1964-09--1969-03   第四军医大学   学士

   

1980-03~2016-05,首都医科大学附属天坛医院, 住院医、主治医、副主任医、主任医
1975-03~1980-03,首都医科大学附属宣武医院, 住院医师
1969-03~1975-03,505医院, 军医
1964-09~1969-03,第四军医大学, 学士

2018-10-01-今,北京脑科学与类脑研究中心, 专家委员会副主任
2018-04-01-今,北京大学医学部神经外科学学系, 名誉主任委员
2018-02-01-2023-02-28,首都医科大学神经外科学院, 院长
2017-09-01-今,香港外科医学院, 荣誉院士
2015-03-06-今,中华神经外科杂志（英文）, 主编
2015-01-01-今,中国卒中学会, 会长
2013-08-06-今,国家神经系统疾病临床医学研究中心, 主任
2005-05-05-今,世界神经外科联盟（WFNS）、提名委员会, 执委、委员

临床岗位综合素质训练－职业道德与职业规范
大脑半球解剖学
职业道德与职业规范-医德讲座
研究生入学讲座－职业道德与职业规范

   

（1） 吴阶平医学奖, 一等奖, 国家级, 2018
（2） 出血性脑卒中规范化外科技术推广及其血肿扩大（HE）机制和临床预测研究, 三等奖, 省级, 2011
（3） 颅脑手术中脑认知功能保护的微创神经外科学基础研究与临床应用, 二等奖, 国家级, 2009
（4） 出血性脑卒中规范化外科技术推广及其HE机制和临床预测研究, 二等奖, 部委级, 2009
（5） 微创神经外科技术平台建立及术中神经功能保护研究, 一等奖, 省级, 2007
（6） 脑血管畸形的外科治疗及其形成和破裂出血机制的研究, 二等奖, 国家级, 2005

（ 1 ） 一种侧卧位约束带, 2023, 第 4 作者, 专利号: CN219397820U

（ 2 ） 一种CRGD序列肽修饰壳聚糖负载的PAD4抑制剂在制备抗肿瘤转移药物中的应用, 2022, 第 8 作者, 专利号: CN115518165A

（ 3 ） 一种静脉窦血流转流阻断装置, 2022, 第 3 作者, 专利号: CN217853137U

（ 4 ） 一种神经外科防误吸显微吸引器, 2022, 第 3 作者, 专利号: CN217566932U

（ 5 ） 一种脊髓电刺激治疗装置, 2022, 第 5 作者, 专利号: CN217311634U

（ 6 ） 一种肿瘤固定装置, 2022, 第 4 作者, 专利号: CN217244695U

（ 7 ） 一种可穿戴体征监测装置, 2022, 第 4 作者, 专利号: CN217218997U

（ 8 ） 微创神经牵引装置, 2022, 第 3 作者, 专利号: CN217090846U

（ 9 ） 3D打印个体化颅骨缺损保护器, 2021, 第 3 作者, 专利号: CN214857885U

（ 10 ） 一种光控定速脑脊液的引流装置及引流系统, 2021, 第 9 作者, 专利号: CN113577518A

（ 11 ） 一种红外颞浅动脉可视化手持装置, 2021, 第 7 作者, 专利号: CN214284882U

（ 12 ） 近硬脑膜动脉瘤及深部近脑实质动脉瘤手术器械套件, 2021, 第 3 作者, 专利号: CN213665584U

（ 13 ） 一种改良头皮拉钩, 2020, 第 6 作者, 专利号: CN209916085U

（ 14 ） 一种微导管, 2018, 第 3 作者, 专利号: CN207545605U

   

