基本信息
顾建文  男  博导  解放军第306医院
电子邮件: 2914081083@qq.com
通信地址: 北京市朝阳区安翔北里7号
邮政编码: 100226

教育背景

2000-09--2003-07   西安交通大学   博士
1983-09--1989-07   第四军医大学 空医系   硕士

工作经历

   
工作简历
2018-11~现在, 战略支援部队特色医学中心, 主任
2015-06~2018-10,解放军第306医院, 院长
2014-04~2015-07,解放军空军总医院, 副院长
2007-06~2014-04,成都军区总医院, 副院长
2003-06~2007-06,成都军区总医院神经外科, 主任
2000-09~2003-07,西安交通大学, 博士
1983-09~1989-07,第四军医大学 空医系, 硕士
社会兼职
2018-04-27-今,北京大学医学部神经外科学学系, 副主任委员
2017-09-01-今,中国医院协会, 理事
2015-12-01-2020-12-31,中华医学会第二十五届理事会, 理事
2015-09-23-今,中国研究型医院协会卫生应急专业委员, 常务副主任委员
2011-10-01-今,中央军委保健委员会, 委员
2011-07-01-今,中国医师协会神经外科医师分会, 委员
2008-09-01-今,中华医学会创伤学分会, 副组长
2006-03-01-今,全军神经外科专业委员会, 副主任委员

教授课程

颈椎病防护
加强“脑控”智能驱动武器研究
生物医用材料应用及前景

专利与奖励

   
奖励信息
(1) 颅脑创伤后过度兴奋应激损害的机制及防护基础研究, 一等奖, 省级, 2014
专利成果
( 1 ) 一种半面罩呼吸器、舒适型医用一次性防护服, 2021, 第 1 作者, 专利号: CN202022268264.9

( 2 ) 一种内置眼镜主视跟踪系统的角膜接触电极及工作方法, 2020, 第 2 作者, 专利号: 201910150034.1

( 3 ) 一种能同时测量瞳孔大小的角膜接触电极及工作方法, 2020, 第 2 作者, 专利号: 201910150452.0

( 4 ) 固定装置及实验定位装置, 2020, 第 2 作者, 专利号: CN201922049260.9

( 5 ) 一种用于治疗糖尿病或者减肥的药物制剂, 2019, 第 1 作者, 专利号: 201811520996.3

( 6 ) 一种GLP-1突变体及其制备方法和用途, 2019, 第 1 作者, 专利号: GY84819P4003

( 7 ) 双通道脑室外引流管, 2017, 第 2 作者, 专利号: 201720193972.6

( 8 ) 长条组织培养皿, 2017, 第 3 作者, 专利号: 201720194011.7

( 9 ) 脑血管硬化演示模型, 2016, 第 1 作者, 专利号: 201621443310.1

( 10 ) 悬浮脑片抗原修复压片夹, 2015, 第 3 作者, 专利号: 201310736656.5

( 11 ) 一种用于颅内压检测的装置, 2015, 第 2 作者, 专利号: 201310513050.5

( 12 ) 一种基于瞳孔反射的便携式颅内压无创检测装置, 2015, 第 2 作者, 专利号: 201310511704.0

( 13 ) 新型喹啉-4-甲酰胺衍生物、其制备方法以及含该衍生物的药物组合物及其医药用途, 2015, 第 1 作者, 专利号: CN201410805658.X

