液质联用代谢组学新方法开发

质谱成像新方法研究

代谢组学在恶性肿瘤、新生儿代谢性疾病中的应用研究

070302-分析化学

代谢组学；色谱质谱联用

2008-09--2014-09   中国科学院大连化学物理研究所   博士
2003-09--2007-07   山东大学   学士

   

2019-07~现在, 中国科学院大连化学物理研究所, 副研究员
2014-11~2019-06,中国科学院大连化学物理研究所, 助理研究员

   

（1） 中国分析测试协会科学技术奖CAIA奖, 特等奖, 其他, 2020

[1] 许国旺, 王宇婷, 周丽娜. 一种用于血清中农、兽药及化学污染物残留的筛查方法. CN202111431309.2, 2021-11-29.
[2] 许国旺, 于迪, 周丽娜. 一种基于芯片纳升电喷雾质谱的稳定同位素标记代谢流的分析方法. CN202011387929.6, 2020-12-01.
[3] 王晓琳, 许国旺, 周丽娜, 尹沛源. 一种与肾病相关的肠道菌群代谢物的检测方法. CN: CN110068618A, 2019-07-30.
[4] 许国旺, 于迪, 周丽娜. 一种基于混合生物样本的酰基肉碱大规模定性方法. CN: CN109870535A, 2019-06-11.
[5] 许国旺, 王霜原, 石先哲, 周丽娜. 一种同时分析短链、中链和长链酰基辅酶A的方法. CN: CN109655531A, 2019-04-19.
[6] 许国旺, 王霜原, 石先哲, 周丽娜. 一种同时分离代谢组和脂质组组份的液相色谱分析方法及其应用. CN: CN107179378A, 2017-09-19.
[7] 许国旺, 周丽娜, 尹沛源, 高鹏, 路鑫. 细胞胞内氨基酸代谢轮廓分析方法. CN: CN105527350A, 2016-04-27.
[8] 尹沛源, 雷纳·莱曼, 黄强, 周丽娜, 赵欣捷, 路鑫, 许国旺. 一种判断用于科学研究的血液样本采集质量的方法. CN: CN103728379A, 2014-04-16.
[9] 尹沛源, 黄强, 周丽娜, 路鑫, 许国旺. 一种检测血中苯丙氨酸二肽的新方法. CN: CN102798691A, 2012-11-28.

   