（1） Metabolic alterations of peripheral blood immune cells and heterogeneity of neutrophil in intracranial aneurysms patients, Clin Transl Med, 2024, 
（2） SingleCell Atlas of Atherosclerosis Patients by Cytof: Circulatory and Local Immune Disorders, Aging Dis, 2024, 
（3） Somatic PDGFRB activating variants promote smooth muscle cell phenotype modulation in intracranial fusiform aneurysm, Journal of biomedical science, 2024, 
（4） Association between methionine sulfoxide and risk of moyamoya disease, FRONTIERS IN NEUROSCIENCE, 2023, 第 13 作者  通讯作者
（5） Exosomal miR���3131 derived from endothelial cells with KRAS mutation promotes EndMT by targeting PICK1 in brain arteriovenous malformations, CNS Neuroscience & Therapeutics, 2023, 
（6） Association of RNF213 Variants With Periventricular Anastomosis in Moyamoya Disease, Stroke, 2022, 
（7） Clinical characteristics and risk factors of perioperative outcomes in elderly patients with intracranial tumors, NEUROSURGICAL REVIEW, 2021, 第 9 作者  通讯作者
（8） Viral Gene Therapy for Glioblastoma Multiforme: A Promising Hope for the Current Dilemma, FRONTIERS IN ONCOLOGY, 2021, 第 6 作者  通讯作者
（9） The CTSC-RAB38 Fusion Transcript Is Associated With the Risk of Hemorrhage in Brain Arteriovenous Malformations, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2021, 第 12 作者
（10） Hyperhomocysteinemia is a risk factor for postoperative ischemia in adult patients with moyamoya disease, NEUROSURGICAL REVIEW, 2021, 第 9 作者  通讯作者
（11） Homocysteine Level and Risk of Hemorrhage in Brain Arteriovenous Malformations, DISEASE MARKERS, 2021, 第 6 作者  通讯作者
（12） Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke, AGING AND DISEASE, 2021, 第 8 作者  通讯作者
（13） Impairment and Plasticity of Language-Related White Matter in Patients With Brain Arteriovenous Malformations, Stroke, 2021, 
（14） FAM225B Is a Prognostic lncRNA for Patients with Recurrent Glioblastoma, DISEASE MARKERS, 2020, 第 7 作者  通讯作者
（15） A Treatment Option for Symptomatic Chronic Complete Internal Carotid Artery Occlusion: Hybrid Surgery, FRONTIERS IN NEUROSCIENCE, 2020, 第 6 作者  通讯作者
（16） Response to Letter to the Editor on "Clinical Features and Surgical Outcomes of Patients With Moyamoya Disease and the Homozygous RNF213 p.R4810 K Variant", JOURNAL OF CHILD NEUROLOGY, 2020, 第 2 作者
（17） Elevated levels of adiponectin associated with major adverse cardiovascular and cerebrovascular events and mortality risk in ischemic stroke, CARDIOVASCULAR DIABETOLOGY, 2020, 第 6 作者  通讯作者
（18） Association between bilateral postoperative neoangiogenesis in patients with moyamoya disease, CLINICAL NEUROLOGY AND NEUROSURGERY, 2020, 第 10 作者  通讯作者
（19） China Stroke Statistics 2019:A Report From the National Center for Healthcare Quality Management in Neurological Diseases,China National Clinical Research Center for Neurological Diseases,the Chinese Stroke Association,National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations, China Stroke Statistics 2019: A Report From the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations, STROKE AND VASCULAR NEUROLOGY, 2020, 第 11 作者
（20） Wilms' tumour 1���associating protein inhibits endothelial cell angiogenesis by m6A���dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation, JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 第 10 作者  通讯作者
（21） Different subtypes of collateral vessels in hemorrhagic moyamoya disease with p.R4810K variant, BMC NEUROLOGY, 2020, 第 10 作者  通讯作者
（22） Clinical features, surgical treatment, and outcome of intracranial aneurysms associated with moyamoya disease, JOURNAL OF CLINICAL NEUROSCIENCE, 2020, 第 11 作者  通讯作者
（23） Mesenchymal Behavior of the Endothelium Promoted by SMAD6 Downregulation Is Associated With Brain Arteriovenous Malformation Microhemorrhage, STROKE, 2020, 第 12 作者
（24） Digital subtraction angiographic characteristics of progression of moyamoya disease 6 months prior to surgical revascularisation, Digital subtraction angiographic characteristics of progression of moyamoya disease 6 months prior to surgical revascularisation, STROKE AND VASCULAR NEUROLOGY, 2020, 第 10 作者  通讯作者
（25） Postoperative collateral formation after indirect bypass for hemorrhagic moyamoya disease, BMC NEUROLOGY, 2020, 第 10 作者  通讯作者
（26） Modifiable Risk Factors Associated With Moyamoya Disease A Case-Control Study, STROKE, 2020, 第 10 作者  通讯作者
（27） Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations, DISEASE MARKERS, 2020, 第 6 作者  通讯作者
（28） Association between p.R4810K Variant and Postoperative Collateral Formation in Patients with Moyamoya Disease, CEREBROVASCULAR DISEASES, 2019, 第 10 作者  通讯作者
（29） RNA Sequencing Reveals the Activation of Wnt Signaling in Low Flow Rate Brain Arteriovenous Malformations, JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2019, 第 10 作者
（30） 颅内动静脉畸形手术评估工具的研究进展, @@, 中华神经外科杂志, 2019, 第 3 作者
（31） Association Between p.R4810K Variant and Long-Term Clinical Outcome in Patients With Moyamoya Disease, FRONTIERS IN NEUROLOGY, 2019, 第 9 作者  通讯作者
（32） Cranioplasty after decompressive craniectomy in hemorrhagic moyamoya disease, JOURNAL OF CLINICAL NEUROSCIENCE, 2019, 第 10 作者  通讯作者
（33） Insulin resistance as estimated by homeostasis model assessment predicts incident post-stroke depression in Chinese subjects from ischemic stroke, JOURNAL OF AFFECTIVE DISORDERS, 2018, 第 5 作者  通讯作者
（34） An immune-related lncRNA signature for patients with anaplastic gliomas, JOURNAL OF NEURO-ONCOLOGY, 2018, 第 11 作者  通讯作者
（35） Neurosurgical management of cavernous malformations located at the foramen of Monro, NEUROSURGICAL REVIEW, 2018, 第 7 作者  通讯作者
（36） Decreased Concentration of Irisin Is Associated with Poor Functional Outcome in Ischemic Stroke, NEUROTHERAPEUTICS, 2018, 第 6 作者  通讯作者
（37） Long noncoding RNA LINC00152 is a potential prognostic biomarker in patients with high���grade glioma, CNS NEUROSCIENCE & THERAPEUTICS, 2018, 第 9 作者  通讯作者
（38） Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population, JOURNALOFNEUROINFLAMMATION, 2018, 第 5 作者  通讯作者
（39） A Novel Staging System to Evaluate Cerebral Hypoperfusion in Patients With Moyamoya Disease, STROKE, 2018, 第 7 作者  通讯作者
（40） Surgical management of giant intrapetrous internal carotid aneurysm presenting with coil exposure after endovascular treatment, NEUROSURGICAL REVIEW, 2018, 第 4 作者  通讯作者
（41） The pathogenesis shared between abdominal aortic aneurysms and intracranial aneurysms: a microarray analysis, NEUROSURGICAL REVIEW, 2018, 第 10 作者  通讯作者
（42） Bioinformatic analysis of gene expression and methylation regulation in glioblastoma, JOURNAL OF NEURO-ONCOLOGY, 2018, 第 7 作者  通讯作者
（43） Disorders of Consciousness in China, Disorders of Consciousness in China, 神经科学通报：英文版, 2018, 第 1 作者
（44） Clinical features and neurosurgical treatment of trigonal cavernous malformations, NEUROSURGICAL REVIEW, 2018, 第 6 作者  通讯作者
