发表论文
[1] Yangxiao Hou, Dong Wei, Zhaoqi Zhang, Tong Lei, Sihong Li, Jiaming Bao, Han Guo, Liang Tan, Xubiao Xie, Yuan Zhuang, Zhongbing Lu, Yong Zhao. Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes. CELL REPORTS[J]. 2024, 43(1): 113658-, https://doaj.org/article/96a8e386ee1540f286a1a761be31fbbe.[2] Fei Feng, Bingqing Cui, Li Fang, Ting Lan, Kai Luo, Xin Xu, Zhongbing Lu, Alessandra Napolitano, Reto Asmis. DDAH1 Protects against Cardiotoxin-Induced Muscle Injury and Regeneration. ANTIOXIDANTS[J]. 2023, 12(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525962/.[3] Shen Xiyue, Luo Kai, Yuan Juntao, Gao Junling, Cui Bingqing, Yu Zhuoran, Lu Zhongbing. Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice: Involvement of reduced S100A11 expression. ACTA PHARMACEUTICA SINICA B[J]. 2023, 13(8): 3352-3364, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7539294&detailType=1.[4] Juntao Yuan, Fang Li, Xiyue Shen, Junling Gao, Zhuoran Yu, Kai Luo, Bingqing Cui, Zhongbing Lu. Genetic and Pharmacological Inhibition of GCN2 Ameliorates Hyperglycemia and Insulin Resistance in Type 2 Diabetic Mice. ANTIOXIDANTS[J]. 2022, 11: https://doaj.org/article/db9eee8f114642dc85012d23e1784e4b.[5] Juntao Yuan, Zhuoran Yu, Junling Gao, Kai Luo, Xiyue Shen, Bingqing Cui, Zhongbing Lu. Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation. REDOX BIOLOGY[J]. 2022, 49: 102224-, [6] Tong Lei, Jiayu Zhang, Qian Zhang, Xinran Ma, Yanan Xu, Yang Zhao, Zhang Lianfeng, Zhongbing Lu, Yong Zhao. Defining newly formed and tissue-resident bone marrow-derived macrophages in adult mice based on lysozyme expression. Cellular & Molecular Immunology[J]. 2022, 19(12): 1333-1346, doi: 10.1038/s41423-022-00936-4.[7] Gao, Junling, Lei, Tong, Wang, Hongyun, Luo, Kai, Wang, Yuanli, Cui, Bingqing, Yu, Zhuoran, Hu, Xiaoqi, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing. Dimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress. PARTICLE AND FIBRE TOXICOLOGY[J]. 2022, 19(1): http://dx.doi.org/10.1186/s12989-022-00505-7.[8] Yuan, Juntao, Li, Fang, Cui, Bingqing, Gao, Junling, Yu, Zhuoran, Lu, Zhongbing. Inhibition of GCN2 Alleviates Cardiomyopathy in Type 2 Diabetic Mice via Attenuating Lipotoxicity and Oxidative Stress. ANTIOXIDANTS[J]. 2022, 11(7): [9] Shen, Xiyue, Ishaq, Saddam Muhammad, Wang, Qiaoe, Yuan, Juntao, Gao, Junling, Lu, Zhongbing. DDAH1 Protects against Acetaminophen-Induced Liver Hepatoxicity in Mice. ANTIOXIDANTS[J]. 2022, 11(5): http://dx.doi.org/10.3390/antiox11050880.[10] Gao, Junling, Yuan, Juntao, Liu, Qun, Wang, Yuanli, Wang, Huiwen, Chen, Yingjie, Ding, Wenjun, Ji, Guangju, Lu, Zhongbing. Adipose-derived stem cells therapy effectively attenuates PM2.5-induced lung injury. STEM CELL RESEARCH & THERAPY[J]. 2021, 12(1): http://dx.doi.org/10.1186/s13287-021-02441-3.[11] Li, Tianhe, Zhang, Tingting, Gao, Huimin, Liu, Ruixia, Gu, Muqing, Yang, Yuxi, Cui, Tianyu, Lu, Zhongbing, Yin, Chenghong. Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction. REDOX BIOLOGY[J]. 2021, 41: https://doaj.org/article/36ce74b7242c46a1a54cec21d6681a88.[12] Gao, Junling, Yuan, Juntao, Wang, Qiaoe, Lei, Tong, Shen, Xiyue, Cui, Bingqing, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing. Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase alpha 2. REDOX BIOLOGY[J]. 2020, 28: http://dx.doi.org/10.1016/j.redox.2019.101345.[13] Wang, Hongyun, Shen, Xiyue, Liu, Jingli, Wu, Chunyan, Gao, Junling, Zhang, Zezhong, Zhang, Fang, Ding, Wenjun, Lu, Zhongbing. The effect of exposure time and concentration of airborne PM2.5 on lung injury in mice: A transcriptome analysis. REDOX BIOLOGY[J]. 