[1] Yanfeng Wang, Qihua Wang, Lina Zhou, Zhijun Zeng, Chunxia Zhao, Lei You, Xin Lu, Xinyu Liu, Runze Ouyang, Yuting Wang, Xijin Xu, Xiwen Tian, Yufeng Guo, Xia Huo, Guowang Xu. Metabolomics insights into the prenatal exposure effects of polybrominated diphenyl ethers on neonatal birth outcomes. Sci Total Environ[J]. 2022, 836: 155601-, [2] Xu, Huan, Chen, Junyi, He, Jingyi, Ji, Jin, Cao, Zhi, Chen, Xi, Xu, Yalong, He, Xing, Xu, Guowang, Zhou, Lina, Wei, Xuedong, Hou, Jianquan, Wang, Zhong, Yang, Bo, Wang, Fubo. Serum Metabolic Profiling Identifies a Biomarker Panel for Improvement of Prostate Cancer Diagnosis. FRONTIERS IN ONCOLOGY[J]. 2021, 11: http://gooa.las.ac.cn/external/index?type=-1&pid=1729934.
[3] Wang, Yanfeng, Zhou, Lina, Zhou, Yang, Zhao, Chunxia, Lu, Xin, Xu, Guowang. A rapid GC method coupled with quadrupole or time of flight mass spectrometry for metabolomics analysis. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2020, 1160: http://dx.doi.org/10.1016/j.jchromb.2020.122355.
[4] Yu, Di, Xuan, Qiuhui, Zhang, Chaoqi, Hu, Chunxiu, Li, Yanli, Zhao, Xinjie, Liu, Shasha, Ren, Feifei, Zhang, Yi, Zhou, Lina, Xu, Guowang. Metabolic Alterations Related to Glioma Grading Based on Metabolomics and Lipidomics Analyses. METABOLITES[J]. 2020, 10(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760389/.
[5] Chen, Di, Zhao, Xinjie, Sui, Zhigang, Niu, Huan, Chen, Luonan, Hu, Cheng, Xuan, Qiuhui, Hou, Xuhong, Zhang, Rong, Zhou, Lina, Li, Yanli, Yuan, Huiming, Zhang, Yukui, Wu, Jiarui, Zhang, Lihua, Wu, Renan, Piao, HaiLong, Xu, Guowang, Jia, Weiping. A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases. THERANOSTICS[J]. 2020, 10(5): 2029-2046, https://www.webofscience.com/wos/woscc/full-record/WOS:000508008300004.
[6] Xuan, Qiuhui, Ouyang, Yang, Wang, Yanfeng, Wu, Liang, Li, Huating, Luo, Yuanyuan, Zhao, Xinjie, Feng, Disheng, Qin, Wangshu, Hu, Chunxiu, Zhou, Lina, Liu, Xinyu, Zou, Haidong, Cai, Chun, Wu, Jiarui, Jia, Weiping, Xu, Guowang. Multiplatform Metabolomics Reveals Novel Serum Metabolite Biomarkers in Diabetic Retinopathy Subjects. ADVANCED SCIENCE[J]. 2020, 7(22): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675050/.
[7] Ma, Zhenhua, Wang, Xiaomei, Yin, Peiyuan, Wu, Ruihong, Zhou, Lina, Xu, Guowang, Niu, Junqi. Serum metabolome and targeted bile acid profiling reveals potential novel biomarkers for drug-induced liver injury. MEDICINE[J]. 2019, 98(31): https://www.webofscience.com/wos/woscc/full-record/WOS:000483216200065.
[8] Yang, Zhihua, Shi, Changhe, Zhou, Lina, Li, Yusheng, Yang, Jing, Liu, Yutao, Mao, Chengyuan, Luo, Haiyang, Xu, Guowang, Xu, Yuming. Metabolic Profiling Reveals Biochemical Pathways and Potential Biomarkers of Spinocerebellar Ataxia 3. FRONTIERS IN MOLECULAR NEUROSCIENCE[J]. 2019, 12: https://doaj.org/article/de3a0ed00cad470abad928c17f292fe3.
[9] Zhou, Lina, Wang, Zhichao, Hu, Chunxiu, Zhang, Chaoqi, KovatchevaDatchary, Petia, Yu, Di, Liu, Shasha, Ren, Feifei, Wang, Xiaolin, Li, Yanli, Hou, Xiaoli, Piao, Hailong, Lu, Xin, Zhang, Yi, Xu, Guowang. Integrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation. JOURNAL OF PROTEOME RESEARCH[J]. 2019, 18(3): 960-969, http://cas-ir.dicp.ac.cn/handle/321008/165894.
