基本信息
王新峦  女  博导  中国科学院深圳先进技术研究院
电子邮件: xl.wang@siat.ac.cn
通信地址: 深圳市南山区西丽大学城学苑大道1068号
邮政编码: 518055

研究领域

骨关节肌肉疾病的药物研发;骨及软骨再生的生物医用材料研究与转化


招生信息

   
招生专业
071010-生物化学与分子生物学
083100-生物医学工程
100706-药理学
研究方向
药理学
生物医学工程
骨生物学

教育背景

2003-08--2008-06   沈阳药科大学   博士学位
1999-08--2003-06   沈阳药科大学   学士学位

工作经历

   
工作简历
2020-01~现在, 中国科学院深圳先进技术研究院, 研究员
2011-05~2019-12,中国科学院深圳先进技术研究院, 副研究员
2009-04~2011-03,香港中文大学矫形外科及创伤学系, 博士后
2007-04~2009-03,香港中文大学矫形外科及创伤学系, 助理研究员

教授课程

创新药物研发

专利与奖励

   
奖励信息
(1) 深圳市技术发明奖, 二等奖, 市地级, 2021
(2) 中国专利银奖, 国家级, 2021
(3) 中国专利优秀奖, 国家级, 2021
(4) 骨科基础研究青年奖, 三等奖, 专项, 2018
(5) 抗骨质疏松传统中药现代化研究及其应用, 二等奖, 部委级, 2013
专利成果
( 1 ) 葫芦素E在制备治疗血管新生不足相关疾病药物或生物医用材料中的用途和应用其的产品, 发明专利, 2021, 第 2 作者, 专利号: ZL201811013796.9

( 2 ) 一种可增加载药量的骨靶向纳米粒递送系统及其制备, 发明专利, 2017, 第 1 作者, 专利号: 201711447704.3

( 3 ) 补骨脂定在抑制脂肪细胞分化、形成及其功能中的应用, 发明专利, 2017, 第 1 作者, 专利号: CN201711009823.0

( 4 ) 骨靶向脂质体及其制备方法, 发明专利, 2016, 第 5 作者, 专利号: PCT/CN2012/081355

( 5 ) 淫羊藿素在制备防治阿尔茨海默病药物中的应用, 发明专利, 2015, 第 1 作者, 专利号: ZL201310362101.9

( 6 ) Novel injectable bone targeted liposome formulation for delivering icaritin to bone formation surface for bone anabolic therapy, 实用新型, 2011, 第 5 作者, 专利号: US61/625510

