纳米医学，微纳仿生药物递送，肿瘤免疫，基因治疗

每年拟招收博士/硕士研究生1-2名。

071010-生物化学与分子生物学
0710J1-纳米科学与技术
071009-细胞生物学

纳米医学，微纳仿生药物递送，肿瘤免疫，基因治疗
仿生微纳机器人
肿瘤学

2017-09--2020-06   中国科学院大学   博士学位

研究生

博士

2012.07-今 中国科学院深圳先进技术研究院

2020-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2017-01~2019-12,中国科学院深圳先进技术研究院, 助理研究员
2012-07~2016-12,中国科学院深圳先进技术研究院, 研究员助理

2020-08-01-今,广东省基础与应用基础研究基金项目评审专家,
2019-03-12-今,ACS NANO, ACS Applied Materials & Interfaces期刊审稿人,

生物技术前沿

   

（1） 优秀员工, 研究所（学校）, 2021
（2） 北京市普通高等学校优秀毕业生, 市地级, 2020
（3） 优秀员工, 研究所（学校）, 2020
（4） 深圳市自然科学奖, 一等奖, 市地级, 2020
（5） 中国科学院大学优秀毕业生, , 研究所（学校）, 2020
（6） 中国科学院院长优秀奖, , 院级, 2019
（7） 朱李月华奖学金, 研究所（学校）, 2019
（8） 博士研究生国家奖学金, 国家级, 2019
（9） 优秀员工, 研究所（学校）, 2018
（10） 优秀员工, 研究所（学校）, 2017
（11） 优秀员工, 研究所（学校）, 2016

（ 1 ） 金纳米笼-二氧化锰复合纳米颗粒及其制备方法和应用, 专利授权, 2020, 第 3 作者, 专利号: CN107670040B

（ 2 ） 一种载miRNA复合纳米颗粒及其制备方法和应用, 专利授权, 2020, 第 3 作者, 专利号: CN108210482B

（ 3 ） 一种改善肿瘤缺氧的新方法, 发明专利, 2020, 第 3 作者, 专利号: CN110893196A

（ 4 ） 一种脑肿瘤靶向的仿生载药纳米颗粒及其制备方法和用途, 发明专利, 2020, 第 5 作者, 专利号: CN110859826A

（ 5 ） 一种纳米颗粒载药系统及其制备方法和应用, 发明专利, 2020, 第 3 作者, 专利号: CN110859817A

（ 6 ） 一种活生物自产氧光敏剂及其应用, 发明专利, 2020, 第 2 作者, 专利号: CN110812482A

（ 7 ） 一种克服肿瘤耐药的方法, 发明专利, 2020, 第 3 作者, 专利号: CN110755457A

（ 8 ） 一种包载免疫佐剂纳米颗粒及应用, 发明专利, 2020, 第 3 作者, 专利号: CN110755387A

（ 9 ） 一种用作光/声敏剂的靶向纳米颗粒及其制备方法和应用, 发明专利, 2019, 第 3 作者, 专利号: CN109568577A

（ 10 ） 复合型纳米疫苗及其制备方法, 发明专利, 2015, 第 3 作者, 专利号: CN104645349A

   

