基本信息
杨郁  女  硕导  中国科学院生态环境研究中心
电子邮件: yuyang@rcees.ac.cn
通信地址: 北京市海淀区双清路18号
邮政编码:

研究领域

环境污染物生物传感分析方法的建立及其毒性分子作用机制的研究

招生信息

   
招生专业
083001-环境科学
招生方向
生物传感检测,环境毒理

教育背景

2006-09--2008-08   北京大学   博士后
2002-09--2005-07   湖南大学   博士

工作经历

   
工作简历
2011-03~现在, 中国科学院生态环境研究中心, 副研究员
2008-09~2011-02,中国科学院生态环境研究中心, 助理研究员

专利与奖励

   
奖励信息
(1) 第41批中国博士后科学基金, 一等奖, 国家级, 2007
专利成果
[1] 杨郁, 郭良宏, 任肖敏, 万斌, 谷玉新. 一种蛋白质O‑GlcNAc糖基转移酶活性电化学传感检测方法. CN: CN107462618A, 2017-12-12.

[2] 杨郁, 郭良宏, 任肖敏. 一种用于蛋白质酪氨酸磷酸酶活性的免标记电化学传感检测方法. CN: CN106957892A, 2017-07-18.

[3] 任肖敏, 曹林英, 杨郁, 郭良宏. 一种荧光标记的全氟烷基酸探针及其应用. CN: CN106187981A, 2016-12-07.

[4] 任肖敏, 曹林英, 杨郁, 郭良宏. 一种检测待测样品与GPR40结合能力的方法及其专用特异荧光探针. CN: CN105675570A, 2016-06-15.