2019, 26: 101264-, http://dx.doi.org/10.1016/j.redox.2019.101264.[14] Yue, Wenhui, Tong, Lei, Liu, Xiaohong, Weng, Xinyu, Chen, Xiaoyu, Wang, Dongzhi, Dudley, Samuel C, Weir, E Kenneth, Ding, Wenjun, Lu, Zhongbing, Xu, Yawei, Chen, Yingjie. Short term Pm2.5 exposure caused a robust lung inflammation, vascular remodeling, and exacerbated transition from left ventricular failure to right ventricular hypertrophy. REDOX BIOLOGY[J]. 2019, 22: 101161-, https://doaj.org/article/7fcc6ef07ceb4c76a84a2d4905fc3e69.[15] Feng, Wei, Lei, Tong, Wang, Yue, Feng, Run, Yuan, Juntao, Shen, Xiyue, Wu, Yongguang, Gao, Junling, Ding, Wenjun, Lu, Zhongbing. GCN2 deficiency ameliorates cardiac dysfunction in diabetic mice by reducing lipotoxicity and oxidative stress. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2019, 130: 128-139, http://dx.doi.org/10.1016/j.freeradbiomed.2018.10.445.[16] Peng Wang PhD, Yana Xu BS, Jiayu Zhang BS, Lu Shi PhD, Tong Lei BS, Yangxiao Hou MS, Zhongbing Lu PhD, Yong Zhao MD PhD. The amino acid sensor general control nonderepressible 2 (GCN2) controls TH9 cells and allergic airway inflammation. THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY[J]. 2019, 144(4): 1091-1105, http://dx.doi.org/10.1016/j.jaci.2019.04.028.[17] Wang, Yue, Lei, Tong, Yuan, Juntao, Wu, Yongguang, Shen, Xiyue, Gao, Junling, Feng, Wei, Lu, Zhongbing. GCN2 deficiency ameliorates doxorubicin-induced cardiotoxicity by decreasing cardiomyocyte apoptosis and myocardial oxidative stress. REDOX BIOLOGY[J]. 2018, 17: 25-34, http://dx.doi.org/10.1016/j.redox.2018.04.009.[18] Guo, Yuting, Wang, Huiwen, Tang, Yinglong, Wang, Yue, Zhang, Mengqi, Yang, Zhiguang, Nyirimigabo, Eric, Wei, Bin, Lu, Zhongbing, Ji, Guangju. GCN2 deficiency protects mice from denervation-induced skeletal muscle atrophy via inhibiting FoxO3a nuclear translocation. PROTEIN & CELL[J]. 2018, 9(11): 966-970, http://lib.cqvip.com/Qikan/Article/Detail?id=676820274.[19] Shasha Liu, Juntao Yuan, Wenhui Yue, Yanwei Bi, Xiyue Shen, Junling Gao, Xin Xu, Zhongbing Lu. GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. BBA - MOLECULAR BASIS OF DISEASE[J]. 2018, 1864(10): 3257-3267, http://dx.doi.org/10.1016/j.bbadis.2018.07.012.[20] Wang, Hongyun, Shen, Xiyue, Tian, Guoxiong, Shi, Xili, Huang, Wei, Wu, Yongguang, Sun, Lei, Peng, Can, Liu, Shasha, Huang, Ying, Chen, Xiaoyu, Zhang, Fang, Chen, Yingjie, Ding, Wenjun, Lu, Zhongbing. AMPK alpha 2 deficiency exacerbates long-term PM2.5 exposure-induced lung injury and cardiac dysfunction. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2018, 121: 202-214, https://www.webofscience.com/wos/woscc/full-record/WOS:000433208200021.[21] Wang, Ting, Mao, Beibei, Cheng, Chi, Zou, Zhuangzhi, Gao, Junling, Yang, Yanglu, Lei, Tong, Qi, Xiaolong, Yuan, Zengqiang, Xu, Wentong, Lu, Zhongbing. YAP promotes breast cancer metastasis by repressing growth differentiation factor-15. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE[J]. 2018, 1864(5): 1744-1753, http://dx.doi.org/10.1016/j.bbadis.2018.02.020.[22] Xu, Jinxia, Zhang, Wei, Lu, Zhongbing, Zhang, Fang, Ding, Wenjun. Airborne PM2.5-Induced Hepatic Insulin Resistance by Nrf2/JNK-Mediated Signaling Pathway. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH[J]. 2017, 14(7): https://doaj.org/article/8cfb36d525fb4313a75912b34d4ebae4.[23] Shi, Linlin, Zhao, Chenyang, Wang, Hongyun, Lei, Tong, Liu, Shasha, Cao, Jianwei, Lu, Zhongbing. Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. ANTIOXIDANTS & REDOX SIGNALING[J]. 2017, 27(16): 1347-1360, https://www.webofscience.com/wos/woscc/full-record/WOS:000413276200006.[24] Li, Tianhe, Feng, Run, Zhao, Chenyang, Wang, Yue, Wang, Jian, Liu, Shasha, Cao, Jianwei, Wang, Hongyun, Wang, Ting, Guo, Yuting, Lu, Zhongbing. Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice. ANTIOXIDANTS & REDOX SIGNALING[J]. 2017, 26(11): 599-611, https://www.webofscience.com/wos/woscc/full-record/WOS:000398467900003.[25] Guo Yuting, Meng Jin, Tang Yinglong, Wang Ting, Wei Bin, Feng Run, Gong Bing, Wang Huiwen, Ji Guangju, Lu Zhongbing. AMP-activated kinase α2 deficiency protects mice from denervation-induced skeletal muscle atrophy. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS[J]. 2016, 600: 56-60, http://dx.doi.org/10.1016/j.abb.2016.04.015.[26] Wang, Hongyun, Guo, Yuting, Liu, Limin, Guan, Longfei, Wang, Ting, Zhang, Luyao, Wang, Yue, Cao, Jianwei, Ding, Wenjun, Zhang, Fang, Lu, Zhongbing. DDAH1 plays dual roles in PM2.5 induced cell death in A549 cells. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS[J]. 2016, 1860(12): 2793-2801, http://dx.doi.org/10.1016/j.bbagen.2016.03.022.[27] Zhao, Chenyang, Li, Tianhe, Han, Bingxing, Yue, Wenhui, Shi, Linlin, Wang, Hongyun, Guo, Yuting, Lu, Zhongbing. DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2016, 92: 50-60, http://dx.doi.org/10.1016/j.freeradbiomed.2016.01.015.[28] Xing, Yingying, Chu, Qiaoyun, Feng, Run, Wang, Wei, Liu, Lixin, Lu, Zhongbing. hCLP46 increases Smad3 protein stability via inhibiting its ubiquitin-proteasomal degradation. PROTEIN & CELL[J]. 2015, 6(10): 767-770, http://lib.cqvip.com/Qikan/Article/Detail?id=666483940.[29] Quan, Xin, Yue, Wenhui, Luo, Yunfeng, Cao, Jianwei, Wang, Hongyun, Wang, Yue, Lu, Zhongbing. The protein arginine methyltransferase PRMT5 regulates A-induced toxicity in human cells and Caenorhabditis elegans models of Alzheimer's disease. JOURNAL OF NEUROCHEMISTRY[J]. 2015, 134(5): 969-977, https://www.webofscience.com/wos/woscc/full-record/WOS:000359383500016.[30] Wang, Yue, Zhang, Ping, Xu, Zhiyu, Yue, Wenhui, Zhuang, Yan, Chen, Yingjie, Lu, Zhongbing. S-nitrosylation of PDE5 increases its ubiquitin-proteasomal degradation. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2015, 86: 343-351, http://dx.doi.org/10.1016/j.freeradbiomed.2015.05.037.[31] Yunfeng Luo, Wenhui Yue, Xin Quan, Yue Wang, Baolu Zhao, Zhongbing Lu. Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2015, 79: 117-126, http://dx.doi.org/10.1016/j.freeradbiomed.2014.12.002.[32] Xin Xu, Zhongbing Lu, John Fassett, Ping Zhang, Xinli Hu, Xiaoyu Liu, Dongmin Kwak, Jingxin Li, Guangshuo Zhu, Yi Tao, Mingxiao Hou, Huan Wang, Haipeng Guo, Benoit Viollet, Edward O McFalls, Robert J Bache, Yingjie Chen. Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase α2. HYPERTENSION. 2014, 63(4): 723-728, [33] Lu, Zhongbing, Xu, Xin, Fassett, John, Kwak, Dongmin, Liu, Xiaoyu, Hu, Xinli, Wang, Huan, Guo, Haipeng, Xu, Dachun, Yan, Shuo, McFalls, Edward O, Lu, Fei, Bache, Robert J, Chen, Yingjie. Loss of the Eukaryotic Initiation Factor 2 alpha Kinase General Control Nonderepressible 2 Protects Mice From Pressure Overload-Induced Congestive Heart Failure Without Affecting Ventricular Hypertrophy. HYPERTENSION[J]. 2014, 63(1): 128-135, https://www.webofscience.com/wos/woscc/full-record/WOS:000328206800026.