Lintao Cai


Ph.D., Full Professor,

Director of Institute of Biomedicine and Biotechnology

Director of Center for Nanomedicine and Nanobiotechnology

Director of Guangdong Key Lab of Nanomedicine

Director of CAS-HK Joint Lab of Biomaterials


Shenzhen Institutes of Advanced Technology (SIAT),

Chinese Academy of Sciences (CAS)

1068 Xueyuan Avenue, Shenzhen University Town,

Xili, Nanshan, Shenzhen 518055, China.

Tel: 86-755-86392210      Fax: 86-755-86392299

Mobile: 86-158-13732028   E-mail:


Research Areas

Nanomedicine and Biomedical Engineering (Cancer Theranostics, Single Molecular Theranostics, Biomimetic Drug Delivery System, Smart Biomaterials, Imaging-guided Phototherapy PDT/PTT, Sonodynamic Therapy SDT, Immunogenetic Cell De​ath, Immunotherapy, Chemotherapy, Cancer Precision Therapy)


1989.9 – 1992.7   Chongqing University, China   M.S. in Physical Chemistry

1992.9 – 1995.7   Xiamen University, China   Ph.D in Physical Chemistry


Selected publications

1.          Y.T. Han, H. Pan, W.J. Li, Z. Chen, A.Q. Ma, T. Yin, R.J. Liang, F.M. Chen, Y.F. Ma, Y. Jin, M.B. Zheng*, B.H. Li*, L.T. Cai*. T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy. Advanced Science, 2019, 6(15), 1900251.

2.          H. Pan, P. Li, G.F. Li, W.J. Li, B. Hu, H.M. He, Z. Chen, F.F. Wang, L.L. Liu, Y.F. Gong, Y.T. Han, Y.M. Luo, M.B. Zheng, Y.F. Ma*, L.T. Cai*, and Y. Jin*. Glycometabolic Bioorthogonal Chemistry-Guided Viral Transduction for Robust Human T Cell Engineering. Advanced Functional Materials, 2019, 29(22), 1807528.

3.          W.J. Li, H. Pan, H.M. He, X.Q. Meng, Q. Ren, P. Gong, X. Jiang, Z.G. Liang, L.L. Liu, M.B. Zheng, X.M. Shao, Y.F. Ma,* and L.T. Cai*. Bioorthogonal T Cell Targeting Strategy For Robustly Enhancing Cytotoxicity Against Tumor Cells. Small, 2019, 15(4), 1804383.

4.          A.Q. Ma, H.Q. Chen, Y.H. Cui, Z.Y. Luo, R.J. Liang, Z.H Wu, Z. Chen, T. Yin, J. Ni, M.B. Zheng*, and L.T. Cai*. Metalloporphyrin Complex-Based Nanosonosensitizers for Deep-Tissue Tumor Theranostics by Noninvasive Sonodynamic Therapy. Small, 2019, 15(5), 1804028.

5.          G.J. Deng, Z.H. Sun, S.P. Li, X.H. Peng, W.J. Li, L.H. Zhou, Y.F. Ma, P. Gong*, and L.T. Cai*. Cell-Membrane Immunotherapy Based on Natural Killer Cell Membrane Coated Nanoparticles for the Effective Inhibition of Primary and Abscopal Tumor Growth. ACS Nano, 2018, 12(12), 12096-12108.

6.          Z.K. Chen L.L. Liu, R.J. Liang, Z.Y. Luo, H.M. He, Z.H. Wu, H.Tian, M.B. Zheng*, Y.F. Ma, and L.T. Cai*. Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect. ACS Nano, 2018, 12(8), 8633-8645.

7.          G.J. Deng, S.P. Li, Z.H. Sun, W.J. Li, L.H. Zhou, J.L. Zhang, P. Gong*, and L.T. Cai*. Near-infrared fluorescence imaging in the largely unexplored window of 900–1,000 nm. Theranostics. 2018, 8(15), 4116-4128.

