环境毒理和环境健康代谢组学研究

   

070302-分析化学

代谢组学

2005-09--2008-06   中国科学院水生生物研究所   博士研究生博士学位
2002-09--2005-06   中南民族大学   研究生硕士学位
1997-09--2001-06   中南民族大学   本科学士学位

   

2014-10~现在, 中国科学院武汉物理与数学研究所, 副研究员
2011-05~2014-09,中国科学院武汉物理与数学研究所, 助理研究员
2008-07~2011-04,中国科学院武汉物理与数学研究所, 博士后

   

[1] Su, Henghai, Yuan, Peihong, Lei, Hehua, Zhang, Li, Deng, Dazhi, Zhang, Limin, Chen, Xiaoyu. Long-term chronic exposure to di-(2-ethylhexyl)-phthalate induces obesity via disruption of host lipid metabolism and gut microbiota in mice. CHEMOSPHERE[J]. 2022, 287: http://dx.doi.org/10.1016/j.chemosphere.2021.132414.
[2] Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, HooiLeng Ser, Xuehang Zhu, Fang Wu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Chuan Chen, Kexin Hu, Yifan Zhu, Xinan Zeng, Jinlin Zhou, Yujing Lu, Andrew D Patterson, Limin Zhang, Robert G Beiko. Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice. MSYSTEMS[J]. 2021, 6(1): http://dx.doi.org/10.1128/mSystems.00985-20.
[3] Lei, Hehua, Song, Yuchen, Dong, Manyuan, Chen, Gui, Cao, Zheng, Wu, Fang, Chen, Chuan, Zhang, Ce, Liu, Caixiang, Shi, Zunji, Zhang, Limin. Metabolomics safety assessments of microcystin exposure via drinking water in rats. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2021, 212: http://dx.doi.org/10.1016/j.ecoenv.2021.111989.
[4] Shi, Zunji, Chen, Gui, Cao, Zheng, Wu, Fang, Lei, Hehua, Chen, Chuan, Song, Yuchen, Liu, Caixiang, Li, Jinquan, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Gut Microbiota and Its Metabolite Deoxycholic Acid Contribute to Sucralose Consumption-Induced Nonalcoholic Fatty Liver Disease. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2021, 69(13): 3982-3991, https://www.webofscience.com/wos/woscc/full-record/WOS:000639018000019.
[5] Wu, Fang, Lei, Hehua, Chen, Gui, Chen, Chuan, Song, Yuchen, Cao, Zheng, Zhang, Ce, Zhang, Cui, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. In Vitro and In Vivo Studies Reveal that Hesperetin-7-O-glucoside, a Naturally Occurring Monoglucoside, Exhibits Strong Anti-inflammatory Capacity. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2021, 69(43): 12753-12762, [6] Chen, Gui, Cao, Zheng, Shi, Zunji, Lei, Hehua, Chen, Chuan, Yuan, Peihong, Wu, Fang, Liu, Caixiang, Dong, Manyuan, Song, Yuchen, Zhou, Jinlin, Lu, Yujing, Zhang, Limin. Microbiome analysis combined with targeted metabolomics reveal immunological anti-tumor activity of icariside I in a melanoma mouse model. BIOMEDICINE & PHARMACOTHERAPY[J]. 2021, 140: http://dx.doi.org/10.1016/j.biopha.2021.111542.
[7] Yuan, Peihong, Dong, Manyuan, Lei, Hehua, Xu, Guangyong, Chen, Gui, Song, Yuchen, Ma, Jianfeng, Cheng, Liming, Zhang, Limin. Targeted metabolomics reveals that 2,3,7,8-tetrachlorodibenzofuran exposure induces hepatic steatosis in male mice. ENVIRONMENTAL POLLUTION[J]. 2020, 259: http://dx.doi.org/10.1016/j.envpol.2019.113820.
[8] Dong, Manyuan, Yuan, Peihong, Song, Yuchen, Lei, Hehua, Chen, Gui, Zhu, Xuehang, Wu, Fang, Chen, Chuan, Liu, Caixiang, Shi, Zunji, Zhang, Limin. In vitro effects of Triclocarban on adipogenesis in murine preadipocyte and human hepatocyte. JOURNAL OF HAZARDOUS MATERIALS[J]. 2020, 399: http://dx.doi.org/10.1016/j.jhazmat.2020.122829.
[9] 郭阳阳, 雷和花, 王玉兰. 亚甲基丁二酸在雄性C57BL/6J小鼠体内半数致死量和半衰期的测定. 上海交通大学学报(医学版)[J]. 2020, 40(11): 1473-1476, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzMw4l1HSOJoTa6GJaEm_ulFfIE3ao4VCAmfzHBFS3I8-&uniplatform=NZKPT.
