​Prof. Horst Vogel is an academician from the Swiss Academy of Sciences and National Academy of Inventors (NAI) from USA. He directs a multidisciplinary laboratory which bridges activities from biophysics, biochemistry, cell and molecular biology to micro- and nanotechnologies. The research activities his laboratory lead to a number of important developments, which have found widespread interest and applications:

- The first optical sensor chip for probing the activation of G protein coupled receptors.

- The first silicon chip for automated planar patch clamp measurements.

- Pioneering the investigation of membrane proteins by single-molecule spectroscopy and imaging in reconstituted systems and living cells.

- The first high-resolution crystal structure of a mammalian Cys-loop ligand gated ion channel.

- Horst Vogel directed from 2013 to 2017 a large European research consortium on Synthetic Biology (

His present focus of research is the elucidation of the structure and function of ligand-gated ion channels and G-protein coupled receptors.

These two classes of membrane proteins cover the majority of human membrane proteins, play a central role in proper functioning of cells, are involved in many severe diseases, and therefore are among the most important targets for presently used therapeutic compounds. High-resolution structures of the proteins as well as their functional interplay in the cellular biochemical network are required for a proper understanding of their function and will facilitate the development of novel medicines to treat diseases which are evoked by a malfunction of these membrane proteins.

The different structural states during the activation process of these receptors and their interactions with cellular signalling molecules will be investigated in their native cellular environment using cryo-electron and optical microscopies, combined with complementary biophysical techniques. Close collaboration with computational biology groups in the institute is of central for these projects.

Research Areas

Biophysics, biochemistry, cell and molecular biology to micro- and nanotechnologies.


Bachelor and master 1968-1974  Julius Maximilians Universität Würzburg   Chemistry

PhD                           1975-1978  Max-Planck Institute for Biophysical Chemistry, Göttingen   Biophysics




1.   A Keppler, S Gendreizig, T Gronemeyer, H     Pick, H Vogel, K JohnssonA general method for the covalent labeling of fusion proteins with     small molecules in vivoNature Biotechnology (2003) volume 21, pages86–89(2003) 他引次数1619

2.   U Meseth, T Wohland, R Rigler, H Vogel*, Resolution of     fluorescence correlation measurements, Biophysical journal, (1999), 76     (3), 1619-1631, 他引次数426

3.   Roslyn M Bill, Peter JF Henderson, So Iwata,     Edmund RS Kunji, Hartmut Michel, Richard Neutze, Simon Newstead, Bert     Poolman, Christopher G Tate, Horst     Vogel*Overcoming barriers to membrane protein     structure determinationNature biotechnology (2011), 29 (4), 335-340, 他引次数 398

4.   Hassaine, G., Deluz, C., Grasso, L., Wyss, R.,     Tol, M. B., Hovius, R., ... Vogel,     H*. &Nury H. X-ray structure of the mouse serotonin 5-HT 3     receptor. Nature, doi:10.1038/nature13552 (2014) 2014.08.21他引次数335

5.       Guignet,     E. G., Hovius, R., & Vogel,     H*. Reversible site-selective labeling of membrane proteins in live     cells. doi10.1038/nbt954 Nature biotechnology,(2004)     22, pages440–444 他引次数308

6.       Pick,     H., Alves, A. C., & Vogel, H*. Single-vesicle assays using     liposomes and cell-derived vesicles: from modeling complex membrane     processes to synthetic biology and biomedical applications. Chemical reviews, (2018) 118, 18, 8598–8654他引次数 39

7.       S     Yuan, S Filipek, H Vogel,     A gating     mechanism of the serotonin 5-HT3 receptor, Structure     (2016), 24 (5), 816-825他引次数     33

8.       Yuan,     S., Palczewski, K., Peng, Q., Kolinski, M., Vogel, H*, & Filipek,     S. The Mechanism of Ligand‐Induced Activation or Inhibition of μ‐and     κ‐Opioid Receptors. Angewandte Chemie International Edition,     (2015) 54 Pages 7560-7563他引次数44

9.       Yuan,     S., Filipek, S., Palczewski, K., & Vogel, H*. Activation of     G-protein-coupled receptors correlates with the formation of a continuous     internal water pathway. Nature communications(2014) 4733     (2014) 他引次数162

10. Yuan, S., Vogel, H*., & Filipek,     S. The Role of Water and Sodium Ions in the Activation of the μ‐Opioid     Receptor. Angewandte Chemie International Edition, (2013)52     Pages 10112-10115他引次数 85



  1. Holger Lang, Bernd Koenig, Horst Vogel, Lipid membrane        sensor. 美国,专利号:WO 9300976 W(1992422).
  1. Horst Vogel, Christian Schmidt, Multiaperture sample        positioning and analysis system. 丹麦、欧盟、美国、加拿大、澳大利亚、香港、西班牙、奥地利、欧盟专利局、国际专利局,专利号:DK1040349 (T4), EP1040349 (B2), US2009153153 (A1), US7387715        (B2), CA2316966 (C), US2007209935 (A1), US7244349 (B2), US7201836 (B2),        US6758961 (B1), WO0224862 (A3), US2003146091 (A1), US2003098248 (A1),        US2003052002 (A1), US2002144905 (A1), US2002104757 (A1), AU746580 (B2),        WO0224862 (A2), HK1028450 (A1), DK1040349 (T3), ES2163284 (T3),        WO0134764 (A3), AT205300 (T), EP1040349 (B1), WO0134764 (A2), EP1040349        (A1), AU8237998 (A), CA2316966 (A1), WO9931503 (A1) PCT/IB98/01150 (2003320).
  1. Jeremy Lakey, Horst Vogel, Biosensor with covalently        attached membrane-spanning protein.欧盟,专利号:EP 1352245 B1 (2002118).
  1. Thorsten Wohland, Horst Vogel, Rudolf Rigler, Assembly        and method for a correlator structure. 美国,专利号:US 6813569 B2 (2002114).
  1. Hahtab Varnous, Horst Vogel, Wolf-Peter Ulrich, Thierry        Stora, Kirsten Leufgen, Maria Ines Velazco, Cellulose Model Surface. 欧盟专利号:EP        1761589 B1 (2005527).
  1. H. Vogel, H. Pick, A. Preuss, E. Schmid, A.P. Tairi M.        Pawlack, Bioanalytical reagent, methods for production thereof, sensor        platforms and detection methods based on use of said bioanalytical reagent.        美国、国际专利局,专利号:PCT/WO 2002/46766A2 , US2008/0139403 A1,(2001124).