出版信息

   
发表论文
[1] Li Wang, Lantian Zhou, Longyu Liu, Yu Yang, Qiang Zhao. Comparative in vitro and in silico study on the estrogenic effects of 2,2-bis(4-chlorophenyl)ethanol, 4,4′-dichlorobenzophenone and DDT analogs. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2023, 876(162734): 1-9, http://dx.doi.org/10.1016/j.scitotenv.2023.162734.
[2] Wang, Li, Qie, Yu, Yang, Yu, Zhao, Qiang. Binding and Activation of Estrogen-Related Receptor γ: A Novel Molecular Mechanism for the Estrogenic Disruption Effects of DDT and Its Metabolites. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2022, 56(17): 12358-12367, http://dx.doi.org/10.1021/acs.est.1c08624.
[3] Fadare, Oluniyi O, Wan, Bin, Liu, Keyang, Yang, Yu, Zhao, Lixia, Guo, LiangHong. Eco-Corona vs Protein Corona: Effects of Humic Substances on Corona Formation and Nanoplastic Particle Toxicity in Daphnia magna. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2020, 54(13): 8001-8009, https://www.webofscience.com/wos/woscc/full-record/WOS:000548584900031.
[4] Cui, Xuejing, Wan, Bin, Yang, Yu, Xin, Yan, Xie, YiChun, Guo, LiangHong, Mantell, Lin L. Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion. TOXICOLOGICAL SCIENCES[J]. 2019, 172(2): 398-410, [5] Fadare, Oluniyi O, Wan, Bin, Guo, LiangHong, Xin, Yan, Qin, Weiping, Yang, Yu. Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna. ENVIRONMENTAL SCIENCE-NANO[J]. 2019, 6(5): 1466-1477, https://www.webofscience.com/wos/woscc/full-record/WOS:000473076700013.
[6] Gu, YuXin, Liang, XiaoXing, Yin, NuoYa, Yang, Yu, Wan, Bin, Guo, LiangHong, Faiola, Francesco. New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells. ARCHIVES OF TOXICOLOGY[J]. 2019, 93(9): 2661-2671, https://www.webofscience.com/wos/woscc/full-record/WOS:000487647300016.
[7] Yang, Yu, Wang, Li, Wan, Bin, Gu, Yuxin, Li, Xinxin. Optically Active Nanomaterials for Bioimaging and Targeted Therapy. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2019, 7(320): 1-24, https://doaj.org/article/000d1c3309b94ce3959a428a1a789f49.
[8] Xie, Yichun, Wan, Bin, Yang, Yu, Cui, Xuejing, Xin, Yan, Guo, LiangHong. Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups. JOURNALOFENVIRONMENTALSCIENCES[J]. 2019, 77: 198-209, http://lib.cqvip.com/Qikan/Article/Detail?id=72747566504849574851484957.
[9] Xin, Yan, Wan, Bin, Yang, Yu, Cui, XueJing, Xie, YiChun, Guo, LiangHong. Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells. ARCHIVES OF TOXICOLOGY[J]. 2018, 92(10): 3131-3147, http://ir.rcees.ac.cn/handle/311016/41009.
[10] Cao, LinYing, Ren, XiaoMin, Yang, Yu, Wan, Bin, Guo, LiangHong, Chen, De, Fan, Yong. Hydroxylated Polybrominated Biphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein-Coupled Estrogen Receptor Mediated Pathways. ENVIRONMENTAL HEALTH PERSPECTIVES[J]. 2018, 126(5): 057005-, http://ir.rcees.ac.cn/handle/311016/40962.
[11] Gu, Yuxin, Yang, Yu, Wan, Bin, Li, Minjie, Guo, LiangHong. Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells - A molecular mechanism of organophosphate flame retardants developmental neurotoxicity. BIOCHEMICAL PHARMACOLOGY[J]. 2018, 152: 21-33, http://dx.doi.org/10.1016/j.bcp.2018.03.017.
[12] Yang Yu, Gu Yuxin, Wan Bin, Ren Xiaomin, Guo LiangHong. Label-free electrochemical biosensing of small-molecule inhibition on O-GlcNAc glycosylation. BIOSENSORS AND BIOELECTRONICS[J]. 2017, 95: 94-99, http://dx.doi.org/10.1016/j.bios.2017.04.009.
[13] Xuejing Cui, Bin Wan, Yu Yang, Xiaomin Ren, LiangHong Guo. Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells. SCIENTIFIC REPORTS[J]. 2017, 7(1518): 1-13, http://ir.rcees.ac.cn/handle/311016/39350.
[14] Yang, Yu, Lv, QiYan, Guo, LiangHong, Wan, Bin, Ren, XiaoMin, Shi, YaLi, Cai, YaQi. Identification of protein tyrosine phosphatase SHP-2 as a new target of perfluoroalkyl acids in HepG2 cells. ARCHIVES OF TOXICOLOGY[J]. 2017, 91(4): 1697-1707, http://ir.rcees.ac.cn/handle/311016/39335.
[15] Wang, Sufang, Lv, Qiyan, Yang, Yu, Guo, LiangHong, Wan, Bin, Ren, Xiaomin, Zhang, Hui. Arginine decarboxylase: A novel biological target of mercury compounds identified in PC12 cells. BIOCHEMICAL PHARMACOLOGY[J]. 2016, 118: 109-120, http://dx.doi.org/10.1016/j.bcp.2016.08.019.
