基本信息
戴磊  男  博导  中国科学院深圳先进技术研究院
电子邮件: lei.dai@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码:

研究领域

实验室利用合成生物学的工具,对微生物组的结构和功能进行理性设计和精准调控,致力于解决人体健康、农业生产等重大问题。研究成果以第一作者或通讯作者发表在ScienceNaturePNASeLife等国际学术期刊。

教育背景

2009-09--2014-08   麻省理工学院   博士
2005-09--2009-06   中国科学技术大学   学士

工作经历

   
工作简历
2018-04~2023-06,中国科学院深圳先进技术研究院, 研究员
2015-01~2018-03,加州大学洛杉矶分校, 博士后

出版信息

   
发表论文
[1] Zheng, Linggang, Tan, Yang, Hu, Yucan, Shen, Juntao, Qu, Zepeng, Chen, Xianbo, Ho, Chun Loong, Leung, Elaine LaiHan, Zhao, Wei, Dai, Lei. CRISPR/Cas-Based Genome Editing for Human Gut Commensal Bacteroides Species. ACS SYNTHETIC BIOLOGY[J]. 2022, 11(1): 464-472, [2] Ying Wang, Jinhui Tang, Qingqing Lv, Yuxiang Tan, Xiaoxiao Dong, Hongbin Liu, Nannan Zhao, Zhen He, Yan Kou, Yan Tan, Xinan Liu, Liping Wang, YangYu Liu, Lei Dai. Establishment and resilience of transplanted gut microbiota in aged mice. iScience[J]. 2022, 25(1): [3] Deng, Yu, Huang, Yue, Che, You, Yang, Yu, Yin, Xiaole, Yan, Aixin, Dai, Lei, Liu, YangYu, Polz, Martin, Zhang, Tong. Microbiome assembly for sulfonamide subsistence and the transfer of genetic determinants. ISME JOURNAL[J]. 2021, 15(10): 2817-2829, http://dx.doi.org/10.1038/s41396-021-00969-z.
[4] Chen, MoXian, Mei, LongCan, Wang, Fan, Boyagane Dewayalage, Iromi Kusum Wijethunge, Yang, JingFang, Dai, Lei, Yang, GuangFu, Gao, Bei, Cheng, ChaoLin, Liu, YingGao, Zhang, Jianhua, Hao, GeFei. PlantSPEAD: a web resource towards comparatively analysing stress-responsive expression of splicing-related proteins in plant. PLANT BIOTECHNOLOGY JOURNALnull. 2021, 19(2): 227-229, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868970/.
[5] 陈沫先, 韦中, 田亮, 谭扬, 黄建东, 戴磊. 合成微生物群落的构建与应用. 科学通报. 2021, 66(3): 273-283, http://lib.cqvip.com/Qikan/Article/Detail?id=7104239786.
[6] Zhang, Jianzhi, Chen, Yongcan, Fu, Lihao, Guo, Erpeng, Wang, Bo, Dai, Lei, Si, Tong. Accelerating strain engineering in biofuel research via build and test automation of synthetic biology. CURRENT OPINION IN BIOTECHNOLOGYnull. 2021, 67: 88-98, http://dx.doi.org/10.1016/j.copbio.2021.01.010.
[7] TianHao Zhang, Lei Dai, John P Barton, Yushen Du, Yuxiang Tan, Wenwen Pang, Arup K Chakraborty, James O LloydSmith, Ren Sun. Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease. PLOS GENETICS[J]. 2020, 16(10): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605711/.
[8] Chen, MoXian, Zhang, KaiLu, Zhang, Min, Das, Debatosh, Fang, YanMing, Dai, Lei, Zhang, Jianhua, Zhu, FuYuan. Alternative splicing and its regulatory role in woody plants. TREE PHYSIOLOGYnull. 2020, 40(11): 1475-1486, https://www.webofscience.com/wos/woscc/full-record/WOS:000593296000001.
[9] Chen, MoXian, Zhang, KaiLu, Gao, Bei, Yang, JingFang, Tian, Yuan, Das, Debatosh, Fan, Tao, Dai, Lei, Hao, GeFei, Yang, GuangFu, Zhang, Jianhua, Zhu, FuYuan, Fang, YanMing. Phylogenetic comparison of 5 ' splice site determination in central spliceosomal proteins of the U1-70K gene family, in response to developmental cues and stress conditions. PLANT JOURNAL[J]. 2020, 103(1): 357-378, https://www.webofscience.com/wos/woscc/full-record/WOS:000528067500001.
[10] Tan, Yang, Shen, Juntao, Si, Tong, Ho, Chun Loong, Li, Yinqing, Dai, Lei. Engineered Live Biotherapeutics: Progress and Challenges. BIOTECHNOLOGY JOURNALnull. 2020, 15(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000568728800001.
[11] Yan Kou, Xiaomin Xu, Zhengnong Zhu, Lei Dai, Yan Tan. Microbe-set enrichment analysis facilitates functional interpretation of microbiome profiling data. SCIENTIFIC REPORTS[J]. 2020, 10(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722755/.