( 7 ) 植物淫羊藿活性成分淫羊藿素的提取与预防激素性骨坏死的研发, 发明专利, 2008, 第 4 作者, 专利号: US61/197319

( 8 ) 携载缓释天然小分子淫羊藿素的快速成形骨支架的研发, 实用新型, 2008, 第 4 作者, 专利号: US61/125378

出版信息

   
发表论文
[1] Zuocheng Qiu, Ling Li, Yuying Huang, Keda Shi, Lizhong Zhang, Cuishan Huang, Jiechao Liang, Qingqiang Zeng, Jiali Wang, Xiangjiu He, Ling Qin, Xinluan Wang. Puerarin specifically disrupts osteoclast activation via blocking integrin-β3 Pyk2/Src/Cbl signaling pathway. Journal of Orthopaedic Translation. 2022, 33: 55-69, [2] Zhang, Xiyue, Liu, Hui, Li, Ling, Huang, Cuishan, Meng, Xiangbo, Liu, Junzuo, Bai, Xueling, Ren, Ling, Wang, Xinluan, Yang, Ke, Qin, Ling. Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats. REGENERATIVE BIOMATERIALS[J]. 2022, 9: http://dx.doi.org/10.1093/rb/rbac011.
[3] Nianye Zheng, Jiankun Xu, Ye Chun Ruan, Liang Chang, Xinluan Wang, Hao Yao, Jiali Wang, Ri Zhang, Qingyun Xue, Ning Tang, Timyun Ong, Jrg Schilcher, Regis J OKeefe, Ling Qin. Magnesium facilitates the healing of atypical femoral fractures: A single-cell transcriptomic study. Materials Today. 2022, 52: 43-62, [4] Meng, Xiangbo, Grad, Sibylle, Wen, Chunyi, Lai, Yuxiao, Alini, Mauro, Qin, Ling, Wang, Xinluan. An impaired healing model of osteochondral defect in papain-induced arthritis. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2021, 26: 101-110, http://dx.doi.org/10.1016/j.jot.2020.07.005.
[5] Wang, Jiali, Xu, Jiankun, Wang, Xinluan, Sheng, Liyuan, Zheng, Lizhen, Song, Bin, Wu, Ge, Zhang, Ri, Yao, Hao, Zheng, Nianye, Ong, Michael Tim Yun, Yung, Patrick Shuhang, Qin, Ling. Magnesium-pretreated periosteum for promoting bone-tendon healing after anterior cruciate ligament reconstruction. BIOMATERIALS[J]. 2021, 268: http://dx.doi.org/10.1016/j.biomaterials.2020.120576.
[6] Cheng, WenXiang, Liu, YanZhi, Meng, XiangBo, Zheng, ZhengTan, Li, LingLi, Ke, LiQing, Li, Ling, Huang, CuiShan, Zhu, GuoYuan, Pan, HuDan, Qin, Ling, Wang, XinLuan, Zhang, Peng. PLGA/beta-TCP composite scaffold incorporating cucurbitacin B promotes bone regeneration by inducing angiogenesis. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2021, 31: 41-51, http://dx.doi.org/10.1016/j.jot.2021.10.002.
[7] Tang, Xiyang, Dai, Ziqin, Shi, Danfeng, Zeng, Jiaxing, Wang, Xinluan, Li, Ling, Yao, Xinsheng, Dai, Yi. An UHPLC-MS/MS method for simultaneous determination of ten sex steroid hormones in ovariectomy-induced osteoporosis rat and its application in discovery of sex steroid hormones regulatory components of Xian-Ling-Gu-Bao capsule. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2021, 195: http://dx.doi.org/10.1016/j.jpba.2020.113888.
[8] Liu, Yanzhi, Peng, Liuqi, Li, Lingli, Huang, Cuishan, Shi, Keda, Meng, Xiangbo, Wang, Pinpin, Wu, Mingming, Li, Ling, Cao, Huijuan, Wu, Kefeng, Zeng, Qingqiang, Pan, Haobo, Lu, William Weijia, Qin, Ling, Ruan, Changshun, Wang, Xinluan. 3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model. BIOMATERIALS[J]. 2021, 279: http://dx.doi.org/10.1016/j.biomaterials.2021.121216.
[9] Cheng, Wenxiang, Gan, Donghao, Hu, Yiping, Zheng, Zhengtan, Zeng, Qingqiang, Li, Ling, Wang, Xinluan, Zhang, Yong, Xu, Zhanwang, Qin, Ling, Zhang, Peng. The effect and mechanism of QufengZhitong capsule for the treatment of osteoarthritis in a rat model. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2021, 28: 65-73, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932897/.
[10] Zheng, LiZhen, Wang, JiaLi, Xu, JianKun, Zhang, XiaoTian, Liu, BaoYi, Huang, Le, Zhang, Ri, Zu, HaiYue, He, Xuan, Mi, Jie, Pang, QianQian, Wang, XinLuan, Ruan, YeChun, Zhao, DeWei, Qin, Ling. Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in a rat model. BIOMATERIALS[J]. 2020, 238: 119828-119828, http://dx.doi.org/10.1016/j.biomaterials.2020.119828.
[11] Ziadlou, Reihane, Barbero, Andrea, Martin, Ivan, Wang, Xinluan, Qin, Ling, Alini, Mauro, Grad, Sibylle. Anti-Inflammatory and Chondroprotective Effects of Vanillic Acid and Epimedin C in Human Osteoarthritic Chondrocytes. BIOMOLECULES[J]. 2020, 10(6): https://doaj.org/article/8c20033c44614ac48aafb109ac45bea0.
