基本信息
张于  男  博导  中国科学院昆明植物研究所
电子邮件: zhangyu@mail.kib.ac.cn
通信地址: 云南省昆明市蓝黑路132号
邮政编码: 650201

研究领域

主要研究方向为以具有重要生理功能的活性生物碱为研究目标,利用植物化学、化学合成、生物学等手段探讨其结构、活性、作用机制以及成药性研究等。

教育背景

2005-09--2010-07   中国科学院昆明植物研究所   博士
2001-09--2005-07   贵州大学   学士

工作经历


2020-11~现在, 中国科学院昆明植物研究所, 研究员
2015-06~2016-06,University of North Carolina at Chapel Hill, Visiting Scholar
2014-01~2020-11,中国科学院昆明植物研究所, 副研究员
2010-07~2014-01,中国科学院昆明植物研究所, 助理研究员

教授课程

天然有机立体化学
ECD在天然产物结构鉴定中的应用
ECD在天然产物结构鉴定中的作用
CD/ORD在天然产物绝对构型

专利与奖励

1. 2009年度云南省自然科学一等奖(R6)

2. 2021年度广西自然科学二等奖(R8)

专利成果
( 1 ) 吲哚生物碱类化合物及其制备方法和其药物组合物与应用, 发明专利, 2022, 第 1 作者, 专利号: 202210007290.7

( 2 ) 一种吲哚生物碱或其药学上可接受的盐及制备方法和应用、吲哚生物碱药物组合物及其应用, 专利授权, 2020, 第 1 作者, 专利号: CN110437255B

( 3 ) 依波加生物碱或其药学上可接受的盐以及制备方法和应用、依波加生物碱药物组合物及应用, 专利授权, 2020, 第 1 作者, 专利号: CN110483515B

( 4 ) 一种天然小分子HEC-23在制备用于促进溶酶体介导的细胞死亡的药物中用途, 发明专利, 2018, 第 2 作者, 专利号: CN108478809A