( 14 ) 一种改进的4-羟基间苯二甲酸的制备方法, 2015, 第 2 作者, 专利号: CN201410446058.9

( 15 ) 高原车载便携式制氧机, 2015, 第 1 作者, 专利号: CN201420553928.8

( 16 ) 单兵便携式高原急救面罩, 2015, 第 2 作者, 专利号: CN201420551470.2

( 17 ) 一种经蝶窦入路手术用鞍内吸引器, 2015, 第 2 作者, 专利号: CN201420554523.6

出版信息

   
发表论文
(1) Epidemiological Survey of Congenital Heart Disease Among Children Aged from 2 to 18 in Suo County, Nagqu, Tibet, High Altitude Medicine & Biology, 2024, 
(2) Long non-coding RNA-NONMMMUT004552.2 regulates the unloading-induced bone loss through the miRNA-15b-5p/Syne1 in mice, npj microgravity, 2024, 
(3) The potential beneficial effects of Lactobacillus plantarum GM11 on rats with chronic unpredictable mild stress- induced depression, Nuture Neuroscience, 2024, 
(4) Rapid Segmentation and Diagnosis of Breast Tumor Ultrasound Images at the Sonographer Level Using Deep Learning, Bioengineering-Basel, 2023, 
(5) Design and validation of a novel knee biomechanical test method, Journal of Biomedical Engineering, 2023, 
(6) Modulating Brain Activity with Invasive Brain-Computer Interface: A Narrative Review, BRAIN SCIENCES, 2023, 第 7 作者  通讯作者
(7) The potential beneficial effects of Lactobacillus plantarum GM11 on rats with chronic unpredictable mild stress-induced depression., Nutr Neurosci, 2023, 第 1 作者  通讯作者
(8) Low-Dose Ketamine-Induced Deficits in Arbitrary Visuomotor Mapping in Monkeys, eNeuro, 2023, 
(9) Post-COVID pain and quality of life in COVID-19 patients: protocol for a meta-analysis and systematic review, BMJ OPEN, 2022, 第 9 作者  通讯作者
(10) The beneficial effects of genetically engineered Escherichia coli Nissle 1917 in obese C57BL/6J mice, INTERNATIONAL JOURNAL OF OBESITY, 2022, 第 5 作者  通讯作者
(11) Establishment and Evaluation of a Novel High-Efficiency Model of Graded Traumatic Brain Injury in Mice, WORLD NEUROSURGERY, 2021, 第 11 作者  通讯作者
(12) LncRNA CCAT1 Protects Astrocytes Against OGD/R-Induced Damage by Targeting the miR-218/NFAT5-Signaling Axis, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2020, 第 9 作者  通讯作者
(13) Improvement in cognitive dysfunction following blast induced traumatic brain injury by thymosin ��1 in rats: Involvement of inhibition of tau phosphorylation at the Thr205 epitope, BRAIN RESEARCH, 2020, 第 8 作者  通讯作者
(14) Prevention and control of coronavirus disease 2019 in Grade-III Class-A hospitals outside of Wuhan, Prevention and control of coronavirus disease 2019 in Grade-III Class-A hospitals outside of Wuhan, CHINESE MEDICAL JOURNAL, 2020, 第 1 作者  通讯作者
(15) Gastrointestinal and liver involvement in patients with COVID-19, LANCET GASTROENTEROLOGY & HEPATOLOGY, 2020, 第 3 作者  通讯作者
(16) Cardiac and Muscle Injury Might Partially Contribute to Elevated Aminotransferases in COVID-19 Patients, CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2020, 第 2 作者
(17) Genetically Engineered Escherichia coli Nissle 1917 Secreting GLP-1 Analog Exhibits Potential Antiobesity Effect in High-Fat Diet-Induced Obesity Mice, OBESITY, 2020, 第 4 作者  通讯作者
(18) A novel model of blast induced traumatic brain injury caused by compressed gas produced sustained cognitive deficits in rats: involvement of phosphorylation of tau at the Thr205 epitope, BRAIN RESEARCH BULLETIN, 2020, 第 8 作者  通讯作者
(19) 航天员中长期飞行骨骼健康管理研究现状, Current status of skeletal health management in middle and long duration astronauts, 中国骨质疏松杂志, 2020, 第 2 作者
(20) Timely blood glucose management for the outbreak of 2019 novel coronavirus disease (COVID-19) is urgently needed, DIABETES RESEARCH AND CLINICAL PRACTICE, 2020, 第 4 作者  通讯作者
(21) Ag@TiO2 Nanoprisms with Highly Efficient Near-Infrared Photothermal Conversion for Melanoma Therapy, CHEMISTRY-AN ASIAN JOURNAL, 2020, 第 11 作者  通讯作者
(22) Managing chronic wounds during novel coronavirus pneumonia outbreak, Managing chronic wounds during novel coronavirus pneumonia outbreak, BURNSTRAUMA, 2020, 第 4 作者  通讯作者
(23) Comparison of the effects of nimodipine and deferoxamine on brain injury in rat with subarachnoid hemorrhage, BEHAVIOURAL BRAIN RESEARCH, 2019, 第 5 作者  通讯作者
(24) 颅脑手术患者废弃脑组织中神经干细胞的培养与鉴定, Culture and identification of autologous neural stem cells from abandoned brain tissue in patients during craniocerebral operation, 解剖学杂志, 2019, 第 5 作者