[12] Xiangbo Meng, Reihane Ziadlou, Sibylle Grad, Mauro Alini, Chunyi Wen, Yuxiao Lai, Ling Qin, Yanyan Zhao, Xinluan Wang. Animal Models of Osteochondral Defect for Testing Biomaterials. Biochemistry Research International[J]. 2020, 2020: https://doaj.org/article/752b9107d83745ecb286fce523071a75.
[13] Li, Ling, Yi, Xiaomin, Huang, Cuishan, Shi, Keda, Wang, Jiani, Zeng, Qingqiang, Cheng, Wenxiang, He, Xiangjiu, Zhang, Peng, Qiu, Guixing, Qin, Ling, Wang, Xinluan. Qu Feng Zhi Tong capsule increases mechanical properties of cortical bone in ovariectomised rats. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2020, 25: 115-124, http://dx.doi.org/10.1016/j.jot.2020.02.001.
[14] Guan, Yidi, Jiang, Shilong, Ye, Wenling, Ren, Xingcong, Wang, Xinluan, Zhang, Yi, Yin, Mingzhu, Wang, Kuansong, Tao, Yongguang, Yang, JinMing, Cao, Dongsheng, Cheng, Yan. Combined treatment of mitoxantrone sensitizes breast cancer cells to rapalogs through blocking eEF-2K-mediated activation of Akt and autophagy. CELL DEATH & DISEASE[J]. 2020, 11(11): https://doaj.org/article/5390f74672ba453bae11ae1978a80622.
[15] Jiang, Shilong, Guan, Yidi, Chen, Xisha, Ge, Peng, Wang, Xinluan, Lao, Yuanzhi, Xiao, Songshu, Zhang, Yi, Yang, Jinming, Xu, Xiaojun, Cao, Dongsheng, Cheng, Yan. Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway. ACTA PHARMACOLOGICA SINICA[J]. 2019, 40(7): 919-928, https://www.webofscience.com/wos/woscc/full-record/WOS:000472610000006.
[16] Wang, Xueqian, Zhang, Mengliu, Zhang, Dawei, Wang, Xinluan, Cao, Huijuan, Zhang, Qian, Yan, Chunyan. Structural elucidation and anti-osteoporosis activities of polysaccharides obtained from Curculigo orchioides. CARBOHYDRATE POLYMERS[J]. 2019, 203: 292-301, http://dx.doi.org/10.1016/j.carbpol.2018.09.059.
[17] Xu, Zhengjiang, Long, Jing, Zhang, Ningfeng, Cao, Huijuan, Tang, Wei, Shi, Keda, Wang, Xinluan, Moya, Sergio, Duan, Li, Pan, Haobo, Lai, Yuxiao, Wang, Daping, Wang, Guocheng. Strong mineralization ability of strontium zinc silicate: Formation of a continuous biomorphic mineralized layer with enhanced osteogenic activity. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2019, 176: 420-430, http://dx.doi.org/10.1016/j.colsurfb.2019.01.026.
[18] Yu, Pian, Wang, Haiyan, Tian, Min, Li, Aoxue, Chen, Xisha, Wang, Xinluan, Zhang, Yi, Cheng, Yan. Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro. ACTA PHARMACOLOGICA SINICA[J]. 2019, 40(9): 1237-1244, http://lib.cqvip.com/Qikan/Article/Detail?id=7002967671.
[19] Wen, Mei, Deng, Zhenke, Jiang, Shilong, Guan, Yidi, Wu, Haizhou, Wang, Xinluan, Xiao, Songshu, Zhang, Yi, Yang, Jinming, Cao, Dongsheng, Cheng, Yan. Identification of a Novel Bcl-2 Inhibitor by Ligand-Based Screening and Investigation of Its Anti-cancer Effect on Human Breast Cancer Cells. FRONTIERS IN PHARMACOLOGY[J]. 2019, 10: https://doaj.org/article/caf8e622526f42f8a8545e011a67fb92.
[20] Cao, Huijuan, Li, Cairong, Wang, Linying, Ziadlou, Reihane, Grad, Sibylle, Zhang, Yan, Cheng, Yan, Lai, Yuxiao, Yao, Xinsheng, Alini, Mauro, Qin, Ling, Wang, Xinluan. Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis. PHYTOMEDICINE[J]. 2019, 61: 152860-, http://dx.doi.org/10.1016/j.phymed.2019.152860.
[21] Lai, Yuxiao, Li, Ye, Cao, Huijuan, Long, Jing, Wang, Xinluan, Li, Long, Li, Cairong, Jia, Qingyun, Teng, Bin, Tang, Tingting, Peng, Jiang, Eglin, David, Alini, Mauro, Grijpma, Dirk W, Richards, Geoff, Qin, Ling. Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect. BIOMATERIALS[J]. 2019, 197: 207-219, http://dx.doi.org/10.1016/j.biomaterials.2019.01.013.
[22] Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang, Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li, Bo Wei, Wayne Yuk Wai Lee. PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. Biomaterials. 2019, 196: 109-121, http://dx.doi.org/10.1016/j.biomaterials.2018.04.004.
