1. 传染病、过敏、自身免疫病、癌症相关获得性免疫反应特征

2. 免疫组、基因组、蛋白质组等多组学大数据分析，AI建模

3. 儿童免疫系统发育，免疫衰老

071010-生物化学与分子生物学
071005-微生物学
071009-细胞生物学

免疫反应，免疫记忆
传染病，癌症，自身免疫病，过敏
AI，大数据分析

2012-09--2017-06   多伦多大学   分子遗传与计算生物学博士学位
2008-09--2012-06   山东大学   数学、生物双学士学位

   

2022-07~现在, 中国科学院深圳先进技术研究院, 研究员
2017-11~2022-02,斯坦福大学, 博士后
2017-01~2017-10,多伦多大学, 博士后

2021-01-01-今,Frontiers in Pharmacology, Editorial Board Member
2017-12-31-今,ACM SIGCSE conference, PC Member
2012-08-31-2017-06-29,International Conference on Systems Biology, Committee Member

   

（ 1 ） SARS-CoV-2抗原特异性免疫记忆特征与免疫印记发生机制的多组学研究, 负责人, 国家任务, 2023-01--2026-12
（ 2 ） 海外优青, 负责人, 国家任务, 2023-01--2025-12
（ 3 ） 中科院%%配套, 负责人, 中国科学院计划, 2023-01--2025-12
（ 4 ） 不同SARS-CoV-2抗原接触史人群针对多种病毒及自身抗原的交叉免疫反 应特征的多组学研究, 负责人, 国家任务, 2024-01--2026-12
（ 5 ） 儿童造血干细胞移植后抗CMV感染的B细胞免疫反应重建过程的多组学研究, 负责人, 地方任务, 2024-01--2026-12

1.         Fan Yang#, Sandra C. A. Nielsen, Ramona A. Hoh, Katharina Röltgen, Oliver Fabian Wirz, Emily Haraguchi, Grace H Jean, Ji-Yeun Lee, Tho D. Pham, Katherine J.L. Jackson, Krishna M. Roskin, Yi Liu, Khoa Nguyen, Rober S. Ohgami, Kari C. Nadeau, Eleanor L. Marshall, Claus U. Niemann, Julie Parsonnet, Scott D. Boyd#. Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues, Science, 2021. 372(6543): p. 738.

2.         Sandra C. A. Nielsen*, Fan Yang*, Katherine J. L. Jackson*, Ramona A. Hoh*, Katharina Röltgen, Bryan Stevens, Ji-Yeun Lee, Arjun Rustagi, Angela J. Rogers, Abigail E. Powell, Javaria Najeeb, Ana R. Otrelo Cardoso, Kathryn E. Yost, Bence Daniel, Howard Y. Chang,  Ansuman T. Satpathy, Theodore S. Jardetzky, Peter S. Kim, Taia T. Wang, Benjamin A. Pinsky, Catherine A. Blish#, Scott D. Boyd#, Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2, Cell Host & Microbe, 2020 October 7, 28(4) 516-525.e5.

3.         Fan Yang, Dae-Kyum Kim, Hidewaki Nakagawa, Seiya Imoto, Lincoln Stein and Frederick P. Roth, Quantifying Immune-Based Counterselection of Somatic Mutations, PLoS Genetics, 2019 July, 15(7): e1008227.

4.         Fan Yang, Song Sun, Guihong Tan, Michael Costanzo, David E. Hill, Marc Vidal, Brenda J. Andrews, Charles Boone, Frederick P. Roth, Identifying pathogenicity of human variants via paralog-based yeast complementation, PLoS Genetics, 2017 May, 13(5), e1006779.

5.         Fan Yang, Evangelia Petsalaki, Thomas Rolland, David E. Hill, Marc Vidal and Frederick P. Roth, Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations, PLoS Computational Biology, 2015 Mar, 11(3): e1004147. DOI: 10.1371/journal.pcbi.1004147

6.         Fan Yang, Lin Wang, Mechanisms classification for glycoside hydrolases by sequence and structure features using computational methods, International Journal of Data Mining and bioinformatic, 2014 Nov, 9(4): 444-457

7.         Ramona A. Hoh, Linnea Thörnqvist, Fan Yang, Magdalena Godzwon, Jasmine J. King, Ji-Yeun Lee, Lennart Greiff, Scott D. Boyd, Mats Ohlin, Clonal evolution and stereotyped sequences of human IgE lineages in aeroallergen-specific immunotherapy, Journal of Allergy and Clinical Immunology, 2023 Feb, 23, DOI: 10.1016/j.jaci.2023.02.009.

