Zhengli Shi    Professor   Wuhan Institute of Virology, CAS  
Address: No.44 Xiao Hong Shan, Wuchang District, Wuhan, Hubei
Zip code: 430071

Research Areas

 Discovery of unknown viruses in wild animals, Molecular epidemiology of zoonotic viruses, Interspecies infection mechanism of zoonotic viruses, bat immunity against virus infection


1983.09- 1987.07,  Bsc, major in Genetics, Department of Biology,Wuhan University,China.

1987.09- 1990.07,  Msc, major in Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China

1996.102000.05,  Ph.D, major in Virology, University Montpellier II, Montpellier, France


Work Experience

1990.07- 1993.06, Research assistant in Wuhan Institute of Virology,Chinese Academy of Sciences,China.

1993.07- 2000.09, Research scientist in Wuhan Institute of Virology,Chinese Academy of Sciences,China.

2000.10- Present, Senior scientist and project investigator, Wuhan Institute of Virology, Chinese Academy of Sciences,China.

Teaching Experience

Molecular Virology, Virus and human diseases

Research Interests

1. Discovery of unknown viruses in wild animals.

2. Molecular epidemiology of zoonotic viruses.

3. Interspecies infection mechanism of zoonotic  viruses.


Shi. Z. (2019) Sino-French collaboration on emerging infectious diseases. The third edition of the Forum "Franco-Chinese Confluences". September 23-24, Lyon, France.

Shi. Z. (2019) Bat origin of emerging coronaviruses. The 1st meeting of the World Society for Virology. August 26-27, Stockholm, Sweden.

Shi. Z. (2019) Bat-borne emerging viral diseases. The 2nd Sino-Brazil Symposium on Infectious Diseases. June 26-29, Rio de Janeiro, Brazil.

Shi. Z. (2018) Risk assessment of bat coronavirus spillover and prevention strategy, 2018. The 2nd Sino-German Symposium “Globalization-Challenge and Response for Infectious Diseases”. September 2-5, Hamburg, Germany.

Shi. Z. (2018) From SARS to SADS: predict of emerging infectious diseases. US-China Workshop on Frontiers in Ecology and Evolution of Infectious Diseases. June 27-28, Berkeley, USA.

Shi. Z. (2018) Coronaviruses associated with human and animal diseases in China-From SARS to SADS. U.S-China Dialogue on the Challenges of Emerging Infections, Laboratory Safety and Global Health Security. January 16-18,  Galveston, USA.

Shi. Z. (2017) SARS coronavirus may have originated from frequent recombination events between SARS-related coronaviruses in a single horseshoe bat habitat. Cell Symposia: Emerging and Re-emerging Viruses 2017. October 1-3, Arlington, USA.

Shi Z. (2017) SARS coronavirus may have originated from frequent recombination events between SARS-related coronaviruses in a single horseshoe bat habitat. 27th Annual Meeting of the Society for Virology (Germany). March 22-25, 2017, Marburg, Germany.

Shi Z. (2016) Prevalence, animal origins and diagnosis of MERS-CoV. Devising Strategies to Control Emerging Viral Hemorrhagic Fever in Pakistan. November 14-16, 2016, Lahore, Pakistan. 

Shi. Z. (2015) Emerging viral zoonosis in China. Annual meeting of Sino-Germany Society for Medicine. October 2-3, Berlin, Germany.

Shi. Z. (2015) Bat coronaviruses associated with human diseases. CAS-NAS Workshop on the Challenges of Emerging Infections, Laboratory Safety, and Global Health Security. September 29-30, Beijing, China.

SHI, Z. (2015) The animal origin of SARS coronavirus; from genome to receptor usage. Annual meeting of Hubei Society for Microbilogy. August 22-23, Enshi, China.

Shi. Z. (2015) New evidence in support of bat origin of SARS coronavirus. In “workshop on Coronavirus and Arterivirus, Special lecture”, ASV2015, July 5-12, London, Canada.

SHI, Z. (2015) The animal origin of SARS coronavirus; from genome to receptor usage. The 3rd annual "host pathogen interaction in biodefense and emerging infectious diseases" conference. Feb. 12, Manassas, Virginia.

