基本信息
周兆才 男 博导 中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)
电子邮件: zczhou@sibcb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码: 200031
电子邮件: zczhou@sibcb.ac.cn
通信地址: 上海市岳阳路320号
邮政编码: 200031
研究领域
肿瘤发生及免疫应答的分子细胞信号机制
招生信息
招生专业
071010-生物化学与分子生物学100102-免疫学
招生方向
肿瘤免疫细胞信号转导
教育背景
1999-08--2004-07 中国科学技术大学 博士
学历
博士
工作经历
工作简历
2009-02~现在, 中科院上海生科院生化与细胞所, 研究员,研究组长2005-11~2009-02,美国宾夕法尼亚大学, 博士后2004-08~2005-10,美国布兰迪斯大学, 博士后
教授课程
实验生物学
专利与奖励
奖励信息
(1) 中科院上海分院第四届杰出青年科技创新人才, 院级, 2014
专利成果
( 1 ) VGLL4基因治疗肿瘤的用途及其相关药物, 发明, 2014, 第 1 作者, 专利号: 201410554627.1( 2 ) MST4基因诊断及细胞治疗感染性疾病的用途及相关药物, 发明, 2014, 第 1 作者, 专利号: 201410705068.X( 3 ) p97基因治疗病毒感染的用途及其相关药物, 发明, 2015, 第 1 作者, 专利号: 201510362643.5( 4 ) 通佐溴胺在制备能够阻断p97与Npl4的相互作用的抑制剂中的用途, 发明, 2015, 第 1 作者, 专利号: 201510359075.3( 5 ) 盐酸表柔比星在制备能够阻断p97与Npl4的相互作用的抑制剂中的用途, 发明, 2015, 第 1 作者, 专利号: 201510359088.0
出版信息
发表论文
(1) VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer, Nat Commun, 2017, 通讯作者(2) DNA-binding Mechanism of the Hippo Pathway Transcriptional Factor TEAD4, Oncogene, 2017, 通讯作者(3) Structural dissection of Hippo signaling, Acta Biochim Biophys Sin, 2016, 通讯作者(4) Non-canonical Role of the p97 Complex in RIG-I Antiviral Signaling, EMBO J, 2015, 通讯作者(5) The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor molecule TRAF6, Nat Immunol, 2015, 通讯作者(6) tructural Insights into Mitochondrial Antiviral-Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) Signaling, J Biol Chem, 2015, 通讯作者(7) The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100, J Biol Chem, 2015, 通讯作者(8) Structural insights into regulatory mechanisms of MO25-mediated kinase activation, J Struct Biol, 2014, 通讯作者(9) Structural and Biochemical Insights into the Activation Mechanisms of Germinal Center Kinase OSR1, J Biol Chem, 2014, 通讯作者(10) A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer, Cancer Cell, 2014, 通讯作者(11) VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex, Cell Res, 2014, 通讯作者(12) Striatins Contain a Noncanonical Coiled Coil That Binds PP2A A to Form a 2:2 Heterotetrameric Core of Striatin-interacting Phosphatase and Kinase (STRIPAK) Complex, J Biol Chem, 2014, 通讯作者(13) Structure of MST2 SARAH domain provides insights into its interaction with RAPL, J Struct Biol, 2014, 通讯作者(14) Structural mechanism of CCM3 heterodimerization with GCKIII kinases, Structure, 2013, 通讯作者(15) Structure of the MST4 in complex with MO25 provides insights into its activation mechanism, Structure, 2013, 通讯作者(16) Structural and biochemical studies of RIG-I antiviral signaling, Protein Cell, 2013, 通讯作者(17) β-Arrestin-1 directly interacts with Gαs and regulates its function, FEBS Lett, 2013, 第 3 作者(18) Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function, Cell Rep, 2012, 通讯作者(19) Structure of the SUN domain defines features of a molecular bridge in the nuclear envelope, J Biol Chem, 2012, 第 1 作者(20) Molecular and biological role of the FOXP3 N-terminal domain in immune regulation by T regulatory/suppressor cells, Exp Mol Pathol, 2012, 第 3 作者(21) Structural insights into SUN-KASH complexes across the nuclear envelope, Cell Res, 2012, 通讯作者(22) Germinal Center Kinases in Immune Regulation, Cell Mol Immunol, 2012, 通讯作者(23) Multiple Functions of Mammalian Germinal Center Kinases, Curr Chem Biol, 2012, 通讯作者(24) Ultra-high resolution crystal structure of a dimeric defensin SPE10, FEBS Letters, 2011, 第 1 作者(25) Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function, Current Opinion in Immunology, 2010, 第 2 作者(26) FOXP3 and its partners: structural and biochemical insights into the regulation of FOXP3 activity, Immunological Research, 2009, 第 1 作者(27) Human glucocorticoid induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states, PNAS, 2008, 第 1 作者(28) Structural basis for dimeric ligand mediated mouse GITR activation, PNAS, 2008, 第 1 作者(29) Structure of tropomyosin’s mid-region: bending and binding sites for actin, PNAS, 2005, 第 1 作者
科研活动
科研项目
( 1 ) STRIPAK相关信号网络调控肠道区域免疫特性的关键细胞功能及病理机制, 主持, 国家级, 2015-01--2017-12( 2 ) Hippo信号通路TEAD转录复合物的结构组装与功能调控, 主持, 国家级, 2015-01--2018-12
参与会议
(1)The MST4 Kinase Touching the Brake of TLR-TRAF6 Signaling to Limit Inflammation 2015 年免疫学进展论坛 周兆才 2015-11-24(2)The MST4 Kinase Touching the Brake of TLR-TRAF6 Signaling to Limit Inflammation 周兆才 2015-11-13(3)MST4 kinase touching the brake of TLR-TRAF6 signaling to limit inflammation 2015年度中国细胞生物学会免疫细胞生物学分年会 周兆才 2015-05-19(4)A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer 中国细胞生物学学学会2015年全国学术大会 周兆才 2015-04-03(5)Development of a peptide-based YAP inhibitor sheds new light on gastric cancer treatment 周兆才 2014-06-28(6)The SUN-KASH complex as a mechanical “LINC”between cytoskeleton and nucleus 周兆才 2014-05-11(7)Structural Insights into SUN-KASH Complexes across the Nuclear Envelope 周兆才 2012-10-23
指导学生
已指导学生
郝茜 01 19183
冯淼 01 19183
王慧珍 01 19183
张文青 01 19183
张振 01 19183
陈翠翠 02 19606
徐亮 02 63228
李川川 01 19183
王聪聪 01 19183
何峰 02 63228
王燕燕 02 63228
华龙 02 19183
王欣 02 63228
现指导学生
陈敏 01 19183
周立 02 19183
汤扬 01 19183
马建 02 63228
王玉功 02 19183
张小满 01 19183
徐琦 02 63228
张慧 02 19183
高紫阳 02 19182
李烨华 01 19183