研究工作的主线是以神经/精神疾病放射诊断及基础研究为牵引，发展探测脑功能及其物质基础的磁共振成像/波谱新方法与新技术，同时开展应用研究：

1、面向脑功能与脑疾病研究的磁共振新方法、新技术

2、面向重大神经/精神疾病的转化型磁共振影像研究

3、网络成瘾/吸烟成瘾与脑神经可塑性改变

4、临床神经影像研究

招收博士研究生，硕士研究生

070302-分析化学
086000-生物与医药

生物医学影像
脑科学
分析化学

1995-01--1999-10 加拿大曼尼托巴大学 博士学位
1990-09--1994-06 重庆大学 学士学位

-- 研究生

-- 博士

1999年12至2000年12月，美国达特茅斯学院  博士后

2001年1月至2002年10月，供职于美国明尼苏达大学医学院磁共振中心 助理研究员

2002年10月至今，中国科学院武汉物理与数学研究所  研究员

2002-10--今 中国科学院武汉物理与数学研究所 研究员
2001-01--2002-10 美国明尼苏达大学 助理研究员
1999-11--2000-12 美国达特茅斯学院 博士后
1998-09--1999-04 加拿大温尼伯大学 助教
1995-01--1999-10 加拿大曼尼托巴大学 研究助理

   

（1） 吸烟成瘾及脑损伤机制与控烟策略的应用, 二等奖, 省级, 2018
（2） 2010年度湖北省科技进步二等奖, 二等奖, 省级, 2010
（3） 2008年度湖北省科技进步二等奖, 二等奖, 省级, 2008
（4） 2003年度湖北省科技进步二等奖, 二等奖, 省级, 2003

[1] 牛海晨, 马原野, 雷皓. D-环丝氨酸在制备治疗应激引发的吗啡心理依赖行为的药物中的应用. 中国: CN102579436A, 2012-07-18.

[2] 李昭, 李少蕊, 乔飞, 秦工, 雷皓. 大鼠双视觉线索训练检测实验装置. 中国: CN201733711U, 2011-02-09.

[3] 李昭, 李少蕊, 乔飞, 秦工, 雷皓. 大鼠双视觉线索训练检测实验系统. 中国: CN101828529A, 2010.09.15.

[4] 李昭, 李少蕊, 乔飞, 秦工, 雷皓. 大鼠强迫游泳实验装置. 中国: CN201564608U, 2010.09.01.

   