[23] 王新峦, 郑力真, 曹会娟, 秦岭. 预防及治疗激素性股骨头坏死的动物模型及实验研究进展. 中华骨科杂志[J]. 2019, 39(23): 1462-1469, http://lib.cqvip.com/Qikan/Article/Detail?id=7100604406.
[24] Li, Ling, Long, Jing, Li, Long, Cao, Huijuan, Tang, Tingting, Xi, Xinghua, Qin, Ling, Lai, Yuxiao, Wang, Xinluan. Quantitative determination of residual 1,4-dioxane in three-dimensional printed bone scaffold. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2018, 13: 58-67, http://dx.doi.org/10.1016/j.jot.2017.06.004.
[25] 王勤, 吴波, 张建华, 李玉前, 周晓中, 王新峦. BMP-2/Smads信号通路在低剂量X射线促成骨细胞分化与矿化中的作用. 山东医药. 2018, 58(29): 20-24, http://lib.cqvip.com/Qikan/Article/Detail?id=675907688.
[26] Chen, Shihui, Zheng, Lizhen, Zhang, Jiayong, Wu, Heng, Wang, Nan, Tong, Wenxue, Xu, Jiankun, Huang, Le, Zhang, Yifeng, Yang, Zhijun, Lin, Ge, Wang, Xinluan, Qin, Ling. A novel bone targeting delivery system carrying phytomolecule icaritin for prevention of steroid-associated osteonecrosis in rats. BONE[J]. 2018, 106: 52-60, http://dx.doi.org/10.1016/j.bone.2017.09.011.
[27] Zheng, LiZhen, Wang, JiaLi, Kong, Ling, Huang, Le, Tian, Li, Pang, QianQian, Wang, XinLuan, Qin, Ling. A rat model of steroid-associated osteonecrosis. JOURNAL OF BONE AND MINERAL RESEARCHnull. 2018, 33: 143-143, http://ir.siat.ac.cn:8080/handle/172644/14890.
[28] Huang, Dong, Zhang, Mengliu, Chen, Wei, Zhang, Dawei, Wang, Xinluan, Cao, Huijuan, Zhang, Qian, Yan, Chunyan. Structural elucidation and osteogenic activities of two novel heteropolysaccharides obtained from water extraction residues of Cibotium barometz. INDUSTRIAL CROPS AND PRODUCTS[J]. 2018, 121: 216-225, http://ir.siat.ac.cn:8080/handle/172644/14425.
[29] Lai, Yuxiao, Cao, Huijuan, Wang, Xinluan, Chen, Shukui, Zhang, Ming, Wang, Nan, Yao, Zhihong, Dai, Yi, Xie, Xinhui, Zhang, Peng, Yao, Xinsheng, Qin, Ling. Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits. BIOMATERIALS[J]. 2018, 153: 1-13, http://dx.doi.org/10.1016/j.biomaterials.2017.10.025.
[30] Dong Huang, Mengliu Zhang, Wei Chen, Dawei Zhang, Xinluan Wang, Huijuan Cao, Qian Zhang, Chunyan Yan. Structural elucidation and osteogenic activities of two novel heteropolysaccharides obtained from water extraction residues of Cibotium barometz. Industrial Crops & Products. 2018, 121: 216-225, http://dx.doi.org/10.1016/j.indcrop.2018.04.070.
[31] Huang, Le, Wang, Xinluan, Cao, Huijuan, Li, Ling, Chow, Dick HoKiu, Tian, Li, Wu, Heng, Zhang, Jiayong, Wang, Nan, Zheng, Lizhen, Yao, Xinsheng, Yang, Zhijun, Qin, Ling. A bone-targeting delivery system carrying osteogenic phytomolecule icaritin prevents osteoporosis in mice. BIOMATERIALS[J]. 2018, 182: 58-71, http://ir.siat.ac.cn:8080/handle/172644/14426.
[32] Zhang, Xi, Geven, Mike A, Wang, Xinluan, Qin, Ling, Grijpma, Dirk W, Peijs, Ton, Eglin, David, Guillaume, Olivier, Gautrot, Julien E. A drug eluting poly(trimethylene carbonate)/poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2018, 13: 5701-5718, http://ir.siat.ac.cn:8080/handle/172644/14427.
[33] Xin-Luan Wang. Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral headdA first multicentre, randomised, double-blind, placebo-controlled clinical trial.. Journal of Orthopaedic Translation. 2018, [34] Jiang, Keming, Huang, Dong, Zhang, Dawei, Wang, Xinluan, Cao, Huijuan, Zhang, Qian, Yan, Chunyan. Investigation of inulins from the roots of Morinda officinalis for potential therapeutic application as anti-osteoporosis agent. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2018, 120: 170-179, http://dx.doi.org/10.1016/j.ijbiomac.2018.08.082.
[35] Zhang, Yan, Li, XiaoLi, Sha, NanNan, Shu, Bing, Zhao, YongJian, Wang, XinLuan, Xiao, HuiHui, Shi, Qi, Wong, ManSau, Wang, YongJun. Differential response of bone and kidney to ACEI in db/db mice: A potential effect of captopril on accelerating bone loss. BONE[J]. 2017, 97: 222-232, http://dx.doi.org/10.1016/j.bone.2017.01.029.
