
Fan Yang, PhD, Professor
Research Areas
1. Immune responses and immune memory characteristics upon infection or cancer
2. Immune repertoire profiling
3. Aging B/T cell repertoire analysis
Education
2012.09-2017.06, University of Toronto, Ph.D.
Experience
Work Experience
Teaching Experience
2015.09 - 2017. 06, Whole-Genome Sequencing and Analysis Laboratory
Publications
Selected Papers
1. Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues
Fan Yang#, Sandra C. A. Nielsen, Ramona A. Hoh, Katharina Röltgen, Oliver Fabian Wirz, Emily Haraguchi, Grace H Jean, Ji-Yeun Lee, Tho D. Pham, Katherine J.L. Jackson, Krishna M. Roskin, Yi Liu, Khoa Nguyen, Rober S. Ohgami, Kari C. Nadeau, Eleanor L. Marshall, Claus U. Niemann, Julie Parsonnet, Scott D. Boyd#. Science, 2021. 372(6543): p. 738.
Highlighted in Faculty Opinions by Dr. Maria C. Castells (Director of Drug Hypersensitivity and Desensitization Center, Director of Mastocytosis Center, Professor of Harvard Medical School), 19 May 2021; 10.3410/f.739921164.793585681
2. Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2
Sandra C. A. Nielsen*, Fan Yang*, Katherine J. L. Jackson*, Ramona A. Hoh*, Katharina Röltgen, Bryan Stevens, Ji-Yeun Lee, Arjun Rustagi, Angela J. Rogers, Abigail E. Powell, Javaria Najeeb, Ana R. Otrelo-Cardoso, Kathryn E. Yost, Bence Daniel, Howard Y. Chang, Ansuman T. Satpathy, Theodore S. Jardetzky, Peter S. Kim, Taia T. Wang, Benjamin A. Pinsky, Catherine A. Blish#, Scott D. Boyd#, Cell Host & Microbe, 2020 October 7, 28(4) 516-525.e5.
3. Quantifying Immune-Based Counterselection of Somatic Mutations
Fan Yang, Dae-Kyum Kim, Hidewaki Nakagawa, Seiya Imoto, Lincoln Stein and Frederick P. Roth,
PLoS Genetics, 2019 July, 15(7): e1008227.
4. Identifying pathogenicity of human variants via paralog-based yeast complementation
Fan Yang, Song Sun, Guihong Tan, Michael Costanzo, David E. Hill, Marc Vidal, Brenda J. Andrews, Charles Boone, Frederick P. Roth, PLoS Genetics, 2017 May, 13(5), e1006779.
5. Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations
Fan Yang, Evangelia Petsalaki, Thomas Rolland, David E. Hill, Marc Vidal and Frederick P. Roth,
PLoS Computational Biology, 2015 Mar, 11(3): e1004147. DOI: 10.1371/journal.pcbi.1004147