[10] Liu, Xinyu, Zhou, Lina, Shi, Xianzhe, Xu, Guowang. New advances in analytical methods for mass spectrometry-based large-scale metabolomics study. TRAC-TRENDS IN ANALYTICAL CHEMISTRYnull. 2019, 121: http://dx.doi.org/10.1016/j.trac.2019.115665.
[11] Lin, Xiaohui, Huang, Xin, Zhou, Lina, Ren, Weijie, Zeng, Jun, Yao, Weihong, Wang, Xingyuan. The Robust Classification Model Based on Combinatorial Features. IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS[J]. 2019, 16(2): 650-657, http://dx.doi.org/10.1109/TCBB.2017.2779512.
[12] Mu, Ying, Zhou, Yang, Wang, Yanfeng, Li, Wei, Zhou, Lina, Lu, Xin, Gao, Peng, Gao, Mingyang, Zhao, Yanhui, Wang, Qi, Wang, Yanfu, Xu, Guowang. Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH[J]. 2019, 18(5): 2175-2184, http://cas-ir.dicp.ac.cn/handle/321008/165468.
[13] Huang, Xin, Lin, Xiaohui, Zhou, Lina, Su, Benzhe. Analyzing omics data by pair-wise feature evaluation with horizontal and vertical comparisons. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2018, 157: 20-26, http://dx.doi.org/10.1016/j.jpba.2018.04.052.
[14] Luo, Ping, Yin, Peiyuan, Hua, Rui, Tan, Yexiong, Li, Zaifang, Qiu, Gaokun, Yin, Zhenyu, Xie, Xingwang, Wang, Xiaomei, Chen, Wenbin, Zhou, Lina, Wang, Xiaolin, Li, Yanli, Chen, Hongsong, Gao, Ling, Lu, Xin, Wu, Tangchun, Wang, Hongyang, Niu, Junqi, Xu, Guowang. A Large-scale, multicenter serum metabolite biomarker identification study for the early detection of hepatocellular carcinoma. HEPATOLOGY[J]. 2018, 67(2): 662-675, http://cas-ir.dicp.ac.cn/handle/321008/168712.
[15] Yu, Di, Zhou, Lina, Xuan, Qiuhui, Wang, Lichao, Zhao, Xinjie, Lu, Xin, Xu, Guowang. Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography-High-Resolution Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2018, 90(9): 5712-5718, http://cas-ir.dicp.ac.cn/handle/321008/167204.
[16] Ma, Wang, Wang, Shuangyuan, Zhang, Tengfei, Zhang, Erik Y, Zhou, Lina, Hu, Chunxiu, Yu, Jane J, Xu, Guowang. Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2018, 155: 148-156, http://dx.doi.org/10.1016/j.jpba.2018.03.062.
[17] Qi Wu, Lina Zhou, Xin Sun, Zhongfang Yan, Chunxiu Hu, Junping Wu, Long Xu, Xue Li, Huiling Liu, Peiyuan Yin, Kuan Li, Jieyu Zhao, Yanli Li, Xiaolin Wang, Yu Li, Qiuyang Zhang, Guowang Xu, Huaiyong Chen. Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection. SCIENTIFIC REPORTS[J]. 2017, 7(1): http://cas-ir.dicp.ac.cn/handle/321008/149812.
[18] Wang, Shuangyuan, Zhou, Lina, Wang, Zhichao, Shi, Xianzhe, Xu, Guowang. Simultaneous metabolomics and lipidomics analysis based on novel heart-cutting two-dimensional liquid chromatography-mass spectrometry. ANALYTICA CHIMICA ACTA[J]. 2017, 966: 34-40, http://cas-ir.dicp.ac.cn/handle/321008/169312.
[19] Zhou, Yang, Song, Ruixiang, Ma, Chong, Zhou, Lina, Liu, Xinyu, Yin, Peiyuan, Zhang, Zhensheng, Sun, Yinghao, Xu, Chuanliang, Lu, Xin, Xu, Guowang. Discovery and validation of potential urinary biomarkers for bladder cancer diagnosis using a pseudotargeted GC-MS metabolomics method. ONCOTARGET[J]. 2017, 8(13): 20719-20728, http://cas-ir.dicp.ac.cn/handle/321008/169394.
[20] Wang, Shuangyuan, Wang, Zhichao, Zhou, Lina, Shi, Xianzhe, Xu, Guowang. Comprehensive Analysis of Short-, Medium-, and Long-Chain AcylCoenzyme A by Online Two-Dimensional Liquid Chromatography/Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2017, 89(23): 12902-12908, http://cas-ir.dicp.ac.cn/handle/321008/169214.