[36] Chen, ShiHui, Wang, XinLuan, Zheng, LiZhen, Dai, Yi, Zhang, JiaYong, Guo, BaoLin, Yang, ZhiJun, Yao, XinSheng, Qin, Ling. Comparative study of two types of herbal capsules with different Epimedium species for the prevention of ovariectomised-induced osteoporosis in rats. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2016, 4(C): 14-27, http://dx.doi.org/10.1016/j.jot.2015.07.001.
[37] Huang, Jie, Wang, Yihai, Li, Chuan, Wang, Xinluan, He, Xiangjiu. Anti-Inflammatory Oleanolic Triterpenes from Chinese Acorns. MOLECULES[J]. 2016, 21(5): http://dx.doi.org/10.3390/molecules21050669.
[38] Xin-Luan Wang. Summary of various treatment options and potential therapies for osteonecrosis of the femoral head.. Journal of Orthopaedic Translation. 2016, [39] Huang, Jie, Wang, Yihai, Li, Chuan, Wang, Xinluan, He, Xiangjiu. Triterpenes isolated from acorns of Quercus serrata var. brevipetiolata exert anti-inflammatory activity. INDUSTRIAL CROPS AND PRODUCTS[J]. 2016, 91: 302-309, http://dx.doi.org/10.1016/j.indcrop.2016.07.033.
[40] Zheng, LiZhen, Wang, XinLuan, Cao, HuiJuan, Chen, ShiHui, Huang, Le, Qin, Ling. Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model. BONE[J]. 2016, 83: 190-196, http://dx.doi.org/10.1016/j.bone.2015.11.010.
[41] Zhang, Yan, Wang, Liang, Liu, JinXin, Wang, XinLuan, Shi, Qi, Wang, YongJun. Involvement of skeletal renin-angiotensin system and kallikrein-kinin system in bone deteriorations of type 1 diabetic mice with estrogen deficiency. JOURNAL OF DIABETES AND ITS COMPLICATIONS[J]. 2016, 30(8): 1419-1425, http://dx.doi.org/10.1016/j.jdiacomp.2016.08.016.
[42] Jie Huang, Yihai Wang, Chuan Li, Xinluan Wang, Xiangjiu He. Triterpenes isolated from acorns of Quercus serrata var. brevipetiolata exert anti-inflammatory activity. Industrial Crops & Products. 2016, 91: 302-309, http://dx.doi.org/10.1016/j.indcrop.2016.07.033.
[43] Wang Xinluan, Lai Yuxiao, Helena, Ng HueiLeng, Yang Zhijun, Qin Ling. Systemic Drug Delivery Systems for Bone Tissue Regeneration- A Mini Review. CURRENT PHARMACEUTICAL DESIGNnull. 2015, 21(12): 1575-1583, https://www.webofscience.com/wos/woscc/full-record/WOS:000350281800007.
[44] Zheng, Lizhen, Cao, Huijuan, Chen, Shihui, Tang, Tao, Fu, Weimin, Huang, Le, Chow, Dick Ho Kiu, Wang, Yixiang, Griffith, James Francis, He, Wei, Zhou, Hong, Zhao, Dewei, Zhang, Ge, Wang, Xinluan, Qin, Ling. Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid-Associated Osteonecrosis in Rabbits. JOURNAL OF BONE AND MINERAL RESEARCH[J]. 2015, 30(11): 2044-2057, http://dx.doi.org/10.1002/jbmr.2542.
[45] 张明, 赖毓霄, 王新峦, 李龙, 张鹏, 秦岭. 基于3D打印技术的新型生物活性复合镁骨修复支架. 国际骨科学杂志. 2015, 36(5): 382-384, http://lib.cqvip.com/Qikan/Article/Detail?id=666145210.
[46] Li, Ye, Chen, ShuKui, Li, Long, Qin, Ling, Wang, XinLuan, Lai, YuXiao. Bone defect animal models for testing efficacy of bone substitute biomaterials. JOURNAL OF ORTHOPAEDIC TRANSLATIONnull. 2015, 3(3): 95-104, http://dx.doi.org/10.1016/j.jot.2015.05.002.
[47] Qin, Ling, Yao, Dong, Zheng, Lizhen, Liu, WaiChing, Liu, Zhong, Lei, Ming, Huang, Le, Xie, Xinhui, Wang, Xinluan, Chen, Yang, Yao, Xinsheng, Peng, Jiang, Gong, He, Griffith, James F, Huang, Yanping, Zheng, Yongping, Feng, Jian Q, Liu, Ying, Chen, Shihui, Xiao, Deming, Wang, Daping, Xiong, Jiangyi, Pei, Duanqing, Zhang, Peng, Pan, Xiaohua, Wang, Xiaohong, Lee, KwongMan, Cheng, ChunYiu. Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits. BIOMATERIALS[J]. 2015, 59: 125-143, http://dx.doi.org/10.1016/j.biomaterials.2015.04.038.
[48] Wang, Xinluan, He, Yixin, Guo, Baosheng, Tsang, ManChing, Tu, Fengjuan, Dai, Yi, Yao, Zhihong, Zheng, Lizhen, Xie, Xinhui, Wang, Nan, Yao, Xinsheng, Zhang, Ge, Qin, Ling. In Vivo Screening for Anti-Osteoporotic Fraction from Extract of Herbal Formula Xianlinggubao in Ovariectomized Mice. PLOS ONE[J]. 2015, 10(2): http://dx.doi.org/10.1371/journal.pone.0118184.
[49] Xie, XinHui, Wang, XinLuan, Yang, HuiLin, Zhao, DeWei, Qin, Ling. Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview). JOURNAL OF ORTHOPAEDIC TRANSLATIONnull. 2015, 3(2): 58-70, http://dx.doi.org/10.1016/j.jot.2014.12.002.