[1] He, Huamei, Zhu, Denghui, Ma, Aiqing, Ren, Jian, Chen, Ze, Ran, Hui, Li, Zhaozhen, Qin, Ruiqing, Liang, Ruijing, Liu, Lanlan, Cai, Lintao. Reconstructing Tumor Microenvironment Using Photoresponsive Cyanobacteria to Reversal Chemoresistance for Robust Chemotherapy. SMALL STRUCTURES[J]. 2023, [2] Lishan Zhang, baozhen zhang, Lanlan Liu, Ma, Aiqing, Cai, Lintao. A Dual-Biomineralized Yeast Micro-/Nanorobot with Self-Driving Penetration for Gastritis Therapy and Motility Recovery. Acs Nano[J]. 2023, [3] chen huaqing, Liu, Lanlan, Liang Ruijing, Cai, Lintao. Biomimetic Nanosonosensitizers Combined with Noninvasive Ultrasound Actuation to Reverse Drug Resistance and Sonodynamic-Enhanced Chemotherapy against Orthotopic Glioblastoma. Acs Nano[J]. 2022, [4] Huang, Guojun, Liu, Lanlan, Pan, Hong, Cai, Lintao. Biomimetic Active Materials Guided Immunogenic Cell Death for Enhanced Cancer Immunotherapy. SMALL METHODS. 2022, [5] Pan, Hong, Zheng, Mingbin, Ma, Aiqing, Liu, Lanlan, Cai, Lintao. Cell/Bacteria-Based Bioactive Materials for Cancer Immune Modulation and Precision Therapy. ADVANCED MATERIALSnull. 2021, 33(50): http://dx.doi.org/10.1002/adma.202100241.
[6] Pan, Hong, Li, Wenjun, Chen, Ze, Luo, Yingmei, He, Wei, Wang, Mengmeng, Tang, Xiaofan, He, Huamei, Liu, Lanlan, Zheng, Mingbin, Jiang, Xin, Yin, Ting, Liang, Ruijing, Ma, Yifan, Cai, Lintao. Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor. BIOACTIVE MATERIALS[J]. 2021, 6(4): 951-962, http://dx.doi.org/10.1016/j.bioactmat.2020.09.025.
[7] Chen, Huaqing, Liu, Lanlan, Ma, Aiqing, Yin, Ting, Chen, Ze, Liang, Ruijing, Qiu, Yuzhi, Zheng, Mingbin, Cai, Lintao. Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer. BIOMATERIALS[J]. 2021, 269: http://dx.doi.org/10.1016/j.biomaterials.2020.120639.
[8] Zhou, Haimei, He, Huamei, Liang, Ruijing, Pan, Hong, Chen, Ze, Deng, Guanjun, Zhang, Shengping, Ma, Yifan, Liu, Lanlan, Cai, Lintao. In situ poly I:C released from living cell drug nanocarriers for macrophage-mediated antitumor immunotherapy. BIOMATERIALS[J]. 2021, 269: http://dx.doi.org/10.1016/j.biomaterials.2021.120670.
[9] Liu, Lanlan, He, Huamei, Luo, Zhenyu, Zhou, Haimei, Liang, Ruijing, Pan, Hong, Ma, Yifan, Cai, Lintao. In Situ Photocatalyzed Oxygen Generation with Photosynthetic Bacteria to Enable Robust Immunogenic Photodynamic Therapy in Triple-Negative Breast Cancer. ADVANCED FUNCTIONAL MATERIALS[J]. 2020, 30(10): [10] Luo, Ying, Yang, Jun, Zhang, Chi, Jin, Yan, Pan, Hong, Liu, Lanlan, Gong, Yifeng, Xia, Yu, Wang, Guobing, Zhang, Jiaosheng, Li, Chengrong, Li, Qiu. Up-regulation of miR-27a promotes monocyte-mediated inflammatory responses in Kawasaki disease by inhibiting function of B10 cells. JOURNAL OF LEUKOCYTE BIOLOGY[J]. 2020, 107(1): 133-144, https://www.webofscience.com/wos/woscc/full-record/WOS:000505244900013.
[11] He, Huamei, Liu, Lanlan, Liang, Ruijing, Zhou, Haimei, Pan, Hong, Zhang, Shengping, Cai, Lintao. Tumor-targeted nanoplatform for in situ oxygenation-boosted immunogenic phototherapy of colorectal cancer. ACTA BIOMATERIALIA[J]. 2020, 104: 188-197, http://dx.doi.org/10.1016/j.actbio.2020.01.012.
[12] Wang, Fangfang, Pan, Hong, Yao, Xiangjie, He, Huamei, Liu, Lanlan, Luo, Yingmei, Zhou, Haimei, Zheng, Mingbin, Zhang, Renli, Ma, Yifan, Cai, Lintao. Bioorthogonal Metabolic Labeling Utilizing Protein Biosynthesis for Dynamic Visualization of Nonenveloped Enterovirus 71 Infection. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(3): 3363-3370, https://www.webofscience.com/wos/woscc/full-record/WOS:000509428300006.
[13] Li, Ping, Yang, Xinyu, Yang, Yang, He, Huamei, Chou, ChonKit, Chen, Fengyang, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan, Chen, Xin. Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice. JOURNALOFCONTROLLEDRELEASE[J]. 2020, 319: 87-103, http://dx.doi.org/10.1016/j.jconrel.2019.12.025.
[14] He, Huamei, Liu, Lanlan, Zhang, Shengping, Zheng, Mingbin, Ma, Aiqing, Chen, Ze, Pan, Hong, Zhou, Haimei, Liang, Ruijing, Cai, Lintao. Smart gold nanocages for mild heat -triggered drug release and breaking chemoresistance. JOURNAL OF CONTROLLED RELEASE[J]. 2020, 323: 387-397, http://dx.doi.org/10.1016/j.jconrel.2020.04.029.
