Zhiyuan Tian, Ph. D.
School of Chemical Sciences
University of Chinese Academy of Sciences (UCAS)
Address: 19-A Yuquan Road, Shijingshan District, Beijing, China
Our research group is interested in the photoactive functional materials and their potential applications. Specifically, we focus on the design and synthesis of functional materials with stimuli-response features to light and their potential applications in biological imaging (super-resolution fluorescence imaging and multimodality correlative imaging), biological optical detection (mapping of tumor markers) and treatment (photoactivated synergistic antitumor with multilevel mechanisms) and etc. Our research interests also include the optical/photonic properties of nanostructures and the potential application of these fundamental properties in the design of new classes of opto-functional materials. The ongoing projects in our group include: (1) dynamic contrast super-resolution fluorescence imaging and its applications in bioimaging, (2) fluorescent tags and sensors, and (3) photoactive materials and their application in diagnosis and treatment of cancers.
B. Sc. 1995, Wuhan University, Wuhan, China
2011.03-present: University of Chinese Academy of Sciences (UCAS), Professor of Chemistry;
2005.11-2011.02: Queen's University (Canada); Washington State University (USA); University of Washington (USA); Clemson University (USA), Postdoctoral Research Associate;
2005.03-2005.04: Regensburg University (Germany), Visiting Student;
1995. 09-2000.07: State-Owned No. 752 Factory (Wuhan), Ministry of Electronic Industry, Assistant Engineer
Honors & Distinctions
LiPei Outstanding Teacher Award, UCAS，2020
Excellent Award of Education & Teaching Achievements, UCAS, 2020
ZhuLiYueHua Outstanding Teacher Award, CAS，2020
Baosteel Outstanding Teacher Award, Baosteel Education Fundation, 2019
Recipient of "CAS Distinguished Research Fellow Program", 2017
Rated as“Excellent”in the final review of CAS xx Plan Program, 2016
Recipient of "CAS xx Plan Program", 2011
Excellent Prize of the President Scholarship for Postgraduate Students, CAS, 2004.
- Z. Y. Tian, W. W. Wu, A. D. Q. Li, Photoswitchable Nanoprobes for Biological Imaging Applications (Chapter 1), in "Trace Analysis with Nanomaterials", Editor: David T. Pierce & Julia Xiaojun Zhao, Wiley-VCH, 3-30.
- W. W. Wu, Z. Y. Tian, A. D. Q. Li, Fluorescent Nanoparticles for Biological Imaging, in "Comprehensive Biomaterials", Editor: Paul Ducheyne, Elsevier, 393-403.
- Z. Y. Tian, Photoswitching-enabled Novel Optical Imaging: Innovative Solutions for Real-world Challenges in Fluorescence Detections, in "2014 Science Development Report", Editted by CAS, Science Press,120-125
Selected publications since 2011
MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload, Nature Communications, 2021, 12: 6399. Corresponding author
Near-infrared light-triggered platelet arsenal for combined photothermal-immunothreapy against cancer, Science Advances, 2021, 7: eabd7614. Corresponding author
Correlative dual-alternating-color photoswitching fluorescence imaging and AFM enable ultrastructural analyses of complex structures with nanoscale resolution, Nanoscale, 2020, 12, 17203. Corresponding author
A long-wavelength turn-on fluorescent probe for intracellular nanomolar level peroxynitrite sensing with second-level response, Talanta, 2020, 219, 121354. Corresponding author
Single-chromophore-based therapeutic agent enables green-light-triggered chemotherapy and simultaneous photodynamic therapy to cancer cells, ACS Appl. Bio Mater., 2019, 2, 3068. Corresponding author
A single-chromophore-based agent enables rapid sensing of intracellular hypochlorous acid and in-situ photodynamic therapy to cancer cells, Anal. Chem. Acta, 2019, 1061, 142. Corresponding author
A super-sensitive ratiometric fluorescent probe for monitoring intracellular subtle pH fluctuation, Sens. Actuators B: Chem. 2018, 273, 167. Corresponding author
A turn-on fluorescent probe for detection of sub-ppm levels of a sulfur mustard simulant with high selectivity, Anal. Chem., 2018, 90, 5481. Corresponding author
