Wei Zhao

Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences


Address: 1068 Xueyuan Boulevard, University Town of Shenzhen, Nanshan, Shenzhen 518055, China

Research Areas

By combined using synthetic biology and a variety of biochemical and genetic methods, we focus on investigating molecular regulatory mechanisms involved in microbial development and subcellular organization,  learning the knowledge from which to guide the relevant applications in molecular design and cell synthesis.


Shanghai Institutes for Biological Sciences,

Chinese Academy of Sciences, Shanghai, China              2006-2011

Ph.D. in Biological Sciences


(1) Deacetylation enhances ParB-DNA interactions affecting chromosome segregation in Streptomyces coelicolor.

Peng Li, Hong Zhang, G-P. Zhao*, W. Zhao*

Nucleic Acids Research. 2020.


(2) ScCobB2-mediated lysine desuccinylation regulates protein biosynthesis and carbon metabolism in Streptomyces coelicolor.

H. Zhang, P. Li, S. X. Ren, Z. Y. Cheng, G-P. Zhao*, W. Zhao*

Molecular & Cellular Proteomics, 18(10):2003-2017. 2019.


(3) Cyclic AMP inhibits the activity and promotes the acetylation of acetyl-CoA synthetase through competitive binding to the ATP/AMP pocket.

X. B. Han#, L. Q. Shen#, Q. Wang, X. Cen, J. Wang, M. Wu, P. Li, W. Zhao*, Y. Zhang* and G-P. Zhao*

Journal of Biological Chemistry 292:1374-1384. 2017.


(4) Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.

L. Xu#, H. Huang#, W. Wei#, Y. Zhong, B. Tang, H. Yuan, L. Zhu, W. Huang, M. Ge, S. Yang, H. Zheng, W. Jiang*, D. Chen*, G-P. Zhao*, W. Zhao*

BMC Genomics 15: 363-369. 2014.


(5) Complete genome sequence of the rifamycin SV-producing Amycolatopsis   mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism.

W. Zhao#, Y. Zhong#, H. Yuan#, J. Wang#, H. Zheng, Y. Wang, X. Cen, F. Xu, J. Bai, X. Han, G. Lu, Y. Zhu, Z. Shao, H. Yan, C. Li, N. Peng, Z. Zhang, Y. Zhang, W. Lin, Y. Fan, Z. Qin, Y. Hu, B. Zhu, S. Wang*, X. Ding*, G-P. Zhao*

Cell Research 20:1096-1108. 2010.