Ph.D, Principle investigator
Office Phone: 86-755-86140451
Investigates neural mechanisms of sleep, learning and memory.
2019- now , Principle Investigator, SIAT CAS
2012-2019, Postdoctoral Fellow, Brandeis University
2004-2007, Research Assistant, Kunming Institute of Zoology, CAS
2003-2004, Biology teacher, Shijiazhuang No. 2 Middle School
Zhiqiang Meng*, Qing Li, Yuanye Ma, Chang Liu*. Transcranial current stimulation of the frontal-parietal-temporal brain areas reduces cigarette consumption in abstinent heroin users. Journal of Psychiatric Research, 2022 doi: https://doi.org/10.1016/j.jpsychires.2022.06.045.
Wei Yan, Zhiqiang Meng*, Chang Liu*. Selective memory consolidation of the binary compound in feature discrimination tasks in Apis mellifera. Progress in Biochemistry and Biophysics, 2021 (accepted)
Xi Jin, Yao Tian, Zi Chao Zhang, Pengyu Gu, Chang Liu, Junhan Han*. A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling. Current Biology, 2021 May 24;31(10):2075-2087.e6
Timothy D. Wiggin, Patricia R. Goodwin, Nathan C. Donelson, Chang Liu, Kien Trinh, Subhabrata Sanyal, Leslie C. Griffith*. Covert sleep-related biological processes are revealed by probabilistic analysis in Drosophila. PNAS, 2020 May 5; 117 (18): 10024-10034
Chang Liu*, Zhiqiang Meng, Timothy D. Wiggin, Junwei Yu, Fang Guo, Martha Reed, Yunpeng Zhang, Michael Rosbash, Leslie C. Griffith*. A serotonin-modulated circuit controls sleep architecture to regulate cognitive function independent of total sleep in Drosophila. Current Biology, 2019, 29(21):3635-3646
Chang Liu, Paula R. Haynes, Nathan C. Donelson, Shani Aharon, Leslie C. Griffith*. Sleep in populations of Drosophila melanogaster. eNeuro, 2015, 2 (4) e0071-15.2015
Chang Liu, Pierre-Yves Plaçais, Nobuhiro Yamagata, Barret D. Pfeiffer, Yoshinori Aso,Anja B. Friedrich, Igor Siwanowicz, Gerald M. Rubin, Thomas Préat, Hiromu Tanimoto*. A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature, 2012, 488(7412):512-6
Sleep, learning and memory are complex phenomena that are of great importance for survival. Although the quantity and quality of sleep have a profound impact on learning and memory, the exact mechanisms are not known. Daily learning experience was suggested to be helpful to improve sleep. However, the interaction mechanism between the two systems is rarely understood. Dysfunctions in sleep and cognition are usually associated with neurodegenerative disorders, such as Alzheimer’s disease. To investigate the molecular and cellular basis of the interaction between sleep and memory, we will employ fruit fly Drosophila melanogaster as the animal model and apply multidisciplinary approach, including behavioral, genetic, anatomical and imaging techniques. We will also take the advantage of the platforms of BCBDI to study the same questions through cross-species verification.
- Monoamines in regulation of sleep and learning in Drosohila. CNS Neuroscince Technology 2019 conference2019.10.29-11.01，Shenzhen （Talk）
- A serotonin-modulated circuit controls sleep architecture in Drosophila. The fifth China Drosophila Biology Conference，2019.08.15-08.17，Dalian（Talk）
- Serotonergic modulation of an ellipsoid body circuit controls sleep architecture in Drosophila. The 2018 Janelia Farm Campus Conference on Structure and Function of the Insect Central Complex. 2018.10.28-31 (poster)
- Experience modifies transient neuronal activity of MB extrinsic neurons. The 2017 Janelia Farm Campus Conference on Structure and Function of the Insect Mushroom Body. 2017.03.05-08 (poster)
- Serotonergic activity controls sleep architecture in Drosophila. 2016 Invited talk at University of Mississippi Medical Center. 2016.09.23.(invited talk)
- Serotonergic activity controls sleep architecture in Drosophila. The 2015 Cold Srping Harbor Laboratory Meeting on Neurobiology of Drosophila. 2015.09.29-10.02 (poster)
- Neural circuits underlying sleep and learning. The 2014 Janelia Farm Campus Conference on Structure and Function of the Insect Mushroom Body. 2014.04.27-30 (poster)
- Characterizing sleep in populations of flies. The 2013 Volen Center for Complex Systems Annual Retreat. Boston. (Poster)
- A subset of dopaminergic neurons signal reward in Drosophila melanogaster. The 2012 53rd Annual Drosophila Research Conference. 2012.03.07-11, Chicago, IL. (poster)
- Identification of dopaminergic neurons in reward signaling. The 2011 Champalimaud Neuroscience Symposium. 2011.09.18-21, Champalimaud Centre, Lisbon, Portugal. (Poster)
- Dopamine signals appetitive and aversive reinforcement in Drosophila.The 2011 Ninth Göttingen Meeting of the German Neuroscience Society. 2011.03.23-26. Gottingen, Germany. (Poster)
Master & Ph.D
Qualifications and Requirements
- Biological or medical background; working experience in a molecular biology laboratory, or Matlab/Pathon programming
- with a strong interest in neurobiology.
- Good physical and mental health.
- Self-driven and strong capability of working independently.Hard, rigorous, serious, have the courage to challenge.