8.          Z.Y. Luo, H.Tian, L.L. Liu, Z.K. Chen, R.J. Liang, Z. Chen, Z.H. Wu, A.Q. Ma, M.B. Zheng*, and L.T. Cai*. Tumor-Targeted Hybrid Protein Oxygen Carrier to Simultaneously Enhance Hypoxia-Dampened Chemotherapy and Photodynamic Therapy at a Single Dose. Theranostics. 2018, 8(13), 3584-3596.

9.          P.F. Zhang, Z. Zhao, C.S. Li, H.F. Su, Y.Y. Wu, R.T.K. Kwok, J.W.Y. Lam, P. Gong, L.T. Cai*, and B.Z. Tang*. Aptamer-Decorated Self-Assembled Aggregation-Induced Emission Organic Dots for Cancer Cell Targeting and Imaging. Anal. Chem., 2018, 90(2), 1063-1067.

10.       H. Tian, Z.Y. Luo, L.L. Liu, M.B. Zheng*, Z. Chen, A.Q. Ma, R.J. Liang,Z.Q. Han, C.Y. Lu, and L.T. Cai*. Cancer Cell Membrane-biomimetic Oxygen Nanocarrier for Breaking Hypoxia-Induced Chemoresistance. Adv. Funct. Mater, 2017, 27(38), 1703197.

11.       Z. Chen, P.F. Zhao, Z.Y. Luo, M.B. Zheng*, H. Tian, P. Gong, G.H. Gao, H. Pan, L.L. Liu, A.Q. Ma, H.D. Cui, Y.F. Ma, L.T. Cai*. Cancer Cell Membrane-Biomimetic Nanoparticles for Homologous-Targeting Dual-Modal Imaging and Photothermal Therapy. ACS Nano, 2016, 10 (11), 10049–10057.

12.       X.B.Xie, G.H.Gao,* S.D. Kang,T.Shibayama, Y.H. Lei, D.Y. Gao, L.T. Cai*. Site-Selective Trimetallic Heterogeneous Nanostructures toward Promoted Electrocatalytic Performance.Adv. Mater, 2015,27 (37), 5573-5577

13.       C. Chen, P.F. Zhang, G.H. Gao, D.Y. Gao, Y. Yang, H. Liu, Y.H. Wang, P. Gong, L.T. Cai*. Near-Infrared-Emitting Two-Dimensional Codes Based on Cu-Doped Lattice-Strained Quantum Dots with Long Fluorescence Lifetime. Adv. Mater, 2014,26 (36), 6313-6317.

14.       Z.H. Sheng, D.H. Hu, M.B. Zheng, P.F. Zhao, H.L Liu, D.Y. Gao, P. Gong, G.H. Gao, P.F. Zhang, Y.F. Ma*, L.T. Cai*. Smart Human Serum Albumin-Indocyanine Green Nanoparticles Generated by Programmed Assembly for Dual-Modal Imaging-Guided Cancer Synergistic Phototherapy. ACS Nano, 2014, 8 (12), 12310–12322. (ESI-Highly Cited Papers 1%)

15.       H. Pan, P.F. Zhang, D.Y. Gao, Y.J. Zhang, P. Li, L.L. Liu, C. Wang, H.Z. Wang, Y.F. Ma*, L.T. Cai*.Noninvasive Visualization of Respiratory Viral Infection Using Bioorthogonal Near-Infrared Quantum Dots. ACS Nano, 2014, 8(6), 5468-77.

16.       M.B. Zheng, C.X. Yue, Y.F. Ma, P. Gong, P.F. Zhao, C.F. Zheng, Z.H. Sheng, P.F. Zhang, Z.H. Wang, L.T. Cai*. Single-Step Assembly of DOX/ICG Loaded Lipid-Polymer Nanoparticles forHighly Effective Chemo-Photothermal Combination Therapy. ACS Nano, 2013, 7(3), 2056–2067. (ESI-Highly Cited Papers 1%)

17.       P.F. Zhang, S.H. Liu, D.Y. Gao, D.H. Hu, P. Gong, Z.H. Sheng, J.Z. Deng, Y.F. Ma,  L.T. Cai*. Click-Functionalized Compact Quantum Dots Protected by Multidentate-Imidazole Ligands: Conjugation-Ready Nanotags for Living-virus Labeling and Imaging. J. Am. Chem. Soc., 2012, 134 (20), 8388–8391.

