有机化学  

刘雄利  博士研究生  070303-有机化学  

韩艳艳  博士研究生  070303-有机化学  

廖玉华  博士研究生  070303-有机化学  

李科  硕士研究生  070303-有机化学  

裴青蓝  博士研究生  070303-有机化学  

韩文勇  博士研究生  070303-有机化学  

崔宝东  博士研究生  070303-有机化学  

侯雪  博士研究生  070303-有机化学  

周鸣强  博士研究生  070303-有机化学  

左建  博士研究生  070303-有机化学  

梅青刚  博士研究生  070303-有机化学  

邓莉萍  硕士研究生  070303-有机化学  

白玫  博士研究生  070303-有机化学  

赵建强  博士研究生  070303-有机化学  

现指导学生

葛真真  博士研究生  070303-有机化学  

邢志奎  博士研究生  070303-有机化学  

游勇  博士研究生  070303-有机化学  

胡文飞  博士研究生  070303-有机化学  

陈剑锋  博士研究生  070303-有机化学  

卢文雅  硕士研究生  070303-有机化学  

袁书培   硕士研究生  070303-有机化学  

发表论文
1. Wen-Bing Chen, Zhi-Jun Wu, Jing Hu, Lin-Feng Cun, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters. Org. Lett. 2011, accept.
2. Xiong-Li Liu, Zhi-Jun Wu, Xi-Lin Du, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Amino-Indanol Catalyzed Asymmetric Michael Additions of Oxindoles to Protected 2-Amino-1-Nitroethenes for the Synthesis of 3,3’-Disubstituted Oxindoles Bearing α,β-Diamino Functionality. J. Org. Chem. 2011, accept.
3. Yu-Hua Liao, Xiong-Li Liu, Zhi-Jun Wu, Xi-Lin Du, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Thiourea-Catalyzed Highly Diastereo- and Enantioselective Conjugate Additions of α-Substituted Cyanoacetates to Maleimides: Efficient Construction of Vicinal Quaternary-Tertiary Stereocenters. Adv. Synth. Catal. 2011, accept.
4. Hong-Wei Sun, Yu-Hua Liao, Zhi-Jun Wu, Hao-Yu Wang, Xiao-Mei Zhang, Wei-Cheng Yuan*. Enantioselective 1,6-Michael addition of anthrone to 3-methyl-4-nitro-5-alkenyl-isoxazoles catalyzed by bifunctional thiourea-tertiary amines. Tetrahedron, 2011, accept.
5. Xiong-Li Liu, Xiao-Mei Zhang, Wei-Cheng Yuan*. A simple and eco-friendly method for the aminomethylation of 3-substituted oxindoles via three-component Mannich reaction in aqueous media. Tetrahedron Letters 2011, 52, 903-906.
6. Yu-Hua Liao, Xiong-Li Liu, Zhi-Jun Wu, Lin-Feng Cun, Xiao-Mei Zhang and Wei-Cheng Yuan*. Highly Diastereo- and Enantioselective Michael Additions of 3-Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea-tertiary amine. Org. Lett., 2010, 12, 2896-2899.
7. Wen-Bing Chen, Zhi-Jun Wu, Qing-Lan Pei, Lin-Feng Cun, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Highly Enantioselective Construction of Spiro[4H-pyran-3,3’-oxindoles] Through Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine. Org. Lett., 2010, 12, 3132-3135.
8. Xiong-Li Liu, Yu-Hua Liao, Zhi-Jun Wu, Lin-Feng Cun, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Direct Catalytic Asymmetric Aldol Reaction of 3-Substituted Oxindoles with Paraformaldehyde by Chiral Bifunctional Thiourea. J. Org. Chem. 2010, 75, 4872-4875.
9. Yu-Hua Liao, Wen-Bing Chen, Zhi-Jun Wu, Xi-Lin Du, Lin-Feng Cun, Xiao-Mei Zhang and Wei-Cheng Yuan*. Organocatalytic Asymmetric Michael Addition of Pyrazolin-5-ones to Nitroolefins with Bifunctional Thiourea: Stereocontrolled Construction of Contiguous Quaternary and Tertiary Stereocenters. Adv. Synth. Catal. 2010, 352, 827-832.
10. Wen-Bing Chen, Xi-Lin Du, Lin-Feng Cun, Xiao-Mei Zhang and Wei-Cheng Yuan*. Highly enantioselective aldol reaction of acetaldehyde and isatins only with 4-hydroxydiarylprolinol as catalyst: concise stereoselective synthesis of (R)-convolutamydines B and E, (−)-donaxaridine and (R)-chimonamidine. Tetrahedron 2010, 66, 1441-1446.
11. Yan-Yan Han, Zhi-Jun Wu, Xiao-Mei Zhang and Wei-Cheng Yuan*. An efficient synthesis of 3-(indol-3-yl)quinoxalin-2-ones with TfOH-catalyzed Friedel-Crafts type coupling reaction in air. Tetrahedron Letters 2010, 51, 2023-2028.
12. Hui Zhang, Lin-Feng Cun, Xiao-Mei Zhang, Wei-Cheng Yuan*. Chiral Phosphoric Acid Catalyzed Diastereo- and Enantioselective 1,4-Conjugate Addition of β-Ketoesters to Nitroolefins. Letters in Organic Chemistry, 2010, 7, 219-225.
13. Yu-Hua Liao, Hui Zhang, Zhi-Jun Wu, Lin-Feng Cun, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Enantioselective Michael addition of anthrone to nitroalkenes catalyzed by bifunctional thiourea-tertiary amines. Tetrahedron: Asymmetry 2009, 20, 2397-2402.
14. Wen-Bing Chen, Yu-Hua Liao, Xi-Lin Du, Xiao-Mei Zhang, and Wei-Cheng Yuan*. Catalyst-free aldol condensation of ketones and isatins under mild reaction conditions in DMF with molecular sieves 4 Å as additive. Green Chem., 2009, 11, 1465-1476.
15. Wei-Cheng Yuan*, Lin-Feng Cun, Ai-Qiao Mi, Yao-Zhong Jiang and Liu-Zhu Gong. A class of readily available optically pure 7,7’-disubstituted BINAPs for asymmetric catalysis. Tetrahedron 2009, 65, 4130-4141.