[1] Zhang, Xiaoqian, Chen, Wei, Wu, Yi, Zeng, Weiqi, Yuan, Yuhao, Cheng, Chi, Yang, Xiaoman, Wang, Jialing, Yang, Xiaomei, Xu, Yu, Lei, Hao, Cao, Xuebing, Xu, Yan. Histological Correlates of Neuroanatomical Changes in a Rat Model of Levodopa-Induced Dyskinesia Based on Voxel-Based Morphometry. FRONTIERS IN AGING NEUROSCIENCE[J]. 2021, 13: http://dx.doi.org/10.3389/fnagi.2021.759934.
[2] Song, Tao, Chen, Wei, Chen, Xi, Zhang, Hui, Zou, Yijuan, Wu, Hao, Lin, Fuchun, Ren, Liyi, Kang, Yan, Lei, Hao. Repeated fluoxetine treatment induces transient and long-term astrocytic plasticity in the medial prefrontal cortex of normal adult rats. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY[J]. 2021, 107: http://dx.doi.org/10.1016/j.pnpbp.2021.110252.
[3] 胡赢丹, 蔡悦, 王旭霞, 刘思婕, 康彦, 雷皓, 林富春. 尼古丁易感的脑结构特征的磁共振成像研究. 波谱学杂志[J]. 2021, 38(3): 345-355, http://lib.cqvip.com/Qikan/Article/Detail?id=7105477469.
[4] 辛红涛, 吴光耀, 文之, 雷皓, 林富春. 抗逆转录病毒治疗对艾滋病患者脑灰质体积的影响. 波谱学杂志[J]. 2021, 69-79, http://lib.cqvip.com/Qikan/Article/Detail?id=7104057171.
[5] Lin, Fuchun, Han, Xu, Wang, Yao, Ding, Weina, Sun, Yawen, Zhou, Yan, Lei, Hao. Sex-specific effects of cigarette smoking on caudate and amygdala volume and resting-state functional connectivity. BRAIN IMAGING AND BEHAVIOR[J]. 2021, 15(1): 1-13, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000505382200002.
[6] Song, Tao, Zhang, Hui, Chen, Xi, Zou, Yijuan, Chen, Wei, Lei, Hao. Repeated Fluoxetine Treatment Induces Transient Morphological Changes in the Medial Prefrontal Cortex of Adult Male Rats. BIOLOGICAL PSYCHIATRYnull. 2020, 87(9): S216-S217, http://dx.doi.org/10.1016/j.biopsych.2020.02.562.
[7] Li, Ronghui, Wang, Xuxia, Lin, Fuchun, Song, Tao, Zhu, Xutao, Lei, Hao. Mapping accumulative whole-brain activities during environmental enrichment with manganese-enhanced magnetic resonance imaging. NEUROIMAGE[J]. 2020, 210: http://dx.doi.org/10.1016/j.neuroimage.2020.116588.
[8] 陈炜, 雷和花, 宋涛, 张利民, 雷皓. 小鼠脑代谢物活体磁共振波谱分析及与离体样本磁共振波谱与质谱定量分析的比较研究. 分析化学[J]. 2019, 47(10): 1671-1679, [9] Lin, Fuchun, Wu, Guangyao, Zhu, Ling, Lei, Hao. Region-Specific Changes of Insular Cortical Thickness in Heavy Smokers. FRONTIERS IN HUMAN NEUROSCIENCE[J]. 2019, 13: https://doaj.org/article/02dae639caa8424c8107942d9fa311de.
[10] Chen Wei, Lei HeHua, Song Tao, Zhang LiMin, Lei Hao. Quantitative Analysis of Cerebral Metabolites in Mice by in Vivo H-1-MRS and Comparison of Detection Results of Tissue Extracts Obtained by H-1-NMR and UHPCL-MS/MS. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY[J]. 2019, 47(10): 1671-1679, http://ir.wipm.ac.cn/handle/112942/21447, http://www.irgrid.ac.cn/handle/1471x/6859276, http://ir.wipm.ac.cn/handle/112942/21448, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000489332700023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[11] Zou, Yijuan, Zhang, Hui, Chen, Xi, Ji, Wenliang, Mao, Lanqun, Lei, Hao. Age-dependent effects of (+)-MK801 treatment on glutamate release and metabolism in the rat medial prefrontal cortex. NEUROCHEMISTRY INTERNATIONAL[J]. 2019, 129: 104503-, http://dx.doi.org/10.1016/j.neuint.2019.104503.
[12] Song, Tao, Wu, Hao, Li, Ronghui, Xu, Hui, Rao, Xiaoping, Gao, Lifeng, Zou, Yijuan, Lei, Hao. Repeated fluoxetine treatment induces long-lasting neurotrophic changes in the medial prefrontal cortex of adult rats. BEHAVIOURAL BRAIN RESEARCH[J]. 2019, 365: 114-124, http://dx.doi.org/10.1016/j.bbr.2019.03.009.
[13] Wang, Kejun, Zha, Yunfei, Lei, Hao, Xu, Xiao. MRI Study on the Changes of Bone Marrow Microvascular Permeability and Fat Content after Total-Body X-Ray Irradiation. RADIATION RESEARCH[J]. 2018, 189(2): 205-212, http://202.127.146.157/handle/2RYDP1HH/4519.