YANG X and SHI, Z et al. (2014) Isolation and identification of bat mammalian orthoreovirus from Chinese bats. The 6th International Symposium on Emerging Viral Diseases. October 29-30, Wuhan, China.

Ge, X., et al., (2013) New evidence further supports bats as natural reservoirs of SARS coronavirus. The 5th Wuhan International Symposium on Modern Virology. Oct. 30-31, Wuhan, China.

SHI, Z (2013) Bat borne viruses. CSIRO-CAS Biosecurity Workshop. 13-15 June 2013, Cairns, Australia.

SHI, Z.(2012) Bat viruses detected in China, 31th annual ASV meeting. Jul 21-25, Madison, USA.

SHI, Z.(2011) Virome in Bat Intestinal Tract, Implication of Important Roles Played by Bats in Ecosystem, XVIth International Union of Microbiological Societies 2. Sep 12-16, Sapporo, Japan.

SHI, Z. (2010) Novel hantavirus detected in Yunnan Red-backed Vole, Eothenomys miletus. Infectious Disease Genomics and Global Health. Sep 11-15, Hinxton, UK.

Shi, Z. (2008) Antibodies to Nipah or Nipah-like viruses among bats in mainland China. The 3rd International Symposium on Emerging Viral Diseases. Oct. 26-28,Wuhan,China.

Shi Z. (2008) Genetic Evolution of SARS coronavirus. The 179thforum of Young Scientists of China Association of Science and Technology. Nov 1-2,Lijiang,China.

Hou, Y., Peng C., Li, Y., Shi Z. (2008) The angiotension converting enzymes-2 of bats display different susceptibility to severe acute respiratory syndrome coronavirus. Annual meeting of Hubei Society for Microbiology. June 26-29, Hohhot, China. 

Shi, Z. (2007) Macrobrachium rosenbergii nodavirus (MrNV) and its associated satellite virus. Aquaculture 2007, Feb. 28- Mar. 2, San Antonio,USA.

Shi, Z. (2007) Functional analysis of structural envelope proteins of white spot syndrome virus (WSSV) and prevalence of WSSV and other shrimp viruses in china - a review. Aquaculture 2007, Feb. 28- Mar. 2,San Antonio,USA.

Shi, Z. (2007) Evolution on SARS Coronavirus. The First Mexico-China Scientific Cooperation Conference. Aug. 27-29, Mexico City, Mexico.

Shi, Z. (2006) Bats are natural reservoirs of SARS-like coronaviruses. France-China Medical Symposium. Oct. 23-24, Paris, France.

Current International Students

Name                                   Nationality                    Year of enrollment       

Cecilia Njeri Waruhiu          Kenya                          2014   Ph.D student

Ali Zohaib                            Pakistan                       2015   Ph.D student

Samson Omondi Onyuok     Kenya                          2016   Master student

Honors & Distinctions

2003, Natural Science Award (the second rank) of Hubei province,China.

2004, Outstanding supervisor of graduate student of Hubei province,China.

2005, Visitor scholarship from the Chinese Academy of Sciences.

2006, Outstanding scientist of the Chinese Academy of Sciences.

2006, Outstanding Natural Science Research Article Award (the first rank) of Hubei province, China

2007, "National May 1st Labour Medal", All-China Federation of Trade Unions

2008, Natural Science Award (the second rank) of the Ministry of Education, China.

2009, "Ten Distinguished Female Scientists", Chinese Academy of Sciences

2012, Outstanding Natural Science Research Article Award (the third rank) of Hubei province, China

2014, Outstanding Natural Science Research Article Award (top award) of Hubei province, China

2014, Young and Middle-Aged Scholar with Outstanding Contribution, Hubei province, China

2017, Provincial Natural Science Award (the first prize) of Hubei, China

2018, National Natural Science Award (the second prize) 


1.        Jiang, R.D.#, Liu, M.Q.#, Chen, Y.#, Shan, C., Zhou, Y.W., Shen, X.R., Li, Q., Zhang, L., Zhu, Y., Si, H.R., Wang, Q., Min, J., Wang, X., Zhang, W., Li, B., Zhang, H.J., Baric, R.S., Zhou, P., Yang, X.L.*, Shi, Z.L*. (2020) Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2. Cell. S0092-8674(20)30622-X.

