Medical synthetic biology on cancer and infectious disease 

1990-1994 Research Assistant, Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, USA

1994-1998 Postdoctoral Research Fellow, ABL-Basic Research Program, National Cancer Institute-FCRDC, NIH, USA, Under the supervision of Drs. Nancy A. Jenkins and Neal G. Copeland

1998-2006 Assistant Professor, Department of Biochemistry, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China

2006-2014 Associate Professor with Tenure, Department of Biochemistry, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China

2014-         Professor with Tenure, Department of Biochemistry/School of Biomedical Sciences, Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China

1.      Bao-Zhong Zhang, JianPiao Cai, Bin Yu, Lifeng Xiong, Qiubin Lin, SongYue Zheng, Richard Yi-Tsun Kao, Konghung SZE, Kwok-Yung Yuen, and Jian-Dong Huang (2017) Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model. Journal of Infectious Diseases V216, p245-253

2.      Lizhong Liu, Wei Huang, and Jian-Dong Huang (19 January 2017, featured article) Synthetic circuits that process multiple light and chemical signal inputs. BMC Systems Biology V11(1): p5-14.

3.      Baozhong Zhang, Jianpiao Cai, Bin Yu, Yanhong Hua, Candy Choiyi Lau, Richard Yi Tsun Kao, Kong-Hung Sze, Kwok-Yung Yuen, and Jian-Dong Huang (2016) A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile. BMC Infectious Diseases V16(596)

4.      Lei Shi, Bin Yu, Chunhui Cai, Wei Huang, Bo-Jian Zheng, David K. Smith, Kwok-Yung Yuen, Jian-Dong Huang (2016) Combined prokaryotic-eukaryotic delivery and expression of therapeutic factors through a primed autocatalytic positive-feedback loop. Journal of Controlled Release V222 pp. 130 – 140

5.      Baozhong Zhang, YanHong Hua, Bin Yu, Candy ChoiYi Lau, JianPiao Cai, SongYue Zheng, WingCheong Yam, Richard Yi-Tsun Kao, Konghung Sze, Bo-Jian Zheng, Kwok-Yung Yuen and Jian-Dong Huang (2015) Recombinant ESAT-6-like proteins provoke protective immune responses against invasive Staphylococcus aureus disease in a murine model. Infection and Immunity V83(1):339-345

1.      HOST CELLS DEFICIENT FOR MISMATCH REPAIR AND THEIR USE IN METHODS FOR INDUCING HOMOLOGOUS RECOMBINATION USING SINGLE-STRANDED NUCLEIC ACIDS.

Filed on May 7, 2004 as US Application # 10/841,125

United States Patent Application 20050079618

Application Number: PCT/US03/14657

2.      METHOD FOR CONSTRUCTING AND MODIFYING LARGE DNA MOLECULES

Application No. 60/490,025 filed on July 24 2003

PCT Patent Application No. PCT/CN2004/000858

United States Patent Application 20050084970

U.S. Non-Provisional Application No. 10/892,579 filed on July 16, 2004.

Issued Patent No.: US 7,781,190 B2

Date of Patent: August 24, 2010

Inventors: Jian-Dong Huang, Xin-Mei Zhang, Julian Alexander Tanner

3.      SYNTHETIC PEPTIDE TARGETING CRITICAL SITES ON THE SARS-ASSOCIATED CORONAVIRUS SPIKE PROTEIN RESPONSIBLE FOR VIRAL INFECTION AND A METHOD OF USE THEREOF

O/R IP00170 U.S. Provisional Patent No. 60/630,334

Inventors: Zheng BJ, Guan Y, Huang JD, He ML

4.      HOST CELLS DEFICIENT FOR MISMATCH REPAIR  

Publication date: 2004-12-09 

Inventor(s): COURT DONALD L [US]; LI XIN-TIAN [CN]; HUANG JIAN-DONG [CN]; COSTANTINO NINA [US]; LIU DEPEI [CN] 

Applicant(s): US GOVERNMENT [US]; UNIV HONG KONG [CN]; CHINESE ACAD MED SCIENCE [CN]; COURT DONALD L [US]; LI XIN-TIAN [CN]; HUANG JIAN-DONG [CN]; COSTANTINO NINA [US]; LIU DEPEI [CN] 

Classification:  

- international: C12N1/19; C12N1/21; C12N15/10; C12N1/19; C12N1/21; C12N15/10; (IPC1-7): C12N15/00; C12N1/19; C12N1/20; C12N1/21; C12N5/10 

- European: C12N15/10B; C12R1/19 

Application number: WO2003US14657 20030509 

Priority number(s): WO2003US14657 20030509 

5.      TWO-WAY, PORTABLE RIBOSWITCH MEDIATED GENE EXPRESSION CONTROL DEVICE

U.S. Non-Provisional Application No. 61/503,453 filed on June 30, 2011.

U.S. Application No. 13/534,774 filed on June 27, 2012

U.S. Patent No. 9,222,093 B2

Date of Patent: Dec. 29, 2015

Chinese Patent: Patent Number: ZL201280032539.4; Date of patent: 4 July 2017

Inventor(s): Jian-Dong Huang and Ye Jin

6.      Modified Bacteria and their Uses thereof for the Treatment of Cancer

U.S. Provisional Application No. 61/687,975 filed on May 4, 2012.

U.S. Non-Provisional Patent Application filed on 26 April 2013, Application No. 13/871,716

Patent No.: US 9,127,284 B2, Date of Patent: Sept. 8, 2015

Inventor(s): Jian-Dong Huang, Bin Yu, Mei Yang, and Lei Shi

7.      Therapeutic Delivery and Expression System, Methods and Uses Thereof

U.S. Provisional Application No. 14/019,058 filed on September 5, 2013.

U.S. Application No. 14/019,058 filed on September 5, 2013

International application No. PCT/CN2014/000282, filed on March 17, 2014

Inventor(s): Jian-Dong Huang, Bin Yu, and Lei Shi

8.      IMMUNOTHERAPEUTIC TARGETS AGAINST STAPHYLOCOCCUS AUREUS

U.S. Provisional Application No. 62/093,752 filed on December 18, 2014.

PCT Application

Application number:       PCT/CN2015/097726

Application date:  17 December 2015

Inventor(s): Jian-Dong Huang, Kwok-Yung Yuen, Zhang Baozhong

1.Investigate the roles of intracellular transportation in development, cellular function and diseases

2.Use synthetic biology approach to investigate biological pattern/structure formation, to develop vaccines against infectious diseases, and to create novel cancer treatment

2006       Outstanding Young Researcher Award 2005-2006, the University of Hong Kong

2006       Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong

2007       Fellow of Salzburg Seminar

2011       Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong

2012       Faculty Outstanding Research Output Award, Li Ka Shing Faculty of Medicine, the University of Hong Kong

2012       Research Output Prize (Faculty of Dentistry), the University of Hong Kong

2013       Outstanding Research Student Supervisor Award 2011-2012, the University of Hong Kong

2014       SRT D & R Best Research Output Prize - 1st Prize, the University of Hong Kong

2016       Outstanding Researcher Award 2014-2015, the University of Hong Kong

2017       Awardee, Global Talent Scheme “521” Plan by Hangzhou City, HKU-ZIRI

2017       Awardee, Thousand Talent Plan by Zhejiang Province, HKU-ZIRI