[14] Lei Hao. Differences in Rat Prefrontal Cortex Measured with in Vivo 1H-MRS Correlate with Regional Histochemical Differences. NMR in Biomedicine. 2018, [15] Li, Yue, Zhang, Lei, Long, Kehong, Gong, Hui, Lei, Hao. Real-time monitoring prefrontal activities during online video game playing by functional near-infrared spectroscopy. JOURNAL OF BIOPHOTONICS[J]. 2018, 11(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000443944500002.
[16] Dai, JianKun, Wang, ShuXia, Shan, Dai, Niu, HaiChen, Lei, Hao. Super-Resolution Track-Density Imaging Reveals Fine Anatomical Features in Tree Shrew Primary Visual Cortex and Hippocampus. NEUROSCIENCE BULLETIN[J]. 2018, 34(3): 438-448, http://lib.cqvip.com/Qikan/Article/Detail?id=675416815.
[17] Zhou, YiFan, Li, PengCheng, Wu, JieHong, Haslam, James Andrew, Mao, Ling, Xia, YuanPeng, He, QuanWei, Wang, XuXia, Lei, Hao, Lan, XiaoLi, Miao, Qing Robert, Yue, ZhenYu, Li, YaNan, Hu, Bo. Sema3E/PlexinD1 inhibition is a therapeutic strategy for improving cerebral perfusion and restoring functional loss after stroke in aged rats. NEUROBIOLOGY OF AGING[J]. 2018, 70: 102-116, http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.003.
[18] Li, Shuang, Wang, Xinghua, Yang, Junjie, Lei, Hao, Wang, Xuxia, Xiang, Yi. Metabolic profile of visual cortex in diabetic rats measured with in vivo proton MRS. NMR IN BIOMEDICINE[J]. 2017, 30(11): http://dx.doi.org/10.1002/nbm.3783.
[19] Lei Hao. A diffusion tensor imaging atlas of white matter in tree shrew.. Brain Structure and Function. 2017, [20] Jin, Li, Gao, LiFeng, Sun, DongSheng, Wu, Hao, Wang, Qun, Ke, Dan, Lei, Hao, Wang, JianZhi, Liu, GongPing. Long-term Ameliorative Effects of the Antidepressant Fluoxetine Exposure on Cognitive Deficits in 3 x TgAD Mice. MOLECULAR NEUROBIOLOGY[J]. 2017, 54(6): 4160-4171, https://www.webofscience.com/wos/woscc/full-record/WOS:000405710900020.
[21] Sun DongSheng, Gao LiFeng, Jin Li, Wu Hao, Wang Qun, Zhou You, Fan Shuhao, Jiang Xia, Ke Dan, Lei Hao, Wang JianZhi, Liu GongPing. Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3×TgAD mice. Neuropharmacology[J]. 2017, 126: 200-212, http://dx.doi.org/10.1016/j.neuropharm.2017.08.037.
[22] Chai, Yuhui, Bi, Guoqiang, Wang, Liping, Xu, Fuqiang, Wu, Ruiqi, Zhou, Xin, Qiu, Bensheng, Lei, Hao, Zhang, Yaoyu, Gao, JiaHong. Direct detection of optogenetically evoked oscillatory neuronal electrical activity in rats using SLOE sequence. NEUROIMAGE[J]. 2016, 125: 533-543, http://dx.doi.org/10.1016/j.neuroimage.2015.10.058.
[23] Lei Hao. Long-term ameliorative effects of the antidepressant fluoxetine exposure on cognitive deficits in 3 × Tg AD mice. Mol Neurobiol. 2016, [24] Wu, H, Wang, X, Gao, Y, Lin, F, Song, T, Zou, Y, Xu, L, Lei, H. NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING. NEUROSCIENCE[J]. 2016, 322: 221-233, http://dx.doi.org/10.1016/j.neuroscience.2016.02.043.
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[26] Hui Zhang, Mingming Huang, Lifeng Gao, Hao Lei. Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study. Journal of Cerebral Blood Flow & Metabolism. 2015, 35(11): 1738-1745, [27] Zhen, Mingming, Shu, Chunying, Li, Jie, Zhang, Guoqiang, Wang, Taishan, Luo, Yi, Zou, Toujun, Deng, Ruijun, Fang, Fang, Lei, Hao, Wang, Chunru, Bai, Chunli. A highly efficient and tumor vascular-targeting therapeutic technique with size-expansible gadofullerene nanocrystals. SCIENCE CHINA-MATERIALS[J]. 2015, 58(10): 799-810, http://ir.wipm.ac.cn/handle/112942/20088, http://www.irgrid.ac.cn/handle/1471x/6858780, http://ir.wipm.ac.cn/handle/112942/20089.
[28] Lin, Fuchun, Zhou, Yan, Du, Yasong, Zhao, Zhimin, Qin, Lindi, Xu, Jianrong, Lei, Hao. Aberrant corticostriatal functional circuits in adolescents with Internet addiction disorder. FRONTIERS IN HUMAN NEUROSCIENCE[J]. 2015, 9: http://ir.wipm.ac.cn/handle/112942/4756.