Cancer cell membrane-biomimetic nanoprobes with two-photon excitation and near-infrared emission for intravital tumor fluorescence imaging, ACS Nano, 2018, 12, 1350. Corresponding author
A new colorimetric, near-infrared fluorescent probe for rapid detection of palladium with high sensitivity and selectivity, Talanta, 2018,183, 164. Corresponding author
Beyond a carrier: graphene quantum dots as a probe for programmatically monitoring anticancer drug delivery, release, and response, ACS Appl. Mater. Interfaces, 2017, 9, 27396. Corresponding author
A BODIPY-based fluorescent probe for detection of subnanomolar phosgene with rapid response and high selectivity, ACS Appl. Mater. Interfaces, 2017, 9, 13920. Corresponding author
A flavone-basedturn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity, Talanta, 2016,146, 41. Corresponding author
Photoswitching near-infrared fluorescence from polymer nanoparticles catapults signals over the region of noises and interferences for enhanced sensitivity, ACS Appl. Mater. Interfaces, 2016, 8, 4399. Corresponding author
Photoswitchable fluorescent nanoparticles and their emerging applications, Nanoscale, 2015, 7, 19342. Corresponding author
Conjugated polymer-based hybrid nanoparticles with two-photon excitation and near-infrared emission features for fluorescence bioimaging within the biological window, ACS Appl. Mater. Interfaces, 2015, 7, 20640. Corresponding author
Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer, Nanoscale, 2015, 7, 9806. Corresponding author
Antiphase dual-color correlation in a reactant−product pair imparts ultrasensitivity in reaction-linked double-photoswitching fluorescence imaging, J. Am. Chem. Soc., 2015, 137, 4312. Corresponding author
Single-fluorophore-based fluorescent probes enable dual-channel detection of Ag+ and Hg2+ with high selectivity and sensitivity, Anal. Chem. Acta, 2014, 839, 74. Corresponding author
Al3+-induced far-red fluorescence enhancement of conjugated polymer nanoparticles and its application in live cell imaging, Nanoscale, 2013, 5, 9340, Corresponding author
Development of polymeric nanoprobes with improved lifetime dynamic range and stability for intracellular oxygen sensing, Small, 2013, 9, 2639. Corresponding author
Photoswitching-enabled novel optical imaging: innovative solutions for real-world challenges in fluorescence detections, Acc. Chem. Res. 2013, 46, 269. Corresponding author
Photoswitching-induced frequency-locked donor-acceptor fluorescence double modulations identify the target analyte in complex environments，J. Am. Chem. Soc., 2011, 133, 16092. Corresponding author
NSFC (grant No. 22077121，630,000 RMB), 2021--2024, PI
NSFC (grant No. 21773241，650,000 RMB), 2018--2021, PI
NSFC (grant No. 21573234，800,000 RMB), 2016--2019 , PI
NSFC (grant No. 21373218，840,000 RMB), 2014--2017 , PI
NSFC (grant No. 21173262，620,000 RMB), 2012--2015 , PI
Instrument Developing Project of CAS (grant No. yz201455, 4190,000 RMB), 2015-2017, PI
Prof. Jiannian Yao (Academician of CAS), Prof. Yongsheng Zhao, Institute of Chemistry, Chinese Academy of Sciences (CAS), China.
Prof. Guanghui Ma (Academician of CAS), Prof. Wei Wei, Institute of Process Engineering, State Key Laboratory of Biochemical Engineering, Chinese Academy of Sciences (CAS) , China.
Prof. Alexander. Li, Department of Chemistry and Center for Materials Research, Washington State University, Pullman, WA, U. S. A.
Chief Physician Zihui Meng, Department of Surgery of the Liver, Biliary and Pancreas, China-Japan Union Hospital of Jilin University, Changchun, China.
- Ming Liu: Postdoctoral fellow (2021-2023)
- Weier Bao: Graduate student (Ph. D. candidate, 2018-2021)
- Jiaqi Meng: Graduate student (Ph. D. candidate, 2017-2022)
- Zicheng Wang: Graduate student (Ph. D. candidate, 2018-2023)
- Xiaojuan Li: Graduate student (Ph. D. candidate, 2019-2024)
- Mingqi Sun: Graduate student (M. Sc. candidate, 2019-2022)
- Zhecheng Ma: Graduate student (M. Sc. candidate, 2020-2023)
- Acta Physio-Chimica Sinica (ISSN:1000-6818) Editorial board member (5th)
- Member of devision of molecular photonics & excited state chemistry (1st), Chinese Chemical Society