8.         Fei Gao, Vamsee Mallajoysula, Prabhu Arunachalam, Kattria van der Ploeg, Monali Manohar, Katharina Röltgen, Fan Yang, Oliver F. Wirz, Ramona Hoh, Emily Haraguchi, Ji Yeun Lee, Richard Willis, Vasanthi Ramachandiran, Jiefu Li, Karan Raj Kathuria, Chunfeng Li, Alexandra S. Lee, Mihir M. Shah, Sayantani B. Sindher, Joseph Gonzalez, John D. Altman, Taia Wang, Scott D. Boyd, Bali Pulendran, Prasanna Jagannathan, Kari Nadeau, Mark M. Davis, Robust T Cell Responses to the Pfizer/BioNTech Vaccine Compared to Infection and Evidence of Attenuated CD8 T Cell Responses Due to COVID-19, Immunity, 2023 Feb 23, doi: 10.1016/j.cell.2022.01.014.

9.         Katharina Röltgen*, Sandra C. A. Nielsen*, Oscar Silva*, Sheren F. Younes*, Maxim Zaslavsky, Cristina Costales, Fan Yang, Oliver F. Wirz, Daniel Solis, Ramona A. Hoh, Aihui Wang, Prabhu S. Arunachalam, Deana Colburg, Shuchun Zhao, Emily Haraguchi, Alexandra S. Lee, Mihir M. Shah, Monali Manohar, Iris Chang, Fei Gao, Vamsee Mallajosyula, Chunfeng Li, James Liu, Massa J. Shoura, Sayantani B. Sindher, Ella Parsons, Naranjargal J. Dashdorj, Naranbaatar D. Dashdorj, Robert Monroe, Geidy E. Serrano, Thomas G. Beach, R. Sharon Chinthrajah, Gregory W. Charville, Jim L. Wilbur, Jacob Wohlstadter, Mark M. Davis, Bali Pulendran, Megan L. Troxell, George B. Sigal, Yasodha Natkunam, Benjamin A. Pinsky, Kari C. Nadeau#, Scott D. Boyd#, Immune imprinting, breadth of variant recognition and germinal center response in human SARS-CoV-2 infection and vaccination, Cell (2022), https://doi.org/10.1016/j.cell.2022.01.018.

10.       Yapeng Su*, Dan Yuan*, Daniel G. Chen*, Rachel H. Ng, Kai Wang, Jongchan Choi,Sarah Li, Sunga Hong, Rongyu Zhang, Jingyi Xie, Sergey A. Kornilov, KelseyScherler, Ana Jimena Pavlovitch-Bedzyk, Shen Dong, Christopher Lausted, InyoulLee, Shannon Fallen, Chengzhen L. Dai, Priyanka Baloni, Brett Smith, Venkata R.Duvvuri, Kristin G. Anderson, Jing Li, Fan Yang, Caroline J. Duncombe, Denise J.McCulloch, Clifford Rostomily, Pamela Troisch, Jing Zhou, Sean Mackay, QuinnDeGottardi, Damon H. May, Ruth Taniguchi, Rachel M. Gittelman, Mark Klinger,Thomas M. Snyder, Ryan Roper, Gladys Wojciechowska, Kim Murray, Rick Edmark,Simon Evans, Lesley Jones, Yong Zhou, Lee Rowen, Rachel Liu, William Chour,Heather A. Algren, William R. Berrington, Julie A. Wallick, Rebecca A. Cochran,Mary E. Micikas, the ISB-Swedish COVID19 Biobanking Unit, Terri Wrin, Christos J.Petropoulos, Hunter R. Cole, Trevan D. Fischer, Wei Wei, Dave S.B. Hoon, NathanD. Price, Naeha Subramanian, Joshua A. Hill, Jennifer Hadlock, Andrew T. Magis,Antoni Ribas, Lewis L. Lanier, Scott D. Boyd, Jeffrey A. Bluestone, Helen Chu, LeroyHood, Raphael Gottardo, Philip D. Greenberg, Mark M. Davis, Jason D. Goldman, James R. Heath, Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae, Cell (2022), doi: https://doi.org/10.1016/j.cell.2022.01.014.

11.       Jason D. Goldman, Kai Wang, Katharina Roltgen, Sandra C. A. Nielsen, Jared C. Roach, Samia N. Naccache, Fan Yang, Oliver F. Wirz, Kathryn E. Yost, Ji-Yeun Lee, Kelly Chun, Terri Wrin, Christos J. Petropoulos, Inyou Lee, Shannon Fallen, Paula M. Manner, Julie A. Wallick, Heather A. Algren, Kim M. Murray, Yapeng Su, Jennifer Hadlock, Joshua Jeharajah, William R. Berrington, George P. Pappas, Sonam T. Nyatsatsang, Alexander L. Greninger, Ansuman T. Satpathy, John S Pauk, Scott D. Boyd, James R. Heath, Reinfection with SARS-CoV-2 and Failure of Humoral Immunity: a case report, Vaccines (Basel), 2022 Dec 20;11(1):5. doi: 10.3390/vaccines11010005.