2.        Zhou, P.#, Yang, X.L.#, Wang, X.G.#, Hu, B., Zhang, L., Zhang, W., Si, H.R., Zhu, Y., Li, B., Huang, C.L., Chen, H.D., Chen, J., Luo, Y., Guo, H., Jiang, R.D., Liu, M.Q., Chen. Y., Shen, X.R., Wang, X., Zheng, X.S., Zhao, K., Chen, Q.J., Deng, F., Liu, L.L., Yan, B., Zhan, F.X., Wang, Y.Y., Xiao, G.F., Shi, Z.L*. (2020) A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature.579(7798):270-273.

3.        Yi, CY#, Sun, XY#, Ye, J#, Ding, LF, Liu, MQ, Yang, Z, Lu, X, Zhang, YG, Ma, LY, Gu, WP, Qu, AD, Xu, JQ, Shi, ZL*, Ling, ZY#*, Sun, B* (2020) Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cell Mol Immunol. 17(6):621-630.

4.        Zhang, W.#, Du, R.H.#, Li, B., Zheng, X.S., Yang, X.L., Hu. B., Wang, Y.Y., Xiao, G.F., Yan, B., Shi, Z.L.*, Zhou, P*. (2020) Molecular and serological investigation of 2019-nCoV infected patients: Implication of multiple shedding routes. Emerg Microbes Infect. 9(1):386-389.

5.        Zhang, W.#, Zheng, X.S.#, Agwanda, B.#, Ommeh, S.#, Zhao, K., Lichoti, J., Wang, N., Chen, J., Li, B., Yang, X.L., Mani, S., Ngeiywa, K.J., Zhu, Y., Hu, B., Onyuok, S.O., Yan, B., Anderson, D.E., Wang, L.F., Zhou, P.*, Shi, Z.L*. (2019) Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels. Emerg Microbes Infect. 8(1):1528-1534.

6.        Yang, X.L.#, Tan, C.W.#, Anderson, D.E, Jiang, R.D., Li, B., Zhang, W., Zhu, Y., Lim, X.F., Zhou, P., Liu, X.L., Guan, W., Zhang, L., Li, S.Y., Zhang, Y.Z., Wang, L.F.*, Shi, Z.L*. (2019) Characterization of a filovirus (Měnglà virus) from Rousettus bats in China. Nature Microbiology, 4(3):390-395.

7.        Cui, J., Li, F., Shi, Z.L*. (2019) Origin and evolution of pathogenic coronaviruses. Nature Reviews Microbiology, 17(3), 181-192.

8.        Zhou, P#., Fan, H#., Lan, T#., Yang, X-L, Shi, W-F, Zhang, W., Zhu. Y., Zhang, Y-W., Xie, Q-M., Mani, S., Zheng, X-S., Li, B., Li, J-M., Guo, H., Pei, G-Q., An, X-P., Chen J-W., Zhou, L., Mai, K-J., Wu, Z-X., Li, D., Anderson, D.E., Zhang, L-B., Li, S-Y., Mi, Z-Q., He, T-T., Cong, F., Guo, P-J., Huang, R., Luo, Y., Liu, X-L., Chen, J., Huang, Y., Sun, Q., Zhang, X-L-L., Wang, Y-Y., Xing, S-Z., Chen, Y-S., Sun, Y., Li, J., Daszak, P.*, Wang, L-F.*, Shi, Z-L.*, Tong, Y-G.*, Ma, J-Y.* (2018). Fatal Swine Acute Diarrhea Syndrome caused by an HKU2-related Coronavirus of Bat Origin. Nature.556(7700):255-258.

9.        Xie, J.Z., Li, Y., Shen, X., Goh, G., Zhu, Y., Wang, L-F., Cui, J., Shi, Z-L.,* Zhou, P.* (2018). Dampened STING-Dependent Interferon Activation in Bats. Cell Host & Microbe. 23(3):297-301.

