基本信息

贾凡  男  博导  中国科学院深圳先进技术研究院
电子邮件: fan.jia@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码: 518055

研究领域

病毒载体技术及其工艺

招生信息

   
招生专业
071005-微生物学
071006-神经生物学
招生方向
脑图谱绘制病毒工具及其技术
细胞基因治疗/溶瘤/疫苗/抗病毒药物筛选的病毒载体、工艺及其技术

教育背景

2007-09--2010-07   中国科学院武汉病毒研究所   研究生/博士
2004-09--2007-07   华中农业大学   研究生/硕士
2000-09--2004-07   长江大学   本科/学士

工作经历

   
工作简历
2019-10~现在, 中国科学院深圳先进技术研究院, 副研究员
2012-12~2019-10,中国科学院武汉物理与数学研究所, 助理研究员/副研究员
2010-07~2012-12,中国科学院武汉病毒研究所, 助理研究员

专利与奖励

   
奖励信息
(1) 湖北省第十四届自然科学优秀学术论文, 三等奖, 省级, 2012
专利成果
[1] 贾凡, 徐富强. 一种新型G基因及其在高效逆向跨单突触中的应用. CN: CN112210565A, 2021-01-12.
[2] 贾凡, 徐富强. 一种重组腺相关病毒及其制备方法和在抗体检测的应用. CN: CN112143712A, 2020-12-29.

出版信息

   
发表论文
[1] Xiang-Wei Shi, Jia, Fan, Pei Lyu, Fu-Qiang Xu. A new anterograde trans-synaptic tracer based on Sindbis virus. Neural Regeneration Research[J]. 2022, [2] Xu, Huan, Liu, Bing, Xiao, Zhen, Zhou, Meiling, Ge, Lin, Jia, Fan, Liu, Yanling, Jin, Hongshan, Zhu, Xiuliang, Gao, Jian, Akhtar, Javed, Xiang, Bai, Tan, Ke, Wang, Guanyu. Computational and Experimental Studies Reveal That Thymoquinone Blocks the Entry of Coronaviruses Into In Vitro Cells. INFECTIOUS DISEASES AND THERAPY[J]. 2021, 10(1): 483-494, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853165/.
[3] Wang, Dejuan, Wang, Xiaojie, Liu, Penglai, Jing, Siqi, Du, Han, Zhang, Lingzhi, Jia, Fan, Li, Anan. Serotonergic afferents from the dorsal raphe decrease the excitability of pyramidal neurons in the anterior piriform cortex. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 117(6): 3239-3247, https://www.webofscience.com/wos/woscc/full-record/WOS:000513898000067.
[4] Zhou, Dengyuan, Li, Qiuyan, Jia, Fan, Zhang, Luping, Wan, Shengfeng, Li, Yunchuan, Song, Yunfeng, Chen, Huanchun, Cao, Shengbo, Ye, Jing. The Japanese Encephalitis Virus NS1' Protein Inhibits Type I IFN Production by Targeting MAVS. JOURNAL OF IMMUNOLOGY[J]. 2020, 204(5): 1287-1298, https://www.webofscience.com/wos/woscc/full-record/WOS:000514841600019.
[5] Liu, YunTao, Shivakoti, Sakar, Jia, Fan, Tao, ChangLu, Zhang, Bin, Xu, Fuqiang, Lau, Pakming, Bi, GuoQiang, Zhou, Z Hong. Biphasic exocytosis of herpesvirus from hippocampal neurons and mechanistic implication to membrane fusion. CELL DISCOVERY[J]. 2020, 6(1): http://dx.doi.org/10.1038/s41421-019-0134-6.
[6] Shen, Qi, Xiao, Goayu, Zheng, Yingwei, Wang, Jie, Liu, Yue, Zhu, Xutao, Jia, Fan, Su, Peng, Nie, Binbin, Xu, Fuqiang, Zhang, Bin. ARMBIS: accurate and robust matching of brain image sequences from multiple modal imaging techniques. BIOINFORMATICS[J]. 2019, 35(24): 5281-5289, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000509361200026.
[7] Hao Wang, Qingyuan Zhu, Lufeng Ding, Yan Shen, ChaoYu Yang, Fang Xu, Chang Shu, Yujie Guo, Zhiwei Xiong, Qinghong Shan, Fan Jia, Peng Su, QianRu Yang, Bing Li, Yuxiao Cheng, Xiaobin He, Xi Chen, Feng Wu, JiangNing Zhou, Fuqiang Xu, Hua Han, PakMing Lau, GuoQiang Bi. Scalable volumetric imaging for ultrahigh-speed brain mapping at synaptic resolution. National Science Review. 2019, 6(5): 982-992, [8] Jia, Fan, Lv, Pei, Miao, Huan, Shi, Xiangwei, Mei, Hongjun, Li, Li, Xu, Xiaoqin, Tao, Sijue, Xu, Fuqiang. Optimization of the Fluorescent Protein Expression Level Based on Pseudorabies Virus Bartha Strain for Neural Circuit Tracing. FRONTIERS IN NEUROANATOMY[J]. 2019, 13: https://doaj.org/article/ba25236662a54954af831e76b62b0529.
[9] Guo, Baolin, Chen, Jing, Chen, Qian, Ren, Keke, Feng, Dayun, Mao, Honghui, Yao, Han, Yang, Jing, Liu, Haiying, Liu, Yingying, Jia, Fan, Qi, Chuchu, LynnJones, Taylor, Hu, Hailan, Fu, Zhanyan, Feng, Guoping, Wang, Wenting, Wu, Shengxi. Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice. NATURE NEUROSCIENCE[J]. 2019, 22(8): 1223-+, [10] Yu, FeiLong, Miao, Huan, Xia, Jinjin, Jia, Fan, Wang, Huadong, Xu, Fuqiang, Guo, Lin. Proteomics Analysis Identifies IRSp53 and Fascin as Critical for PRV Egress and Direct Cell-Cell Transmission. PROTEOMICS[J]. 2019, 19(23): https://www.webofscience.com/wos/woscc/full-record/WOS:000500997200002.
[11] Fangxiao Xu, Lin Zhou, Ying Shen. Magneto is ineffective in controlling electrical properties of cerebellar Purkinje cells. IBRO Reports. 2019, 6: S394-S394, http://dx.doi.org/10.1016/j.ibror.2019.07.1251.
[12] Jia, Fan, Zhu, Xutao, Lv, Pei, Hu, Liang, Liu, Qing, Jin, Sen, Xu, Fuqiang. Rapid and Sparse Labeling of Neurons Based on the Mutant Virus-Like Particle of Semliki Forest Virus. NEUROSCIENCE BULLETIN[J]. 2019, 35(3): 378-388, http://lib.cqvip.com/Qikan/Article/Detail?id=7002279806.
[13] Zhou, Dengyuan, Jia, Fan, Li, Qiuyan, Zhang, Luping, Chen, Zheng, Zhao, Zikai, Cui, Min, Song, Yunfeng, Chen, Huanchun, Cao, Shengbo, Ye, Jing. Japanese Encephalitis Virus NS1 Protein Antagonizes Interferon Beta Production. VIROLOGICA SINICA[J]. 2018, 33(6): 515-523, http://lib.cqvip.com/Qikan/Article/Detail?id=90666888504849564854484855.
[14] Jia, Fan, Miao, Huan, Zhu, Xutao, Xu, Fuqiang. Pseudo-typed Semliki Forest virus delivers EGFP into neurons. JOURNAL OF NEUROVIROLOGY[J]. 2017, 23(2): 205-215, [15] Zhou, JiaHuan, Wang, XinTai, Zhou, Liang, Zhou, Lin, Xu, FangXiao, Su, LiDa, Wang, Hao, Jia, Fan, Xu, FuQiang, Chen, GuiQuan, De Zeeuw, Chris I, Shen, Ying. Ablation of TFR1 in Purkinje Cells Inhibits mGlu1 Trafficking and Impairs Motor Coordination, But Not Autistic-Like Behaviors. JOURNAL OF NEUROSCIENCE[J]. 2017, 37(47): 11335-11352, https://www.webofscience.com/wos/woscc/full-record/WOS:000416595200006.
[16] Jia, Fan, Zhu, Xutao, Xu, Fuqiang. A single adaptive point mutation in Japanese encephalitis virus capsid is sufficient to render the virus as a stable vector for gene delivery. VIROLOGY[J]. 2016, 490: 109-118, http://dx.doi.org/10.1016/j.virol.2016.01.001.
[17] 张志建, 靳森, 朱续涛, 贾凡, 王华东, 刘青, 何晓斌, 徐富强. 利用嗜神经病毒跨突触追踪神经网络研究进展. 生命科学[J]. 2014, 26(6): 634-, http://ir.wipm.ac.cn/handle/112942/18844, http://www.irgrid.ac.cn/handle/1471x/6858374, http://ir.wipm.ac.cn/handle/112942/18845.
[18] Jia Fan, Fan Jingjing, Zhang Bo, Yuan Zhiming. Mutagenesis of D80-82 and G83 Residues in West Nile Virus NS2B: Effects on NS2B-NS3 Activity and Viral Replication. 中国病毒学:英文版[J]. 2013, 16-23, http://lib.cqvip.com/Qikan/Article/Detail?id=44858760.
[19] Jia, Fan, Zou, Gang, Fan, Jingjing, Yuan, Zhiming. Identification of palmatine as an inhibitor of West Nile virus. ARCHIVES OF VIROLOGY[J]. 2010, 155(8): 1325-1329, http://www.corc.org.cn/handle/1471x/2375781.