（45） Expression profile of long noncoding RNAs in human cerebral aneurysms: a microarray analysis, JOURNAL OF NEUROSURGERY, 2017, 第 9 作者  通讯作者
（46） Integrated Analysis of LncRNA-mRNA Co-Expression Profiles in Patients with Moyamoya Disease, SCIENTIFIC REPORTS, 2017, 第 10 作者  通讯作者
（47） Ischemic Stroke in Young Adults with Moyamoya Disease: Prognostic Factors for Stroke Recurrence and Functional Outcome after Revascularization, WORLD NEUROSURGERY, 2017, 第 8 作者  通讯作者
（48） Comparison of Stroke Prediction Accuracy of ABCD2 and ABCD3-I in Patients with Transient Ischemic Attack: A Meta-Analysis, JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES, 2017, 第 6 作者
（49） Altered expression of circular RNAs in Moyamoya disease, JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 第 11 作者
（50） Steroid sulfatase and filaggrin mutations in a boy with severe ichthyosis, elevated serum IgE level and moyamoya syndrome, GENE, 2017, 第 12 作者  通讯作者
（51） Adolescents with moyamoya disease: clinical features, surgical treatment and long-term outcomes, ACTA NEUROCHIRURGICA, 2017, 第 8 作者  通讯作者
（52） The Collateral Circulation in Moyamoya Disease: A Single-Center Experience in 140 Pediatric Patients, PEDIATRIC NEUROLOGY, 2017, 第 6 作者  通讯作者
（53） Identification of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Intracranial Aneurysm, WORLD NEUROSURGERY, 2017, 第 7 作者  通讯作者
（54） VITAMIN D STATUS AND THE RISK OF RECURRENT STROKE AND MORTALITY IN ISCHEMIC STROKE PATIENTS: DATA FROM A 24-MONTH FOLLOW-UP STUDY IN CHINA, JOURNAL OF NUTRITION HEALTH & AGING, 2017, 
（55） Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review, CHILDS NERVOUS SYSTEM, 2017, 第 8 作者  通讯作者
（56） DNA Methylation Regulates Gene Expression in Intracrianial Aneurysms, World Neurosurgery, 2017, 第 1 作者  通讯作者
（57） Portable near-infrared rapid detection of intracranial hemorrhage in Chinese population, JOURNAL OF CLINICAL NEUROSCIENCE, 2017, 第 11 作者  通讯作者
（58） Comparison between smaller ruptured intracranial aneurysm and larger un-ruptured intracranial aneurysm: gene expression profile analysis, NEUROSURGICAL REVIEW, 2017, 第 8 作者  通讯作者
（59） Aberrant expression of lncRNAs and mRNAs in patients with intracranial aneurysm, ONCOTARGET, 2017, 第 10 作者  通讯作者
（60） The Association of the RNF213 p.R4810K Polymorphism with Quasi-Moyamoya Disease and a Review of the Pertinent Literature, WORLD NEUROSURGERY, 2017, 第 15 作者  通讯作者
（61） RNF213 as the major susceptibility gene for Chinese patients with moyamoya disease and its clinical relevance, JOURNAL OF NEUROSURGERY, 2017, 第 12 作者  通讯作者
（62） Clinical Features of Hemorrhagic Moyamoya Disease in China, WORLD NEUROSURGERY, 2017, 第 11 作者
（63） Transient Ischemic Attack in Pediatric Patients With Moyamoya Disease: Clinical Features, Natural History, and Predictors of Stroke, PEDIATRIC NEUROLOGY, 2017, 第 6 作者  通讯作者
（64） Giant Intracranial Aneurysms: Surgical Treatment and Analysis of Risk Factors, WORLD NEUROSURGERY, 2017, 第 10 作者  通讯作者
（65） Clinical Characteristics and Natural History of Quasi-Moyamoya Disease, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2017, 第 11 作者  通讯作者
（66） Comparison of 7.0-and 3.0-T MRI and MRA in ischemic-type moyamoya disease: preliminary experience, JOURNAL OF NEUROSURGERY, 2016, 第 10 作者  通讯作者
（67） Clinical and Angiographic Features of Patients with Moyamoya Disease and the p.R4810K Heterozygous Variant, WORLD NEUROSURGERY, 2016, 第 7 作者  通讯作者
（68） Prediction of pediatric meningioma recurrence by preoperative MRI assessment, NEUROSURGICAL REVIEW, 2016, 第 5 作者  通讯作者
（69） Prediction of High-Grade Pediatric Meningiomas: Magnetic Resonance ImagingFeatures Based on T1-Weighted, T2-Weighted, and Contrast-Enhanced T1-WeightedImages, WORLD NEUROSURGERY, 2016, 第 11 作者
（70） Symptomatic large or giant capillary telangiectasias: management and outcome in 5 cases, JOURNAL OF NEUROSURGERY, 2016, 第 9 作者  通讯作者
（71） Comparative proteome analysis of saccular intracranial aneurysms with iTRAQ quantitative proteomics, JOURNAL OF PROTEOMICS, 2016, 第 5 作者  通讯作者
（72） Role of Ring Finger Protein 213 in Moyamoya Disease, Role of Ring Finger Protein 213 in Moyamoya Disease, 中华医学杂志：英文版, 2016, 第 4 作者
（73） Antiplatelet Agents for the Secondary Prevention of Ischemic Stroke or Transient Ischemic Attack: A Network Meta-Analysis, JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES, 2016, 第 6 作者
（74） Differential long non-coding rna and mrna expression in differentiated human glioblastoma stem cells, MOLECULAR MEDICINE REPORTS, 2016, 第 10 作者  通讯作者
（75） Difference of language cortex reorganization between cerebral arteriovenous malformations, cavernous malformations, and gliomas: a functional MRI study Comments, NEUROSURGICAL REVIEW, 2016, 
（76） Long Noncoding RNAs and Their Regulatory Network: Potential Therapeutic Targets for Adult Moyamoya Disease, WORLD NEUROSURGERY, 2016, 第 6 作者  通讯作者
（77） LncRNA profile study reveals four-lncRNA signature associated with the prognosis of patients with anaplastic gliomas, ONCOTARGET, 2016, 第 13 作者  通讯作者
（78） Clinical Features and Long-Term Outcomes of Unilateral Moyamoya Disease, WORLD NEUROSURGERY, 2016, 第 16 作者  通讯作者
（79） MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression, MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression, 生物医学与环境科学：英文版, 2015, 第 10 作者
（80） Comparison of language cortex reorganization patterns between cerebral arteriovenous malformations and gliomas: a functional MRI study, JOURNAL OF NEUROSURGERY, 2015, 第 10 作者  通讯作者
（81） Clinical features and long-term outcomes of moyamoya disease: a single-center experience with 528 cases in China, JOURNAL OF NEUROSURGERY, 2015, 第 10 作者  通讯作者
（82） Multiple Cerebral Myxomatous Aneurysms: What Is the Optimal Treatment?, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2015, 第 6 作者
（83） A comparative study of 43 patients with mirror-like intracranial aneurysms: risk factors, treatment, and prognosis, NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2014, 
（84） Intracranial hemorrhage from moyamoya disease during pregnancy and puerperium, INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2014, 第 9 作者  通讯作者
（85） Gene expression profiles in intracranial aneurysms, NEUROSCIENCE BULLETIN, 2014, 第 7 作者  通讯作者
（86） Carotid Endarterectomy with Stent Removal in Management of In-stent Restenosis: A Safe, Feasible, and Effective Technique European, european Journal of Vascular and Endovascular Surgery, 2014, 第 1 作者  通讯作者
（87） Risk of cerebral arteriovenous malformation rupture during pregnancy and puerperium, NEUROLOGY, 2014, 第 11 作者  通讯作者
（88） Accuracy of Vessel-Encoded Pseudocontinuous Arterial Spin-Labeling in Identification of Feeding Arteries in Patients with Intracranial Arteriovenous Malformations, AMERICAN JOURNAL OF NEURORADIOLOGY, 2014, 
（89） Different Grading Scales for Spontaneous Subarachnoid Hemorrhage and Health-Related Quality Evaluations, WORLD NEUROSURGERY, 2013, 第 3 作者  通讯作者