   

（1） 四川省第十三届青年科技奖, 省级, 2015
（2） 成都人才计划, 市地级, 2014
（3） 国家工程研究中心先进个人, 国家级, 2012
（4） 四川省"****"人才, 其他, 2012
（5） 中科院朱李月华优秀教师奖, 院级, 2011
（6） 四川省直机关工委优秀共产党员, 院级, 2010

（ 1 ） 一种四氢呋喃-2-甲酸工业化消旋工艺, 发明, 2016, 第 1 作者, 专利号: 201610000558.9
（ 2 ） 一种高光学纯度乙酰基四氢呋喃的工业化制备方法, 发明, 2016, 第 1 作者, 专利号: 201610000556.X
（ 3 ） 一种高光学纯度1-[(2S)-四氢-2-呋喃基]乙酮的工业化制备方法, 发明, 2016, 第 1 作者, 专利号: 201610000557.4
（ 4 ） 一种合成环丙贝特的新方法, 发明, 2015, 第 1 作者, 专利号: 201510711121.1
（ 5 ） 一种采用对香豆酸制备降血脂药环丙贝特的方法, 发明, 2015, 第 1 作者, 专利号: 201510711339.7
（ 6 ） 一种制备脲类化合物的新方法, 发明, 2015, 第 1 作者, 专利号: 201510018993.X
（ 7 ） 一种喹啉酮类衍生物及其制备方法, 发明, 2015, 第 1 作者, 专利号: 201510019003.4
（ 8 ） 氮杂二苯并环辛炔盐酸盐类化合物及其制备方法, 发明, 2015, 第 1 作者, 专利号: 201510018994.4
（ 9 ） 一种氟氯西林钠一水合物的合成方法., 发明, 2015, 第 1 作者, 专利号: 201510380228.
（ 10 ） 一种高光学纯度盐酸坦索罗辛的制备方法, 发明, 2015, 第 1 作者, 专利号: 201510380212.1
（ 11 ） 一种L-苯丙氨酸不对称转换制备D-苯丙氨酸的方法., 发明, 2015, 第 1 作者, 专利号: 201510380183.9
（ 12 ） 一种2-(2-乙氧基苯氧基)溴代乙烷的工业化制备方法, 发明, 2015, 第 1 作者, 专利号: 201510380235.2
（ 13 ） 一种2-(2-甲氧基乙氧基)乙醛缩二醇的制备方法, 发明, 2015, 第 1 作者, 专利号: 201510380237.1
（ 14 ） 一种合成氧化呋咱化合物的新方法, 发明, 2014, 第 1 作者, 专利号: 201410338114.7
（ 15 ） 3,3’-二取代的3-吡咯氧化吲哚化合物及其不对称合成方法., 发明, 2016, 第 1 作者, 专利号: 201410338206.5;