[15] Li, Wenjun, Pan, Hong, He, Huamei, Meng, Xiaoqing, Ren, Qian, Gong, Ping, Jiang, Xin, Liang, Zhenguo, Liu, Lanlan, Zheng, Mingbin, Shao, Ximing, Ma, Yifan, Cai, Lintao. Bio-Orthogonal T Cell Targeting Strategy for Robustly Enhancing Cytotoxicity against Tumor Cells. SMALL[J]. 2019, 15(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000456849600008.
[16] Pan, Hong, Li, Ping, Li, Guifei, Li, Wenjun, Hu, Bian, He, Huamei, Chen, Ze, Wang, Fangfang, Liu, Lanlan, Gong, Yifeng, Han, Yutong, Luo, Yingmei, Zheng, Mingbin, Ma, Yifan, Cai, Lintao, Jin, Yan. Glycometabolic Bioorthogonal Chemistry-Guided Viral Transduction for Robust Human T Cell Engineering. ADVANCED FUNCTIONAL MATERIALS[J]. 2019, 29(22): [17] Chen, Zhikuan, Liu, Lanlan, Liang, Ruijing, Luo, Zhenyu, He, Huamei, Wu, Zhihao, Tian, Hao, Zheng, Mingbin, Ma, Yifan, Cai, Lintao. Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect. ACSNANO[J]. 2018, 12(8): 8633-8645, http://ir.siat.ac.cn:8080/handle/172644/14607.
[18] Liang, Ruijing, Liu, Lanlan, He, Huamei, Chen, Zhikuan, Han, Zhiqun, Luo, Zhenyu, Wu, Zhihao, Zheng, Mingbin, Ma, Yifan, Cai, Lintao. Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases. BIOMATERIALS[J]. 2018, 177: 149-160, http://ir.siat.ac.cn:8080/handle/172644/14596.
[19] Liu, Lanlan, He, Huamei, Liang, Ruijing, Yi, Huqiang, Meng, Xiaoqing, Chen, Zhikuan, Pan, Hong, Ma, Yifan, Cai, Lintao. ROS-Inducing Micelles Sensitize Tumor-Associated Macrophages to TLR3 Stimulation for Potent Immunotherapy. BIOMACROMOLECULES[J]. 2018, 19(6): 2146-2155, http://ir.siat.ac.cn:8080/handle/172644/14597.
[20] Pan, Hong, Yao, Xiangjie, Chen, Weihua, Wang, Fangfang, He, Huamei, Liu, Lanlan, He, Yaqing, Chen, Jinquan, Jiang, Puzi, Zhang, Renli, Ma, Yifan, Cai, Lintao. Dissecting complicated viral spreading of enterovirus 71 using in situ bioorthogonal fluorescent labeling. BIOMATERIALS[J]. 2018, 181: 199-209, http://ir.siat.ac.cn:8080/handle/172644/14610.
[21] Luo, Zhenyu, Tian, Hao, Liu, Lanlan, Chen, Zhikuan, Liang, Ruijing, Chen, Ze, Wu, Zhihao, Ma, Aiqing, Zheng, Mingbin, Cai, Lintao. Tumor-targeted hybrid protein oxygen carrier to simultaneously enhance hypoxia-dampened chemotherapy and photodynamic therapy at a single dose. THERANOSTICS[J]. 2018, 8(13): 3584-3596, http://ir.siat.ac.cn:8080/handle/172644/14598.
[22] Tian, Hao, Luo, Zhenyu, Liu, Lanlan, Zheng, Mingbin, Chen, Ze, Ma, Aiqing, Liang, Ruijing, Han, Zhiqun, Lu, Chengyu, Cai, Lintao. Cancer Cell Membrane-Biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance. ADVANCED FUNCTIONAL MATERIALS[J]. 2017, 27(38): [23] Liu, Lanlan, Yi, Huqiang, He, Huamei, Pan, Hong, Cai, Lintao, Ma, Yifan. Tumor associated macrophage-targeted microRNA delivery with dual-responsive polypeptide nanovectors for anti-cancer therapy. BIOMATERIALS[J]. 2017, 134: 166-179, http://dx.doi.org/10.1016/j.biomaterials.2017.04.043.
[24] Pan, Hong, Li, Wenjun, Yao, Xiangjie, Wu, Yayun, Liu, Lanlan, He, Huamei, Zhang, Renli, Ma, Yifan, Cai, Lintao. In Situ Bioorthogonal Metabolic Labeling for Fluorescence Imaging of Virus Infection In Vivo. SMALL[J]. 2017, 13(17): https://www.webofscience.com/wos/woscc/full-record/WOS:000400452200013.
[25] Chen, Ze, Zhao, Pengfei, Luo, Zhenyu, Zheng, Mingbin, Tian, Hao, Gong, Ping, Gao, Guanhui, Pan, Hong, Liu, Lanlan, Ma, Aiqing, Cui, Haodong, Ma, Yifan, Cai, Lintao. Cancer Cell Membrane-Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy. ACS NANO[J]. 2016, 10(11): 10049-10057, https://www.webofscience.com/wos/woscc/full-record/WOS:000388913100033.
[26] Zhang, Yijuan, Li, Ping, Pan, Hong, Liu, Lanlan, Ji, Manyi, Sheng, Nan, Wang, Ce, Cai, Lintao, Ma, Yifan. Retinal-conjugated pH-sensitive micelles induce tumor senescence for boosting breast cancer chemotherapy. BIOMATERIALS[J]. 2016, 83: 219-232, http://dx.doi.org/10.1016/j.biomaterials.2016.01.023.
[27] Wang, Ce, Li, Ping, Liu, Lanlan, Pan, Hong, Li, Hongchang, Cai, Lintao, Ma, Yifan. Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation. BIOMATERIALS[J]. 2016, 79: 88-100, http://dx.doi.org/10.1016/j.biomaterials.2015.11.040.