10.    Hu, B#., Zeng, L.P#., Yang, X.L#., Ge, X.Y., Zhang, W., Li, B., Xie, J.Z., Shen, X.R., Zhang, Y.Z., Wang, N., Luo, D.S., Zheng, X.S., Wang, M.N., Daszak, P., Wang, L.F., Cui, J.*, Shi, Z.L*(2017). Discovery of A Rich Gene Pool of Bat SARS-related Coronaviruses Provides New Insights into the Origin of SARS Coronavirus. PloS Pathogens. 13(11): e1006698.

11.    Zeng, L.P, Ge, X.Y, Peng, C., Tai, W.B, Jiang, S.B, Du, L.Y*, Shi, Z.L*(2017). Cross-neutralization of SARS coronavirus-specific antibodies against bat SARA-like coronaviruses. Sci China Life Sci. 60(12):1399-1402.

12.    Tan, B., Yang, X. L., Ge, X. Y., Peng, C., Liu, H. Z., Zhang, Y. Z., Zhang, L. B. & Shi, Z. L*. (2017). Novel bat adenoviruses with low G+C content shed new light on the evolution of adenoviruses. J Gen Virol., 98, 739-748.

13.    Yang, X. L., Zhang, Y. Z., Jiang, R. D., Guo, H., Zhang, W., Li, B., Wang, N., Wang, L., Waruhiu, C., Zhou, J. H., Li, S. Y., Daszak, P., Wang, L. F. & Shi, Z. L*. (2017). Genetically Diverse Filoviruses in Rousettus and Eonycteris spp. Bats, China, 2009 and 2015. Emerg Infect Dis., 23, 482-486.

14.    Zeng, L. P., Gao, Y. T., Ge, X. Y., Zhang, Q., Peng, C., Yang, X. L., Tan, B., Chen, J., Chmura, A. A., Daszak, P. & Shi, Z. L*. (2016). Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. J Virol 90, 6573-6582.

15.    Yang, X.-L., Hu, B., Wang, B., Wang, M.-N., Zhang, Q., Zhang, W., Wu, L.-J., Ge, X.-Y., Zhang, Y.-Z., Daszak, P., Wang, L.-F. & Shi, Z.-L*. (2016). Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus. J Virol., 90, 3253-3256.

16.    Yang, X. L., Tan, B., Wang, B., Li, W., Wang, N., Luo, C. M., Wang, M. N., Zhang, W., Li, B., Peng, C., Ge, X. Y., Zhang, L. B., Shi, Z*. (2015). Isolation and identification of bat viruses closely related to human, porcine, and mink orthoreoviruses. J Gen Virol. 96(12):3525-3531.

17.    Menachery VD, Yount Jr BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge X-Y, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi Z-L, Baric RS*. (2015). A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med 21:1508-1513.

18.    Ge, X-Y., Li, J-L., Yang, X-L., Chmura, A.A., Zhu, G., Epstein, J.H., Mazet, J.K., Hu, B., Zhang, W., Peng, C., Zhang, Y.J., Luo, C.M., Tan, B., Wang, N., Zhu, Y., Crameri, G., Zhang, S.Y., Wang, L.F., Daszak, P.*, Shi, Z-L*. (2013). Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature, 503(7477):535-538.

19.    Zhang, G#., Cowled, C#., Shi, Z#., Huang, Z#., Bishop-Lilly, K. A#., Fang, X., Wynne, J. W., Xiong, Z., Baker, M. L., Zhao, W., Tachedjian, M., Zhu, Y., Zhou, P., Jiang, X., Ng, J., Yang, L., Wu, L., Xiao, J., Feng, Y., Chen, Y., Sun, X., Zhang, Y., Marsh, G. A., Crameri, G., Broder, C. C., Frey, K. G*., Wang, L. F*. & Wang, J*. (2013). Comparative Analysis of Bat Genomes Provides Insight into the Evolution of Flight and Immunity. Science 339 (6118):456-460.