[21] Huang, Xin, Lin, Xiaohui, Zeng, Jun, Wang, Lichao, Yin, Peiyuan, Zhou, Lina, Hu, Chunxiu, Yao, Weihong. A Computational Method of Defining Potential Biomarkers based on Differential Sub-Networks. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/43abd7386e2c427abc43fd8ce5492144.
[22] Zhou, Lina, Yin, Peiyuan, Luo, Ping, Tang, Ling, Wang, Zhichao, Gao, Peng, Piao, Hailong, Lu, Xin, Xu, Guowang. High-throughput metabolic profiling based on small amount of hepatic cells. ELECTROPHORESIS[J]. 2017, 38(18): 2296-2303, http://cas-ir.dicp.ac.cn/handle/321008/149919.
[23] Huang, Xin, Zeng, Jun, Zhou, Lina, Hu, Chunxiu, Yin, Peiyuan, Lin, Xiaohui. A New Strategy for Analyzing Time-Series Data Using Dynamic Networks: Identifying Prospective Biomarkers of Hepatocellular Carcinoma. SCIENTIFIC REPORTS[J]. 2016, 6: http://cas-ir.dicp.ac.cn/handle/321008/170288.
[24] Zhang, Weijian, Zhou, Lina, Yin, Peiyuan, Wang, Jinbing, Lu, Xin, Wang, Xiaomei, Chen, Jianguo, Lin, Xiaohui, Xu, Guowang. A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma. SCIENTIFIC REPORTS[J]. 2015, 5: http://dx.doi.org/10.1038/srep08984.
[25] 赵燕妮, 赵婕妤, 赵春霞, 周丽娜, 李艳丽, 张俊杰, 李丽丽, 胡春秀, Xiaojun Peng, 路鑫, Fucheng Lin, 许国旺. A metabolomics study delineating geographical location-associated metabolic changes in the leaves of growing tobacco plants. SCIENTIFIC REPORTS[J]. 2015, 5: 163461-, http://cas-ir.dicp.ac.cn/handle/321008/148057.
[26] Weijian Zhang, 周丽娜, 尹沛源, Jinbing Wang, 路鑫, Xiaomei Wang, Jianguo Chen, 林晓慧, 许国旺. A weighted relative difference accumulation algorithm for analyzing the dynamic metabolomics data: long-term elevated serum bile acids are risk factors for hepatocellular carcinoma. SCIENTIFIC REPORTS[J]. 2015, 5: 89841-, http://cas-ir.dicp.ac.cn/handle/321008/147915.
[27] Zeng, Jun, Huang, Xin, Zhou, Lina, Tan, Yexiong, Hu, Chunxiu, Wang, Xiaomei, Niu, Junqi, Wang, Hongyang, Lin, Xiaohui, Yin, Peiyuan. Metabolomics Identifies Biomarker Pattern for Early Diagnosis of Hepatocellular Carcinoma: from Diethylnitrosamine Treated Rats to Patients. SCIENTIFIC REPORTS[J]. 2015, 5: http://cas-ir.dicp.ac.cn/handle/321008/147916.
[28] 林晓慧, JiuchongGao, 周丽娜, 尹沛源, 许国旺. A Modified TSP Algorithm and its Application in LC-MS-based Metabolomics Study of Hepatocellular Carcinoma and Chronic Liver Diseases. JOURNAL OF CHROMATOGRAPHY B[J]. 2014, 966(1): 100-, http://cas-ir.dicp.ac.cn/handle/321008/144496.
[29] Lina Zhou, Yuan Liao, Peiyuan Yin, Zhongda Zeng, Jia Li, Xin Lu, Limin Zheng, Guowang Xu. Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry. JOURNALOFCHROMATOGRAPHYB. 2014, 966: 163-170, http://dx.doi.org/10.1016/j.jchromb.2014.01.057.
[30] Xiaohui Lin, Jiuchong Gao, Lina Zhou, Peiyuan Yin, Guowang Xu. A modified k-TSP algorithm and its application in LC–MS-based metabolomics study of hepatocellular carcinoma and chronic liver diseases. JOURNAL OF CHROMATOGRAPHY B. 2014, 966: 100-108, http://dx.doi.org/10.1016/j.jchromb.2014.05.044.
[31] Lin, Xiaohui, Gao, Jiuchong, Zhou, Lina, Yin, Peiyuan, Xu, Guowang. A modified k-TSP algorithm and its application in LC-MS-based metabolomics study of hepatocellular carcinoma and chronic liver diseases. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2014, 966: 100-108, http://dx.doi.org/10.1016/j.jchromb.2014.05.044.