[28] Yi, Huqiang, Liu, Lanlan, Sheng, Nan, Li, Ping, Pan, Hong, Cai, Lintao, Ma, Yifan. Synergistic Therapy of Doxorubicin and miR-129-5p with Self-Cross-Linked Bioreducible Polypeptide Nanoparticles Reverses Multidrug Resistance in Cancer Cells. BIOMACROMOLECULES[J]. 2016, 17(5): 1737-1747, https://www.webofscience.com/wos/woscc/full-record/WOS:000375886500019.
[29] Liu, Lanlan, Yi, Huqiang, Wang, Ce, He, Huamei, Li, Ping, Pan, Hong, Sheng, Nan, Ji, Manyi, Cai, Lintao, Ma, Yifan. Integrated Nanovaccine with MicroRNA-148a Inhibition Reprograms Tumor-Associated Dendritic Cells by Modulating miR-148a/DNMT1/SOCS1 Axis. JOURNAL OF IMMUNOLOGY[J]. 2016, 197(4): 1231-1241, https://www.webofscience.com/wos/woscc/full-record/WOS:000384999100023.
[30] Ji, Manyi, Li, Ping, Sheng, Nan, Liu, Lanlan, Pan, Hong, Wang, Ce, Cai, Lintao, Ma, Yifan. Sialic Acid-Targeted Nanovectors with Phenylboronic Acid-Grafted Polyethylenimine Robustly Enhance siRNA-Based Cancer Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(15): 9565-9576, https://www.webofscience.com/wos/woscc/full-record/WOS:000374812000006.
[31] Wang, Ce, Liu, Peng, Zhuang, Yan, Li, Ping, Jiang, Boling, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan. Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory. JOURNAL OF CONTROLLED RELEASEnull. 2015, 213: E16-E16, http://dx.doi.org/10.1016/j.jconrel.2015.05.022.
[32] Luo, Zichao, Wang, Ce, Yi, Huqiang, Li, Ping, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan. Co-delivery of poly I:C and STAT3 siRNA by nanovaccines effectively overcomes tumor-associated dendritic cell dysfunction and elicits anti-tumor immune response. JOURNAL OF CONTROLLED RELEASEnull. 2015, 213: E133-E134, http://dx.doi.org/10.1016/j.jconrel.2015.05.225.
[33] Luo, Zichao, Wang, Ce, Yi, Huqiang, Li, Ping, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan. Nanovaccine loaded with poly I:C and STAT3 siRNA robustly elicits anti-tumor immune responses through modulating tumor-associated dendritic cells in vivo. BIOMATERIALS[J]. 2015, 38: 50-60, http://dx.doi.org/10.1016/j.biomaterials.2014.10.050.
[34] Pan, Hong, Zhang, Yijuan, Luo, Zichao, Li, Ping, Liu, Lanlan, Wang, Ce, Wang, Hanzhong, Li, Hongchang, Ma, Yifan. Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-kappa B and p38 MAPK signaling pathways. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY[J]. 2014, 306(2): L183-L195, http://dx.doi.org/10.1152/ajplung.00147.2013.
[35] Pan, Hong, Zhang, Pengfei, Gao, Duyang, Zhang, Yijuan, Li, Ping, Liu, Lanlan, Wang, Ce, Wang, Hanzhong, Ma, Yifan, Cai, Lintao. Noninvasive Visualization of Respiratory Viral Infection Using Bioorthogonal Conjugated Near-Infrared-Emitting Quantum Dots. ACS NANO[J]. 2014, 8(6): 5468-5477, https://www.webofscience.com/wos/woscc/full-record/WOS:000338089200012.
[36] Wang, Ce, Liu, Peng, Zhuang, Yan, Li, Ping, Jiang, Boling, Pan, Hong, Liu, Lanlan, Cai, Lintao, Ma, Yifan. Lymphatic-targeted cationic liposomes: A robust vaccine adjuvant for promoting long-term immunological memory. VACCINE[J]. 2014, 32(42): 5475-5483, http://dx.doi.org/10.1016/j.vaccine.2014.07.081.
[37] Zhang, Yijuan, Pan, Hong, Zhang, Pengfei, Gao, Ningning, Lin, Yi, Luo, Zichao, Li, Ping, Wang, Ce, Liu, Lanlan, Pang, Daiwen, Cai, Lintao, Ma, Yifan. Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways. NANOSCALE[J]. 2013, 5(13): 5919-5929, https://www.webofscience.com/wos/woscc/full-record/WOS:000320398300033.
[38] Liu, Lanlan, Yang, Zhaojuan, Xu, Yingqian, Li, Jingyi, Xu, Dongxu, Zhang, Li, Sun, Jiabin, Xia, Suhua, Zou, Feiyan, Liu, Yongzhong. Inhibition of Oxidative Stress-Elicited AKT Activation Facilitates PPAR gamma Agonist-Mediated Inhibition of Stem Cell Character and Tumor Growth of Liver Cancer Cells. PLOS ONE[J]. 2013, 8(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000323880200064.
[39] Li, Ping, Luo, Zichao, Liu, Peng, Gao, Ningning, Zhang, Yijuan, Pan, Hong, Liu, Lanlan, Wang, Ce, Cai, Lintao, Ma, Yifan. Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses. JOURNAL OF CONTROLLED RELEASE[J]. 2013, 168(3): 271-279, http://dx.doi.org/10.1016/j.jconrel.2013.03.025.