[50] Cao, HuiJuan, Zheng, LiZhen, Wang, Nan, Wang, LinYing, Li, Ye, Li, Dan, Lai, YuXiao, Wang, XinLuan, Qjn, Ling. Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. BONE[J]. 2015, 74: 58-68, http://dx.doi.org/10.1016/j.bone.2014.12.060.
[51] Qin Ling. Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis.. Bone. 2014, [52] Xiao, HuiHui, Fung, ChungYan, Mok, SaoKing, Wong, KaChun, Ho, MingXian, Wang, XinLuan, Yao, XinSheng, Wong, ManSau. Flavonoids from Herba epimedii selectively activate estrogen receptor alpha (ER alpha) and stimulate ER-dependent osteoblastic functions in UMR-106 cells. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY[J]. 2014, 143: 141-151, https://www.webofscience.com/wos/woscc/full-record/WOS:000341465500016.
[53] 王勤, 王新峦, 邓晔坤, 周晓中, 秦岭. 成骨微环境中低剂量射线对成骨细胞的影响. 中华实验外科杂志[J]. 2014, 31(8): 1775-1777, [54] Wang, XinLuan, Wang, Nan, Zheng, LiZhen, Xie, XinHui, Yao, Dong, Liu, MingYan, Yao, ZhiHong, Dai, Yi, Zhang, Ge, Yao, XinSheng, Qin, Ling. Phytoestrogenic molecule desmethylicaritin suppressed adipogenesis via Wnt/beta-catenin signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2013, 714(1-3): 254-260, http://dx.doi.org/10.1016/j.ejphar.2013.06.008.
[55] Xin-Luan Wang, Nan Wang, Li-Zhen Zheng, Xin-Hui Xie, Dong Yao, Ming-Yan Liu, Zhi-Hong Yao, Yi Dai, Ge Zhang, Xin-Sheng Yao, Ling Qin. Phytoestrogenic molecule desmethylicaritin suppressed adipogenesis via Wnt/β-catenin signaling pathway. European Journal of Pharmacology. 2013, 714(1-3): 254-260, http://dx.doi.org/10.1016/j.ejphar.2013.06.008.
[56] Wang, XinLuan, Xie, XinHui, Zhang, Ge, Chen, ShiHui, Yao, Dong, He, Kai, Wang, XiaoHong, Yao, XinSheng, Leng, Yang, Fung, KwokPui, Leung, KwokSui, Qin, Ling. Exogenous phytoestrogenic molecule icaritin incorporated into a porous scaffold for enhancing bone defect repair. JOURNAL OF ORTHOPAEDIC RESEARCH[J]. 2013, 31(1): 164-172, https://www.webofscience.com/wos/woscc/full-record/WOS:000311568700023.
[57] Wang, Nan, Wang, Xinluan, Cheng, Wenxiang, Cao, Huijuan, Zhang, Peng, Qin, Ling. Puerarin promotes osteogenesis and inhibits adipogenesis in vitro. CHINESE MEDICINE[J]. 2013, 8(1): 17-17, http://dx.doi.org/10.1186/1749-8546-8-17.
[58] Xin-Luan Wang. Dual effects of puerarin on promoting osteogenesis and inhibiting adipogenesis-an in vitro efficacy and mechanistic study.. Chinese Medicine. 2013, [59] Cheng, Wenxiang, Yue, Ye, Fan, Wenbin, Hu, Yiping, Wang, Xinluan, Pan, Xiaohua, Zhou, Xiaoxiao, Qin, Ling, Zhang, Peng. Effects of tetracyclines on bones: an ambiguous question needs to be clarified. PHARMAZIEnull. 2012, 67(5): 457-459, [60] Cao, HuiJuan, Tan, RuiRong, He, RongRong, Tang, LuPing, Wang, XinLuan, Yao, Nan, Duan, WenJun, Hu, YuanAo, Yao, XinSheng, Kurihara, Hiroshi. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE[J]. 2012, 2012: https://doaj.org/article/8b62a65f7993475486e51c65609d0fb8.
[61] Chen, S H, Wang, X L, Xie, X H, Zheng, L Z, Yao, D, Wang, D P, Leng, Y, Zhan, G, Qin, L. Comparative study of osteogenic potential of a composite scaffold incorporating either endogenous bone morphogenetic protein-2 or exogenous phytomolecule icaritin: An in vitro efficacy study. ACTA BIOMATERIALIA[J]. 2012, 8(8): 3128-3137, http://dx.doi.org/10.1016/j.actbio.2012.04.030.
[62] Xie, XinHui, Wang, XinLuan, He, YiXin, Liu, Zhong, Sheng, Hui, Zhang, Ge, Qin, Ling. Promotion of bone repair by implantation of cryopreserved bone marrow-derived mononuclear cells in a rabbit model of steroid-associated osteonecrosis. ARTHRITIS AND RHEUMATISM[J]. 2012, 64(5): 1562-1571, https://www.webofscience.com/wos/woscc/full-record/WOS:000303239000048.
[63] Yao, Dong, Xie, XinHui, Wang, XinLuan, Wan, Chao, Lee, YukWai, Chen, ShiHui, Pei, DuanQing, Wang, YiXiang, Li, Gang, Qin, Ling. Icaritin, an Exogenous Phytomolecule, Enhances Osteogenesis but Not Angiogenesis-An In Vitro Efficacy Study. PLOS ONE[J]. 2012, 7(8): https://doaj.org/article/f4a61fe0faac4fffb92bb09263b32947.