[32] Zhou, Lina, Liao, Yuan, Yin, Peiyuan, Zeng, Zhongda, Li, Jia, Lu, Xin, Zheng, Limin, Xu, Guowang. Metabolic profiling study of early and late recurrence of hepatocellular carcinoma based on liquid chromatography-mass spectrometry. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2014, 966: 163-170, http://dx.doi.org/10.1016/j.jchromb.2014.01.057.
[33] 许国旺, 戴伟东, 黄强, 陈世礼, 叶国柱, 周丽娜, 尹沛源, 路鑫. Novel Analytical Methods of HPLC-MS Based Metabolomics. THE 39TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID-PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2013, 48-, http://159.226.238.44/handle/321008/116899.
[34] 叶国柱, 尹沛源, 周丽娜, 路鑫, 许国旺. Towards Personalised Medicine of Cancer based on MS-based Metabolomics. 9TH ANNUAL INTERNATIONAL CONFERENCE OF THE METABOLOMICS SOCIETYnull. 2013, 45-, http://159.226.238.44/handle/321008/116897.
[35] Zhou, Lina, Ding, Lili, Yin, Peiyuan, Lu, Xin, Wang, Xiaomei, Niu, Junqi, Gao, Pujun, Xu, Guowang. Serum Metabolic Profiling Study of Hepatocellular Carcinoma Infected with Hepatitis B or Hepatitis C Virus by Using Liquid Chromatography-Mass Spectrometry. JOURNAL OF PROTEOME RESEARCH[J]. 2012, 11(11): 5433-5442, http://dx.doi.org/10.1021/pr300683a.
[36] Zhou, Lina, Wang, Quancai, Yin, Peiyuan, Xing, Wenbin, Wu, Zeming, Chen, Shili, Lu, Xin, Zhang, Yong, Lin, Xiaohui, Xu, Guowang. Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2012, 403(1): 203-213, http://dx.doi.org/10.1007/s00216-012-5782-4.
[37] Chen, Yu, Xu, Zhiliang, Kong, Hongwei, Chen, Nan, Chen, Jing, Zhou, Lina, Wang, Feiling, Dong, Yuejiao, Zheng, Shufa, Chen, Zhenjing, Xu, Guowang, Li, Lanjuan. Differences between the metabolic profiles of decompensated and compensated cirrhosis patients with Hepatitis B virus infections under high-performance liquid chromatography-mass spectrometry. METABOLOMICS[J]. 2012, 8(5): 845-853, http://www.irgrid.ac.cn/handle/1471x/721154.
[38] Lin, Xiaohui, Yang, Fufang, Zhou, Lina, Yin, Peiyuan, Kong, Hongwei, Xing, Wenbin, Lu, Xin, Jia, Lewen, Wang, Quancai, Xu, Guowang. A support vector machine-recursive feature elimination feature selection method based on artificial contrast variables and mutual information. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES[J]. 2012, 910: 149-155, http://dx.doi.org/10.1016/j.jchromb.2012.05.020.
[39] Chen, Jing, Zhou, Lina, Zhang, Xiaoyan, Lu, Xin, Cao, Rui, Xu, Congjian, Xu, Guowang. Urinary hydrophilic and hydrophobic metabolic profiling based on liquid chromatography-mass spectrometry methods: Differential metabolite discovery specific to ovarian cancer. ELECTROPHORESIS[J]. 2012, 33(22): 3361-3369, http://159.226.238.44/handle/321008/143117.
[40] 周丽娜, 尹沛源, 路鑫, 许国旺. Urinary Metabolic Profiling Analysis to Discover Potential Diagnostic Biomarkers Based on LTQ-Orbitrap High Resolution Mass Spectrometry. 36TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 323-, http://159.226.238.44/handle/321008/117357.
[41] 周丽娜, QuancaiWang, 尹沛源, WenbinXing, 吴泽明, 陈世礼, 路鑫, YongZhang, 林晓惠, 许国旺. Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases. PROCEEDING OF HPLC 2011null. 2011, 489-0, http://159.226.238.44/handle/321008/116072.
[42] 林晓惠, 阮强, 周丽娜, 尹沛源, 许国旺. A Feature Selection Method based on SVM and ReliefF and its Application in the Analysis of HPLC-MS Data. PROCEEDING OF HPLC 2011null. 2011, 491-0, http://159.226.238.44/handle/321008/116074.