20.    Wu, L., Zhou, P., Ge, X., Wang, L. F., Baker, M. L. & Shi, Z*. (2013). Deep RNA sequencing reveals complex transcriptional landscape of a bat adenovirus. J Virol 87, 503-511.

21.    Yuan, J., Zhang, Y., Li, J., Zhang, Y., Wang, L. F. & Shi, Z*. (2012). Serological evidence of ebolavirus infection in bats, China. Virology Journal 9, 236.

22.    Ge, X., Li, Y., Yang, X., Zhang, H., Zhou, P., Zhang, Y. & Shi, Z*. (2012). Metagenomic analysis of viruses from bat fecal samples reveals many novel viruses in insectivorous bats in china. J Virol 86(8):4620-4630.

23.    Ge, X., Li, J., Peng, C., Wu, L., Yang, X., Wu, Y., Zhang, Y. and Shi, Z*. (2011). Genetic diversity of novel circular ssDNA viruses in bats in China. J Gen Virol., 92:2646-2653.

24.    Yuan, J., Marsh, G., Khetawat, D., Broder, C. C., Wang, L. F. and Shi, Z*. (2011). Mutations in the G-H loop region of ephrin-B2 can enhance Nipah virus binding and infection. J Gen Virol 92:2142-2152.

25.    Li, Y., Ge X., Hon C. C., Zhang H., Zhou P., Zhang Y., Wang L. F. and Shi Z*. (2010). Prevalence and Genetic Diversity of Adeno-Associated Viruses in Bats, China. J Gen Virol. 91(10): 2601-2609.

26.    Li, Y., Ge X., Zhang H., Zhou P., Zhu Y., Zhang Y., Yuan J., Wang L-F., Shi Z.* (2010). Host Range, Prevalence and Genetic Diversity of Adenoviruses in Bats. J. Virol. 84 (8):3889–3897.

27.    Li,* Y., Wang, J., Hickey, A. C., Zhang, Y., Li, Y., Wu, Y., Zhang, H., Yuan, J., Han,* Z., McEachern, J., Broder, C. C., Wang, L. F. and Shi, Z*. (2008) Potential nipah virus infection in Chinese bats. Emerg Infect Dis 14(12):1974-1976.

28.    Ren, W., Qu, X., Li, W., Han, Z., Yu, M., Zhang, S., Wang, L. F., Deng, H., Shi, Z*. (2008) Difference in receptor usage between SARS coronavirus and SARS-like coronavirus of bat origin. J Virol 82(4): 1899–1907.

29.    Li, W., Shi Z*., Yu M., Ren W., Smith C., Epstein H. J., Zhang S*., Wang H., Crameri G., Hu Z., Zhang H., Zhang J., Mceachern J., Field H., Daszak P., Eaton T.B. and Wang L. F*. (2005) Bats are natural reservoirs of SARS-like coronaviruses. Science 310(5748): 676-679.

Book chapters

(1)   Hu Z. and Shi Z. Investigation of animal reservoir(s) of SARS-CoV. In Emerging Infections in Asia. Ed. Lu Yi., EsseX M., Robert B. 2008, pp57-74. Springer Science+Business Media, LLC, New York.

(2)   Zhengli Shi, Lin-Fa Wang. Evolution of SARS coronavirus and the relevance of modern molecular epidemiology. In “Genetics and Evolution of Infectious Disease”, Ed. Michel Tibayrenc, 2010, Elsevier.

(3)   Xing-Yi Ge, Ben Hu, and Zheng-Li Shi. Chapter 5: Bat coronaviruses. In ‘Bats and Viruses: A New Frontier of Emerging Infectious Diseases’. Ed. by Lin-fa Wang and C. Cowled, 2015, p127-155, John Wiley & Sons, Inc., Hoboken, New Jersey.

(4)   Xing-Lou Yang, Xing-Yi Ge, Ben Hu, Zheng-Li Shi. Epidemilogy. In «’Ebolavirus disease’, 2015, P36-51. Ed. By Lan-Juan Li. Published by Zhejiang University.