[64] Xin-Luan Wang. Exogenous Phytoestrogenic Molecule Icaritin Incorporated into a Porous Scaffold for Enhancing Bone Defect Repair.. 2012, [65] Wang, Y B, Xie, X H, Li, H F, Wang, X L, Zhao, M Z, Zhang, E W, Bai, Y J, Zheng, Y F, Qin, L. Biodegradable CaMgZn bulk metallic glass for potential skeletal application. ACTA BIOMATERIALIA[J]. 2011, 7(8): 3196-3208, http://dx.doi.org/10.1016/j.actbio.2011.04.027.
[66] Chen, WenFang, Mok, SaoKeng, Wang, XinLuan, Lai, KaHang, Lai, WanPing, Luk, HonKit, Leung, PingChung, Yao, XinSheng, Wong, ManSau. Total flavonoid fraction of the Herba epimedii extract suppresses urinary calcium excretion and improves bone properties in ovariectomised mice. BRITISH JOURNAL OF NUTRITION[J]. 2011, 105(2): 180-189, https://www.webofscience.com/wos/woscc/full-record/WOS:000287602800003.
[67] Xin-Luan Wang. Triterpenoid saponins from Dipsacus asperoides and their activity research in vitro. Journal of Asian Natural Products Research. 2011, [68] Wang Xinluan, Zhen Lizhen, Zhang Ge, Wong ManSau, Qin Ling, Yao Xinsheng. Osteogenic effects of flavonoid aglycones from an osteoprotective fraction of Drynaria fortunei-An in vitro efficacy study. PHYTOMEDICINE[J]. 2011, 18(10): 868-872, http://dx.doi.org/10.1016/j.phymed.2011.01.022.
[69] Tu, Fengjuan, Dai, Yi, Yao, Zhihong, Wang, Xinluan, Yao, Xinsheng, Qin, Ling. Flavonol Glycosides from Epimedium pubescens. CHEMICAL & PHARMACEUTICAL BULLETIN[J]. 2011, 59(11): 1317-1321, https://www.webofscience.com/wos/woscc/full-record/WOS:000296300900001.
[70] Xie, X H, Wang, X L, Zhang, G, Liu, Z, Yao, D, Hung, L K, Hung, V W Y, Qin, L. Impaired bone healing in rabbits with steroid-induced osteonecrosis. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME[J]. 2011, 93B(4): 558-565, https://www.webofscience.com/wos/woscc/full-record/WOS:000289311000025.
[71] Xin-Luan Wang. Promoted repair of steroid-associated osteonecrosis by implantation of cryopreserved bone marrow mononuclear cells in a rabbit model. Arthritis and Rheumatism. 2011, [72] Xin-Luan Wang. Phenylpropanoid and flavonoids from osteoprotective fraction of Drynaria fortune. Nature Product Research. 2010, [73] Xin-Luan Wang. Icariin protects against bone loss induced by oestrogen de?ciency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells. British Journal of Pharmacology. 2010, [74] , 王新峦. A New Compound with Anti-oxidative Activity from Seeds of Jatropha curcas. 中草药:英文版. 2010, http://lib.cqvip.com/Qikan/Article/Detail?id=1002074515.
[75] Xie, XinHui, Wang, XinLuan, Zhang, Ge, He, YiXin, Wang, XiaoHong, Liu, Zhong, He, Kai, Peng, Jiang, Leng, Yang, Qin, Ling. Structural and degradation characteristics of an innovative porous PLGA/TCP scaffold incorporated with bioactive molecular icaritin. BIOMEDICAL MATERIALS[J]. 2010, 5(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000282277300010.
[76] Pang, WaiYin, Wang, XinLun, Mok, SauKeng, Lai, WanPing, Chow, HungKay, Leung, PingChung, Yao, XinSheng, Wong, ManSau. Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2010, 159(8): 1693-1703, https://www.webofscience.com/wos/woscc/full-record/WOS:000276127000014.
[77] Kai, He, Wang, Xinluan, Madhukar, Kumta Shekhar, Qin, Ling, Yan, Yongnian, Zhang, Renji, Wang, Xiaohong. Fabrication of a two-level tumor bone repair biomaterial based on a rapid prototyping technique. BIOFABRICATION[J]. 2009, 1(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000278082400005.
[78] Jiang, Fang, Wang, XinLuan, Wang, NaiLi, Yao, XinSheng. Two new flavonol glycosides from Epimedium koreanum Nakai. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2009, 11(5): 401-409, https://www.webofscience.com/wos/woscc/full-record/WOS:000266720100003.
[79] Peng Songlin, Zhang Ge, He Yixin, Wang Xinluan, Leung Pingchung, Leung Kwoksui, Qin Ling. Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone. BONE[J]. 2009, 45(3): 534-544, http://dx.doi.org/10.1016/j.bone.2009.05.022.
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科研活动