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[31] Wang, Xuxia, Lin, Fuchun, Gao, Yunling, Lei, Hao. Bilateral common carotid artery occlusion induced brain lesions in rats: A longitudinal diffusion tensor imaging study. MAGNETIC RESONANCE IMAGING[J]. 2015, 33(5): 551-558, http://dx.doi.org/10.1016/j.mri.2015.02.010.
[32] Zhang, Hui, Huang, Mingming, Gao, Lifeng, Lei, Hao. Region-specific cerebral metabolic alterations in streptozotocin-induced type 1 diabetic rats: an in vivo proton magnetic resonance spectroscopy study. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM[J]. 2015, 35(11): 1738-1745, http://ir.wipm.ac.cn/handle/112942/9049.
[33] 潘永信. Targeted in vivo imaging of microscopic tumors with ferritin- based nanoprobes across biological barriers. Advanced Materials[J]. 2014, 26(16): 2566-2571, http://ir.iggcas.ac.cn/handle/132A11/7996.
[34] Leung, Arthur HoHon, Jin, Jiefu, Wang, Shuxia, Lei, Hao, Wong, WingTak. Inflammation Targeted Gd3+-Based MRI Contrast Agents Imaging Tumor and Rheumatoid Arthritis Models. BIOCONJUGATE CHEMISTRY[J]. 2014, 25(6): 1112-1123, http://ir.wipm.ac.cn/handle/112942/1278.
[35] Zhang, Run, Fa, Zhiqiang, Liu, Yi, Sun, Haitao, Li, Peng, Li, Shaorui, Wang, Xuxia, Lei, Hao, Jiang, Xiaodan. Dynamic MRI of rat brain following manganese administration through the internal carotid artery. NEUROLOGICAL RESEARCH[J]. 2014, 36(7): 679-686, http://ir.iphy.ac.cn/handle/311004/59397.
[36] Xiang, Mei, Wang, Lang, Guo, Sen, Lu, YanYun, Lei, Hao, Jiang, DingSheng, Zhang, Yan, Liu, Yi, Zhou, Yan, Zhang, XiaoDong, Li, Hongliang. Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury. JOURNAL OF NEUROCHEMISTRY[J]. 2014, 129(6): 988-1001, http://ir.wipm.ac.cn/handle/112942/1382.
[37] Lei Hao. Structural Brain Imaging and Internet Addiction. One chapter in Studies in Neurosci.. Psychol., Behavioral Economics (Internet Addiction). 2014, [38] Hou, Zhongyu, Zhang, Zhonghe, Meng, Haiwei, Lin, Xiangtao, Sun, Bo, Lei, Hao, Fang, Ke, Fang, Fang, Liu, Maili, Liu, Shuwei. Parkinson's disease: in vivo metabolic changes in the frontal and parietal cortices in 6-OHDA treated rats during different periods. INTERNATIONAL JOURNAL OF NEUROSCIENCE[J]. 2014, 124(2): 125-132, http://ir.wipm.ac.cn/handle/112942/1282.
[39] Xiao, Yan, Xue, Rong, You, Tianyan, Li, Xiaojing, Pei, Fengkui, Wang, Xuxia, Lei, Hao. Gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid conjugate of arabinogalactan as a potential liver-targeting magnetic resonance imaging contrast agent. CARBOHYDRATE RESEARCH[J]. 2014, 395(33): 9-14, http://dx.doi.org/10.1016/j.carres.2014.05.022.
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[42] Liqin Yang, Fuchun Lin, Yan Zhou, Jianrong Xu, Chunshui Yu, WenJu Pan, Hao Lei. Iterative Cross-Correlation Analysis of Resting State Functional Magnetic Resonance Imaging Data. PLOS ONE[J]. 2013, 8(3): http://ir.wipm.ac.cn/handle/112942/1010.
[43] Shi, Wei, Mei, Heng, Deng, Jun, Chen, Chen, Wang, Huafang, Guo, Tao, Zhang, Bo, Pang, Zhiqing, Jiang, Xinguo, Wang, Xuxia, Lei, Hao, Hu, Yu. The delivery of thrombi-specific nanoparticles incorporating oligonucleotides into injured cerebrovascular endothelium. BIOMATERIALS[J]. 2013, 34(16): 4128-4136, http://dx.doi.org/10.1016/j.biomaterials.2013.02.013.
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[45] Lei Hao. Magnetic/upconversion fuorescent NaGdF4:Yb, Er nanoparticle-based dual-modal molecular probes for imaging tiny tumors in vivo. ACS Nano. 2013, [46] Qin, YuanYuan, Li, MuWei, Zhang, Shun, Zhang, Yan, Zhao, LingYun, Lei, Hao, Oishi, Kenichi, Zhu, WenZhen. In vivo quantitative whole-brain diffusion tensor imaging analysis of APP/PS1 transgenic mice using voxel-based and atlas-based methods. NEURORADIOLOGY[J]. 2013, 55(8): 1027-1038, http://ir.wipm.ac.cn/handle/112942/934.