( 5 ) 菲啶类衍生物及其药物组合物和其制备方法与应用, 发明专利, 2013, 第 8 作者, 专利号: CN103145617A

( 6 ) 抗肿瘤生物碱类化合物,其药物组合物及其制备方法和应用, 发明专利, 2011, 第 2 作者, 专利号: CN102225937A

( 7 ) 3-丙酮基-3-羟基羟吲哚的制备方法, 发明专利, 2011, 第 6 作者, 专利号: CN101979379A

出版信息

   
发表论文
(1) New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit b-Amyloid42 Production and Phospho-Tau (Thr217), International Journal of Molecular Sciences, 2023, 通讯作者
(2) Monoterpenoid indole alkaloid dimers from Kopsia arborea inhibit cyclin-dependent kinase 5 and tau phosphorylation, Phytochemistry, 2022, 通讯作者
(3) Tabernaesine J,a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon, Tabernaesine J, a Novel Vincamine-Type Indole Alkaloid with 6/5/6/6/6/5/5 Heptacyclic-Ring System Scaffold from Tabernaemontana pachysiphon, CHINESE JOURNAL OF CHEMISTRY, 2022, 通讯作者
(4) Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway, ORGANIC & BIOMOLECULAR CHEMISTRY, 2021, 第 6 作者
(5) Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities, FITOTERAPIA, 2021, 通讯作者
(6) Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans, BIOORGANIC CHEMISTRY, 2021, 通讯作者
(7) Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity, PHYTOCHEMISTRY, 2021, 通讯作者
(8) Isolation and structure elucidation of tabercetimines A-D, four new quaternary monoterpenoid indole alkaloids from Tabernaemontana divaricata, TETRAHEDRON LETTERS, 2021, 通讯作者
(9) Two new steroidal alkaloids from the rhizomes of Veratrum nigrum L. and their anti-TYLCV activity, FITOTERAPIA, 2020, 第 2 作者
(10) Synthesis and PDE-10 Inhibition of 3-substituted Phenylimino-indolin-2-ones, BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2020, 第 4 作者
(11) Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L, FITOTERAPIA, 2020, 第 4 作者
(12) Bousangine A, a novel C-17-nor aspidosperma-type monoterpenoid indole alkaloid from Bousigonia angustifolia, FITOTERAPIA, 2020, 通讯作者
(13) Taberdivamines A and B, two new quaternary indole alkaloids from Tabernaemontana divaricata, TETRAHEDRON LETTERS, 2020, 通讯作者
(14) A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud, NATURAL PRODUCT RESEARCH, 2020, 通讯作者
(15) Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification, Journal of Natural Products, 2020, 
(16) Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification, JOURNAL OF NATURAL PRODUCTS, 2020, 通讯作者
(17) Acotarines A-G, new diterpenoid alkaloids from Aconitum taronense induce lysosomal biogenesis, FITOTERAPIA, 2020, 通讯作者
(18) Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti-TMV activity, FITOTERAPIA, 2020, 通讯作者
(19) Tabernaesines A-I, Cytotoxic Aspidosperma-Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon, JOURNAL OF NATURAL PRODUCTS, 2020, 通讯作者
(20) Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization, MOLECULES, 2019, 第 1 作者
(21) Two new monoterpenoid indole alkaloids from Tabernaemontana divaricata, NATURAL PRODUCT RESEARCH, 2019, 通讯作者
(22) Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings, JOURNAL OF NATURAL PRODUCTS, 2019, 第 6 作者
(23) Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius ., JOURNAL OF NATURAL PRODUCTS, 2019, 第 2 作者
(24) Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization, MOLECULES, 2019, 第 1 作者
(25) Acoapetaludines A-K, C20 and C19-diterpenoid alkaloids from the whole plants of Aconitum apetalum (Huth) B.Fedtsch, PHYTOCHEMISTRY, 2019, 通讯作者
(26) Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus, FITOTERAPIA, 2019, 通讯作者
(27) Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum, BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 第 2 作者
(28) Melocochines A and B, Two Alkaloids from the Fruits of Melodinus cochinchinensis ., ORGANIC LETTERS, 2019, 第 1 作者
(29) Fluevirines E and F, two new alkaloids from Flueggea virosa, Natural Product Research, 2019, 通讯作者
(30) Alkaloids from the roots of Stemona tuberosa and their anti-tobacco mosaic virus activities, TETRAHEDRON, 2019, 通讯作者
(31) Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new wnt/beta-catenin signalling pathway agonists, BIOORGANIC CHEMISTRY, 2019, 第 8 作者
(32) Five new alkaloids from Aconitum apetalum (Ranunculaceae), PHYTOCHEMISTRY LETTERS, 2019, 通讯作者
(33) Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii., JOURNAL OF NATURAL PRODUCTS, 2018, 第 2 作者
(34) Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus., FITOTERAPIA, 2018, 通讯作者