18.       D.Y. Gao, P.F. Zhang, Z.H. Sheng, D.H. Hu, P. Gong, C. Chen, Q. Wan, G.H. Gao, L.T. Cai*. Highly Bright and Compact Alloyed Quantum Rods with Near Infrared Emitting: aPotential Multifunctional Nanoplatform for Multimodal Imaging in vivo. Adv. Funct. Mater, 2014, 24(25), 3897-3905.

19.       P.F. Zhao, M.B. Zheng, C.X. Yue, P. Gong, Z.Y. Luo, G.H. Gao, C.F. Zheng, Z.H. Sheng, L.T. Cai*. Improving Drug Accumulation and Photothermal Efficacy in Tumor Depending on Size of ICG Loaded Lipid-Polymer Nanoparticles. Biomaterials, 2014, 35(23), 6037-6046.

20.   C.F. Zheng, M.B. Zheng, P. Gong, D.X Jia, P.F. Zhang, B.H. Shi, Z.H. Sheng, Y.F. Ma, L.T. Cai*.Indocyanine green-loaded biodegradable tumor targeting nanoprobes for in vitro and in vivo imaging. Biomaterials, 2012, 33 (22), 5603-5609.


      77 authorized patents, and 7 PCT international patents.


1.     Lintao Cai, Mingbinzheng, Pengfei Zhao, Zhenyu Luo, Ping Gong, Cuifang Zheng. Laser nanometer-scale optical diagnostic device. 2016-06-02. PCT/CN2015/083870.

2.     Lintao Cai, Mingbinzheng, Ze Chen, Zhenyu Luo, Pengfei Zhao, Ping Gong. ICG-encapsulated polymer-phospholipid nanoparticle and preparation method therefor. 2016-06-30, PCT/CN2015/098050.

3.     Lintao Cai, Yifan Ma, Hong Pan, Yan Jin, Ping Li, Wenjun Li. A virus transfection synergist and virus transfection application based click chemistry. 2017-07-21, PCT/CN2017/093870.

4.     Yifan Ma, Xiangjun Zhou, Shang Chen, Lintao Cai, Ce Wang, Peng Liu. Method for preparing dendritic cell loaded with antigen. 2015-05-20, PCT/CN2015/079416.

5.     Yifan Ma, Xiangjun Zhou, Shang Chen, Lintao Cai, Ce Wang, Peng Liu. Method for preparing dendritic cell loaded with antigen. 2017-10-19, PCT/CN2015/079416.

6.     QingguoRuan, Youhai Chen, Tingting Fan, Yifan Ma, Lintao Cai, Shaowen Wang, Xiaochun Wang. C-Rel-Specific siRNA and application thereof for treating autoimmune psoriasis. 2017-04-20, PCT/CN2015/092124.

7.  Xiujun Fan, Baozheng Zhang, Lunbo Tan,Baobei Wang, Guogang Chen, Zhonglin Xiao, JIngyu Han, Zhilong Chen, Tianxia Xiao, Mengxia Li, Mingbin Zheng, Lintao Cai, Jian Zhang.Preparation method and application of Placental Chondroitin Sulfate A (plCSA)-targeting peptides and drug delivery systems.2017.10.31, PCT/CN2017/108646.



1.      “Single Molecular Theranostics” (Invited talk), The 3rd International Conference on Nanomedicine, ChinaNanomedicine 2018, Shanghai, China. Oct 15-17, 2018.

2.      Annual AcademicMeeting of Chinese Society of Biomedical Engineering (CBME2018). Shenzhen, Sep 20-22, 2018. (Session Chair)

3.      “Single Molecular Theranostics for Cancer Targeted Therapy”(Invited talk).Chinese Conference on Oncology 2018, Shenyang, Aug 17-19, 2018.