[47] Li, Shangxun, Sun, Yan, Shan, Dai, Feng, Bin, Xing, Jingjun, Duan, Yijie, Dai, Jiapei, Lei, Hao, Zhou, Yiwu. Temporal profiles of axonal injury following impact acceleration traumatic brain injury in rats-a comparative study with diffusion tensor imaging and morphological analysis. INTERNATIONAL JOURNAL OF LEGAL MEDICINE[J]. 2013, 127(1): 159-167, http://ir.wipm.ac.cn/handle/112942/1029.
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[57] Fuchun Lin, Yan Zhou, Yasong Du, Lindi Qin, Zhimin Zhao, Jianrong Xu, Hao Lei. Abnormal White Matter Integrity in Adolescents with Internet Addiction Disorder: A Tract-Based Spatial Statistics Study. PLOS ONE[J]. 2012, 7(1): http://ir.wipm.ac.cn/handle/112942/1596.
[58] 黄明明, 林富春, 高丽凤, 雷皓. 糖尿病脑病的磁共振研究. 波谱学杂志[J]. 2012, 29(3): 446-456, http://lib.cqvip.com/Qikan/Article/Detail?id=43089286.
[59] 林富春, 王旭霞, 赵前程, 雷皓. 小动物高分辨扩散磁共振成像数据分析方法. 生物化学与生物物理进展[J]. 2012, 39(6): 513-518, http://lib.cqvip.com/Qikan/Article/Detail?id=42213446.
[60] Niu, Haichen, Zheng, Yingwei, Rizak, Joshua D, Fan, Yaodong, Huang, Wei, Ma, Yuanye, Lei, Hao. The effects of lesion of the olfactory epithelium on morphine-induced sensitization and conditioned place preference in mice. BEHAVIOURAL BRAIN RESEARCH[J]. 2012, 233(1): 71-78, http://dx.doi.org/10.1016/j.bbr.2012.04.047.
[61] 杨时骐, 吴光耀, 林富春, 孔祥泉, 周国锋, 庞浩鹏, 朱凌, 刘国兵, 雷皓. 重度吸烟依赖者脑局部一致性静息态功能MRI研究. 中华放射学杂志[J]. 2012, 46(3): 215-219, http://lib.cqvip.com/Qikan/Article/Detail?id=41386805.
[62] Tang, Meng, Zhang, Ting, Xue, Yuying, Wang, Shu, Huang, Mingming, Yang, Yang, Lu, Minyu, Lei, Hao, Kong, Lu, Wang, Yiqing, Pu, Yuepu. Metabonomic Studies of Biochemical Changes in the Serum of Rats by Intratracheally Instilled TiO2 Nanoparticles. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY[J]. 2011, 11(4): 3065-3074, http://ir.wipm.ac.cn/handle/112942/8208.
[63] Han, Liang, Li, Jianfeng, Huang, Shixian, Huang, Rongqin, Liu, Shuhuan, Hu, Xing, Yi, Peiwei, Shan, Dai, Wang, Xuxia, Lei, Hao, Jiang, Chen. Peptide-conjugated polyamidoamine dendrimer as a nanoscale tumor-targeted T1 magnetic resonance imaging contrast agent. BIOMATERIALS[J]. 2011, 32(11): 2989-2998, http://dx.doi.org/10.1016/j.biomaterials.2011.01.005.
[64] Kailiang Hu, Yuguang Meng, Hao Lei, Shuyi Zhang. Differential changes of regional cerebral blood flow in two bat species during induced hypothermia measured by perfusion-weighted magnetic resonance imaging. Journal of Comparative Physiology B,. 2011, 181(1): [65] Zhou, Yan, Lin, Fuchun, Du, Yasong, Qin, Lingdi, Zhao, Zhimin, Xu, Jianrong, Lei, Hao. Gray matter abnormalities in Internet addiction: A voxel-based morphometry study. EUROPEAN JOURNAL OF RADIOLOGY[J]. 2011, 79(1): 92-95, http://dx.doi.org/10.1016/j.ejrad.2009.10.025.
[66] Lin F, Yu C, Liu Y, Li K, Lei H. Diffusion tensor group tractography of the corpus callosum in clinically isolated syndrome.. AJNR. American journal of neuroradiology. 2011, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD615A0866A31370F3D6BA5FDCE05000C4&DbName=SJPD_06&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[67] 唐惠儒, 陈芬儿, 邓风, 陈文学, 楼海燕, 张红萍, 聂秀, 蓝文贤, 杨永霞, 向赟, 漆剑频, 雷皓. 用高分辨魔角旋转核磁共振氢谱技术结合模式识别方法对人类神经上皮肿瘤进行分级. 中国科学：生命科学[J]. 2011, 41(7): 532-543, http://lib.cqvip.com/Qikan/Article/Detail?id=38618417.
[68] Hu, Kailiang, Meng, Yuguang, Lei, Hao, Zhang, Shuyi. Differential changes of regional cerebral blood flow in two bat species during induced hypothermia measured by perfusion-weighted magnetic resonance imaging. JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY[J]. 2011, 181(1): 117-123, http://www.irgrid.ac.cn/handle/1471x/960299.