(35) Munronin O, a potential activator for plant resistance, PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2018, 第 8 作者
(36) Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation, COMPTES RENDUS CHIMIE, 2018, 第 7 作者
(37) Taburnaemines A-I, cytotoxic vobasinyl-ibogan-type bisindole alkaloids from Tabernaemontana corymbosa, Journal of Natural Products, 2018, 第 1 作者
(38) C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT, 2018, 第 7 作者
(39) C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, PROTEIN & CELL, 2018, 第 2 作者
(40) Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis, JOURNAL OF NATURAL PRODUCTS, 2018, 第 7 作者
(41) Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis, ORGANIC CHEMISTRY FRONTIERS, 2018, 第 6 作者
(42) Two new monoterpenoid indole alkaloids from Alstonia rostrata., NATURAL PRODUCT RESEARCH, 2018, 通讯作者
(43) Seven new anthranilamide derivatives from Aconitum apetalum, FITOTERAPIA, 2018, 通讯作者
(44) Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation, MOLECULES, 2018, 第 2 作者
(45) Baeckfrutones A-L, polymethylated phloroglucinol meroterpenoids from the twigs and leaves of Baeckea frutescens, INDUSTRIAL CROPS AND PRODUCTS, 2018, 第 8 作者
(46) Polycyclic monoterpenoid indole alkaloids from Alstonia rostrata and their reticulate derivation, PHYTOCHEMISTRY LETTERS, 2017, 通讯作者
(47) Melohenryines A and B, two new indole alkaloids from Melodinus henryi, PHYTOCHEMISTRY LETTERS, 2017, 通讯作者
(48) (+/-)-Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata, NATURAL PRODUCT COMMUNICATIONS, 2017, 第 5 作者
(49) Tabercorymines A and B, Two Vobasinyl−Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa, ORGANIC LETTERS, 2017, 通讯作者
(50) Polycyclic monoterpenoid indole alkaloids from Alstonia rostrata and their reticulate derivation, PHYTOCHEMISTRY LETTERS, 2017, 第 6 作者
(51) Two new kaurane-type diterpenoids from Wedelia chinensis (Osbeck.) Merr, NATURAL PRODUCT RESEARCH, 2017, 第 2 作者
(52) Phytotoxic Terpenoids from Ligularia cymbulifera Roots, FRONTIERS IN PLANT SCIENCE, 2017, 第 3 作者
(53) Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A, SCIENTIFICREPORTS, 2017, 第 6 作者
(54) Melohenryines A and B, two new indole alkaloids from Melodinus henryi, PHYTOCHEMISTRY LETTERS, 2017, 第 5 作者
(55) 16-nor Limonoids from Harrisonia perforata as promising selective 11 beta-HSD1 inhibitors, SCIENTIFIC REPORTS, 2016, 第 6 作者
(56) New findings of cyclohexane-fused octahydroquinolizine alkaloids from Myrioneuron faberi, TETRAHEDRON LETTERS, 2016, 第 3 作者
(57) (±)-Evodiakine, A Pair of Rearranged Rutaecarpine-Type Alkaloids From Evodia rutaecarpa, NATURAL PRODUCTS AND BIOPROSPECTING, 2016, 第 2 作者
(58) Three new alkaloids from Myrioneuron faberi, TETRAHEDRON LETTERS, 2016, 第 2 作者
(59) Myritonines A-C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton, JOURNAL OF NATURAL PRODUCTS, 2016, 第 2 作者
(60) Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata, PHYTOCHEMISTRY LETTERS, 2016, 第 4 作者
(61) Schoberine B, an alkaloid with an unprecedented straight C-5 side chain, and myriberine B from Myrioneuron faberi, RSC ADVANCES, 2016, 第 2 作者
(62) (+)- and (-)-ganodilactone, a pair of meroterpenoid dimers with pancreatic lipase inhibitory activities from the macromycete Ganoderma leucocontextum, RSC ADVANCES, 2016, 第 3 作者
(63) Four new tetracyclic alkaloids with cis-decahydroquinoline motif from Myrioneuron effusum, FITOTERAPIA, 2016, 第 6 作者
(64) Synthesis, Neuro-protection and Anti-cancer Activities of Simple Isatin Mannich and Schiff Bases, LETTERS IN DRUG DESIGN & DISCOVERY, 2016, 第 5 作者
(65) A novel gamma-lactone derivative from the twigs of Turraea pubescens, ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2015, 第 4 作者
(66) Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors, FUTURE MEDICINAL CHEMISTRY, 2015, 第 9 作者
(67) New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa., FITOTERAPIA, 2015, 第 1 作者
(68) A novel isocoumarin with anti-influenza virus activity from Strobilanthes cusia, FITOTERAPIA, 2015, 第 4 作者
(69) Theoretical study of regioselectivity in the synthesis of spiro pyrrolidine-2,3'-oxindole compounds by 3+2 cycloaddition, RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 第 4 作者
(70) Bioactive Limonoid Constituents of Munronia henryi, JOURNAL OF NATURAL PRODUCTS, 2015, 通讯作者
(71) Synthesis, Cytoprotective and Anti-tumor Activities of Isatin Schiff Bases, LETTERS IN DRUG DESIGN & DISCOVERY, 2015, 第 3 作者