   

[1] Lu, WenYa, You, Yong, Li, TingTing, Wang, ZhenHua, Zhao, JianQiang, Yuan, WeiCheng. Cul-Catalyzed Decarboxylative Thiolation of Propargylic Cyclic Carbonates/Carbamates to Access Allenyl Thioethers. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(9): 6711-6720, http://dx.doi.org/10.1021/acs.joc.1c00453.
[2] 全保学, 赵建强, 袁伟成. α-卤代腙与异氰的4+1环化反应合成5-氨基吡唑类化合物. 合成化学[J]. 2020, 28(11): 11-, http://lib.cqvip.com/Qikan/Article/Detail?id=7103320993.
[3] 卓俊睿, 杨磊, 赵建强, 袁伟成. 吡唑啉-5-酮水相无催化的硫化反应. 合成化学[J]. 2020, 28(12): 1017-1021, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzI3srjNehjxfVQNjKw7n-ORf0tUrab-fjPKkNESHAz3k&uniplatform=NZKPT.
[4] Zhang, XiaYan, You, Yong, Wang, ZhenHua, Zhao, JianQiang, Yuan, WeiCheng. Organocatalytic asymmetric tandem alpha-functionalization/1,3-proton shift reaction of benzylidene succinimides with beta-trifluoromethyl enones. CHEMICAL COMMUNICATIONS[J]. 2020, 56(87): 13449-13452, https://www.webofscience.com/wos/woscc/full-record/WOS:000584203400034.
[5] Zhang, YanPing, You, Yong, Zhao, JianQiang, Zhou, XiaoJian, Zhang, XiaoMei, Xu, XiaoYing, Yuan, WeiCheng. A AgOAc/quinine-derived aminophosphine complex as an efficient catalyst for diastereo- and enantioselective 1,3-dipolar cycloaddition of alpha,beta-unsaturated 7-azaindoline amides and azomethine ylides. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(11): 1879-1884, [6] 张颜萍, 游勇, 袁伟成. 钪催化的傅克反应合成含三氟甲基化合物. 合成化学[J]. 2019, 27(12): 930-934+945, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=HCHX201912002&v=MTUyOTh2SUxTN0Rkckc0SDlqTnJZOUZab1I4ZVgxTHV4WVM3RGgxVDNxVHJXTTFGckNVUjdxZVorZHZGaWpuV3I=.
[7] 徐小英. An asymmetric organocatalytic vinylogous Mannich reaction of 3-methyl-5-arylfuran-2(3H)-ones with N-(2-pyridinesulfonyl) imines: enantioselective synthesis of δ-amino γ,γ-disubstituted butenolides.. Org. Biomol. Chem.. 2018, [8] Chen, XinMeng, Xie, KeXin, Yue, DengFeng, Zhang, XiaoMei, Xu, XiaoYing, Yuan, WeiCheng. Catalyst-free synthesis of 2,3-dihydrobenzofurans through 4+1 cycloaddition of ortho-hydroxyphenylsubstituted para-quinone methides and sulfur ylides. TETRAHEDRON[J]. 2018, 74(5): 600-605, http://dx.doi.org/10.1016/j.tet.2017.12.038.
[9] Zhao, JianQiang, Zhou, XiaoJian, Chen, YongZheng, Xu, XiaoYing, Zhang, XiaoMei, Yuan, WeiCheng. Zn-Catalyzed Diastereo- and Enantioselective Dearomative 3+2 Cycloaddition Reaction of 2-Nitroindoles and 2-Nitrobenzothiophenes. ADVANCED SYNTHESIS & CATALYSIS[J]. 2018, 360(13): 2482-2487, [10] Luo, Yuan, Xie, KeXin, Yue, DengFeng, Zhang, XiaoMei, Xu, XiaoYing, Yuan, WeiCheng. An organocatalytic asymmetric Mannich reaction of pyrazoleamides with cyclic trifluoromethyl ketimines: enantioselective access to dihydroquinazolinone skeletons. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2018, 16(18): 3372-3375, https://www.webofscience.com/wos/woscc/full-record/WOS:000433444900008.