[69] CHEN WenXue, LOU HaiYan, ZHANG HongPing, NIE Xiu, LAN WenXian, YANG YongXia, XIANG Yun, QI JianPin, LEI Hao, TANG HuiRu, CHEN FenEr, DENG Feng. Grade classification of neuroepithelial tumors using highresolution magic-angle spinning proton nuclear magnetic resonance spectroscopy and pattern recognition. 中国科学：生命科学英文版. 2011, 54(7): 606-616, http://lib.cqvip.com/Qikan/Article/Detail?id=38455049.
[70] Huang, Rongqin, Han, Liang, Li, Jianfeng, Liu, Shuhuan, Shao, Kun, Kuang, Yuyang, Hu, Xing, Wang, Xuxia, Lei, Hao, Jiang, Chen. Chlorotoxin-modified macromolecular contrast agent for MRI tumor diagnosis. BIOMATERIALS[J]. 2011, 32(22): 5177-5186, http://dx.doi.org/10.1016/j.biomaterials.2011.03.075.
[71] Yan, Huihui, Wang, Jiyao, Yi, Peiwei, Lei, Hao, Zhan, Changyou, Xie, Cao, Feng, Linglin, Qian, Jun, Zhu, Jianhua, Lu, Weiyue, Li, Cong. Imaging brain tumor by dendrimer-based optical/paramagnetic nanoprobe across the blood-brain barrier. CHEMICAL COMMUNICATIONS[J]. 2011, 47(28): 8130-8132, http://www.irgrid.ac.cn/handle/1471x/960354.
[72] Lin, Fuchun, Weng, Shenhong, Xie, Baojun, Wu, Guangyao, Lei, Hao. Abnormal frontal cortex white matter connections in bipolar disorder: A DTI tractography study. JOURNAL OF AFFECTIVE DISORDERS[J]. 2011, 131(1-3): 299-306, http://www.irgrid.ac.cn/handle/1471x/960249.
[73] 方芳, 雷皓. 活体质子磁共振波谱观察戊四氮慢性致癫痫大鼠海马损伤. 中国医学影像技术[J]. 2010, 1430-1433, http://lib.cqvip.com/Qikan/Article/Detail?id=35235382.
[74] 杨丽琴, 林富春, 雷皓. 静息状态下脑功能连接的磁共振成像研究. 波谱学杂志[J]. 2010, 27(3): 326-340, http://lib.cqvip.com/Qikan/Article/Detail?id=35181859.
[75] Meng, Yuguang, Lei, Hao. An Efficient Gridding Reconstruction Method for Multishot Non-Cartesian Imaging With Correction of Off-Resonance Artifacts. MAGNETIC RESONANCE IN MEDICINE[J]. 2010, 63(6): 1691-1697, http://www.irgrid.ac.cn/handle/1471x/960418.
[76] Xu, Wei, Zhan, Yanqiang, Huang, Wei, Wang, Xuxia, Zhang, Sumin, Lei, Hao. Reduction of Hippocampal N-Acetyl Aspartate Level in Aged APP(Swe)/PS1(dE9) Transgenic Mice Is Associated With Degeneration of CA3 Pyramidal Neurons. JOURNAL OF NEUROSCIENCE RESEARCH[J]. 2010, 88(14): 3155-3160, http://www.irgrid.ac.cn/handle/1471x/960538.
[77] 杨丽琴, 林富春, 雷皓. Resting State Functional Connectivity in Brain Studied by fMRI Approach. 波谱学杂志[J]. 2010, 27(3): 326-340, http://ir.wipm.ac.cn/handle/112942/2127.
[78] 方芳, 雷皓. In vivo 1H magnetic resonance spectroscopic observation of hippocampal injury subjected to chronic administration of pentylenetetrazol in rats. 中国医学影像技术[J]. 2010, 26(8): 1430-1433, http://ir.wipm.ac.cn/handle/112942/2123.
[79] 雷皓. 静息状态下脑功能连接的磁共振成像研究杨. 波谱学杂志. 2010, [80] Fang, Fang, Lei, Hao. Increased hippocampal T-2 in a rat model of pentylenetetrazol-induced kindling correlates with seizure scores. JOURNAL OF THE NEUROLOGICAL SCIENCES[J]. 2010, 292(1-2): 16-23, http://dx.doi.org/10.1016/j.jns.2010.02.014.
[81] Tang, Meng, Zhang, Ting, Xue, Yuying, Wang, Shu, Huang, Mingming, Yang, Yang, Lu, Minyu, Lei, Hao, Kong, Lu, Pu Yuepu. Dose Dependent In Vivo Metabolic Characteristics of Titanium Dioxide Nanoparticles. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY[J]. 2010, 10(12): 8575-8583, http://www.irgrid.ac.cn/handle/1471x/960557.
[82] Hou, Zhongyu, Lei, Hao, Hong, Shuhui, Sun, Bo, Fang, Ke, Lin, Xiangtao, Liu, Maili, Yew, David T W, Liu, Shuwei. Functional changes in the frontal cortex in Parkinson's disease using a rat model. JOURNAL OF CLINICAL NEUROSCIENCE[J]. 2010, 17(5): 628-633, http://dx.doi.org/10.1016/j.jocn.2009.07.101.
[83] Meng, Huan, Xing, Gengmei, Sun, Baoyun, Zhao, Feng, Lei, Hao, Li, Wei, Song, Yan, Chen, Zhen, Yuan, Hui, Wang, Xuxia, Long, Jing, Chen, Chunying, Liang, Xingjie, Zhang, Ning, Chai, Zhifang, Zhao, Yuliang. Potent Angiogenesis Inhibition by the Particulate Form of Fullerene Derivatives. ACS NANO[J]. 2010, 4(5): 2773-2783, http://ir.ihep.ac.cn/handle/311005/239820.