12.       Lisa E. Wagar, Ameen Salahudeen, Christian M. Constantz, Ben S. Wendel1, Michael M. Lyons, Vamsee Mallajosyula, Lauren P. Jatt, Julia Z. Adamska, Lisa K. Blum, Neha Gupta, Katherine J. L. Jackson, Fan Yang, Katharina Röltgen, Krishna M. Roskin, Kelly Blaine, Kara D. Meister, Iram N. Ahmad, Mario Cortese, Emery Dora, Sean N. Tucker, Anne Sperling, Aarti Jain, D. Huw Davies, Philip L. Felgner, Gregory B. Hammer, Peter S. Kim, William H. Robinson, Scott D. Boyd, Calvin J. Kuo, & Mark M. Davis, Modeling human adaptive immune responses in vitro with tonsil organoids, Nature Medicine, 2021, 27, 125–135.

13.       Jochen Weili, Song Sun, Atina G. Cote, Jennifer Knapp, Marta,Verby, Joseph Mellor, Yingzhou Wu, Jesse D. Bloom, Carles Pons, Cassandra Wong, Natascha van Lieshout, Fan Yang, Murat Tasan, Guihong Tan, Shan Yang, Robert Nussbaum, Marc Vidal, David E Hill, Patrick Aloy, Frederick P. Roth, A framework for exhaustively mapping functional missense variants, Molecular systems biology, 2017 Dec, 13 (12), 957.

14.       Song Sun, Fan Yang, Guihong Tan, Michael Costanzo, Rose Oughtred, Jodi Hirschman, Chandra Theesfeld, Paul Bansal, Nidhi Sahni, Song Yi, Analyn Yu, Tanya Tyagi, David E. Hill, Marc Vidal, Brenda J. Andrews, Charles Boone, Kara Dolinski, Frederick P. Roth, An extended set of yeast-based functional assays accurately identifies human disease mutations, Genome Research, 2016 May;26(5):670-80. DOI: 10.1101/gr.192526.115

15.       Xinping Yang*, Jasmin Coulombe-Huntington*, Shuli Kang*, Gloria M. Sheynkman*, Tong Hao*,Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran- Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Trigg, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia and Marc Vidal, Widespread expansion of protein interaction capabilities by alternative splicing, Cell, 2016 Feb 11;164(4):805-817. DOI: 10.1016/j.cell.2016.01

16.       Nidhi Sahni*, Song Yi*, Mikko Taipale*, Juan I. Fuxman Bass*, Jasmin Coulombe-Huntington*, Fan Yang, Jian Peng, Jochen Weile, Atanas Kamburov, Irina Krykbaeva, George Tucker, Vikram Khurana, Georgios I. Karras, Amitabh Sharma, Yang-Yu Liu, Nozomu Yachie, Quan Zhong, Yun Shen, Alexandre Palagi, Adriana San-Miguel, Changyu Fan, Dawit Balcha, Amelie Dricot, Daniel M. Jordan, Jennifer M. Walsh, Akash A. Shah, Xinping Yang, Ani Stoyanova, Alex Leighton, Michael A. Calderwood, Yves Jacob, Michael E. Cusick, Luke J. Whitesell, Shamil Sunyaev, Benoit Charloteaux, Bonnie Berger, David E. Hill, Albert-László Barabási, Tong Hao, Frederick P. Roth, Yu Xia, Albertha J.M. Walhout, Susan Lindquist, and Marc Vidal, Widespread macromolecular interaction perturbations in human genetic disorders Cell, 2015 Apr 23;161(3):647-60. DOI: 10.1016/j.cell.2015.04.013

17.       Rongrong Wei, Fan Yang, Thomas J. Urban, Lang Li, Naga Chalasani, David A. Flockhart, Wanqing Liu, Impact of the interaction between 3’-UTR SNPs and microRNA on the expression of human xenobiotic metabolism enzyme (XMEs) genes, Frontiers in Pharmacogenetics and Pharmacogenomics, 2012 Nov, 3(248), DOI: 10.3389/fgene.2012.00248.

18.       Xiaomei Zhang, Ning Liu, Fan Yang, Jinghua Li, Lushan Wang, Guanjun Chen, and Peiji Gao, In Situ Demonstration and Quantitative Analysis of the Intrinsic Properties of Glycoside Hydrolases, ELECTROPHORESIS, 2012 Jan, 33(2), 280-7. DOI: 10.1002/elps.201100333