[11] Zhao, JianQiang, Zhou, XiaoJian, Zhou, Yan, Xu, XiaoYing, Zhang, XiaoMei, Yuan, WeiCheng. Diastereo- and Enantioselective Dearomative 3+2 Cycloaddition Reaction of 2-Nitrobenzofurans with 3-Isothiocyanato Oxindoles. ORGANIC LETTERS[J]. 2018, 20(4): 909-912, [12] Yue, DengFeng, Zhao, JianQiang, Chen, YongZheng, Zhang, XiaoMei, Xu, XiaoYing, Yuan, WeiCheng. Zinc-Catalyzed Enantioselective Dearomative 3+2 Cycloaddition Reaction of 3-Nitrobenzothiophenes and 3-Nitrothieno2,3-byridine with 3-Isothiocyanato Oxindoles. ADVANCED SYNTHESIS & CATALYSIS[J]. 2018, 360(7): 1420-1425, [13] Yue, DengFeng, Zhao, JianRiang, Chen, XiaoZhen, Zhou, Yan, Zhang, XiaoMei, Xu, XiaoYing, Yuan, WeiCheng. Multiple Hydrogen-Bonding Bifunctional Thiourea-Catalyzed Asymmetric Dearomative 4+2 Annulation of 3-Nitroindoles: Highly Enantioselective Access to Hydrocarbazole Skeletons. ORGANIC LETTERS[J]. 2017, 19(17): 4508-4511, https://www.webofscience.com/wos/woscc/full-record/WOS:000409566400025.
[14] Yuan Luo, KeXin Xie, DengFeng Yue, XiaoMei Zhang, XiaoYing Xu, WeiCheng Yuan. Organocatalytic asymmetric Michael addition of pyrazoleamides to β -phthalimidonitroethene. TETRAHEDRON. 2017, 6217-6222, http://dx.doi.org/10.1016/j.tet.2017.09.019.
[15] 袁伟成. Organocatalytic asymmetric Michael addition of pyrazoleamides to b-phthalimidonitroethene. Tetrahedron. 2017, [16] Jian-Qiang Zhao, Shu-Wen Luo, Xiao-Mei Zhang, Xiao-Ying Xu, Ming-Qiang Zhou, Wei-Cheng Yuan. Base-catalyzed bis-sulfenylation of γ-substituted butenolides for the synthesis of α,α-bisthiofunctionalized butenolide derivatives. TETRAHEDRON. 2017, 73(36): 5444-5450, http://dx.doi.org/10.1016/j.tet.2017.07.053.
[17] Yue, DengFeng, Zhao, JianQiang, Wang, ZhenHua, Zhang, XiaoMei, Xu, XiaoYing, Yuan, WeiCheng. A Neber approach for the synthesis of spiro-fused 2H-azirine-pyrazolone. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(6): 1946-1949, [18] 徐小英. Enantioselective synthesis of chiral a,β-unsaturated γ-substituted butyrolactams by organocatalyzed direct asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam to 2-enoylpyridines.. Org. Biomol. Chem.. 2016, [19] You Yong, Wu ZhiJun, Chen JianFeng, Wang ZhenHua, Xu XiaoYing, Zhang XiaoMei, Yuan WeiCheng. Organocatalytic Asymmetric Michael Addition of 3-Pyrrolyloxindoles to β-Phthalimidonitroethene for the Synthesis of 3,3’-Disubstituted Oxindoles Bearing Contiguous 3,α,β-Triamino Functionality.. THE JOURNAL OF ORGANIC CHEMISTRY. 2016, [20] Zhao, JianQiang, Yue, DengFeng, Zhang, XiaoMei, Xu, XiaoYing, Yuan, WeiCheng. The organocatalytic asymmetric Neber reaction for the enantioselective synthesis of spirooxindole 2H-azirines. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2016, 14(46): 10946-10952, [21] Zhang, MingLiang, Yue, DengFeng, Wang, ZhenHua, Luo, Yuan, Xu, XiaoYing, Zhang, XiaoMei, Yuan, WeiCheng. Organocatalytic asymmetric Henry reaction of 1H-pyrrole-2,3-diones with bifunctional amine-thiourea catalysts bearing multiple hydrogen-bond donors. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2016, 12(1): 295-300, https://doaj.org/article/9391cf57c081434fa83bf3abb491bc9e.