[84] 刘华, 廖维靖, 魏黎, 雷皓. 灯盏细辛对脑缺血再灌注后血脑屏障通透性及脑代谢物质的影响. 中国中药杂志[J]. 2009, 208-211, http://lib.cqvip.com/Qikan/Article/Detail?id=1000644334.
[85] 高丽凤, 黄明明, 雷皓. 糖尿病大鼠视神经病变方向性扩散加权MRI表现. 波谱学杂志[J]. 2009, 26(4): 485-491, http://lib.cqvip.com/Qikan/Article/Detail?id=32364087.
[86] 陈淮菁, 易黎, 张海鸥, 雷皓, 魏黎. 磁共振质子波谱研究大鼠急性脑梗死后VEGF介导的脑保护作用. 华中科技大学学报：医学版[J]. 2009, 38(4): 515-519, http://lib.cqvip.com/Qikan/Article/Detail?id=31836553.
[87] 蒙宇光, 胡开良, 雷皓. 蝙蝠脑血流的磁共振脑灌注成像测量. 中国医学影像技术[J]. 2009, 571-573, http://lib.cqvip.com/Qikan/Article/Detail?id=30128874.
[88] 王姝, 唐萌, 张婷, 黄明明, 雷皓, 杨扬, 陆敏玉, 孔璐, 薛玉英. 大鼠气管内注入纳米二氧化钛后的血浆代谢组学研究. 中华预防医学杂志[J]. 2009, 43(5): 399-403, http://lib.cqvip.com/Qikan/Article/Detail?id=30368409.
[89] 李春霞, 王亚强, 潘文举, 向赟, 雷皓. 长期慢性强迫游泳应激抑郁模型大鼠前额叶脑代谢物的^1HNMR研究. 武汉大学学报：理学版[J]. 2008, 54(4): 451-456, http://lib.cqvip.com/Qikan/Article/Detail?id=28033705.
[90] 吴光耀, 雷皓. CT检查辐射风险的研究进展. 临床放射学杂志[J]. 2008, 27(7): 978-980, http://lib.cqvip.com/Qikan/Article/Detail?id=27827251.
[91] WEN-ZHEN ZHU, XIANG LI, JIAN-PIN QI, ZHOU-PING TANG, WEI WANG, LI WEI, AND HAO LEI. Experimental Study of Cell Migration and Functional Differentiation of Transplanted Neural Stem Cells Co-labeled with Superparamagnetic Iron Oxide and Brdu in an Ischemic Rat Model. 生物医学与环境科学：英文版. 2008, 21(5): 420-424, http://lib.cqvip.com/Qikan/Article/Detail?id=28889249.
[92] 周滟, 陶静, 林富春, 朱炯, 钱黎俊, 路青, 李磊, 戈欣, 许建荣, 雷皓. 无痴呆的血管性认知损害全脑DTI直方图分析. 放射学实践. 2008, 23(3): 254-257, http://lib.cqvip.com/Qikan/Article/Detail?id=26858449.
[93] 潘文举, 吴光耀, 李春霞, 林富春, 孙骏谟, 雷皓. 早期盲人大脑灰质不对称的基于体素脑形态学初步研究. 中国医学影像技术[J]. 2008, 24(3): 333-335, http://lib.cqvip.com/Qikan/Article/Detail?id=26937146.
[94] 陈文学, 楼海燕, 张红萍, 聂秀, 向云, 杨永霞, 吴光耀, 漆剑频, 岳勇, 雷皓, 唐惠儒, 邓风. 高分辨魔角旋转核磁共振和主成分分析研究人类低级星形细胞瘤和脑膜瘤的代谢组特征. 生物化学与生物物理进展. 2008, 35(10): 1142-1153, http://lib.cqvip.com/Qikan/Article/Detail?id=28567074.
[95] Zhou, Yan, Lin, Fuchun, Zhu, Jiong, Zhuang, Zhiguo, Li, Yansheng, Tao, Jing, Qian, Lijun, Xu, Hanrong, Lei, Hao. Whole brain diffusion tensor imaging histogram analysis in vascular cognitive impairment. JOURNAL OF THE NEUROLOGICAL SCIENCES[J]. 2008, 268(1-2): 60-64, http://dx.doi.org/10.1016/j.jns.2007.11.005.
[96] Meng, Yuguang, Lei, Hao. A Single-Scan T-2* Mapping Method Based on Two Gradient-Echo Images with Compensation for Macroscopic Field Inhomogeneity. MAGNETIC RESONANCE IN MEDICINE[J]. 2008, 60(6): 1388-1395, http://ir.wipm.ac.cn/handle/112942/8065.
[97] Chen WenXue, Lou HaiYan, Zhang HongPing, Nie Xiu, Xiang Yun, Yang YongXia, Wu GuangYao, Qi JianPin, Yue Yong, Lei Hao, Tang HuiRu, Deng Feng. Metabonomic Characterization of The Low-grade Human Astrocytomas and Meningiomas Using Magic-angle Spinning H-1 Nuclear Magnetic Resonance Spectroscopy and Principal Component Analysis. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2008, 35(10): 1142-1153, http://ir.wipm.ac.cn/handle/112942/8107.
[98] Chen Wenxue, Lou Haiyan, Zhang Hongping, Nie Xiu, Xiang Yun, Yang Yongxia, Qi Jianpin, Lei Hao, Tang Huiru, Deng Feng, Yue Yong, Wu Guangyao. metabonomiccharacterizationofthelowgradehumanastrocytomasandmeningiomasusingmagicanglespinning1hnuclearmagneticresonancespectroscopyandprincipalcomponentanalysis. 生物化学与生物物理进展[J]. 2008, 35(10): 1142-, http://ir.wipm.ac.cn/handle/112942/20859, http://www.irgrid.ac.cn/handle/1471x/6859037, http://ir.wipm.ac.cn/handle/112942/20860.
[99] Liu, Huilang, Fang, Fang, Zhu, Hang, Xia, Shengan, Han, Dan, Hu, Ling, Lei, Hao, Liu, Maili. Metabolic changes in temporal lobe structures measured by HR-MAS NMR at early stage of electrogenic rat epilepsy. EXPERIMENTAL NEUROLOGY[J]. 2008, 212(2): 377-385, http://dx.doi.org/10.1016/j.expneurol.2008.04.013.
[100] 吴光耀, 雷皓. 胸廓入口食管恶性纤维组织细胞瘤一例. 中华放射学杂志[J]. 2008, 42(5): 535-, http://lib.cqvip.com/Qikan/Article/Detail?id=27228185.