(72) Synthesis of 4-ethyl-5-methyl-5,6-dihydrophenanthridine-8,9-diol as the key intermediate of potent agonists of the Wnt signalling pathway, JOURNAL OF CHEMICAL RESEARCH, 2015, 第 3 作者
(73) Cytotoxic indole alkaloids from the fruits of Melodinus cochinchinensis., PHYTOCHEMISTRY, 2015, 第 4 作者
(74) Alstoscholarisines F and G, two unusual monoterpenoid indole alkaloids from the leaves of Alstonia scholaris, TETRAHEDRON LETTERS, 2015, 第 3 作者
(75) Further Alkaloids from the Leaves of Trigonostemon lii, HELVETICA CHIMICA ACTA, 2015, 第 2 作者
(76) Alkaloids with Different Carbon Units from Myrioneuron faberi, JOURNAL OF NATURAL PRODUCTS, 2015, 第 2 作者
(77) Compounds with Antifouling Activities from the Roots of Notopterygium franchetii, NATURAL PRODUCT COMMUNICATIONS, 2015, 第 4 作者
(78) (±)-Salviaprione, a pair of unprecedented abietane-type diterpeniods from Salvia prionitis, TETRAHEDRON LETTERS, 2015, 第 2 作者
(79) Two new pentacyclic triterpenoids from the stems of Manihot esculenta, PHYTOCHEMISTRY LETTERS, 2015, 第 6 作者
(80) Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 第 3 作者
(81) 臭常山喹啉生物碱化学成分及活性研究, 江苏农业科学, 2015, 第 5 作者
(82) Indole Alkaloid Glycosides from the Aerial Parts of Strobilanthes cusia, JOURNAL OF NATURAL PRODUCTS, 2014, 第 2 作者
(83) New acyclic diterpenoids from the fruits of Aphanamixis grandifolia and structure revision of nemoralisin B, PHYTOCHEMISTRY LETTERS, 2014, 第 6 作者
(84) Japodagricanones A and B, novel diterpenoids from Jatropha podagrica, FITOTERAPIA, 2014, 第 2 作者
(85) 佛肚树的化学成分研究, Chemical Constituents from the Leaves and Twigs of Jatropha podagrica, 天然产物研究与开发, 2014, 第 3 作者
(86) Fluevirines A–D, four new securinega-type alkaloids from Flueggea virosa, TETRAHEDRON LETTERS, 2014, 第 3 作者
(87) Myrifabine, the First Dimeric Myrioneuron Alkaloid from Myrioneuron faberi, ORGANIC LETTERS, 2014, 通讯作者
(88) Indole alkaloids from cultivated Vinca major, TETRAHEDRON, 2014, 第 3 作者
(89) Angustifonines A and B, cytotoxic bisindole alkaloids from Bousigonia angustifolia., JOURNAL OF NATURAL PRODUCTS, 2014, 通讯作者
(90) Anguistifonines A and B, cytotoxic bisindole alkaloids from Bousigonia angustifolia, Journal of Natural Products, 2014, 通讯作者
(91) Diarylheptanoids and phenylphenalenones from Musa itinerans fruits, PHYTOCHEMISTRY, 2014, 第 2 作者
(92) Antimicrobial Constituents of the Mature Carpels of Manglietiastrum sinicum, JOURNAL OF NATURAL PRODUCTS, 2014, 第 7 作者
(93) Phragmalin Limonoids from the Stem Barks of Chukrasia tabularis var. velutina, PLANTA MEDICA, 2014, 第 6 作者
(94) 瑞香狼毒的化学成分, 大理学院学报, 2014, 第 3 作者
(95) Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 第 7 作者
(96) Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis, FITOTERAPIA, 2014, 通讯作者
(97) Limonoids from Aphanamixis polystachya and Their Antifeedant Activity, JOURNAL OF NATURAL PRODUCTS, 2014, 第 5 作者
(98) Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus, JOURNAL OF ORGANIC CHEMISTRY, 2014, 第 2 作者
(99) 盆架树中单萜吲哚生物碱成分的分离与结构鉴定, The Isolation and Structural Identification of Monoterpenoid Indole Alkaloids from Winchia calophylla, 天然产物研究与开发, 2014, 第 4 作者
(100) Theoretical study of the regioselectivity of the Huisgen reaction, RESEARCH ON CHEMICAL INTERMEDIATES, 2013, 第 4 作者
(101) Two new compounds from Khaya senegalensis, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2013, 第 4 作者
(102) 割舌树中一个新的胡萝卜烷型倍半萜(英文), 中国天然药物, 2013, 第 3 作者
(103) Bioactive Limonoid and Triterpenoid Constituents of Turraea pubescens, JOURNAL OF NATURAL PRODUCTS, 2013, 第 3 作者
(104) A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata, CHINESE JOURNAL OF NATURAL MEDICINES, 2013, 第 2 作者
(105) Myriberine A, a New Alkaloid with an Unprecedented Heteropentacyclic Skeleton from Myrioneuron faberi, ORGANIC LETTERS, 2013, 第 2 作者
(106) Two new flavonols, including one flavan dimer, from the roots of Indigofera stachyodes, PHYTOCHEMISTRY LETTERS, 2013, 第 5 作者
(107) Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity, PHYTOCHEMISTRY, 2013, 第 2 作者
(108) New steroids and sesquiterpene from Turraea pubescens, FITOTERAPIA, 2013, 第 4 作者
(109) Daphmacromines K-O, alkaloids from Daphniphyllum macropodum, FITOTERAPIA, 2013, 第 3 作者
(110) 大叶桃花心木中的柠檬苦素成分(英文), 天然产物研究与开发, 2013, 第 4 作者
(111) 红花石蒜中的一个新石蒜生物碱(英文), 中国天然药物, 2013, 第 2 作者
(112) 异叶三宝木叶的化学成分研究(英文), 天然产物研究与开发, 2013, 第 2 作者