科研活动

   
科研项目
( 1 ) 改造乙型脑炎病毒作为神经环路示踪工具的探索性研究, 主持, 国家级, 2015-01--2017-12
( 2 ) 神经回路示踪及其在感知觉等联结图谱研究中的应用, 参与, 部委级, 2012-07--2016-06
( 3 ) 伪狂犬病毒跨突触传输机制的研究, 参与, 国家级, 2014-01--2017-12
( 4 ) 灵长类动物脑细胞和神经回路的特异性光学标记, 参与, 国家级, 2015-01--2019-08
( 5 ) 情绪相关的皮层下通路--基于猕猴的研究, 参与, 国家级, 2014-01--2016-12
( 6 ) 单次感染性的乙型脑炎病毒VLP疫苗的研究, 主持, 省级, 2012-01--2013-12
( 7 ) 用于非人灵长类动物特定类型神经元的稀疏精细标记工具, 主持, 国家级, 2018-01--2019-12
( 8 ) 神经环路结构和功能兼顾的新型逆向示踪工具的建立及应用, 主持, 国家级, 2021-01--2024-12
( 9 ) 一种新型高效的逆向跨单级突触神经环路示踪工具, 主持, 省级, 2021-01--2023-12
( 10 ) 基于人工进化技术的高滴度病毒疫苗研究, 主持, 院级, 2020-07--2022-06
( 11 ) 病毒载体及其技术与工艺, 主持, 市地级, 2021-01--2022-12