   

（ 1 ） 基于磁共振的脑网络研究, 参与, 国家级, 2011-01--2015-08
（ 2 ） 9.4T 超高场代谢成像磁共振系统研制--控制系统, 主持, 国家级, 2011-01--2018-12
（ 3 ） 生物核磁共振波谱学, 参与, 部委级, 2010-01--2012-12
（ 4 ） 急性诱发痛与慢性神经病理性痛的神经机制比较－锰离子增强磁共振成像研究, 主持, 国家级, 2009-01--2011-12
（ 5 ） 丰富环境抑止吗啡依赖行为的神经机制-动物模型, 主持, 国家级, 2012-01--2015-12
（ 6 ） 基于磁共振的脑网络研究, 参与, 国家级, 2011-01--2015-12
（ 7 ） 超高分辨率PET的开发和应用-高场磁场兼容的PET探测器部件研制, 参与, 国家级, 2013-10--2017-09
（ 8 ） 帕金森综合症重要生理活性分子的成像分析, 主持, 国家级, 2018-01--2021-02

已指导学生

方芳  博士研究生  070208-无线电物理  

魏黎  博士研究生  070208-无线电物理  

李英霞  博士研究生  070208-无线电物理  

潘文举  博士研究生  070208-无线电物理  

吴杞柱  博士研究生  070208-无线电物理  

杜小霞  博士研究生  070208-无线电物理  

向赟  博士研究生  070208-无线电物理  

高红昌  博士研究生  070208-无线电物理  

王旭霞  博士研究生  070208-无线电物理  

吴光耀  博士研究生  070208-无线电物理  

何睿  博士研究生  070208-无线电物理  

李春霞  博士研究生  070208-无线电物理  

王亚强  硕士研究生  070208-无线电物理  

钱俊超  硕士研究生  070208-无线电物理  

蒙宇光  博士研究生  070208-无线电物理  

高丽凤  硕士研究生  070208-无线电物理  

秦元  硕士研究生  070208-无线电物理  

徐威  硕士研究生  070208-无线电物理  

黄明明  博士研究生  070302-分析化学  

牛海晨  博士研究生  070208-无线电物理  

高丽凤  博士研究生  070208-无线电物理  

李少蕊  硕士研究生  070208-无线电物理  

林婷竹  硕士研究生  070208-无线电物理  

李昭  硕士研究生  070208-无线电物理  

黄微  硕士研究生  070302-分析化学  

杨丽琴  博士研究生  070208-无线电物理  

山黛  硕士研究生  070302-分析化学  

王书霞  硕士研究生  070302-分析化学  

曹子钰  硕士研究生  085238-生物工程  

代建昆  博士研究生  070208-无线电物理  

方文恒  博士研究生  070302-分析化学  

张慧  博士研究生  070302-分析化学  

现指导学生

徐慧  博士研究生  070302-分析化学  

陈炜  博士研究生  070302-分析化学  

龙克鸿  博士研究生  070302-分析化学  

刘思婕  硕士研究生  070302-分析化学  

陈茜  博士研究生  070302-分析化学  

张绪柘  博士研究生  070302-分析化学