[43] 周丽娜, QuancaiWang, 尹沛源, WenbinXing, 吴泽明, 陈世礼, 路鑫, YongZhang, 林晓惠, 许国旺. Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases. 37TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 489-, http://159.226.238.44/handle/321008/117342.
[44] Yao, Zhenzhen, Yin, Peiyuan, Su, Dongwei, Peng, Zhijun, Zhou, Lina, Ma, Long, Guo, Wei, Ma, Lie, Xu, Guowang, Shi, Junyi, Jiao, Binhua. Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter. MOLECULAR BIOSYSTEMS[J]. 2011, 7(9): 2608-2614, http://dx.doi.org/10.1039/c1mb05029j.
[45] 许国旺, 赵欣捷, 尹沛源, 黄强, 周丽娜, 路鑫. LC-MS based metabolomics for disease biomarker discovery and confirmation. 36TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 1-, http://159.226.238.44/handle/321008/117361.
[46] 李佳, 赵欣捷, 胡春秀, 陈世礼, 周丽娜, 许国旺. Qualitative and quantitative analysis of ceramide species in biological samples in an untargeted lipidomic profiling platform by high resolution LC-MS. PROCEEDING OF HPLC 2011null. 2011, 498-0, http://159.226.238.44/handle/321008/116078.
[47] 陈世礼, 尹沛源, 赵欣捷, WenbinXing, 胡春秀, 周丽娜, 许国旺. Serum lipid profiling of patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma by ultra fast liquid chromatography/ion trap-time of flight mass spectrometry. 37TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 721-, http://159.226.238.44/handle/321008/117333.
[48] 李佳, 赵欣捷, 胡春秀, 陈世礼, 周丽娜, 许国旺. Qualitative and quantitative analysis of ceramide species in biological samples in an untargeted lipidomic profiling platform by high resolution LC-MS. 37TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 498-, http://159.226.238.44/handle/321008/117336.
[49] 林晓惠, 阮强, 周丽娜, 尹沛源, 许国旺. A Feature Selection Method based on SVM and ReliefF and its Application in the Analysis of HPLC-MS Data. 37TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 491-, http://159.226.238.44/handle/321008/117340.
[50] 陈世礼, 尹沛源, 赵欣捷, WenbinXing, 胡春秀, 周丽娜, 许国旺. Serum lipid profiling of patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma by ultra fast liquid chromatography/ion trap-time of flight mass spectrometry. PROCEEDINGOFHPLC2011null. 2011, 721-0, http://159.226.238.44/handle/321008/116081.
[51] 林晓惠, 阮强, 周丽娜, 尹沛源, 许国旺. Feature Grouping Technique Based on Biclustering for the Analysis of LC-MS Metabolomic Data. 37TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 492-, http://159.226.238.44/handle/321008/117339.
[52] 林晓惠, 阮强, 周丽娜, 尹沛源, 许国旺. Feature Grouping Technique Based on Biclustering for the Analysis of LC-MS Metabolomic Data. PROCEEDING OF HPLC 2011null. 2011, 492-0, http://159.226.238.44/handle/321008/116075.
[53] 许国旺, 王文昭, 尹佩源, 黄强, 赵新捷, 陈世礼, 陈静, 周丽娜, 孔宏伟, 路鑫. Where and how to 'fish' disease-related metabolite biomarkers by using LC-MS based metabonomics. the metabolomics conference 2010null. 2010, 44/2-, http://159.226.238.44/handle/321008/114122.

（1） Sample collection and preparation of biofluids and extracts for liquid chromatography-mass spectrometry., Springer Nature, 2015-01, 第 2 作者
（2） Liquid chromatography-mass spectrometry of biofluids and extracts., Springer Nature., 2015-01, 第 2 作者

   

（1）The simultaneous analysis of metabolome and lipidome based on novel two dimensional liquid chromatography mass spectrometry   45th HPLC会议   2017-06-23