Chao Zhao, Associate Professor

Shenzhen Institutes of Advanced Technology

Chinese Academy of Sciences

Shenzhen, China, 518055


Research Areas


Mass spectrometry-based multi-omics analysis

Mass spectrometry imaging

Tumor metabolism

Environmental toxicology


Ph. D., State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, 2013

M.E., Dalian Maritime University, P. R. China, 2009

B.E., Shenyang University of Technology, P. R. China, 2006


Work Experience

Associate Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 2019

Postdoc (Hong Kong Scholars), State Key Laboratory of Environmental & Biological Analysis, Hong Kong Baptist University, 2014-2019


Publications (first or corresponding author)

(1) iMS2Net: A Multiscale networking methodology to decipher metabolic synergy of organism. iScience, 2022, 2022.104896.

(2). Molecular network strategy in multi-omics and mass spectrometry imaging. Current Opinion in Chemical Biology. 2022, accepted.

(3). Mass spectrometry imaging-based multi-modal technique: The next-generation of biochemical analysis strategy. The Innovation, 2021, 2, 100151 (from Cell Press).

(4). Data filtering and its prioritization in pipelines for spatial segmentation of mass spectrometry imaging. Analytical Chemistry, 2021, 93, 4788-4793.

(5). Breast cancer proliferation and deterioration-associated metabolic heterogeneity changes induced by exposure of bisphenol S, a widespread replacement of bisphenol A. Journal of Hazardous Materials, 2021, 414, 125391.

(6). Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy. Science Bulletin, 2021, 66, 578-591.

(7). Three-dimensional quantitative mass spectrometry imaging in complex system: from subcellular to whole organism. Mass Spectrometry Reviews, 2020, DOI: 10.1002/mas.21674.

(8). Evaluation of the splenic injury following exposure of mice to bisphenol S: A mass spectrometry-based lipidomics and imaging analysis, Environment International, 2020,135, 105378.

(9). Preparation of frozen sections of multicellular tumor spheroids coated with ice for mass spectrometry imaging. Analytical Chemistry, 2020. analchem.9b05812.

(10). Immunotoxic potentials of bisphenol F mediated through lipid signaling pathways on macrophages. Environmental Science & Technology, 2019, 53, 11420-11428.

(11). Omics approach reveals metabolic disorders associated with the cytotoxicity of airborne particulate matter in human lung carcinoma cells. Environmental Pollution, 2019, 246, 45-52.

(12). Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7. Environmental Pollution, 2019, 246, 697-703.

(13). Metabolic perturbation, proliferation and reactive oxygen species jointly contribute to cytotoxicity of human breast cancer cell induced by tetrabromo and tetrachloro bisphenol A. Ecotoxicology and Environmental Safety, 2019, 170, 495-501.

(14). MALDI-MS imaging reveals asymmetric spatial distribution of lipid metabolites from bisphenol S-induced nephrotoxicity. Analytical Chemistry, 2018, 90, 3196-3204.

(15). Liquid chromatography-mass spectrometry-based metabolomics and lipidomics reveal toxicological mechanisms of bisphenol F in breast cancer xenografts. Journal of Hazardous Materials, 2018, 358, 503- 507.

(16). Identification of glycerophospholipid fatty acid remodeling by using mass spectrometry imaging in bisphenol S induced mouse liver. Chinese Chemical Letters, 2018, 29,1281-1283.

(17). Bisphenol S exposure modulate macrophage phenotype as defined by cytokines profiling, global metabolomics and lipidomics analysis. Science of the Total Environment, 2017, 592, 357-365.


Oral presentation (invited)

(1). 6th National Ecotoxicology Conference, Guangzhou, 2019.

(2). China Mass Spectrometry Conference (CMSC), 2018. Guangzhou, 2018.

(3). The 3rd International Symposium of Epigenetic Mechanism and Human Health, Shenzhen, 2018.

(4). The international conference on environmental pollution and Health, Nankai University, 2018.

(5). Clinical & Pharmaceutical Solutions through Analysis (CPSA), Shanghai, 2018.

(6). 7th Asia Oceania Mass Spectrometry Conference 2017, Biopolis, Singapore, 2017

(7). 15th International Conference on Environmental Science and Technology, Rhodes, Greece, 2017.

(8). HKSMS Symposium 2017 & 19th Annual General Meeting, Hong Kong Polytechnic University, Hong Kong, 2017.


Honors & Distinctions

2020 Recognized as Overseas High-Caliber Personnel (Level C) in Shenzhen, China

2020 Chao Zhao (6/10), China Association for Instrumental Analysis Award (CAIA), the special prize

2017 Young Scientist Travel Award, 7th Asia Oceania Mass Spectrometry Conference, Singapore

2015 Chao Zhao (4/10), China Association for Instrumental Analysis Award (CAIA), the special prize

2014 “Hong Kong Scholars Program” Funding

2013 Chao Zhao (7/10), China Association for Instrumental Analysis Award, the first prize