[16] Cui, Xuejing, Wan, Bin, Yang, Yu, Ren, Xiaomin, Guo, LiangHong, Zhang, Hui. Crucial Role of P2X(7) Receptor in Regulating Exocytosis of Single-Walled Carbon Nanotubes in Macrophages. SMALL[J]. 2016, 12(43): 5998-6011, http://ir.rcees.ac.cn/handle/311016/35825.
[17] Ren, Xiaomin, Cao, Linying, Yang, Yu, Wan, Bin, Wang, Sufang, Guo, Lianghong. In vitro assessment of thyroid hormone receptor activity of four organophosphate esters. JOURNAL OF ENVIRONMENTAL SCIENCES[J]. 2016, 45: 185-190, http://dx.doi.org/10.1016/j.jes.2015.12.021.
[18] Hou, Jie, Wan, Bin, Yang, Yu, Ren, XiaoMin, Guo, LiangHong, Liu, JingFu. Biodegradation of Single-Walled Carbon Nanotubes in Macrophages through Respiratory Burst Modulation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2016, 17(3): http://ir.rcees.ac.cn/handle/311016/35808.
[19] Cui, Xuejing, Wan, Bin, Guo, LiangHong, Yang, Yu, Ren, Xiaomin. Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X(7) Receptor. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2016, 50(22): 12473-12483, http://ir.rcees.ac.cn/handle/311016/35877.
[20] Lv, QiYan, Wan, Bin, Guo, LiangHong, Yang, Yu, Ren, XiaoMin, Zhang, Hui. In vivo immunotoxicity of perfluorooctane sulfonate in BALB/c mice: Identification of T-cell receptor and calcium-mediated signaling pathway disruption through gene expression profiling of the spleen. CHEMICO-BIOLOGICAL INTERACTIONS[J]. 2015, 240(1): 84-93, http://dx.doi.org/10.1016/j.cbi.2015.07.015.
[21] Wang, Sufang, Wan, Bin, Zhang, Lianying, Yang, Yu, Guo, LiangHong. In vitro inhibition of lysine decarboxylase activity by organophosphate esters. BIOCHEMICAL PHARMACOLOGY[J]. 2014, 92(3): 506-516, http://dx.doi.org/10.1016/j.bcp.2014.09.011.
[22] Wang, Sufang, Lv, Qiyan, Yang, Yu, Guo, LiangHong, Wan, Bin, Zhao, Lixia. Cellular target recognition of perfluoroalkyl acids: In vitro evaluation of inhibitory effects on lysine decarboxylase. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2014, 496(1): 381-388, http://dx.doi.org/10.1016/j.scitotenv.2014.07.034.
[23] Yang, Yu, Guo, LiangHong, Qu, Na, Wei, MingYuan, Zhao, LiXia, Wan, Bin. Label-free electrochemical measurement of protein tyrosine kinase activity and inhibition based on electro-catalyzed tyrosine signaling. BIOSENSORS & BIOELECTRONICS[J]. 2011, 28(1): 284-290, http://dx.doi.org/10.1016/j.bios.2011.07.033.
[24] Yu Yang, Lixia Zhao. Sensitive fluorescent sensing for DNA assay. TRENDS IN ANALYTICAL CHEMISTRY[J]. 2010, 29(9): 980-1003, http://dx.doi.org/10.1016/j.trac.2010.05.009.
[25] Yang, Yu, Jiang, Jianhui, Shen, Guoli, Yu, Ruqin. An optical sensor for mercury ion based on the fluorescence quenching of tetra(p-dimethylaminophenyl)porphyrin. ANALYTICA CHIMICA ACTA[J]. 2009, 636(1): 83-88, http://dx.doi.org/10.1016/j.aca.2009.01.038.
[26] 杨郁, 郭良宏. 超分子主体化合物环糊精应用于环境污染物分离分析的研究进展. 科学通报[J]. 2009, 128-137, http://lib.cqvip.com/Qikan/Article/Detail?id=29472453.
[27] Yang, Yu, Long, Yuanyuan, Li, Zhiyu, Li, Na, Li, Kean, Liu, Feng. Real-time molecular recognition between protein and photosensitizer of photodynamic therapy by quartz crystal microbalance sensor. ANALYTICAL BIOCHEMISTRY[J]. 2009, 392(1): 22-27, http://dx.doi.org/10.1016/j.ab.2009.05.035.
[28] Yang, Yu, Long, Yuanyuan, Cao, Qing, Li, Kean, Liu, Feng. Molecularly imprinted polymer using beta-cyclodextrin as functional monomer for the efficient recognition of bilirubin. ANALYTICA CHIMICA ACTA[J]. 2008, 606(1): 92-97, http://159.226.238.44/handle/321008/140848.
发表著作
(1) 分析化学学科前沿与展望, Frontiers and perspectives of analytical chemistry, 科学出版社, 2012-04, 第 3 作者

科研活动

   
科研项目
( 1 ) 基于超分子荧光分子开关体系实时动态高通量研究二恶英对氨基酸脱羧酶的毒性作用, 主持, 国家级, 2011-01--2013-12
( 2 ) 共振光散射法研究多环芳烃代谢物与P53基因的相互作用和基因毒性, 主持, 国家级, 2010-01--2012-12
( 3 ) 纳米材料与纳米技术在水污染物检测与治理中的应用基础研究, 参与, 国家级, 2009-01--2013-12
( 4 ) 用于磺酰脲类除草剂快速检测的纳米生物传感器技术研究, 参与, 部委级, 2009-01--2011-12
( 5 ) 纳米粒子催化降解环境有机氯代物的化学发光行为及其机制研究, 参与, 国家级, 2010-01--2012-12
( 6 ) 环境污染物对蛋白质可逆糖基化过程干扰效应的快速筛查和干扰机制, 主持, 国家级, 2014-01--2017-12
( 7 ) 全氟化合物毒性作用新靶点蛋白质酪氨酸磷酸酶的识别及分子机制研究, 主持, 国家级, 2016-01--2019-12

指导学生

已指导学生

谷玉新  硕士研究生  085229-环境工程