   
科研项目
( 1 ) VEFG-Src信号阻断预防激素性骨坏死性骨修复的基础研究, 参与, 国家任务, 2012-01--2015-12
( 2 ) PLGA/TCP/Icariin复合骨生物材料制备及生物性能评估, 参与, 地方任务, 2011-01--2012-12
( 3 ) 预防骨质疏松中药“仙灵骨葆胶囊”的二次开发, 参与, 国家任务, 2011-01--2013-12
( 4 ) 基于新型快速成型技术构建的活性骨修复材料修复难治愈性骨缺损的研究, 参与, 国家任务, 2013-02--2016-01
( 5 ) GSK-3β/β-catenin信号通路介导的淫羊藿素预防绝经后骨质疏松的机制研究, 负责人, 国家任务, 2014-01--2016-12
( 6 ) 含中药分子的递送系统治疗骨性关节炎的研究, 负责人, 国家任务, 2015-05--2018-04
( 7 ) 含有葛根素的新型医用生物支架用以修复骨关节炎中骨软骨缺损的研究, 负责人, 地方任务, 2015-08--2017-08
( 8 ) 祛风止痛胶囊预防去势大鼠骨质疏松的研究, 负责人, 企业委托, 2016-02--2018-06
( 9 ) 颈舒颗粒在颈椎病的药理作用研究, 负责人, 企业委托, 2015-07--2017-07
( 10 ) 具有骨关节修复与保健功能的活性物质研发, 负责人, 企业委托, 2015-08--2017-12
( 11 ) 生物活性节段骨缺损修复体的研制, 参与, 国家任务, 2016-07--2020-12
( 12 ) 仙灵骨葆通过雄激素信号通路增强骨骼肌功能的物质基础和作用机制研究, 负责人, 国家任务, 2018-01--2021-12
( 13 ) 高脂血症分子机制及药学评估平台, 参与, 地方任务, 2017-07--2020-06
( 14 ) 骨关节肌肉疾病研究联合实验室, 负责人, 企业委托, 2020-07--2026-06
( 15 ) 含中药分子的新型仿生支架促进关节炎中骨软骨再生的研究, 负责人, 地方任务, 2020-08--2022-07
( 16 ) 中药石杉碱甲衍生物二聚体用于骨软骨修复和再生, 负责人, 国家任务, 2021-08--2023-07
( 17 ) 朝藿定C治疗关节炎的作用及机制研究, 负责人, 地方任务, 2021-10--2024-09
( 18 ) 基于“益气补血”理论探讨当归补血汤治疗气血虚弱型膝骨关节炎的物质基础及作用机制, 负责人, 地方任务, 2021-10--2024-09
参与会议
(1)股骨头骨坏死实验动物模型   第10届中国骨科医师年会   2017-05-12
(2)Epimedium-Derived Flavonoids Reduce Incidence of Steroid-Associated Osteonecorsis via Their Metabolite(s) in vivo   第一届国际华人骨研学会(ICMRS)-美国骨矿研究学会(ASBMR)国际华人骨科研究大会    Wang Xinluan, Zheng Lizhen, Wang Nan, Cao Huijuan, Zhang Ge, Qin Ling   2013-05-22

指导学生

已指导学生

李烨  硕士研究生  083100-生物医学工程  

现指导学生

曹会娟  博士研究生  071010-生物化学与分子生物学  

高必敏  硕士研究生  086000-生物与医药