(25) “神舟十一号”飞船舱前急救心肺复苏与应对策略, First aid cardiopulmonary resuscitation at the exit of capsule and strategy coping with the ���Shenzhou 11���spacecraft, 中华急诊医学杂志, 2018, 第 13 作者
(26) Establishment of a novel rat model of blast-related diffuse axonal injury, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2018, 第 2 作者  通讯作者
(27) 国产神经外科医疗机器人Remebot行无框架立体定向活检术的应用研究, Clinical application for domestic neurosurgery medical robot Remebot in biopsy of intracranial lesions, 中华神经医学杂志, 2017, 第 8 作者
(28) Epidemiological characteristics of Chinese paediatric traumatic brain injury inpatients, BRAIN INJURY, 2017, 第 13 作者  通讯作者
(29) “老年脑”是什么意思,如何注意?, 老年健康, 2017, 第 1 作者
(30) Mangiferin attenuates blast-induced traumatic brain injury via inhibiting NLRP3 inflammasome, CHEMICO-BIOLOGICAL INTERACTIONS, 2017, 第 9 作者  通讯作者
(31) Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2017, 第 6 作者  通讯作者
(32) “神舟十一号载人航天飞船”主着陆场航天员的医疗保障, 中华卫生应急电子杂志, 2017, 第 14 作者
(33) 加强“脑控”智能驱动武器研究, 空军医学杂志, 2016, 第 1 作者
(34) Myocyte enhancer factor 2D promotes tumorigenicity in malignant glioma cells, TUMOR BIOLOGY, 2016, 第 11 作者  通讯作者
(35) Propofol Inhibits NLRP3 Inflammasome and Attenuates Blast-Induced Traumatic Brain Injury in Rats, INFLAMMATION, 2016, 第 7 作者  通讯作者
(36) A Surgical Method to Improve the Homeostasis of CSF for the Treatment of Alzheimer���s Disease, FRONTIERS IN AGING NEUROSCIENCE, 2016, 
(37) “神舟十一号”飞船航天员医疗救护保障特点与应对策略, The specialty and coping strategies of ���ShenZhou 11��� astronauts��� rescue and medical aid, 中华急诊医学杂志, 2016, 第 2 作者
(38) microRNA-7 Protects Against 1-Methyl-4-Phenylpyridinium Iodide-Induced Cell Apoptosis in SH-SY5Y Cells by Directly Targeting Krupple-Like Factor 4, DNA AND CELL BIOLOGY, 2016, 第 9 作者  通讯作者
(39) Cerebral vasospasm and corticospinal tract injury induced by a modified rat model of subarachnoid hemorrhage, JOURNAL OF THE NEUROLOGICAL SCIENCES, 2015, 第 2 作者  通讯作者
(40) Emodin Inhibits Inducible Nitric Oxide Synthase in a Rat Model of Craniocerebral Explosive Injury, NEUROCHEMICAL RESEARCH, 2014, 第 8 作者  通讯作者
(41) Gene expression profiles of patients with cerebral hematoma following spontaneous intracerebral hemorrhage, MOLECULAR MEDICINE REPORTS, 2014, 第 2 作者  通讯作者
(42) Pharmacokinetics of Dexamethasone and Nefopam Administered Alone or in Combination Using a Newly Developed Prefilled Multi-Drug Injector in Rats, PHARMACOLOGY, 2014, 第 5 作者  通讯作者
(43) Comparison of the safety and efficacy of propofol with midazolam for sedation of patients with severe traumatic brain injury: A meta-analysis, JOURNAL OF CRITICAL CARE, 2014, 第 1 作者  通讯作者
(44) Overexpression of MACC1 protein and its clinical implications in patients with glioma, TUMOR BIOLOGY, 2014, 第 5 作者  通讯作者
(45) Protein���protein interaction network analysis and gene set enrichment analysis in epilepsy patients with brain cancer, JOURNAL OF CLINICAL NEUROSCIENCE, 2014, 第 5 作者  通讯作者
(46) Electrical Stimulation of the Substantia Nigra Pars Reticulata (SNr) Suppresses Chemically Induced Neocortical Seizures in Rats, JOURNAL OF MOLECULAR NEUROSCIENCE, 2014, 第 6 作者  通讯作者
(47) Comparison of therapeutic effects between selective amygdalohippocampectomy and anterior temporal lobectomy for the treatment of temporal lobe epilepsy: A meta-analysis, BRITISH JOURNAL OF NEUROSURGERY, 2014, 第 3 作者  通讯作者
(48) Epileptiform Discharges and Frontal Paroxysmal EEG Abnormality Act as Predictive Marker for Subsequent Epilepsy in Children With Complex Febrile Seizures, CLINICAL EEG AND NEUROSCIENCE, 2014, 第 5 作者  通讯作者
(49) Anti-apoptotic and Anti-oxidative Roles of Quercetin After Traumatic Brain Injury, CELLULAR AND MOLECULAR NEUROBIOLOGY, 2014, 第 3 作者  通讯作者

科研活动

   
科研项目
( 1 ) 网络空间******医学保障研究, 负责人, 其他, 2023-10--2025-10
( 2 ) 战略支援部队特殊******与防治研究, 负责人, 其他国际合作项目, 2023-03--2026-02
( 3 ) 航天临床医学*****实验室, 负责人, 其他国际合作项目, 2022-08--2024-08
( 4 ) 一体式****的研发及生理指标评估, 负责人, 其他国际合作项目, 2020-03--2021-12
( 5 ) 植物大黄成分治疗脑外伤后认知功能障碍效应通路研究, 负责人, 国家任务, 2018-01--2021-12
( 6 ) 铁在脑出血认知障碍中的作用, 负责人, 中国科学院计划, 2016-12--2019-12
( 7 ) 深部脑***********应用, 负责人, 其他国际合作项目, 2016-12--2021-12
( 8 ) 颅底肿瘤精准外科治疗的临床研究, 负责人, 地方任务, 2015-12--2018-12
( 9 ) 磁共振分子影像动态载体观测脑损伤机制, 负责人, 国家任务, 2013-12--2017-06
( 10 ) 颅脑爆炸冲击伤致伤机制及防护研究, 负责人, 国家任务, 2012-12--2017-12