   

（ 1 ） 基于光合细菌负载纳米光敏剂的免疫光动力治疗及机制研究（国自然青基，21万）, 负责人, 国家任务, 2019-01--2021-12
（ 2 ） 靶向纳米氧载体增效光动力及其抗肿瘤免疫学机制研究（广东省自然，10万）, 负责人, 地方任务, 2018-05--2021-04
（ 3 ） 基于光合细菌联合光动力纳米颗粒用于抗肿瘤免疫治疗的研究（深圳市自由探索，30万））, 负责人, 地方任务, 2019-04--2021-03
（ 4 ） 基于工程化蓝细菌微纳仿生机器人的肿瘤微环境调控和精准治疗研究（国自然面上，56万））, 负责人, 国家任务, 2021-01--2024-12
（ 5 ） 新型光合微纳生物机器人的定向合成及诊疗应用研究（深圳市重点项目，250万）, 负责人, 地方任务, 2021-03--2024-02
（ 6 ） 仿生纳米基因载体的构建及肿瘤精准光免疫研究, 负责人, 地方任务, 2022-01--2023-12

（1）基于蓝细菌光合产氧介导的抗肿瘤免疫光动力治疗   中国化学会第32届学术年会   2021-04-19
（2）Targeted oxygen-enhanced photodynamic therapy for inducing anti-tumor immunity   中美纳米医学与纳米生物技术学会   2019-08-20
（3）Targeted Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-Tumor Immunity and Abscopal Effect.   2018-08-14
（4）Integrated nanovaccine with microRNA-148a inhibition reprograms tumor-associated dendritic cells by modulating miR-148a/DNMT1/SOCS1 axis.    2016-08-25
（5）Nanovaccine-based gene-immune therapy robustly elicits anti-tumor immune response in vivo   2015-10-14
（6）复合型肿瘤疫苗调控肿瘤相关树突状细胞增强抗肿瘤免疫的研究   中国免疫学会第九届全国免疫学学术大会   2014-11-22

现指导学生

蔡佳璇  硕士研究生  086000-生物与医药