（ 1 ） 血管神经外科学, 人民卫生出版社, 2013-04, 第 1 作者
（ 2 ） 临床诊疗指南神经外科分册, 人民卫生出版社, 2013-10, 第 1 作者
（ 3 ） 神经外科手册, 江苏科学技术出版社, 2013-10, 第 1 作者
（ 4 ） 神经外科学第三版, 人民卫生出版社, 2014-08, 第 1 作者
（ 5 ） 神经外科学科发展报告, 中国科学技术出版社, 2016-04, 第 1 作者
（ 6 ） 颅脑创伤第二卷, 湖北科学技术出版社, 2016-11, 第 1 作者
（ 7 ） 神经外科手术精要与并发症（第2版）, 北京大学医学出版社, 2017-08, 第 1 作者
（ 8 ） 神经外科手册（第八版）, 江苏凤凰科学技术出版社, 2017-08, 第 1 作者
（ 9 ） 神经外科手册快速复习, 江苏凤凰科学技术出版社, 2018-07, 第 1 作者
（ 10 ） 《中华医学百科全书神经外科学》, 中国协和医科大学出版社, 2020-01, 第 1 作者
（ 11 ） 《颅脑肿瘤外科学（第二版）》, 人民卫生出版社, 2020-10, 第 1 作者
（ 12 ） 《神经外科手册》第9版, 江苏凤凰科学技术出版社, 2021-05, 第 其他 作者

