Tian-Sheng Mei; Shanghai Institute of Organic Chemistry
Telephone: 021-54925326
Address: Shanghai Lingling Road 345
Postcode:  200032

Research Areas

Organometallic Chemistry; Electrochemistry; CO2 fixation; C-H functionalization; Asymmetric Catalysis


1997-2001, Lanzhou University (B. S.), Supervisor: Prof. Yu-Lin Li

2005-2007, Brandeis University (M.S), Supervisor: Prof. Jin-Quan Yu

2007-2012, The Scripps Research Institute (Ph.D), Supervisor: Prof. Jin-Quan Yu

2012-2014, The University of Utah (Post-doc), Supervisor: Prof. Matt Sigman

Honors & Distinctions

·         “Thieme Chemistry Journals Award”, 2016

·         “Shanghai Pujiang Talent Plan”, 2015

·         Travel Award, University of Utah, 2013

·         Chinese Government Award for Outstanding Self-Financed Students Abroad, 2009

·         Best Poster in Chemistry Award-TSRI Symposium, 2009


1.Yang, Q.-L.; Wang, X. Y.; Weng, X.-J.; Yang, X.; Xu, X.-T.; Tong, X.; Fang, P.; Wu, X.-Y.; Mei, T.-S. “Palladium-Catalyzed ortho-Selective C–H Chlorination of Arenes Using Anodic Oxidation” Acta Chim. Sinica 201977, 866873. 

2.Sun, X.; Ma, H.-X.; Mei, T.-S.; Fang, P.; Hu, Y. “Elecrochemical Radical Formyloxylation–Bromination, –Chlorination, and –Trifluoromethylation of Alkenes. Org. Lett.  2019, 21, 3167–3171.

3.Yang, Q.-L.; Wang, X. Y.; Wang, T.-L.; Yang, X.; Liu, D.; Tong, X.; Wu, X.-Y.; Mei, T.-S. “Palladium-Catalyzed Electrochemical C–H Bromination Using NH4Br as the Brominating Reagent” Org. Lett. 201921, 2645–2649.

4.Ma, C.; Zhao, C.-Q.; Xu, X.-T.; Li, Z.-M.; Wang, X.-Y.; Zhang, K.; Mei, T.-S. Nickel-Catalyzed Carboxylation of Aryl and Heteroaryl Fluorosulfates Using Carbon Dioxide. Org. Lett.  201921, 2464–2467.

5.Zhao, C.-Q.; Chen, Y.-G.; Qiu, H. Wei, L.; Fang, P.; Mei, T.-S. “Water as a Hydrogenating Agent: Stereodivergent Pd-Catalyzed Semihydrogenation of Alkynes” Org. Lett. 2019, 21, 1412–1416.

6.Chen, Y.-G.; Shuai, B.; Xu, X.-T.; Li, Y.-Q.; Yang, Q.-L.; Qiu, H.; Zhang, K. Fang, P.; Mei, T.-S. “Nickel-catalyzed Enantioselective Hydroarylation and Hydroalkenylation of Styrenes” J. Am. Chem. Soc. 2019141, 3395–3399.

7.Liu, D.; Ma, H.-X.; Fang, P.; Mei, T.-S. “Nickel-Catalyzed Thiolation of Aryl Halides and Heteroaryl Halides via Electrochemistry” Angew. Chem. Int. Ed. 201958, 5033–5037.

8.Yang, Q.-L.; Li, C.-Z.; Zhang, L.-W.; Li, Y.-Y.; Tong, X.; Wu, X.-Y.; Mei, T.-S. “Palladium-Catalyzed Electrochemical C−H Alkylation of Arenes” Organometallics 2019, 38, 1208–1212.

9.Yang, Q.-L.; Wang, X.-Y.; Lu, J.-Y.; Zhang, L.-P.; Fang, P.; Mei, T.-S. “Copper-Catalyzed Electrochemical C–H Functionalization of Arenes with Secondary Amines” J. Am. Chem. Soc. 2018, 140, 1148711494.

10.Ma, C.; Fang, P.; Mei, T.-S. “Recent Advances in C–H Functionalization Using Electrochemical Transition Metal Catalysis” ACS. Catal. 2018, 8, 7179–7189.

11.Jiao, K.-J.; Li, Z.-M.; Xu, X.-T.; Zhang, L.-P.; Li, Y.-Q.; Zhang, K.; Mei, T.-S. “Palladium-catalyzed reductive electrocarboxylation of allyl esters with carbon dioxide” Org. Chem. Front. 2018, 5, 2244–2248.

12.Chen, Y.-G.; Xu, X.-T.; Zhang, K.; Li, Y.-Q.; Zhang, L.-P.; Fang, P.; Mei, T.-S. “Transition-Metal-Catalyzed Carboxylation of Organic Halides and Their Surrogates with Carbon Dioxide” Synthesis 2018, 50, 35–48.

13.Yang, Q.-L.; Fang, P.; Mei, T.-S. “Recent Advances in Organic Electrochemical C–H Functionalization” Chin. J. Chem. 2018, 36, 338–352.

14.Chen, Y.-G.; Shuai, B.; Ma, C.; Zhang, X.-J.; Fang, P.; Mei, T.-S. “Regioselective Ni-Catalyzed Carboxylation of Allylic and Propargylic Alcohols with Carbon Dioxide” Org. Lett. 2017, 19, 2969–2972.

15.Li, Y.-Q.; Yang, Q.-L.; Fang, P.; Mei, T.-S.; Zhang, D. “Palladium-Catalyzed C(sp2)–H Acetoxylation via Electrochemical Oxidation” Org. Lett. 2017, 19, 2905–2908.