[34] Shi, Zhenhua, Lu, Zhongbing, Zhao, Yashuo, Wang, Yueqi, Xi ZhaoWilson, Guan, Peng, Duan, Xianglin, Chang, YanZhong, Zhao, Baolu. Neuroprotective effects of aqueous extracts of Uncaria tomentosa: Insights from 6-OHDA induced cell damage and transgenic Caenorhabditis elegans model. NEUROCHEMISTRY INTERNATIONAL[J]. 2013, 62(7): 940-947, http://dx.doi.org/10.1016/j.neuint.2013.03.001.[35] Lu, Zhongbing, Xu, Xin, Hu, Xinli, Lee, Sangjin, Traverse, Jay H, Zhu, Guangshuo, Fassett, John, Tao, Yi, Zhang, Ping, dos Remedios, Cris, Pritzker, Marc, Hall, Jennifer L, Garry, Daniel J, Chen, Yingjie. Oxidative Stress Regulates Left Ventricular PDE5 Expression in the Failing Heart. CIRCULATION[J]. 2010, 121(13): 1474-U48, https://www.webofscience.com/wos/woscc/full-record/WOS:000276348600003.[36] Lu, Zhongbing, Xu, Xin, Hu, Xinli, Fassett, John, Zhu, Guangshuo, Tao, Yi, Li, Jingxin, Huang, Yimin, Zhang, Ping, Zhao, Baolu, Chen, Yingjie. PGC-1 alpha Regulates Expression of Myocardial Mitochondrial Antioxidants and Myocardial Oxidative Stress After Chronic Systolic Overload. ANTIOXIDANTS & REDOX SIGNALING[J]. 2010, 13(7): 1011-1022, http://www.irgrid.ac.cn/handle/1471x/757206.[37] Lu, Zhongbing, Nie, Guangjun, Li, Yiye, Soelin, Shan, Tao, Yi, Cao, Yuanlin, Zhang, Zhiyong, Liu, Nianqing, Ponka, Prem, Zhao, Baolu. Overexpression of Mitochondrial Ferritin Sensitizes Cells to Oxidative Stress Via an Iron-Mediated Mechanism. ANTIOXIDANTS & REDOX SIGNALING[J]. 2009, 11(8): 1791-1803, http://ir.ihep.ac.cn/handle/311005/239528.[38] Lu, Zhongbing, Fassett, John, Xu, Xin, Hu, Xinli, Zhu, Guangshuo, Schnermann, Jurgen, Bache, Robert J, Chen, Yingjie. Adenosine A3 Receptor Deficiency Exerts Unanticipated Protective Effects on Pressure Overloaded-Induced Left Ventricular Hypertrophy and Dysfunction In Mice. CIRCULATION[J]. 2008, 118(18): S351-S351, https://www.webofscience.com/wos/woscc/full-record/WOS:000262104500367.[39] Lu, Zhongbing, Xu, Xin, Hu, Xinli, Zhu, Guangshuo, Zhang, Ping, Van Deel, Elza D, French, Joel P, Fassett, John T, Oury, Tim D, Bache, Robert J, Chen, Yingjie. Extracellular superoxide dismutase deficiency exacerbates pressure overload-induced left ventricular hypertrophy and dysfunction. HYPERTENSION[J]. 2008, 51(1): 19-25, https://www.webofscience.com/wos/woscc/full-record/WOS:000251774400004.[40] Elza D van Deel, Zhongbing Lu, Xin Xu, Guangshuo Zhu, Xinli Hu, Tim D Oury, Robert J Bache, Dirk J Duncker, Yingjie Chen. Extracellular SOD protects the heart against oxidative stress and hypertrophy after myocardial infarction. FREE RADICAL BIOLOGY & MEDICINE. 2007, 44(7): 1305-1313, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386859/.[41] Cui, Yanhong, Lu, Zhongbing, Bai, Lin, Shi, Zhenhua, Zhao, WenEn, Zhao, Baolu. beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. EUROPEAN JOURNAL OF CANCER[J]. 2007, 43(17): 2590-2601, https://www.webofscience.com/wos/woscc/full-record/WOS:000251706000029.[42] Lu, ZB, Nie, GJ, Belton, PS, Tang, HR, Zhao, BL. Structure-activity relationship analysis of antioxidant ability and neuroprotective effect of gallic acid derivatives. NEUROCHEMISTRY INTERNATIONAL[J]. 2006, 48(4): 263-274, http://dx.doi.org/10.1016/j.neuint.2005.10.010.[43] Lu, Zhongbing, Tao, Yi, Zhou, Zhixiang, Zhang, Junjing, Li, Cong, Ou, Lingcheng, Zhao, Baolu. Mitochondrial reactive oxygen species and nitric oxide-mediated cancer cell apoptosis in 2-butylamino-2-demethoxyhypocrellin B photodynamic treatment. FREE RADICAL BIOLOGY AND MEDICINE[J]. 2006, 41(10): 1590-1605, http://www.corc.org.cn/handle/1471x/2378835.