   

（ 1 ） 神经外科高灵巧性智能化数字显微镜关键技术研究, 负责人, 地方任务, 2023-11--2026-12
（ 2 ） 神经再生胶原支架移植治疗脊髓损伤临床转化研究, 负责人, 国家任务, 2019-01--2023-12
（ 3 ） 复合手术治疗多种危险因素并存的复杂性脑血管病的临床研究, 负责人, 地方任务, 2016-01--2019-12
（ 4 ） 医管局使命计划, 负责人, 地方任务, 2016-01--2019-12
（ 5 ） 缺血性脑血管病和脑肿瘤防治关键技术研究, 负责人, 国家任务, 2015-04--2017-12
（ 6 ） 脑肿瘤和脑血管病临床诊疗关键技术的研发应用与推广, 负责人, 国家任务, 2014-01--2016-12

（1）Intraoperative angiography in treatment of neurovascular disorders   2019-02-05
（2）Combined Surgical and Endovascular Treatment of Cerebral Arteriovenous Malformations in the Hybrid Operating Room   2018-04-28
（3）Effects of Different Surgical Modalities on Clinical Outcome of Moyamoya Disease: A Prospective Cohort Study   美国神经外科医师年会   2017-10-07
（4）Combined Surgery and Endovascular Treatment of AVM in the Hybrid Operating Room   美国Dandy神经外科学会第六次年会   2017-10-02
（5）Combined surgical and endovascular treatment of cerebral arteriovenous malformations in the hybrid operating room   日本神经外科年会   赵继宗   2016-10-02
（6）Clinical features and long-term outcomes of 528 patients with moyamoya disease(MMD)   美国神经外科年会   赵继宗   2016-04-30