(113) Cincholenines A and B, two unprecedented quinoline alkaloids from Cinchona ledgeriana, TETRAHEDRON LETTERS, 2013, 第 2 作者
(114) Aphagrandinoids A-D, cycloartane triterpenoids with antibacterial activities from Aphanamixis grandifolia, FITOTERAPIA, 2013, 第 4 作者
(115) Anti-HIV active daphnane diterpenoids from Trigonostemon thyrsoideum, PHYTOCHEMISTRY, 2013, 第 4 作者
(116) Trigoflavidols A-C, Degraded Diterpenoids with Antimicrobial Activity, from Trigonostemon flavidus, JOURNAL OF NATURAL PRODUCTS, 2012, 第 2 作者
(117) Three novel beta-carboline alkaloids from Gelsemium elegans, FITOTERAPIA, 2012, 第 2 作者
(118) Cycloartane Triterpenoids from Cassia occidentalis, PLANTAMEDICA, 2012, 第 7 作者
(119) Trichilone, a New C-21 Steroid from Trichilia connaroides, NATURAL PRODUCT COMMUNICATIONS, 2012, 第 2 作者
(120) Aphanamixoid A, a Potent Defensive Limonoid, with a New Carbon Skeleton from Aphanamixis polystachya, ORGANIC LETTERS, 2012, 第 2 作者
(121) Daphmacromines A-J, Alkaloids from Daphniphyllum macropodum, JOURNAL OF NATURAL PRODUCTS, 2012, 第 2 作者
(122) Daphhimalenines C and D. New Alkaloids from Daphniphyllum himalense, ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2012, 第 1 作者
(123) Mekongenines A and B, two new alkaloids from Bousigonia mekongensis, TETRAHEDRON LETTERS, 2012, 通讯作者
(124) Two new tirucallane triterpenoids from Aphanamixis grandifolia, NATURAL PRODUCTS AND BIOPROSPECTING, 2012, 第 4 作者
(125) Indole alkaloids from Ervatamia chinensis, PHYTOCHEMISTRY, 2012, 通讯作者
(126) Phragmalin-type Limonoids from Heynea trijuga, PLANTA MEDICA, 2012, 第 3 作者
(127) Cleidbrevoids A-C, new clerodane diterpenoids from Cleidion brevipetiolatum, FITOTERAPIA, 2012, 第 3 作者
(128) Senegalensions A-C, Three Limonoids from Khaya senegalensis, CHEMISTRY-AN ASIAN JOURNAL, 2012, 第 2 作者
(129) 3,4-seco-Diterpenoids from Trigonostemon flavidus, TETRAHEDRON, 2012, 通讯作者
(130) Daphnioldhamine A, a novel alkaloid from Daphniphyllum oldhami, TETRAHEDRON LETTERS, 2012, 通讯作者
(131) Trigonosins A-F, Daphnane Diterpenoids from Trigonostemon thyrsoideum, JOURNAL OF NATURAL PRODUCTS, 2011, 第 4 作者
(132) Psychotripine: A New Trimeric Pyrroloindoline Derivative from Psychotria pilifera, ORGANIC LETTERS, 2011, 第 2 作者
(133) A new type of monoterpenoid indole alkaloid precursor from Alstonia rostrata., ORGANIC LETTERS, 2011, 第 3 作者
(134) Daphmalenines A and B: Two New Alkaloids with Unusual Skeletons from Daphniphyllum himalense, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 第 1 作者
(135) Trigonoines A and B, two novel alkaloids from the leaves of Trigonostemon lii, TETRAHEDRON LETTERS, 2011, 第 4 作者
(136) Three New Indole Alkaloids from Trigonostemon Iii, ORGANIC LETTERS, 2010, 第 4 作者
(137) 脉叶虎皮楠的生物碱成分研究, Alkaloids from Daphniphyllum paxianum, 天然产物研究与开发, 2009, 第 1 作者
(138) Tetranortriterpenoids from the Leaves of Cipadessa cinerascens, JOURNAL OF NATURAL PRODUCTS, 2009, 第 6 作者
(139) Gelegamines A-E: five new oxindole alkaloids from Gelsemium elegans, TETRAHEDRON, 2009, 第 7 作者
(140) Dapholdhamines A-D, Alkaloids from Daphniphyllum oldhami, JOURNAL OF NATURAL PRODUCTS, 2009, 第 1 作者
(141) Structural elucidation of daphniacetal A, a new oxa-cage compound isolated from Daphniphyllum macropodum Miq., TETRAHEDRON LETTERS, 2009, 第 2 作者
(142) Daphhimalenine A, a New Alkaloid with an Unprecedented Skeleton, from Daphniphyllum himalense, ORGANIC LETTERS, 2009, 第 1 作者
(143) Alkaloids from the Leaves of Daphniphyllum longeracemosum ROSENTH., HELVETICA CHIMICA ACTA, 2009, 第 4 作者
(144) Yunnandaphninines F and G, new C(30) alkaloids from Daphniphyllum yunnanense, HELVETICA CHIMICA ACTA, 2008, 第 4 作者
(145) Daphnoldines A and B, two new yuzurine alkaloids with a four-ring system, from the fruits of Daphniphyllum oldhami, HELVETICA CHIMICA ACTA, 2008, 第 7 作者
(146) Daphniphyllum and diterpenoid alkaloids from Daphniphyllum longeracemosum, JOURNAL OF NATURAL PRODUCTS, 2008, 第 7 作者
(147) Three New Alkaloids, Paxiphyllines C-E, from Daphniphyllum paxianum, HELVETICA CHIMICA ACTA, 2008, 第 1 作者
(148) Alkaloids from Daphniphyllum oldhami, JOURNAL OF NATURAL PRODUCTS, 2008, 第 8 作者
(149) Paxiphyllines a and b, new alkaloids from Daphniphyllum paxianum, TETRAHEDRON LETTERS, 2007, 第 1 作者
(150) Four new Myrioneuron alkaloids from Mycetia effusa (Myrioneuron effusum), PHYTOCHEMISTRY LETTERS, 第 3 作者