[12] Liu, Zhao, Hong, CanJian, Yang, Yongshuai, Dai, Lei, Ho, Chun Loong. Advances in Bacterial Biofilm Management for Maintaining Microbiome Homeostasis. BIOTECHNOLOGY JOURNALnull. 2020, 15(10): [13] 曲泽鹏, 陈沫先, 曹朝辉, 左文龙, 陈业, 戴磊. 合成微生物群落研究进展. 合成生物学. 2020, 1(6): 621-634, http://lib.cqvip.com/Qikan/Article/Detail?id=7103713713.
[14] Shenshen Wang, Lei Dai. Evolving generalists in switching rugged landscapes.. PLoS Computational Biology[J]. 2019, 15(10): https://doaj.org/article/bdb319c5d05446cdaf66e7f4fdc8523e.
[15] Chen, MoXian, Wijethunge, Boyagane D I K, Zhou, ShaoMing, Yang, JingFang, Dai, Lei, Wang, ShanShan, Chen, Chen, Fu, LiJun, Zhang, Jianhua, Hao, GeFei, Yang, GuangFu. Chemical Modulation of Alternative Splicing for Molecular-Target Identification by Potential Genetic Control in Agrochemical Research. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRYnull. 2019, 67(18): 5072-5084, [16] Du, Yushen, Xin, Li, Shi, Yuan, Zhang, TianHao, Wu, Nicholas C, Dai, Lei, Gong, Danyang, Brar, Gurpreet, Shu, Sara, Luo, Jiadi, Reiley, William, Tseng, YenWen, Bai, Hongyan, Wu, TingTing, Wang, Jieru, Shu, Yuelong, Sun, Ren. Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design. SCIENCE[J]. 2018, 359(6373): 290-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000423236700031.
[17] 戴磊. Effects of mutations on replicative fitness and MHC-I binding affinity are among the determinants underlying CTL escape of HIV-1 Gag Epitopes. mBio. 2017, [18] Rindi, Luca, Dal Bello, Martina, Dai, Lei, Gore, Jeff, BenedettiCecchi, Lisandro. Direct observation of increasing recovery length before collapse of a marine benthic ecosystem. NATURE ECOLOGY & EVOLUTION[J]. 2017, 1(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000417174700012.
[19] Ramaiah, Arunachalam, Dai, Lei, Contreras, Deisy, Sinha, Sanjeev, Sun, Ren, Arumugaswami, Vaithilingaraja. Comparative analysis of protein evolution in the genome of pre-epidemic and epidemic Zika virus. INFECTION GENETICS AND EVOLUTION[J]. 2017, 51: 74-85, http://dx.doi.org/10.1016/j.meegid.2017.03.012.
[20] Du, Yushen, Chi, Xiumei, Wang, Chong, Jiang, Jing, Kong, Fei, Yan, Hongqing, Wang, Xiaomei, Li, Jie, Wu, Nicholas C, Dai, Lei, Zhang, TianHao, Shu, Sara, Zhou, Jian, Yoshizawa, Janice M, Li, Xinmin, Bhattacharya, Debika, Wu, TingTing, Niu, Junqi, Sun, Ren. Quantifying perinatal transmission of Hepatitis B viral quasispecies by tag linkage deep sequencing. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/667238a36fb2463ba601b02dbbcc23d8.
[21] Wu, Nicholas C, Dai, Lei, Olson, C Anders, LloydSmith, James O, Sun, Ren. Adaptation in protein fitness landscapes is facilitated by indirect paths. ELIFE[J]. 2016, 5: https://doaj.org/article/5d42d0dd627a407dae1f05bedf456743.
[22] Dai, Lei, Korolev, Kirill S, Gore, Jeff. Relation between stability and resilience determines the performance of early warning signals under different environmental drivers. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2015, 112(32): 10056-10061, https://www.webofscience.com/wos/woscc/full-record/WOS:000359285100076.
[23] Chen, Andrew, Sanchez, Alvaro, Dai, Lei, Gore, Jeff. Dynamics of a producer-freeloader ecosystem on the brink of collapse. NATURE COMMUNICATIONS[J]. 2014, 5: 3713-3713, https://www.webofscience.com/wos/woscc/full-record/WOS:000337365100002.
[24] Dai, Lei, Korolev, Kirill S, Gore, Jeff. Slower recovery in space before collapse of connected populations. NATURE[J]. 2013, 496(7445): 355-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000317599200036.
[25] Dai, Lei, Vorselen, Daan, Korolev, Kirill S, Gore, Jeff. Generic Indicators for Loss of Resilience Before a Tipping Point Leading to Population Collapse. SCIENCE[J]. 2012, 336(6085): 1175-1177, https://www.webofscience.com/wos/woscc/full-record/WOS:000304647900054.