16.Ma, C.; Zhao, C.-Q.; Li, Y.-Q.; Zhang, L.-P.; Xu, X.-T.; Zhang, K.; Mei, T.-S. “Palladium-catalyzed C–H activation/C–C cross-coupling reactions via electrochemistry” Chem. Commun. 2017, 53, 12189–12192.

17.Jiao, K.-J.; Zhao, C.-Q.; Fang, P.; Mei, T.-S. “Palladium-catalyzed C–H functionalization with electrochemical oxidation” Tetrahedron Lett. 2017, 58, 797–802.

18.Yang, Q.-L.; Li, Y.-Q.; Ma, C.; Fang, P.; Zhang, X.-J.; Mei, T.-S. “Palladium-Catalyzed C(sp3)–H Oxygenation via Electrochemical Oxidation” J. Am. Chem. Soc. 2017, 139, 3293–3298.

19.Liu, T.; Mei, T.-S.; Yu, J.-Q. “gamma, delta, epsilon-C(sp3)–H Functionalization through Directed Radical H-Abstraction” J. Am. Chem. Soc. 2015, 137, 5871–5874.

20.Mei, T.-S.; Patel, H. H.; Sigman, M. S. “Enantioselective construction of remote quaternary stereocentres” Nature 2014, 508, 340–344.

21.Mei, T.-S.; Werner, E. W.; Burckle, A. J.; Sigman, M. S. “Enantioselective Redox-Relay Oxidative Heck Arylations of Acyclic Alkenyl Alcohols using Boronic Acids” J. Am. Chem. Soc. 2013, 135, 6830–6833.

22.Mei, T.-S.; Leow, D.; Xiao, H.; Laforteza, B.; Yu, J.-Q. “Synthesis of Indolines via Pd(II)-Catalyzed Amination of C–H Bonds” Org. Lett. 2013, 15, 3058–3061.

23.Werner, E. W.; Mei, T.-S.; Burckle, A. J.; Sigman, M. S. “Enantioselective Heck Arylations of Acyclic Alkenyl Alcohols Using a Redox-Relay Strategy” Science 2012, 338, 1455–1458.

24.Leow, D.; Li, G.; Mei, T.-S.; Yu, J.-Q. “Activation of remote meta-C–H Bonds assisted by an 'end-on' template” Nature 2012, 486, 518–522.

25.Mei, T.-S.; Kou, L.; Engle, K. M.; Yu, J.-Q. “Heterocycle Formation via Palladium-Catalyzed C–H Funtionalization” Synthesis 2012, 44, 1778–1791.

26.Engle, K. M.; Mei, T.-S.; Wasa, M.; Yu, J.-Q. “Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions” Acc. Chem. Res. 2012, 45, 788–802.

27.Engle, K. M.; Mei, T.-S.; Wang, X.; Yu, J.-Q. “Bystanding F+ Oxidants Enable Selective Reductive Elimination from High-Valent Metal Centers in Catalysis” Angew. Chem. Int. Ed. 2011, 50, 1478–1491.

28.Yoo, E. J.; Ma, S.; Mei, T.-S.; Chan, K.; Yu, J.-Q. “Pd(II)-Catalyzed Intermolecular C–H Amination with Alkylamine Surrogates” J. Am. Soc. Chem. 2011, 133, 7652–7655.

29.Mei, T.-S.; Wang, D.-H.; Yu, J.-Q. “Expedient Drug Synthesis and Diversification via ortho-C–H Iodination Using Recyclable PdI2 as the Precatalyst” Org. Lett. 2010, 12, 3140–3143.

30.Vikers, C. J.; Mei, T.-S.; Yu, J.-Q. “Pd(II)-Catalyzed o-C–H Acetoxylation of Phenylalanine and Ephedrine Derivatives with MeCOOOtBu/Ac2O” Org. Lett. 2010, 12, 2511–2513.

31. Mei, T.-S.; Wang, X.; Yu, J.-Q. “Pd(II)-Catalyzed Amination of C–H Bonds Using Single-Electron or Two-Electron Oxidants” J. Am. Chem. Soc. 2009, 131, 10806–10807.

32.Wang, X.; Mei, T.-S.; Yu, J.-Q. “Versatile Pd(OTf)2•2H2O-Catalyzed ortho-Fluorination Using NMP as a Promoter” J. Am. Chem. Soc. 2009, 131, 7520–7521.

33.Wang, D.-H.; Mei, T.-S.; Yu, J.-Q. “Versatile Pd(II)-Catalyzed C−H Activation/Aryl−Aryl Coupling of Benzoic and Phenyl Acetic AcidsJ. Am. Chem. Soc. 2008, 130, 17676–17677.

34.Li, J.-J.; Mei, T.-S.; Yu, J.-Q. “Synthesis of Indolines and Tetrahydroisoquinolines from Arylethylamines by PdII-Catalyzed C–H Activation ReactionsAngew. Chem. Int. Ed. 2008, 47, 6452–6455.

35.Mei, T.-S.; Giri, R.; Maugel, N.; Yu, J.-Q. “PdII-Catalyzed Monoselective ortho-Halogenation of C–H Bonds Assisted by Counter Cations: a Complementary Method to Directed ortho-Lithiation” Angew. Chem. Int. Ed. 2008, 47, 5215–5219. 

Research Interests

CO2 utilization; organometallic electrochemistry; C-H Functionalization


Collaborate with Prof. Matt Sigman (The University of Utah)



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