科研活动

   
科研项目
( 1 ) 影响自噬-溶酶体通路的vobasinyl-ibogan类型生物碱的发现及其抗肿瘤机制研究, 负责人, 国家任务, 2015-01--2018-12
( 2 ) 三种植物中抗肿瘤二聚单萜吲哚生物碱活性成分研究, 负责人, 国家任务, 2012-01--2014-12
( 3 ) 密脉木属植物中抗丙肝病毒生物碱活性成分及其分子设计, 负责人, 地方任务, 2014-10--2017-09
( 4 ) 中国科学院青年创新促进会人才项目, 负责人, 中国科学院计划, 2015-01--2018-12
( 5 ) 密脉木生物碱抗HCV活性及其分子设计, 负责人, 中国科学院计划, 2012-10--2015-10
( 6 ) 天然翠雀花中二萜类生物碱的分离分析及结构修饰, 负责人, 中国科学院计划, 2013-01--2014-12
( 7 ) 具有重要活性的新结构生物碱的发现, 负责人, 中国科学院计划, 2016-10--2019-09
( 8 ) Aspidosperma-eburnea类生物碱促溶酶体生成的构效关系与作用机制 研究, 负责人, 国家任务, 2019-01--2022-12
( 9 ) 抑制微管蛋白聚合活性的白坚木类型生物碱的发现、构 效关系以及机制研究, 负责人, 地方任务, 2018-06--2021-05
( 10 ) 云南省万人计划青年拔尖人才, 负责人, 地方任务, 2019-01--2023-12
( 11 ) 典型天然植物化合物精准表征技术体系构建和构效关系研究, 负责人, 国家任务, 2022-12--2026-12
( 12 ) 调控溶酶体生成功能的柯南因类型生物碱的发现及作用机制研究, 负责人, 地方任务, 2023-06--2026-05
( 13 ) 蕊木属植物中新颖CDK5抑制剂的发现及其抗阿尔兹海默病活性研究, 负责人, 国家任务, 2024-01--2027-12

指导学生

已指导学生

霍宗庆  硕士研究生  105500-药学  

赵倩  硕士研究生  078001-药物化学  

马叶含  硕士研究生  105500-药学  

现指导学生

魏银铃  硕士研究生  078001-药物化学  

李晓宇  硕士研究生  105500-药学  

张伯斗  博士研究生  100701-药物化学  

张信笺  硕士研究生  105500-药学