4.      2018 CASNN Annual Meeting, The Third Sino-American Nanomedicine Symposium. Nanjing, July 28-30, 2018.(Session Chair)

5.      “Single Molecular Theranostics”(Invited talk).International Summit Forum for Medicine and MolecularImaging, Shenzhen University, July 11-12, 2018.

6.      “Quantum Dots for in situ Labelling and Imaging in Vivo”(Invited talk). Symposium for Quantum Dots Chemistry – Physics – Application,Zhejiang University, Hangzhou, Apr 14-15, 2018.

7.      “Oxygen Nanocarrier for Cancer Theranostics”(Invited talk). AnnualNanobiology AcademicMeetingof Biophysical Society of China (BSC 2017), Ningbo, Nov 18-20, 2017.

8.      “Smart Nanomedicines for Imaging-guided Cancer Combination Phototherapy”(Invited talk), The 7th International Conference on Nanoscience& Technology, ChinaNANO 2017,Beijing, Aug 29-31, 2017.

9.      2017 CASNN Annual Meeting. Suzhou, China, July 28-31, 2017.(Session Chair)

10.    “Cancer Cell Membrane-Functionalized Oxygen-Nanocarrier for Breaking Hypoxia-Induced Chemoresistance”(Invited talk). The 39th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC'17),JeJu Island, S. Korea, July 11-15,2017.

11.    “Small Molecule Nanoprobe for Cancer Theranostics”(Invited talk). 12th Sino-US Nano Forum, Beijing, May 26-28, 2017.

12.    “Click Chemistry on Cell Labelling and Imaging Analysis in Vivo”(Invited talk).2016 Annual Academic Meeting of Life Analytical Chemistry. NanjingDec. 16-192016.

13.    ”Smart Nanocarriers for Cancer Phototherapy”(Invited talk). 2016FrontierSymposiuminNanobiotechnology and NanomedicineSuzhouNov.18-19, 2016.

14.    “Enhanced Phototherapy with TheranosticNanoparticles”(Invited talk). The 2nd International Conference on Nanomedicine,ChinaNanomedicine 2016, WuhanOct. 18-212016.

15.    “Near-infrared and optoacoustic imaging-guided theranostic phototherapy”(Invited talk). NanoBio CHINA 2016, Nanjing, Oct. 17-19, 2016.



郑明彬  博士研究生  071010-生物化学与分子生物学  

吕亚琳  硕士研究生  085204-材料工程  

倪大鹏  硕士研究生  085204-材料工程  

赵鹏飞  博士研究生  071010-生物化学与分子生物学  

罗震宇  博士研究生  071010-生物化学与分子生物学  

孟晓青  博士研究生  071010-生物化学与分子生物学  

邓冠军  博士研究生  071010-生物化学与分子生物学  

陈志宽  硕士研究生  071009-细胞生物学  

王芳芳  硕士研究生  085204-材料工程  

潘宏  博士研究生  071010-生物化学与分子生物学  


刘兰兰  博士研究生  071010-生物化学与分子生物学  

张保珍  博士研究生  0703Z1-化学生物学  

张秀文  硕士研究生  085204-材料工程  

Honors & Distinctions


“High-Level Leading Talents”of Special Support Plan of Guangdong Province (2016)

The Second Prizeof Science and Technology of Guangdong Province (2016)

The Second Prize of Science and Technology of Shenzhen City (2015)

International Service

Fellow of American Institute for Medical and Biological Engineering (AIMBE)

Council member of Chinese Chemical Society (CCS)

Board of Director for Chinese American Society of Nanomedicine and Nanobiotechnology (CASNN)

Council member of Nanobiology Academic Committee, Biophysical Society of China (BSC)

Advanced member of Chinese Society of Micro-Nano Technology (CSMNT)

Member of American Chemical Society (ACS) and Royal Society of Chemistry (RSC)