[22] Wang, ZhenHua, Wu, ZhiJun, Yue, DengFeng, Hu, WenFei, Zhang, XiaoMei, Xu, XiaoYing, Yuan, WeiCheng. Organocatalytic asymmetric 3+2 cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with 3-alkenyl-5-arylfuran-2(3H)-ones. CHEMICAL COMMUNICATIONS[J]. 2016, 52(78): 11708-11711, https://www.webofscience.com/wos/woscc/full-record/WOS:000385475700023.
[23] 徐小英. β,γ-Unsaturated α-Keto Esters for the Synthesis of Chiral syn-3,4-Dihydropyranones and 5,6-Dihydropyranones.. Org. Lett.. 2016, [24] 徐小英. Arylacetyl Phosphonates as Michael Donors for the Asymmetric Michael Reaction to Construct alpha-Substituted Chiral Carboxylic Esters.. Tetrahedron. 2016, [25] 袁伟成. Quinine-catalyzed asymmetric domino Mannich-cyclization reactions of 3-isothiocyanato oxindoles with imines for the synthesis of spirocyclic oxindoles.. Org. Biomol. Chem.. 2016, [26] Bai, Mei, Cui, BaoDong, Zuo, Jian, Zhao, JianQiang, You, Yong, Chen, YongZheng, Xu, XiaoYing, Zhang, XiaoMei, Yuan, WeiCheng. Quinine-catalyzed asymmetric domino Mannich-cyclization reactions of 3-isothiocyanato oxindoles with imines for the synthesis of spirocyclic oxindoles. TETRAHEDRON[J]. 2015, 71(6): 949-955, http://dx.doi.org/10.1016/j.tet.2014.12.074.
[27] 徐小英. Diastereo- and Enantioselective Direct Vinylogous Michale Addition of γ-Substituted Butenolides to 2‑Enoylpyridines Catalyzed by Chiral Bifunctional Amine-Squaramides.. Chem. Commun.. 2015, [28] 徐小英. Zn-Catalyzed Diastereo- and Enantioselective ascade Reaction of 3-Isothiocyanato Oxindoles and 3-Nitroindoles: Stereocontrolled Syntheses of Polycyclic Spirooxindoles. ORG. LETT.. 2015, [29] Chen Lin, Wu ZhiJun, Zhang MingLiang, Yue DengFeng, Zhang XiaoMei, Xu XiaoYing, Yuan WeiCheng. Organocatalytic Asymmetric Michael/Cyclization Cascade Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with α,β-Unsaturated Acyl Phosphonates for the Construction of Spirocyclic Oxindole-γ-lactones/lactams.. THE JOURNAL OF ORGANIC CHEMISTRY. 2015, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=22&recid=&FileName=SJPD3235BB1C1865A47B63DF35C55DC094B7&DbName=SJPD_05&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[30] Zuo, Jian, Wu, ZhiJun, Zhao, JianQiang, Zhou, MingQiang, Xu, XiaoYing, Zhang, XiaoMei, Yuan, WeiCheng. Preparation of 3-Sulfonylated 3,3-Disubstituted Oxindoles by the Addition of Sulfinate Salts to 3-Halooxindoles. JOURNAL OF ORGANIC CHEMISTRY[J]. 2015, 80(1): 634-640, http://210.75.237.14/handle/351003/27421.
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Organocatalyzed Asymmetric Reaction Using α-Isothiocyanato Compounds, InTechOpen, 2016-06, 第 1 作者

   

（ 1 ） 新型双手性双钒金属催化剂与不对称氧化偶联反应, 主持, 国家级, 2009-01--2011-12
（ 2 ） 手性催化的重要科学基础, 参与, 国家级, 2010-01--2012-12
（ 3 ） 多种含手性螺环结构氧化吲哚类化合物的催化不对称合成研究, 主持, 省级, 2011-01--2013-12
（ 4 ） 抗艾滋病药依非韦伦(Efavirenz)的不对称合成新工艺开发, 主持, 部委级, 2010-01--2012-12
（ 5 ） 手性Lewis Acids催化的分子内串联1,5-氢迁移/环合反应及其在构建结构多样性手性含氮杂环化合物中的应用, 主持, 国家级, 2014-01--2017-12
（ 6 ） 基于α-卤代腙的不对称环化反应在构建含多氮杂环手性化合物中的应, 主持, 国家级, 2016-01--2019-12

（1）3-NCS氧化吲哚参与的不对称反应研究   2015年西部有机化学论坛   2015-11-07