[10] 张利民, Fang Wu, Zunji Shi, Hehua Lei, Gui Chen, Peihong Yuan, Zheng Cao, Chuan Chen, Xuehang Zhu, Caixiang Liu, Manyuan Dong, Yuchen Song, Yangyang Guo, Jinlin Zhou, Yujing Lu, and Limin Zhang. Short-Term Intake of Hesperetin-7‑O‑Glucoside Affects Fecal Microbiota and Host Metabolic Homeostasis in Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2020, 69: 1478-1486, [11] Dong, Manyuan, Xu, Xiaoyi, Huang, Qingxia, Lei, Hehua, Xu, Guangyong, Ma, Jianfeng, Hatzakis, Emmanuel, Wang, Xian, Zhang, Limin. Dose-Dependent Effects of Triclocarban Exposure on Lipid Homeostasis in Rats. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2019, 32(11): 2320-2328, https://www.webofscience.com/wos/woscc/full-record/WOS:000498282300016.
[12] 陈炜, 雷和花, 宋涛, 张利民, 雷皓. 小鼠脑代谢物活体磁共振波谱分析及与离体样本磁共振波谱与质谱定量分析的比较研究. 分析化学[J]. 2019, 47(10): 1671-1679, [13] 黄庆霞, 雷和花, 唐惠儒, 王玉兰. 基于超高效液相色谱-质谱联用技术的神经酰胺定量分析. 上海交通大学学报(医学版)[J]. 2019, 39(12): 1353-1359, http://lib.cqvip.com/Qikan/Article/Detail?id=7100826127.
[14] Huang, Qingxia, Lei, Hehua, Dong, Manyuan, Tang, Huiru, Wang, Yulan. Quantitative analysis of 10 classes of phospholipids by ultrahigh-performance liquid chromatography tandem triple-quadrupole mass spectrometry. ANALYST[J]. 2019, 144(13): 3980-3987, [15] Liu, Caixiang, Chen, Fangfang, Zhang, Jingtao, Liu, Laixing, Lei, Hehua, Li, Heping, Wang, Yulan, Liao, YuCai, Tang, Huiru. Metabolic Changes of Fusarium graminearum Induced by TPS Gene Deletion. JOURNAL OF PROTEOME RESEARCH[J]. 2019, 18(9): 3317-3327, [16] Huang, Qingxia, Lei, Hehua, Ding, Laifeng, Wang, Yulan. Stimulated phospholipid synthesis is key for hepatitis B virus replications. SCIENTIFIC REPORTS[J]. 2019, 9(1): http://dx.doi.org/10.1038/s41598-019-49367-8.
[17] Chen, Fangfang, Liu, Caixiang, Zhang, Jingtao, Lei, Hehua, Li, HePing, Liao, YuCai, Tang, Huiru. Combined Metabonomic and Quantitative RT-PCR Analyses Revealed Metabolic Reprogramming Associated with Fusarium graminearum Resistance in Transgenic Arabidopsis thaliana. FRONTIERS IN PLANT SCIENCE[J]. 2018, 8: http://202.127.146.157/handle/2RYDP1HH/3372.
[18] Wang, Qi, Zeng, Shaohua, Wu, Xiangyu, Lei, Hehua, Wang, Ying, Tang, Huiru. Interspecies Developmental Differences in Metabonomic Phenotypes of Lycium ruthenicum and L-barbarum Fruits. JOURNAL OF PROTEOME RESEARCH[J]. 2018, 17(9): 3223-3236, https://www.webofscience.com/wos/woscc/full-record/WOS:000444364700025.
[19] Jin Wang, Lihong Zhou, Hehua Lei, Fuhua Hao, Xin Liu, Yulan Wang, Huiru Tang. Simultaneous Quantification of Amino Metabolites in Multiple Metabolic Pathways Using Ultra-High Performance Liquid Chromatography with Tandemmass Spectrometry. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/e67b50712e324c568660366d51ee3e68.
[20] Liu, Caixiang, Du, Ba, Hao, Fuhua, Lei, Hehua, Wan, Qianfen, He, Guangcun, Wang, Yulan, Tang, Huiru. Dynamic metabolic responses of brown planthoppers towards susceptible and resistant rice plants. PLANT BIOTECHNOLOGY JOURNAL[J]. 2017, 15(10): 1346-1357, http://dx.doi.org/10.1111/pbi.12721.
[21] Liu, Caixiang, Ding, Feng, Hao, Fuhua, Yu, Men, Lei, Hehua, Wu, Xiangyu, Zhao, Zhengxi, Guo, Hongxiang, Yin, Jun, Wang, Yulan, Tang, Huiru. Reprogramming of Seed Metabolism Facilitates Pre-harvest Sprouting Resistance of Wheat. SCIENTIFIC REPORTS[J]. 2016, 6: http://ir.wipm.ac.cn/handle/112942/9189.
[22] Wu, Junfang, Fu, Bin, Lei, Hehua, Tang, Huiru, Wang, Yulan. GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE. NEUROSCIENCE[J]. 2016, 332: 160-169, http://dx.doi.org/10.1016/j.neuroscience.2016.06.049.

   

（ 1 ） 微囊藻毒素低剂量暴露影响大鼠代谢组变化的核磁共振研究, 主持, 国家级, 2013-01--2015-12